| Regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+ T cells. | Regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+ T cells.
Hiramatsu S, Watanabe KS, Zeggar S, Asano Y, Miyawaki Y, Yamamura Y, Katsuyama E, Katsuyama T, Watanabe H, Takano-Narazaki M, Matsumoto Y, Kawabata T, Sada KE, Wada J., Free PMC Article | 09/26/2020 |
| Cathepsin-E deficient animals were highly resistant to (MOG35-55) induced mechanical allodynia. | Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis.
Harada Y, Zhang J, Imari K, Yamasaki R, Ni J, Wu Z, Yamamoto K, Kira JI, Nakanishi H, Hayashi Y., Free PMC Article | 08/1/2020 |
| Infact, decreased CtsE expression levels in BMDM of V30Mmice and their apparent impairment observed to LPSresponse could explain the mechanism for lower immunecell chemotaxis and impaired macrophage function observedin familial amyloid polyneuropathy. | Downregulated Cathepsin E expression in bone marrow-derived macrophages from the pre-clinical familial amyloid polyneuropathy model.
Moreira J, Saraiva M, Saraiva MJ. | 01/18/2020 |
| Cathepsin E, mitochondrial fission, and caspase activation/apoptosis are linked in the pathogenesis of pulmonary emphysema. | Cathepsin E promotes pulmonary emphysema via mitochondrial fission.
Zhang X, Shan P, Homer R, Zhang Y, Petrache I, Mannam P, Lee PJ., Free PMC Article | 05/7/2016 |
| These results indicate that cathepsin E deficiency causes autophagy impairment concomitantly with increased aberrant mitochondria as well as increased oxidative stress. | Cathepsin E deficiency impairs autophagic proteolysis in macrophages.
Tsukuba T, Yanagawa M, Kadowaki T, Takii R, Okamoto Y, Sakai E, Okamoto K, Yamamoto K., Free PMC Article | 09/20/2014 |
| impaired adipose tissue development in high fat diet-induced CatE(-/-) mice was probably due to reduced infiltration of macrophages and may lead to hepatomegaly accompanied by hepatic steatosis and hypercholesterolemia | Defective adipose tissue development associated with hepatomegaly in cathepsin E-deficient mice fed a high-fat diet.
Kadowaki T, Kido MA, Hatakeyama J, Okamoto K, Tsukuba T, Yamamoto K. | 06/14/2014 |
| L1 stimulation triggers sumoylation and cleavage of L1, thus generating the L1-70 fragment which is cleaved by cathepsin E | Cathepsin E generates a sumoylated intracellular fragment of the cell adhesion molecule L1 to promote neuronal and Schwann cell migration as well as myelination.
Lutz D, Wolters-Eisfeld G, Schachner M, Kleene R. | 05/3/2014 |
| Intradermal cathepsin E has pruritogenic activity, which is at least partly mediated by the production of endothelin-1. | Cathepsin E induces itch-related response through the production of endothelin-1 in mice.
Andoh T, Yoshida T, Lee JB, Kuraishi Y. | 10/6/2012 |
| Low expression levels of MHC class II and cathepsin E might contribute to the defect in induction of Ag-specific T cells in NC mice. | Decreased expression of MHC class II and cathepsin E in dendritic cells might contribute to impaired induction of antigen-specific T cell response in NC/Nga mice.
Sakai T, Shuto E, Taki T, Imamura H, Kioka M, Nakamoto A, Mizoguchi S, Amano S, Kawano Y, Nakamoto M, Tsutumi R, Hosaka T. | 07/28/2012 |
| Results suggest that Sp1 binding plays a particularly important role in the regulation of cathepsin E gene expression. | Role of the transcription factor Sp1 in regulating the expression of the murine cathepsin E gene.
Okamoto K, Okamoto Y, Kawakubo T, Iwata J, Yasuda Y, Tsukuba T, Yamamoto K. | 06/30/2012 |
| the findings suggest that in keratinocytes CatE is functionally linked to the expression of terminal differentiation markers, thereby regulating epidermis formation and homeostasis. | The role of cathepsin E in terminal differentiation of keratinocytes.
Kawakubo T, Yasukochi A, Okamoto K, Okamoto Y, Nakamura S, Yamamoto K. | 10/29/2011 |
| The defects in chemotaxis and cell adhesion are likely to be involved in the imperfect function of CatE(-/-)macrophages. | Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages.
Tsukuba T, Yanagawa M, Okamoto K, Okamoto Y, Yasuda Y, Nakayama KI, Kadowaki T, Yamamoto K. | 01/21/2010 |
| Cathepsin E deficient mice are behaviorally normal when housed communally, but they become more aggressive compared with wild-type littermates when housed individually. | Association of cathepsin E deficiency with the increased territorial aggressive response of mice.
Shigematsu N, Fukuda T, Yamamoto T, Nishioku T, Yamaguchi T, Himeno M, Nakayama KI, Tsukuba T, Kadowaki T, Okamoto K, Higuchi S, Yamamoto K. | 01/21/2010 |
| A total of 654 genes were identified as overexpressed (>2-fold) in CatE(-/-) mammary glands. | Gene expression profiling of mammary glands of cathepsin E-deficient mice compared with wild-type littermates.
Kawakubo T, Yasukochi A, Tsukuba T, Kadowaki T, Yamamoto K. | 01/21/2010 |
| cathepsin E plays a substantial role in host defense against tumor cells through TRAIL-dependent apoptosis and/or tumor-associated macrophage-mediated cytotoxicity | Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface.
Kawakubo T, Okamoto K, Iwata J, Shin M, Okamoto Y, Yasukochi A, Nakayama KI, Kadowaki T, Tsukuba T, Yamamoto K. | 01/21/2010 |
| Cathepsin E is expressed in mice myeloid dendritic cells, where it has an important nonredundant role in the class II major histocompatibility complex antigen processing pathway. | The expression and function of cathepsin E in dendritic cells.
Chain BM, Free P, Medd P, Swetman C, Tabor AB, Terrazzini N. | 01/21/2010 |
| required for the generation of an antigenic epitope from OVA but not for the processing of Ii in microglia | Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia.
Nishioku T, Hashimoto K, Yamashita K, Liou SY, Kagamiishi Y, Maegawa H, Katsube N, Peters C, von Figura K, Saftig P, Katunuma N, Yamamoto K, Nakanishi H. | 01/21/2010 |
| cathepsin E is important for preventing the accumulation of lysosomal membrane sialoglycoproteins that can induce a new form of lysosomal storage disorder | Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages.
Yanagawa M, Tsukuba T, Nishioku T, Okamoto Y, Okamoto K, Takii R, Terada Y, Nakayama KI, Kadowaki T, Yamamoto K. | 01/21/2010 |
| Development of atopic dermatitis in cathepsin E-deficient mouse model is initiated by systemic accumulation of interleukin (IL)-18 and IL-1 beta, mainly due to their reduced turnover rates. | Association of cathepsin E deficiency with development of atopic dermatitis.
Tsukuba T, Okamoto K, Okamoto Y, Yanagawa M, Kohmura K, Yasuda Y, Uchi H, Nakahara T, Furue M, Nakayama K, Kadowaki T, Yamamoto K, Nakayama KI. | 01/21/2010 |
| cathepsin E is located in mast-cell secretory granules in complex with heparin proteoglycans, and has a role in the processing of procarboxypeptidase A into active protease | A role for cathepsin E in the processing of mast-cell carboxypeptidase A.
Henningsson F, Yamamoto K, Saftig P, Reinheckel T, Peters C, Knight SD, Pejler G. | 01/21/2010 |
| results indicate an essential role of cathepsin E in immune defense against invading microorganisms, most probably due to regulation of the cell surface expression of TLR family members required for innate immune responses | Cathepsin E-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface Toll-like receptors.
Tsukuba T, Yamamoto S, Yanagawa M, Okamoto K, Okamoto Y, Nakayama KI, Kadowaki T, Yamamoto K. | 01/21/2010 |