| [Deficiency of cathepsin K improves ischemic angiogenesis in high-fat diet fed mice]. | [Deficiency of cathepsin K improves ischemic angiogenesis in high-fat diet fed mice].
Wang XY, Wang X, He ZJ, Chen SP, Li WJ, Cui RS, Jiang HY. | 03/7/2024 |
| Altering osteoclast numbers using CTSK models in utero affects mice offspring craniofacial morphology. | Altering osteoclast numbers using CTSK models in utero affects mice offspring craniofacial morphology.
Hassan MG, Vargas R, Zhang B, Marcel N, Cox TC, Jheon AH. | 07/7/2023 |
| Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasis. | Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasis.
Zhu G, Chen W, Tang CY, McVicar A, Edwards D, Wang J, McConnell M, Yang S, Li Y, Chang Z, Li YP., Free PMC Article | 10/1/2022 |
| Oral microbial extracellular DNA initiates periodontitis through gingival degradation by fibroblast-derived cathepsin K in mice. | Oral microbial extracellular DNA initiates periodontitis through gingival degradation by fibroblast-derived cathepsin K in mice.
Kondo T, Okawa H, Hokugo A, Shokeen B, Sundberg O, Zheng Y, McKenna CE, Lux R, Nishimura I., Free PMC Article | 10/1/2022 |
| Cathepsin K Deficiency Prevented Kidney Damage and Dysfunction in Response to 5/6 Nephrectomy Injury in Mice With or Without Chronic Stress. | Cathepsin K Deficiency Prevented Kidney Damage and Dysfunction in Response to 5/6 Nephrectomy Injury in Mice With or Without Chronic Stress.
Yue X, Piao L, Wang H, Huang Z, Meng X, Sasaki T, Inoue A, Nakamura K, Wan Y, Xu S, Shi GP, Kim W, Murohara T, Kuzuya M, Cheng XW., Free PMC Article | 07/30/2022 |
| Cathepsin K activity controls cachexia-induced muscle atrophy via the modulation of IRS1 ubiquitination. | Cathepsin K activity controls cachexia-induced muscle atrophy via the modulation of IRS1 ubiquitination.
Meng X, Huang Z, Inoue A, Wang H, Wan Y, Yue X, Xu S, Jin X, Shi GP, Kuzuya M, Cheng XW., Free PMC Article | 04/9/2022 |
| The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K. | The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K.
Khan IZ, Del Guzzo CA, Shao A, Cho J, Du R, Cohen AO, Owens DM., Free PMC Article | 01/8/2022 |
| [Activation of mir-30a-wnt/beta-catenin signaling pathway upregulates cathepsin K expression to promote cementogenic differentiation of periodontal ligament stem cells]. | [Activation of mir-30a-wnt/β-catenin signaling pathway upregulates cathepsin K expression to promote cementogenic differentiation of periodontal ligament stem cells].
Liu F, Zhou Z, Xue Y, Zhu B, Wu B, Chen F., Free PMC Article | 12/11/2021 |
| Expression of tartrate-resistant acid phosphatase and cathepsin K during osteoclast differentiation in developing mouse mandibles. | Expression of tartrate-resistant acid phosphatase and cathepsin K during osteoclast differentiation in developing mouse mandibles.
Nakamura M, Aoyama N, Yamaguchi S, Sasano Y. | 11/6/2021 |
| Silencing of Ac45 Simultaneously Inhibits Osteoclast-Mediated Bone Resorption and Attenuates Dendritic Cell-Mediated Inflammation through Impairing Acidification and Cathepsin K Secretion. | Silencing of Ac45 Simultaneously Inhibits Osteoclast-Mediated Bone Resorption and Attenuates Dendritic Cell-Mediated Inflammation through Impairing Acidification and Cathepsin K Secretion.
Yang W, Zhu Z, Li L, McVicar A, Gao N, Wang L, Li YP, Chen W., Free PMC Article | 06/26/2021 |
| Inhibition of Cathepsin K Alleviates Autophagy-Related Inflammation in Periodontitis-Aggravating Arthritis. | Inhibition of Cathepsin K Alleviates Autophagy-Related Inflammation in Periodontitis-Aggravating Arthritis.
Yue Y, Yin W, Yang Q, Ren J, Tan L, Wang J, Liu J, Lu Q, Ding H, Zhan W, Hao L, Wang M., Free PMC Article | 05/22/2021 |
| Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification. | Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification.
Feng H, Xing W, Han Y, Sun J, Kong M, Gao B, Yang Y, Yin Z, Chen X, Zhao Y, Bi Q, Zou W., Free PMC Article | 02/20/2021 |
| Function of Cathepsin K in the Central Nervous System of Male Mice is Independent of Its Role in the Thyroid Gland. | Function of Cathepsin K in the Central Nervous System of Male Mice is Independent of Its Role in the Thyroid Gland.
Dauth S, Rakov H, Sîrbulescu RF, Ilieş I, Weber J, Batbajar Dugershaw B, Braun D, Rehders M, Wirth EK, Führer D, Schweizer U, Brix K. | 02/2/2021 |
| Cbl-PI3K interaction regulates Cathepsin K secretion in osteoclasts. | Cbl-PI3K interaction regulates Cathepsin K secretion in osteoclasts.
Yu J, Adapala NS, Doherty L, Sanjay A., Free PMC Article | 09/19/2020 |
| Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer. | Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer.
Li R, Zhou R, Wang H, Li W, Pan M, Yao X, Zhan W, Yang S, Xu L, Ding Y, Zhao L., Free PMC Article | 09/12/2020 |
| osteocyte-derived Ctsk contributes not only to osteocyte perilacunar remodeling, but also to the regulation of PTH, PTHrP, 1,25-Dyhydroxyvitamin D (1,25(OH)2D), osteoclastogenesis and bone loss in response to the high calcium demand associated with lactation. | Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression.
Lotinun S, Ishihara Y, Nagano K, Kiviranta R, Carpentier VT, Neff L, Parkman V, Ide N, Hu D, Dann P, Brooks D, Bouxsein ML, Wysolmerski J, Gori F, Baron R., Free PMC Article | 05/30/2020 |
| This study advanced a novel role for Ctsk in TLR9 and autophagy to explain the interaction between periodontitis and RA. | Inhibition of Ctsk modulates periodontitis with arthritis via downregulation of TLR9 and autophagy.
Wei W, Ren J, Yin W, Ding H, Lu Q, Tan L, Deng S, Liu J, Yang Q, Wang J, Wang M, Yue Y, Hao L., Free PMC Article | 02/29/2020 |
| CatK-deficiency impairs post-myocardial infarction cardiac function. | Cathepsin K-deficiency impairs mouse cardiac function after myocardial infarction.
Fang W, He A, Xiang MX, Lin Y, Wang Y, Li J, Yang C, Zhang X, Liu CL, Sukhova GK, Barascuk N, Larsen L, Karsdal M, Libby P, Shi GP. | 01/11/2020 |
| his study is the first to provide molecular insights into Ctsk-regulated Haemorrhagic Transformation after cerebral ischaemia. | Cathepsin K Knockout Exacerbates Haemorrhagic Transformation Induced by Recombinant Tissue Plasminogen Activator After Focal Cerebral Ischaemia in Mice.
Zhao R, He XW, Shi YH, Liu YS, Liu FD, Hu Y, Zhuang MT, Feng XY, Zhao L, Zhao BQ, Liu HQ, Shi GP, Liu JR. | 12/21/2019 |
| data reveal that periodontitis and RA may have additive pathological effects through dysregulation of the TLR9 pathway and that Ctsk is a critical mediator of this pathway and contributes to the pathogenesis of RA and periodontitis | Inhibition of Ctsk alleviates periodontitis and comorbid rheumatoid arthritis via downregulation of the TLR9 signalling pathway.
Pan W, Yin W, Yang L, Xue L, Ren J, Wei W, Lu Q, Ding H, Liu Z, Nabar NR, Wang M, Hao L. | 12/21/2019 |
| Cathepsin K-deficiency reconciled the disturbance in cardiac energy homeostasis and attenuated NF-kappaB signaling and apoptosis to ameliorate doxorubicin-induced cardiotoxicity. | Cardiomyocyte-specific disruption of Cathepsin K protects against doxorubicin-induced cardiotoxicity.
Guo R, Hua Y, Ren J, Bornfeldt KE, Nair S., Free PMC Article | 11/30/2019 |
| Ctsk(-/-) mice had fewer physis-derived chondroclasts than WT when OA was present..Our data provide insight into the cellular mechanisms by which Cathepsin K (CatK) deletion delays Osteoarthritis (OA) progression in mice. | Articular cartilage protection in Ctsk(-/-) mice is associated with cellular and molecular changes in subchondral bone and cartilage matrix.
Soki FN, Yoshida R, Paglia DN, Duong LT, Hansen MF, Drissi H. | 09/28/2019 |
| Found fewer periosteal osteoclast precursors in Ctsk(-/-) mice under homeostatic conditions; however, after fracture, this population increased in number relative to that seen in wild-type (WT) mice. Enhanced TRAP staining and greater expression of PDGF-BB were observed in fractured Ctsk(-/-) femurs relative to WT femurs. | A novel role for cathepsin K in periosteal osteoclast precursors during fracture repair.
Walia B, Lingenheld E, Duong L, Sanjay A, Drissi H. | 08/3/2019 |
| cathepsin K may represent a potential target in treating diabetes-associated cardiac dysfunction. | Cathepsin K knockout protects against cardiac dysfunction in diabetic mice.
Guo R, Hua Y, Rogers O, Brown TE, Ren J, Nair S., Free PMC Article | 03/23/2019 |
| Beta-catenin deletion in cathepsin K (CtsK)-expressing cells causes a severe loss of bone mass. | CathepsinKCre mediated deletion of βcatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells.
Ruiz P, Martin-Millan M, Gonzalez-Martin MC, Almeida M, González-Macias J, Ros MA., Free PMC Article | 05/26/2018 |