| Human ACVR1C missense variants that correlate with altered body fat distribution produce metabolic alterations of graded severity in knock-in mutant mice. | Human ACVR1C missense variants that correlate with altered body fat distribution produce metabolic alterations of graded severity in knock-in mutant mice.
Tangseefa P, Jin H, Zhang H, Xie M, Ibáñez CF., Free PMC Article | 03/11/2024 |
| Regulation of metabolic homeostasis by the TGF-beta superfamily receptor ALK7. | Regulation of metabolic homeostasis by the TGF-β superfamily receptor ALK7.
Ibáñez CF. | 10/15/2022 |
| Activin receptor-like kinase 7 silencing alleviates cardiomyocyte apoptosis, cardiac fibrosis, and dysfunction in diabetic rats. | Activin receptor-like kinase 7 silencing alleviates cardiomyocyte apoptosis, cardiac fibrosis, and dysfunction in diabetic rats.
Liu L, Zhou X, Zhang Q, Li L, Shang Y, Wang Z, Zhong M, Chen Y, Zhang W, Tang M., Free PMC Article | 10/1/2022 |
| UV-Induced Reduction of ACVR1C Decreases SREBP1 and ACC Expression by the Suppression of SMAD2 Phosphorylation in Normal Human Epidermal Keratinocytes. | UV-Induced Reduction of ACVR1C Decreases SREBP1 and ACC Expression by the Suppression of SMAD2 Phosphorylation in Normal Human Epidermal Keratinocytes.
Tian YD, Chung MH, Quan QL, Lee DH, Kim EJ, Chung JH., Free PMC Article | 05/29/2021 |
| Knockdown of ALK7 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells. | Knockdown of ALK7 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells.
Shi Q, Dong X, Zhang M, Cheng Y, Pei C. | 05/8/2021 |
| Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7. | Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7.
Marmol P, Krapacher F, Ibáñez CF., Free PMC Article | 03/20/2021 |
| The activin-ALK7 pathway as a mediator of endothelial ablation by PDAC. | A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling.
Nguyen DT, Lee E, Alimperti S, Norgard RJ, Wong A, Lee JJ, Eyckmans J, Stanger BZ, Chen CS., Free PMC Article | 05/16/2020 |
| Authors report that the TGFss superfamily receptor ALK7 is a suppressor of tumorigenesis and metastasis, as revealed by functional studies in mouse models of pancreatic neuroendocrine and luminal breast cancer, complemented by experimental metastasis assays. | ALK7 Signaling Manifests a Homeostatic Tissue Barrier That Is Abrogated during Tumorigenesis and Metastasis.
Michael IP, Saghafinia S, Tichet M, Zangger N, Marinoni I, Perren A, Hanahan D. | 01/11/2020 |
| Taken together, our observations suggest that activin signaling mediated through ALK7 could therefore contribute to the hormonal heterogeneity and increased proliferation of prolactinomas. | ALK7 expression in prolactinoma is associated with reduced prolactin and increased proliferation.
Principe M, Chanal M, Karam V, Wierinckx A, Mikaélian I, Gadet R, Auger C, Raverot V, Jouanneau E, Vasiljevic A, Hennino A, Raverot G, Bertolino P. | 07/20/2019 |
| ACVR1C/SMAD2 pathway in promoting invasion and growth of retinoblastoma | ACVR1C/SMAD2 signaling promotes invasion and growth in retinoblastoma.
Asnaghi L, White DT, Key N, Choi J, Mahale A, Alkatan H, Edward DP, Elkhamary SM, Al-Mesfer S, Maktabi A, Hurtado CG, Lee GY, Carcaboso AM, Mumm JS, Safieh LA, Eberhart CG., Free PMC Article | 05/4/2019 |
| MiR-454 binds to the 3'-UTR of ALK7 and regulates ALK7 expression in placenta.ALK7 signaling is regulated by MicroRNA-454 in the placental tissues from pre-eclampsia patients. | MicroRNA-454 contributes to sustaining the proliferation and invasion of trophoblast cells through inhibiting Nodal/ALK7 signaling in pre-eclampsia.
Shi Z, She K, Li H, Yuan X, Han X, Wang Y. | 01/12/2019 |
| reduced expression in sensitive skin; plays crucial roles in the pathogenesis of sensitive skin | Decreased expression of activin A receptor 1C may result in Ca(2+) -induced aberrant skin hypersensitivity.
Kim EJ, Lee DH, Kim YK, Lee YM, Eun HC, Chung JH. | 02/17/2018 |
| Loss of ALK7 expression are associated with invasion, metastasis of the pancreatic ductal adenocarcinoma. | Overexpression of B2M and loss of ALK7 expression are associated with invasion, metastasis, and poor-prognosis of the pancreatic ductal adenocarcinoma.
Liu C, Yang Z, Li D, Liu Z, Miao X, Yang L, Zou Q, Yuan Y. | 10/22/2016 |
| Alk7 is expressed in male germ cells and Sertoli cells. | NODAL secreted by male germ cells regulates the proliferation and function of human Sertoli cells from obstructive azoospermia and nonobstructive azoospermia patients.
Tian RH, Yang S, Zhu ZJ, Wang JL, Liu Y, Yao C, Ma M, Guo Y, Yuan Q, Hai Y, Huang YR, He Z, Li Z., Free PMC Article | 08/13/2016 |
| ACVR 1C is a tumor suppressor, and lowered ACVR 1C expression is an important marker for the metastasis, invasion, and prognosis of gallbladder cancer. | PKM2 and ACVR 1C are prognostic markers for poor prognosis of gallbladder cancer.
Li J, Yang Z, Zou Q, Yuan Y, Li J, Liang L, Zeng G, Chen S. | 10/11/2014 |
| Our findings suggested that the ALK7 gene polymorphism rs13010956 was significantly associated with metabolic syndrome risk in females and may be involved in cardiovascular remodeling in metabolic syndrome patients. | ALK7 gene polymorphism is associated with metabolic syndrome risk and cardiovascular remodeling.
Zhang W, Wang H, Zhang W, Lv R, Wang Z, Shang Y, Zhang Y, Zhong M, Chen Y, Tang M., Free PMC Article | 03/15/2014 |
| reduction or lack of ALK7 expression may account for the loss of its ligand sensitivity of breast cancer cells, thereby leading to breast tumor progression. | Reduced expression of activin receptor-like kinase 7 in breast cancer is associated with tumor progression.
Zeng F, Xu G, Zhou T, Yang C, Wang X, Peng C, Zhou H. | 07/27/2013 |
| These findings suggest that the Nodal/ALK7 pathway plays important roles in human placentation and that its abnormal signaling may contribute to the development of preeclampsia. | Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia.
Nadeem L, Munir S, Fu G, Dunk C, Baczyk D, Caniggia I, Lye S, Peng C., Free PMC Article | 05/28/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | A large-scale candidate gene association study of age at menarche and age at natural menopause.
He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ., Free PMC Article | 12/5/2010 |
| Microarray analysis showed that adipose tissue expressed activin type I and II receptors and that the expression of activin receptor-like kinase 7 was adipose tissue specific. | ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease.
Carlsson LM, Jacobson P, Walley A, Froguel P, Sjöström L, Svensson PA, Sjöholm K., Free PMC Article | 01/21/2010 |
| The antiproliferative effect of Nodal/ALK7 on ovarian cancer cells is in part mediated by cyclin G2. | Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7.
Xu G, Bernaudo S, Fu G, Lee DY, Yang BB, Peng C., Free PMC Article | 01/21/2010 |
| One of the direct target genes in the ALK7 signaling pathway is the insulin gene in pancreatic beta-cells, and that PDX-1 is directly involved in this pathway through interaction with Smad2 and Smad3. | Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells.
Watanabe R, Shen ZP, Tsuda K, Yamada Y. | 01/21/2010 |
| GDF3 regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the ALK7 receptor | Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity.
Andersson O, Korach-Andre M, Reissmann E, Ibáñez CF, Bertolino P., Free PMC Article | 01/21/2010 |
| ALK7 induces apoptosis through activation of the traditional TGF-beta pathway components | Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells.
Kim BC, van Gelder H, Kim TA, Lee HJ, Baik KG, Chun HH, Lee DA, Choi KS, Kim SJ. | 01/21/2010 |
| ALK7 and its isoforms are expressed in human placentae of different stages of pregnancy and that their expression is developmentally regulated | Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta.
Roberts HJ, Hu S, Qiu Q, Leung PC, Caniggia I, Gruslin A, Tsang B, Peng C. | 01/21/2010 |