| Direct reprogramming of oligodendrocyte precursor cells into GABAergic inhibitory neurons by a single homeodomain transcription factor Dlx2. | Direct reprogramming of oligodendrocyte precursor cells into GABAergic inhibitory neurons by a single homeodomain transcription factor Dlx2.
Boshans LL, Soh H, Wood WM, Nolan TM, Mandoiu II, Yanagawa Y, Tzingounis AV, Nishiyama A., Free PMC Article | 11/13/2021 |
| Dlx1/2 mice have abnormal enteric nervous system function. | Dlx1/2 mice have abnormal enteric nervous system function.
Wright CM, Garifallou JP, Schneider S, Mentch HL, Kothakapa DR, Maguire BA, Heuckeroth RO., Free PMC Article | 05/29/2021 |
| Dlx1/2 are Central and Essential Components in the Transcriptional Code for Generating Olfactory Bulb Interneurons. | Dlx1/2 are Central and Essential Components in the Transcriptional Code for Generating Olfactory Bulb Interneurons.
Guo T, Liu G, Du H, Wen Y, Wei S, Li Z, Tao G, Shang Z, Song X, Zhang Z, Xu Z, You Y, Chen B, Rubenstein JL, Yang Z., Free PMC Article | 10/24/2020 |
| Dlx1 and Dlx2 promote interneuron GABA synthesis, synaptogenesis, and dendritogenesis. Dlx1&2 coordinate key components of cortical interneurons postnatal development by promoting their excitability, inhibitory output, and survival. | Dlx1 and Dlx2 Promote Interneuron GABA Synthesis, Synaptogenesis, and Dendritogenesis.
Pla R, Stanco A, Howard MA, Rubin AN, Vogt D, Mortimer N, Cobos I, Potter GB, Lindtner S, Price JD, Nord AS, Visel A, Schreiner CE, Baraban SC, Rowitch DH, Rubenstein JLR., Free PMC Article | 12/21/2019 |
| Overexpression of Dlx2 enhances early chondrocyte differentiation by increasing accumulation of Col2alpha1, type II collagen and aggrecan, but interferes later stages of chondrocyte differentiation through inhibiting MMP13 expression. | Dlx2 overexpression enhanced accumulation of type II collagen and aggrecan by inhibiting MMP13 expression in mice chondrocytes.
Zhang J, Zhang W, Shi J, Dai J, Shen SG. | 12/22/2018 |
| Studies revealed that Dlx1/2 and Otp are required for the specification of growth hormone-releasing hormone (GHRH)- and AgRP-neurons, respectively. Dlx1/2 suppress agouti-related protein (AgRP)-neuronal fate by directly binding and repressing the Otp gene, uncovering a novel Dlx1/2-Otp gene regulatory axis critical for the segregation of GHRH- and AgRP-neuronal fates. | Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons.
Lee B, Kim J, An T, Kim S, Patel EM, Raber J, Lee SK, Lee S, Lee JW., Free PMC Article | 12/22/2018 |
| Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis. | Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis.
Chang H, Wang Y, Liu H, Nan X, Wong S, Peng S, Gu Y, Zhao H, Feng H., Free PMC Article | 07/28/2018 |
| Dlx2 overexpression may alter the alveolar bone, cementum and periodontal ligament (PDL) phenotypes in mice. | Dental and periodontal phenotypes of Dlx2 overexpression in mice.
Dai J, Si J, Ouyang N, Zhang J, Wu D, Wang X, Shen G., Free PMC Article | 02/24/2018 |
| GABA is the major inhibitory neurotransmitter in the brain. We show that Dlx1/Dlx2 homeobox genes regulate GABA synthesis during forebrain development through direct activation of glutamic acid decarboxylase enzyme isoforms that convert glutamate to GABA. | GABAergic Interneuron Differentiation in the Basal Forebrain Is Mediated through Direct Regulation of Glutamic Acid Decarboxylase Isoforms by Dlx Homeobox Transcription Factors.
Le TN, Zhou QP, Cobos I, Zhang S, Zagozewski J, Japoni S, Vriend J, Parkinson T, Du G, Rubenstein JL, Eisenstat DD., Free PMC Article | 09/30/2017 |
| Dlx1 and Dlx2 function both downstream of ATOH7 and in parallel, but cooperative, pathways that involve regulation of Brn3b expression to determine retinal ganglion cell fate. | Regulation of Brn3b by DLX1 and DLX2 is required for retinal ganglion cell differentiation in the vertebrate retina.
Zhang Q, Zagozewski J, Cheng S, Dixit R, Zhang S, de Melo J, Mu X, Klein WH, Brown NL, Wigle JT, Schuurmans C, Eisenstat DD., Free PMC Article | 09/16/2017 |
| the expression level and the spatiotemporal expression patterns of Dlx2 may be important in regulating the development of post-natal condyle in mice, and also offered a possible temporalmandibular joint osteoarthritis model animal for future studies. | Overexpression of Dlx2 leads to postnatal condyle degradation.
Dai J, Si J, Zhu X, Zhang L, Wu D, Lu J, Ouyang N, Wang X, Shen G., Free PMC Article | 04/8/2017 |
| The activation of DLX2 signaling might improve tissue regeneration mediated by MSCs of dental origin. Results provide insight into the mechanism underlying the directed differentiation of MSCs of dental origin. | Distal-less homeobox 2 promotes the osteogenic differentiation potential of stem cells from apical papilla.
Qu B, Liu O, Fang X, Zhang H, Wang Y, Quan H, Zhang J, Zhou J, Zuo J, Tang J, Tang Z. | 04/18/2015 |
| the prethalamic factors Dlxs upregulated by Ascl1/Helt deficiency play unique roles in regulating thalamic progenitor specification. | Ascl1 and Helt act combinatorially to specify thalamic neuronal identity by repressing Dlxs activation.
Song H, Lee B, Pyun D, Guimera J, Son Y, Yoon J, Baek K, Wurst W, Jeong Y. | 04/11/2015 |
| despite their redundant properties, Gsx1 and -2 have distinct interactions with Dlx1 and -2 | Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants.
Wang B, Long JE, Flandin P, Pla R, Waclaw RR, Campbell K, Rubenstein JL., Free PMC Article | 08/31/2013 |
| Dlx2 overexpression in neural crest stem cells may be a new pathogenesis of facial cleft and spinal kyphosis in mammals. | The effect of overexpression of Dlx2 on the migration, proliferation and osteogenic differentiation of cranial neural crest stem cells.
Dai J, Kuang Y, Fang B, Gong H, Lu S, Mou Z, Sun H, Dong Y, Lu J, Zhang W, Zhang J, Wang Z, Wang X, Shen G. | 06/8/2013 |
| The functions of Dlx1 and Dlx2 are crucial for the initial formation of the posterior palatal shelves, and that the Dlx genes lie upstream of multiple signaling molecules and transcription factors important for later stages of palatogenesis. | Cleft palate defect of Dlx1/2-/- mutant mice is caused by lack of vertical outgrowth in the posterior palate.
Jeong J, Cesario J, Zhao Y, Burns L, Westphal H, Rubenstein JL., Free PMC Article | 03/23/2013 |
| Brn-3b suppresses the role of DLX1/2 through physical interaction and biases the competent precursors toward retinal ganglion cell fates. | Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina.
Feng L, Eisenstat DD, Chiba S, Ishizaki Y, Gan L, Shibasaki K. | 02/11/2012 |
| Dlx2 is one critical player in shifting TGFbeta from its tumour suppressive to its tumour-promoting functions. | Transcription factor Dlx2 protects from TGFβ-induced cell-cycle arrest and apoptosis.
Yilmaz M, Maass D, Tiwari N, Waldmeier L, Schmidt P, Lehembre F, Christofori G., Free PMC Article | 01/7/2012 |
| Dlx2 and FoxJ1 physically interact and synergistically regulate the Dlx2, FoxJ1, and amelogenin promoters | Hierarchical interactions of homeodomain and forkhead transcription factors in regulating odontogenic gene expression.
Venugopalan SR, Li X, Amen MA, Florez S, Gutierrez D, Cao H, Wang J, Amendt BA., Free PMC Article | 09/3/2011 |
| in hippocampal precursors Dlx2 promoted neurogenesis but not neural stem cell activation | Multipotent precursors in the anterior and hippocampal subventricular zone display similar transcription factor signatures but their proliferation and maintenance are differentially regulated.
Carrillo-García C, Suh Y, Obernier K, Hölzl-Wenig G, Mandl C, Ciccolini F. | 11/13/2010 |
| Results suggest that DLX2 and EGFR signalling interact at multiple levels to coordinate neuronal proliferation in the postnatal subventricular zone. | Interaction between DLX2 and EGFR regulates proliferation and neurogenesis of SVZ precursors.
Suh Y, Obernier K, Hölzl-Wenig G, Mandl C, Herrmann A, Wörner K, Eckstein V, Ciccolini F. | 04/12/2010 |
| These analyses define core transcriptional components that differentially specify the identity and differentiation of the globus pallidus, basal telencephalon, and pallial interneurons. | Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.
Long JE, Cobos I, Potter GB, Rubenstein JL., Free PMC Article | 01/21/2010 |
| Data show that Cre-recombinase is active in a "Dlx-pattern" in the embryonic forebrain of transgenic mice, and suggest that both I12b and URE2 are direct targets of DLX2 and require Dlx1 and Dlx2 expression for proper activity. | Generation of Cre-transgenic mice using Dlx1/Dlx2 enhancers and their characterization in GABAergic interneurons.
Potter GB, Petryniak MA, Shevchenko E, McKinsey GL, Ekker M, Rubenstein JL., Free PMC Article | 01/21/2010 |
| Results identify Dlx-dependent and Dlx-independent pathways, and show that the Dlx-independent pathway depends in part on the function of the Mash1 b-HLH transcription factor. | Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.
Long JE, Swan C, Liang WS, Cobos I, Potter GB, Rubenstein JL., Free PMC Article | 01/21/2010 |
| Dlx2 acts potently neurogenic in adult lateral subependymal zone cells in vitro. | A dlx2- and pax6-dependent transcriptional code for periglomerular neuron specification in the adult olfactory bulb.
Brill MS, Snapyan M, Wohlfrom H, Ninkovic J, Jawerka M, Mastick GS, Ashery-Padan R, Saghatelyan A, Berninger B, Götz M., Free PMC Article | 01/21/2010 |