| FGF23 directly inhibits osteoprogenitor differentiation in Dmp1-knockout mice. | FGF23 directly inhibits osteoprogenitor differentiation in Dmp1-knockout mice.
Courbon G, Kentrup D, Thomas JJ, Wang X, Tsai HH, Spindler J, Von Drasek J, Ndjonko LM, Martinez-Calle M, Lynch S, Hivert L, Wang X, Chang W, Feng JQ, David V, Martin A., Free PMC Article | 01/3/2024 |
| The role of proteoglycan form of DMP1 in cranial repair. | The role of proteoglycan form of DMP1 in cranial repair.
Liu Y, Niu P, Zhou M, Xue H., Free PMC Article | 10/8/2022 |
| Improved cognitive impairments by silencing DMP1 via enhancing the proliferation of neural progenitor cell in Alzheimer-like mice. | Improved cognitive impairments by silencing DMP1 via enhancing the proliferation of neural progenitor cell in Alzheimer-like mice.
Zhao H, Wei J, Du Y, Chen P, Liu X, Liu H, Alzheimer’s Disease Neuroimaging Initiative., Free PMC Article | 05/28/2022 |
| Osteocytes but not osteoblasts directly build mineralized bone structures. | Osteocytes but not osteoblasts directly build mineralized bone structures.
Wang K, Ren Y, Lin S, Jing Y, Ma C, Wang J, Yuan XB, Han X, Zhao H, Wang Z, Zheng M, Xiao Y, Chen L, Olsen BR, Feng JQ., Free PMC Article | 03/19/2022 |
| Pten deletion in Dmp1-expressing cells does not rescue the osteopenic effects of Wnt/beta-catenin suppression. | Pten deletion in Dmp1-expressing cells does not rescue the osteopenic effects of Wnt/β-catenin suppression.
Lim KE, Hoggatt AM, Bullock WA, Horan DJ, Yokota H, Pavalko FM, Robling AG., Free PMC Article | 04/3/2021 |
| Glycosylation of DMP1 promotes bone reconstruction in long bone defects. | Glycosylation of DMP1 promotes bone reconstruction in long bone defects.
Xue H, Niu P, Liu Y, Sun Y. | 11/28/2020 |
| Glycosylation of DMP1 maintains cranial sutures in mice. | Glycosylation of DMP1 maintains cranial sutures in mice.
Cai M, Li J, Yue R, Wang Z, Sun Y. | 11/28/2020 |
| Upon inspection, fewer cartilaginous calluses and down-regulated expression levels of chondrogenesis genes were observed in the fracture sites of S89G-DMP1 mice. The results suggest that DMP1-PG is an indispensable proteoglycan in chondrogenesis during fracture healing. | Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis.
Xue H, Tao D, Weng Y, Fan Q, Zhou S, Zhang R, Zhang H, Yue R, Wang X, Wang Z, Sun Y. | 03/14/2020 |
| results suggest that the expression of Dmp1 is up-regulated in Opn KO mice both in vivo and in vitro, and DMP1 compensates for the lack of OPN in regulating odontoblastlike cell differentiation after tooth injury. | Dentin Matrix Protein 1 Compensates for Lack of Osteopontin in Regulating Odontoblastlike Cell Differentiation after Tooth Injury in Mice.
Saito K, Nakatomi M, Ohshima H. | 02/1/2020 |
| Twist1 Inactivation in Dmp1-Expressing Cells Increases Bone Mass but Does Not Affect the Anabolic Response to Sclerostin Neutralization. | Twist1 Inactivation in Dmp1-Expressing Cells Increases Bone Mass but Does Not Affect the Anabolic Response to Sclerostin Neutralization.
Lewis KJ, Choi RB, Pemberton EZ, Bullock WA, Firulli AB, Robling AG., Free PMC Article | 02/1/2020 |
| study not only revealed a novel element, i.e., DMP1-PG, that regulated BBB formation, but also assigned a new function to DMP1-PG. | Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity.
Jing B, Zhang C, Liu X, Zhou L, Liu J, Yao Y, Yu J, Weng Y, Pan M, Liu J, Wang Z, Sun Y, Sun YE., Free PMC Article | 02/23/2019 |
| This study provides a new understanding of DMP1's function in regulation of osteogenesis: not only an enhancer of bone formation, but also a negative regulator of mesenchymal stem cell differentiation in bone. | Extracellular matrix protein DMP1 suppresses osteogenic differentiation of Mesenchymal Stem Cells.
Zhang S, Wan H, Wang P, Liu M, Li G, Zhang C, Sun Y. | 10/13/2018 |
| Findings support the critical role of DMP1 in maintaining the integrity of the auditory ossicles and its bony membrane | A novel auditory ossicles membrane and the development of conductive hearing loss in Dmp1-null mice.
Lv K, Huang H, Yi X, Chertoff ME, Li C, Yuan B, Hinton RJ, Feng JQ., Free PMC Article | 05/19/2018 |
| Results show that transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice and suggest that DSPP and DMP1 may function synergistically within the complex milieu of bone matrices. | Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice.
Jani PH, Gibson MP, Liu C, Zhang H, Wang X, Lu Y, Qin C., Free PMC Article | 12/23/2017 |
| The collective results indicate that the osteoanabolic response to loading can occur on the periosteal surface when beta-cat levels are significantly reduced in Dmp1-expressing cells. | Postnatal β-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation.
Kang KS, Hong JM, Robling AG., Free PMC Article | 12/23/2017 |
| Nestin(+) cells are one important type of progenitor cell in bone marrow and are associated with bone remodeling. These data indicate that DMP1 plays negative roles in differentiation of Nestin(+) cells and bone formation. | Overexpression of Dentin matrix protein 1 in Nestin(+) cells causes bone loss in mouse long bone.
Pan M, Weng Y, Sun Y. | 08/5/2017 |
| mutation creates a lower set point for extracellular phosphate and maintains it through the regulation of Fgf23 cleavage and expression | A Mutation in the Dmp1 Gene Alters Phosphate Responsiveness in Mice.
Ichikawa S, Gerard-O'Riley RL, Acton D, McQueen AK, Strobel IE, Witcher PC, Feng JQ, Econs MJ., Free PMC Article | 07/1/2017 |
| Data show that the phenotype of Notch activation in osteocytes was prevented in matrix protein 1 (Dmp1)-Cre;Rosa(Notch) mice hemizygous for the Dmp1-sclerostin (SOST) transgene. | The Dmp1-SOST Transgene Interacts With and Downregulates the Dmp1-Cre Transgene and the Rosa(Notch) Allele.
Zanotti S, Canalis E., Free PMC Article | 12/17/2016 |
| Klf10 is involved in tooth development and promotes odontoblastic differentiation via the up-regulation of Dmp1 and Dspp transcription. | Klf10 regulates odontoblast differentiation and mineralization via promoting expression of dentin matrix protein 1 and dentin sialophosphoprotein genes.
Chen Z, Li W, Wang H, Wan C, Luo D, Deng S, Chen H, Chen S., Free PMC Article | 10/29/2016 |
| These findings indicate that glycosylation of DMP1 is a key posttranslational modification process during development and that DMP1-PG functions as an indispensable proteoglycan in osteogenesis. | Glycosylation of Dentin Matrix Protein 1 is critical for osteogenesis.
Sun Y, Weng Y, Zhang C, Liu Y, Kang C, Liu Z, Jing B, Zhang Q, Wang Z., Free PMC Article | 10/8/2016 |
| the hypophosphatemia induced osteomalacia phenotype in Dmp1 KO mice is contributed by at least two factors: the low Pi level and the DMP1 local function in mineralization | The in vivo role of DMP-1 and serum phosphate on bone mineral composition.
Maginot M, Lin S, Liu Y, Yuan B, Feng JQ, Aswath PB. | 09/3/2016 |
| These results suggest that the LPV motif is essential for the efficient export of secretory DMP1 from the ER to the Golgi complex. | The LPV Motif Is Essential for the Efficient Export of Secretory DMP1 From the Endoplasmic Reticulum.
Liang T, Meng T, Wang S, Qin C, Lu Y., Free PMC Article | 08/6/2016 |
| An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage. | An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage.
Fujikawa K, Yokohama-Tamaki T, Morita T, Baba O, Qin C, Shibata S., Free PMC Article | 07/16/2016 |
| It was concluded that endogenously secreted PTH and GHR signaling in bone are necessary to establish radial bone growth and optimize mineral acquisition during growth. | DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH.
Liu Z, Kennedy OD, Cardoso L, Basta-Pljakic J, Partridge NC, Schaffler MB, Rosen CJ, Yakar S., Free PMC Article | 06/28/2016 |
| We conclude that DMP-1 may be involved in regulating the temporal expression at embryonic stages in the mouse tongue | Expression of DMP1 in the developing mouse tongue embryo.
Murata H, Sunohara M, Sato I. | 03/5/2016 |