| WDR36-Associated Neurodegeneration: A Case Report Highlights Possible Mechanisms of Normal Tension Glaucoma. | WDR36-Associated Neurodegeneration: A Case Report Highlights Possible Mechanisms of Normal Tension Glaucoma.
Meer E, Aleman TS, Ross AG., Free PMC Article | 02/12/2022 |
| Study suggests that WDR36 gene is involved in the pathogenesis of juvenile open-angle glaucoma in Taiwan population as a subordinate modifier gene. | An Application of NGS for WDR36 Gene in Taiwanese Patients with Juvenile-Onset Open-Angle Glaucoma.
Su HA, Li SY, Yang JJ, Yen YC., Free PMC Article | 06/23/2018 |
| Meta-analysis does not support a significant role of WDR36 in the genetic susceptibility of primary open angle glaucoma or its subtypes. | Association of WDR36 polymorphisms with primary open angle glaucoma: A systematic review and meta-analysis.
Liu K, He W, Zhao J, Zeng Y, Cheng H., Free PMC Article | 07/22/2017 |
| The association between WDR36 and POAG was not supported, and the majority of POAG cases did not harbor a potentially disease-causing variant in the remaining Mendelian genes. | Contribution of Mutations in Known Mendelian Glaucoma Genes to Advanced Early-Onset Primary Open-Angle Glaucoma.
Zhou T, Souzeau E, Siggs OM, Landers J, Mills R, Goldberg I, Healey PR, Graham S, Hewitt AW, Mackey DA, Galanopoulos A, Casson RJ, Ruddle JB, Ellis J, Leo P, Brown MA, MacGregor S, Sharma S, Burdon KP, Craig JE. | 07/1/2017 |
| Familial linkage studies for primary angle-closure glaucoma have been performed and identified WDR36 causative primary angle-closure glaucoma disease | Advances in glaucoma genetics.
Sakurada Y, Mabuchi F. | 11/5/2016 |
| According to molecular genetic studies, WDR36 causative gene involved in the development of Primary open-angle glaucoma. | [Genetic studies of primary open-angle glaucoma].
Tikunova EV, Churnosov MI. | 03/28/2015 |
| Single nucleotide polymorphism in the WDR36 gene, rs10038177 (c.710+30C>T), was found to be strongly associated with the high tension glaucoma cases, but not with controls in the East Indian population. | WDR36 variants in East Indian primary open-angle glaucoma patients.
Mookherjee S, Chakraborty S, Vishal M, Banerjee D, Sen A, Ray K., Free PMC Article | 02/11/2012 |
| Rare WDR36 variants and the P53 p.R72P polymorphism behaved as moderate glaucoma risk factors in Spanish patients. The authors provide evidence for a genetic interaction between WDR36 and P53 variants in glaucoma susceptibility. | WDR36 and P53 gene variants and susceptibility to primary open-angle glaucoma: analysis of gene-gene interactions.
Blanco-Marchite C, Sánchez-Sánchez F, López-Garrido MP, Iñigez-de-Onzoño M, López-Martínez F, López-Sánchez E, Alvarez L, Rodríguez-Calvo PP, Méndez-Hernández C, Fernández-Vega L, García-Sánchez J, Coca-Prados M, García-Feijoo J, Escribano J., Free PMC Article | 01/21/2012 |
| WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, Galphaq and phospholipase C beta 2 in a signalling complex | WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, Gαq and phospholipase Cβ in a signalling complex.
Cartier A, Parent A, Labrecque P, Laroche G, Parent JL. | 01/14/2012 |
| WDR36 sequence variance was only a rare cause of primary open-angel glaucoma glaucoma in Italian families with glaucoma. | Association between primary open-angle glaucoma (POAG) and WDR36 sequence variance in Italian families affected by POAG.
Frezzotti P, Pescucci C, Papa FT, Iester M, Mittica V, Motolese I, Peruzzi S, Artuso R, Longo I, Mencarelli MA, Mittica P, Motolese E, Renieri A. | 06/25/2011 |
| Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg | [Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg].
Motushchuk AE, Komarova TIu, Grudinina NA, Rakhmanov VV, Mandel'shtam MIu, Astakhov IuS, Vasil'ev VB, Motushchuk AE, Komarova TIu, Grudinina NA, Rakhmanov VV, Mandel'shtam MIu, Astakhov IuS, Vasil'ev VB. | 04/12/2010 |
| WDR36 is associated with sporadic high tension glaucoma but not with normal tension glaucoma or juvenile-onset primary open-angle glaucoma. | Different WDR36 mutation pattern in Chinese patients with primary open-angle glaucoma.
Fan BJ, Wang DY, Cheng CY, Ko WC, Lam SC, Pang CP, Fan BJ, Wang DY, Cheng CY, Ko WC, Lam SC, Pang CP., Free PMC Articles: PMC2664842, PMC2664842 | 01/21/2010 |
| WDR36 sequence variants can lead to an altered cellular phenotype, supporting the theory that WDR36 participates in polygenic forms of glaucoma. | Glaucoma-associated WDR36 variants encode functional defects in a yeast model system.
Footz TK, Johnson JL, Dubois S, Boivin N, Raymond V, Walter MA. | 01/21/2010 |
| SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma. | Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, Jonsdottir GM, Thorleifsson G, Helgadottir H, Steinthorsdottir V, Stefansson H, Williams C, Hui J, Beilby J, Warrington NM, James A, Palmer LJ, Koppelman GH, Heinzmann A, Krueger M, Boezen HM, Wheatley A, Altmuller J, Shin HD, Uh ST, Cheong HS, Jonsdottir B, Gislason D, Park CS, Rasmussen LM, Porsbjerg C, Hansen JW, Backer V, Werge T, Janson C, Jönsson UB, Ng MC, Chan J, So WY, Ma R, Shah SH, Granger CB, Quyyumi AA, Levey AI, Vaccarino V, Reilly MP, Rader DJ, Williams MJ, van Rij AM, Jones GT, Trabetti E, Malerba G, Pignatti PF, Boner A, Pescollderungg L, Girelli D, Olivieri O, Martinelli N, Ludviksson BR, Ludviksdottir D, Eyjolfsson GI, Arnar D, Thorgeirsson G, Deichmann K, Thompson PJ, Wjst M, Hall IP, Postma DS, Gislason T, Gulcher J, Kong A, Jonsdottir I, Thorsteinsdottir U, Stefansson K, Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, Jonsdottir GM, Thorleifsson G, Helgadottir H, Steinthorsdottir V, Stefansson H, Williams C, Hui J, Beilby J, Warrington NM, James A, Palmer LJ, Koppelman GH, Heinzmann A, Krueger M, Boezen HM, Wheatley A, Altmuller J, Shin HD, Uh ST, Cheong HS, Jonsdottir B, Gislason D, Park CS, Rasmussen LM, Porsbjerg C, Hansen JW, Backer V, Werge T, Janson C, Jönsson UB, Ng MC, Chan J, So WY, Ma R, Shah SH, Granger CB, Quyyumi AA, Levey AI, Vaccarino V, Reilly MP, Rader DJ, Williams MJ, van Rij AM, Jones GT, Trabetti E, Malerba G, Pignatti PF, Boner A, Pescollderungg L, Girelli D, Olivieri O, Martinelli N, Ludviksson BR, Ludviksdottir D, Eyjolfsson GI, Arnar D, Thorgeirsson G, Deichmann K, Thompson PJ, Wjst M, Hall IP, Postma DS, Gislason T, Gulcher J, Kong A, Jonsdottir I, Thorsteinsdottir U, Stefansson K. | 01/21/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesCommon variants at 5q22 associate with pediatric eosinophilic esophagitis.
Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin LJ, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE, Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, Jonsdottir GM, Thorleifsson G, Helgadottir H, Steinthorsdottir V, Stefansson H, Williams C, Hui J, Beilby J, Warrington NM, James A, Palmer LJ, Koppelman GH, Heinzmann A, Krueger M, Boezen HM, Wheatley A, Altmuller J, Shin HD, Uh ST, Cheong HS, Jonsdottir B, Gislason D, Park CS, Rasmussen LM, Porsbjerg C, Hansen JW, Backer V, Werge T, Janson C, Jönsson UB, Ng MC, Chan J, So WY, Ma R, Shah SH, Granger CB, Quyyumi AA, Levey AI, Vaccarino V, Reilly MP, Rader DJ, Williams MJ, van Rij AM, Jones GT, Trabetti E, Malerba G, Pignatti PF, Boner A, Pescollderungg L, Girelli D, Olivieri O, Martinelli N, Ludviksson BR, Ludviksdottir D, Eyjolfsson GI, Arnar D, Thorgeirsson G, Deichmann K, Thompson PJ, Wjst M, Hall IP, Postma DS, Gislason T, Gulcher J, Kong A, Jonsdottir I, Thorsteinsdottir U, Stefansson K, Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, Jonsdottir GM, Thorleifsson G, Helgadottir H, Steinthorsdottir V, Stefansson H, Williams C, Hui J, Beilby J, Warrington NM, James A, Palmer LJ, Koppelman GH, Heinzmann A, Krueger M, Boezen HM, Wheatley A, Altmuller J, Shin HD, Uh ST, Cheong HS, Jonsdottir B, Gislason D, Park CS, Rasmussen LM, Porsbjerg C, Hansen JW, Backer V, Werge T, Janson C, Jönsson UB, Ng MC, Chan J, So WY, Ma R, Shah SH, Granger CB, Quyyumi AA, Levey AI, Vaccarino V, Reilly MP, Rader DJ, Williams MJ, van Rij AM, Jones GT, Trabetti E, Malerba G, Pignatti PF, Boner A, Pescollderungg L, Girelli D, Olivieri O, Martinelli N, Ludviksson BR, Ludviksdottir D, Eyjolfsson GI, Arnar D, Thorgeirsson G, Deichmann K, Thompson PJ, Wjst M, Hall IP, Postma DS, Gislason T, Gulcher J, Kong A, Jonsdottir I, Thorsteinsdottir U, Stefansson K. | 03/25/2009 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (10) articlesAnalyses of shared genetic factors between asthma and obesity in children.
Melén E, Himes BE, Brehm JM, Boutaoui N, Klanderman BJ, Sylvia JS, Lasky-Su J. [Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg].
Motushchuk AE, Komarova TIu, Grudinina NA, Rakhmanov VV, Mandel'shtam MIu, Astakhov IuS, Vasil'ev VB, Motushchuk AE, Komarova TIu, Grudinina NA, Rakhmanov VV, Mandel'shtam MIu, Astakhov IuS, Vasil'ev VB. Genetic evidence for a role of IL33 in nasal polyposis.
Buysschaert ID, Grulois V, Eloy P, Jorissen M, Rombaux P, Bertrand B, Collet S, Bobic S, Vlaminck S, Hellings PW, Lambrechts D. Different WDR36 mutation pattern in Chinese patients with primary open-angle glaucoma.
Fan BJ, Wang DY, Cheng CY, Ko WC, Lam SC, Pang CP, Fan BJ, Wang DY, Cheng CY, Ko WC, Lam SC, Pang CP. Multiple gene polymorphisms analysis revealed a different profile of genetic polymorphisms of primary open-angle glaucoma in northern Chinese.
Jia LY, Tam PO, Chiang SW, Ding N, Chen LJ, Yam GH, Pang CP, Wang NL. Profiling of WDR36 missense variants in German patients with glaucoma.
Pasutto F, Mardin CY, Michels-Rautenstrauss K, Weber BH, Sticht H, Chavarria-Soley G, Rautenstrauss B, Kruse F, Reis A, Pasutto F, Mardin CY, Michels-Rautenstrauss K, Weber BH, Sticht H, Chavarria-Soley G, Rautenstrauss B, Kruse F, Reis A. Association between primary open-angle glaucoma and WDR36 DNA sequence variants in Japanese.
Miyazawa A, Fuse N, Mengkegale M, Ryu M, Seimiya M, Wada Y, Nishida K, Miyazawa A, Fuse N, Mengkegale M, Ryu M, Seimiya M, Wada Y, Nishida K. No association between variations in the WDR36 gene and primary open-angle glaucoma.
Fingert JH, Alward WL, Kwon YH, Shankar SP, Andorf JL, Mackey DA, Sheffield VC, Stone EM. A Glaucoma Case-control Study of the WDR36 Gene D658G sequence variant.
Hewitt AW, Dimasi DP, Mackey DA, Craig JE, Hewitt AW, Dimasi DP, Mackey DA, Craig JE. Distribution of WDR36 DNA sequence variants in patients with primary open-angle glaucoma.
Hauser MA, Allingham RR, Linkroum K, Wang J, LaRocque-Abramson K, Figueiredo D, Santiago-Turla C, del Bono EA, Haines JL, Pericak-Vance MA, Wiggs JL, Hauser MA, Allingham RR, Linkroum K, Wang J, LaRocque-Abramson K, Figueiredo D, Santiago-Turla C, del Bono EA, Haines JL, Pericak-Vance MA, Wiggs JL. | 03/13/2008 |
| The occurrence of several rare putative disease-causing variants in patients with glaucoma suggests that WDR36 may be a minor disease-causing gene in glaucoma, at least in the German population. | Profiling of WDR36 missense variants in German patients with glaucoma.
Pasutto F, Mardin CY, Michels-Rautenstrauss K, Weber BH, Sticht H, Chavarria-Soley G, Rautenstrauss B, Kruse F, Reis A, Pasutto F, Mardin CY, Michels-Rautenstrauss K, Weber BH, Sticht H, Chavarria-Soley G, Rautenstrauss B, Kruse F, Reis A. | 01/21/2010 |
| Timolol can reduce MYOC RNA levels in HTM cultures from some individuals. Timolol does not alter OPTN or WDR36 levels or ameliorate MYOC induction by dexamethasone in vitro. | Effects of timolol on MYOC, OPTN, and WDR36 RNA levels.
Rozsa FW, Scott K, Pawar H, Moroi S, Richards JE. | 01/21/2010 |
| One nonsynonymous variant, p.S664L, and association of allelic variants (p.I264V and c.1965-30A>G) in WDR36 and their prevalence in unrelated Japanese patients with high tension glaucoma (HTG) suggest they are probably involved in pathogenesis of HTG. | Association between primary open-angle glaucoma and WDR36 DNA sequence variants in Japanese.
Miyazawa A, Fuse N, Mengkegale M, Ryu M, Seimiya M, Wada Y, Nishida K, Miyazawa A, Fuse N, Mengkegale M, Ryu M, Seimiya M, Wada Y, Nishida K. | 01/21/2010 |
| Our results provided mapping of a novel locus for juvenile-onset primary open angle glaucoma at 5q and excluded coding or splicing junctions mutations within the WDR36 gene. | A genome-wide scan maps a novel juvenile-onset primary open angle glaucoma locus to chromosome 5q.
Pang CP, Fan BJ, Canlas O, Wang DY, Dubois S, Tam PO, Lam DS, Raymond V, Ritch R. | 01/21/2010 |
| The finding that the WDR36 gene is probably not the responsible gene in this family further documents the genetic heterogeneity of POAG (primary open-angle glaucoma). | The role of the WDR36 gene on chromosome 5q22.1 in a large family with primary open-angle glaucoma mapped to this region.
Kramer PL, Samples JR, Monemi S, Sykes R, Sarfarazi M, Wirtz MK. | 01/21/2010 |
| The WDR36 D658G is a neutral variant in the Australian population. | A Glaucoma Case-control Study of the WDR36 Gene D658G sequence variant.
Hewitt AW, Dimasi DP, Mackey DA, Craig JE, Hewitt AW, Dimasi DP, Mackey DA, Craig JE. | 01/21/2010 |
| role in etiology of both high- and low-pressure glaucoma. | Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1.
Monemi S, Spaeth G, DaSilva A, Popinchalk S, Ilitchev E, Liebmann J, Ritch R, Héon E, Crick RP, Child A, Sarfarazi M. | 01/21/2010 |
| The association of WDR36 sequence variants with more severe disease in affected individuals suggests that defects in the WDR36 gene can contribute to POAG and that WDR36 may be a glaucoma modifier gene. | Distribution of WDR36 DNA sequence variants in patients with primary open-angle glaucoma.
Hauser MA, Allingham RR, Linkroum K, Wang J, LaRocque-Abramson K, Figueiredo D, Santiago-Turla C, del Bono EA, Haines JL, Pericak-Vance MA, Wiggs JL, Hauser MA, Allingham RR, Linkroum K, Wang J, LaRocque-Abramson K, Figueiredo D, Santiago-Turla C, del Bono EA, Haines JL, Pericak-Vance MA, Wiggs JL. | 01/21/2010 |
| WDR36 gene variants may be only rare causes of normal tension glaucoma in the German population. | Variations in the WDR36 gene in German patients with normal tension glaucoma.
Weisschuh N, Wolf C, Wissinger B, Gramer E., Free PMC Article | 01/21/2010 |