| Insights into the molecular roles of FOXR2 in the pathology of primary pediatric brain tumors. | Insights into the molecular roles of FOXR2 in the pathology of primary pediatric brain tumors.
Gharbaran R. | 11/30/2023 |
| The Relationship of FOXR2 Gene Expression Profile with Epithelial-Mesenchymal Transition Related Markers in Epithelial Ovarian Cancer. | The Relationship of FOXR2 Gene Expression Profile with Epithelial-Mesenchymal Transition Related Markers in Epithelial Ovarian Cancer.
Asadollahi S, Mazaheri MN, Karimi-Zarchi M, Fesahat, Farzaneh. | 03/14/2023 |
| FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits. | FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits.
Tsai JW, Cejas P, Wang DK, Patel S, Wu DW, Arounleut P, Wei X, Zhou N, Syamala S, Dubois FPB, Crane A, Pelton K, Vogelzang J, Sousa C, Baguette A, Chen X, Condurat AL, Dixon-Clarke SE, Zhou KN, Lu SD, Gonzalez EM, Chacon MS, Digiacomo JJ, Kumbhani R, Novikov D, Hunter J, Tsoli M, Ziegler DS, Dirksen U, Jager N, Balasubramanian GP, Kramm CM, Nathrath M, Bielack S, Baker SJ, Zhang J, McFarland JM, Getz G, Aguet F, Jabado N, Witt O, Pfister SM, Ligon KL, Hovestadt V, Kleinman CL, Long H, Jones DTW, Bandopadhayay P, Phoenix TN., Free PMC Article | 09/17/2022 |
| Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation. | Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation.
Korshunov A, Okonechnikov K, Schmitt-Hoffner F, Ryzhova M, Sahm F, Stichel D, Schrimpf D, Reuss DE, Sievers P, Suwala AK, Kumirova E, Zheludkova O, Golanov A, Jones DTW, Pfister SM, Kool M, von Deimling A., Free PMC Article | 11/22/2021 |
| Long noncoding RNA LINC00520 accelerates lung adenocarcinoma progression via miR-1252-5p/FOXR2 pathway. | Long noncoding RNA LINC00520 accelerates lung adenocarcinoma progression via miR-1252-5p/FOXR2 pathway.
Chen X, Chen H, Liu M, Xiong J, Song Z. | 08/7/2021 |
| E3 ubiquitin ligase PJA1 regulates lung adenocarcinoma apoptosis and invasion through promoting FOXR2 degradation. | E3 ubiquitin ligase PJA1 regulates lung adenocarcinoma apoptosis and invasion through promoting FOXR2 degradation.
Luo Z, Ye X, Cheng Y, Li F, Shou F, Wang G. | 07/24/2021 |
| Down-regulation of FOXR2 inhibits hypoxia-driven ROS-induced migration and invasion of thyroid cancer cells via regulation of the hedgehog pathway. | Down-regulation of FOXR2 inhibits hypoxia-driven ROS-induced migration and invasion of thyroid cancer cells via regulation of the hedgehog pathway.
Liao CW, Zheng C, Wang L. | 07/17/2021 |
| The tumor suppressor NOR1 suppresses cell growth, invasiveness, and tumorigenicity in glioma. | The tumor suppressor NOR1 suppresses cell growth, invasiveness, and tumorigenicity in glioma.
Cai J, Liu C, Yi M, Tan Y, Chen S, Ren N, Cheng H, Li X, Xiong W, Li G, Wu M, Wang W, Xiang B. | 11/21/2020 |
| CircABCB10 promotes non-small cell lung cancer cell proliferation and migration by regulating the miR-1252/FOXR2 axis. | CircABCB10 promotes nonsmall cell lung cancer cell proliferation and migration by regulating the miR-1252/FOXR2 axis.
Tian X, Zhang L, Jiao Y, Chen J, Shan Y, Yang W., Free PMC Article | 06/20/2020 |
| Study found that FoxR2 is frequently upregulated in ovarian cancer (OC) and associated with worse histologic grade and poor survival. FOXR2 expression was related to cell growth, migration, and epithelial-mesenchymal transition, whereas its silencing suppressed the malignant phenotype. Angiogenesis was also stimulated by FoxR2 overexpression by enhancing VEGF expression. | Forkhead-box R2 promotes metastasis and growth by stimulating angiogenesis and activating hedgehog signaling pathway in ovarian cancer.
Li B, Huang W, Cao N, Lou G. | 10/12/2019 |
| FOXR2 up-regulation can promote the proliferation and inhibit the apoptosis of prostate cancer cells because that HOTAIR restrains the expression of miR-152 | [The mechanism of HOTAIR regulating the proliferation and apoptosis of prostate cancer cells by targeting down-regulation of miR-152 to improve the expression of FOXR2].
Xu WB, Hou JQ, Chang JK, Li S, Liu GC, Cao SQ. | 07/13/2019 |
| FOXR2 might be considered as a promising therapeutic target for non-small cell lung cancer treatment. | Down-regulation of FOXR2 inhibits non-small cell lung cancer cell proliferation and invasion through the Wnt/β-catenin signaling pathway.
Wang XH, Cui YX, Wang ZM, Liu J. | 09/22/2018 |
| FOXR2 was up-regulated and significantly associated with poor endometrial adenocarcinoma prognosis. FOXR2 is a target gene of miR-202. | miR-202 Suppresses Cell Proliferation by Targeting FOXR2 in Endometrial Adenocarcinoma.
Deng X, Hou C, Liang Z, Wang H, Zhu L, Xu H., Free PMC Article | 05/5/2018 |
| FOXR2 acts with MYC to promote cancer cell proliferation, which is a potential tumor-specific target for therapeutic intervention against MYC-driven cancers. | FOXR2 Interacts with MYC to Promote Its Transcriptional Activities and Tumorigenesis.
Li X, Wang W, Xi Y, Gao M, Tran M, Aziz KE, Qin J, Li W, Chen J., Free PMC Article | 12/2/2017 |
| our data suggested that FOXR2 significantly promoted proliferation, invasion, and EMT of CRC cells. All these findings provided evidence for the role of FOXR2 as an oncogene in CRC development. | FOXR2 Promotes the Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Human Colorectal Cancer Cells.
Lu SQ, Qiu Y, Dai WJ, Zhang XY., Free PMC Article | 11/4/2017 |
| Knockdown of FOXR2 significantly down-regulated the protein expression levels of beta-catenin. | Knockdown of FOXR2 suppresses the tumorigenesis, growth and metastasis of prostate cancer.
Xu W, Chang J, Liu G, Du X, Li X. | 02/25/2017 |
| FOXR2 is frequently upregulated in hepatocellular carcinoma specimens compared with neighboring non-cancerous tissues in both messenger RNA and protein. It promoted cell growth and colony formation, and it facilitated tumor xenograft growth. beta-catenin, Skp2, c-Myc, and Gli-1 are the potential downstream effectors of FOXR2. | FOXR2 contributes to cell proliferation and malignancy in human hepatocellular carcinoma.
Wang X, He B, Gao Y, Li Y. | 02/18/2017 |
| we observed that the highly expressed FOXR2 in breast and overexpression of FOXR2 was positively associated with the progression and poor prognosis in patients with breast cancer, which indicated that FOXR2 might serve as a valuable prognosis biomarker for breast cancer individuals. | High expression of FOXR2 in breast cancer correlates with poor prognosis.
Song H, He W, Huang X, Zhang H, Huang T. | 02/18/2017 |
| Human FOXN6 gene was identified within human genome sequence RP11-167P23 ( | Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico.
Katoh M, Katoh M. | 01/21/2010 |