| Loss of function of Lgr6 did not impact epidermal cell proliferation, cell migration and wound healing. | Lgr6 is dispensable for epidermal cell proliferation and wound repair.
Jiang L, Wang L, Chen CP, Li MQ, Liao XH. | 09/22/2018 |
| Results suggest that DES causes testicular maldescent by altering the LGR8 pathway in mouse gubernaculum testis cells. | Diethylstilbestrol Regulates the Expression of LGR8 in Mouse Gubernaculum Testis Cells.
Duan S, Jiang X, Zhang X, Xie L, Sun Z, Ma S, Li J., Free PMC Article | 12/17/2016 |
| The results displayed that INSL3 changed RXFP2 expression in mouse gubernaculum testis cells in vitro | An insight into insulin-like factor 3 regulate its receptor RXFP2 in mouse gubernaculum testis cells.
Duan S, Zhang X, Jiang X, Xie L, Sun Z, Ma S, Li J., Free PMC Article | 10/29/2016 |
| data suggest a novel role for Rln in craniofacial skeletal development and metabolism through Rxfp2 | RELAXIN enhances differentiation and matrix mineralization through Relaxin/insulin-like family peptide receptor 2 (Rxfp2) in MC3T3-E1 cells in vitro.
Duarte C, Kobayashi Y, Kawamoto T, Moriyama K. | 02/14/2015 |
| Rxfp1, Rxfp2, and Nr3c1 mRNAs were expressed on the developing maxilla and mandible, Meckel's cartilage, tongue, and tooth primordia between mouse embryonic days 13.5-18.5. | Relaxin receptors 1 and 2 and nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) mRNAs are expressed in oral components of developing mice.
Duarte C, Kobayashi Y, Kawamoto T, Moriyama K. | 11/8/2014 |
| Spermatogonial stem cells undergo drastic depletion in the cryptorchid testes of RXFP2 deficient mice. | The fate of spermatogonial stem cells in the cryptorchid testes of RXFP2 deficient mice.
Ferguson L, How JJ, Agoulnik AI., Free PMC Article | 05/3/2014 |
| Data suggest that Insl3/Rxfp2 (insulin-like peptide 3/relaxin receptor 2) signaling is important for testicular descent; however, germ-cell deletion of Rxfp2 did not affect spermatogenesis, germ cell survival, or male fertility. | Insulin-like 3 signaling is important for testicular descent but dispensable for spermatogenesis and germ cell survival in adult mice.
Huang Z, Rivas B, Agoulnik AI., Free PMC Article | 05/18/2013 |
| Prenatal exposure to diethylstilbestrol increased the expression of LGR8 mRNA in the mouse gubernaculum testis. | [Diethylstilbestrol affects LGR8 expression in mouse gubernaculum testis].
Yang XB, Jiang XW, Duan SX, Qi YW, Zhang X, Li JH. | 04/27/2013 |
| A deficiency for Rxfp2 on Cav1-deficient background led to more than a 2-fold increase in the incidence of uterine cysts. | Uterine cysts in female mice deficient for caveolin-1 and insulin-like 3 receptor RXFP2.
Li Z, Feng S, Lopez V, Elhammady G, Anderson ML, Kaftanovskaya EM, Agoulnik AI., Free PMC Article | 11/26/2011 |
| A mouse model was created containing a novel missense mutation in Relaxin/insulin-like family peptide receptor 2 which likely prevents binding to its ligand, Insulin-like peptide 3, resulting in failure of the transabdominal phase of testicular descent. | A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism.
Harris RM, Finlayson C, Weiss J, Fisher L, Hurley L, Barrett T, Emge D, Bathgate RA, Agoulnik AI, Jameson JL. | 02/26/2011 |
| RXFP2 signaling pathway plays an important role in mediating androgen action to stimulate gubernaculum development during inguinoscrotal testis descent. | The role of RXFP2 in mediating androgen-induced inguinoscrotal testis descent in LH receptor knockout mice.
Yuan FP, Li X, Lin J, Schwabe C, Büllesbach EE, Rao CV, Lei ZM., Free PMC Article | 07/12/2010 |
| The data suggest that Pod1 may negatively regulate Rxfp2 expression in the developing glomerulus to promote cell proliferation. | Regulation of Rxfp2 (Lgr8) expression in the mouse fetal kidney by the transcription factor Pod1 (Tcf 21).
Familari M, Vu D, Parry LJ. | 01/21/2010 |
| Rxfp2-deficient mice showed decreased bone mass, mineralizing surface, bone formation, and osteoclast surface. | New roles for INSL3 in adults.
Ferlin A, Pepe A, Gianesello L, Garolla A, Feng S, Facciolli A, Morello R, Agoulnik AI, Foresta C. | 01/21/2010 |
| Rxfp2 gene expression at different stages of embryonic and postnatal mouse development in male reproductive tissues was examined | Developmental expression and gene regulation of insulin-like 3 receptor RXFP2 in mouse male reproductive organs.
Feng S, Bogatcheva NV, Truong A, Korchin B, Bishop CE, Klonisch T, Agoulnik IU, Agoulnik AI. | 01/21/2010 |
| Disruption of the Greatgene causes failure of the transabdominal phase of descent, identical to that seen in the Insl3-deficient mutants, consistent with the recent data suggesting that Great gene encodes the Insl3 transmembrane receptor. | Transabdominal testicular descent is disrupted in mice with deletion of insulinlike factor 3 receptor.
Tomiyama H, Hutson JM, Truong A, Agoulnik AI. | 01/21/2010 |
| neither Insl3 nor Lgr8 contribute to the RLN signaling pathway; Insl3/Lgr8 and Rln1/Lgr7 actions do not overlap in vivo | Genetic targeting of relaxin and insulin-like factor 3 receptors in mice.
Kamat AA, Feng S, Bogatcheva NV, Truong A, Bishop CE, Agoulnik AI. | 01/21/2010 |
| Insulin-like 3 peptide or great cause cryptorchidism (undescended testes) in mice. | GREAT/LGR8 is the only receptor for insulin-like 3 peptide.
Bogatcheva NV, Truong A, Feng S, Engel W, Adham IM, Agoulnik AI. | 01/21/2010 |