| Ambivalent role of FasL in murine acute graft-versus-host-disease. | Ambivalent role of FasL in murine acute graft-versus-host-disease.
Bernard-Bloch R, Lebrault E, Li X, Sutra Del Galy A, Garcia A, Doliger C, Parietti V, Legembre P, Socié G, Karray S. | 09/6/2023 |
| CRISPR/Cas9-mediated abrogation of CD95L/CD95 signaling-induced glioma cell growth and immunosuppression increases survival in murine glioma models. | CRISPR/Cas9-mediated abrogation of CD95L/CD95 signaling-induced glioma cell growth and immunosuppression increases survival in murine glioma models.
Quijano-Rubio C, Silginer M, Weller M., Free PMC Article | 03/8/2023 |
| FasL is a catabolic factor in alveolar bone homeostasis. | FasL is a catabolic factor in alveolar bone homeostasis.
Apaza Alccayhuaman KA, Heimel P, Lee JS, Tangl S, Kuchler U, Marchesan J, Panahipour L, Lettner S, Matalová E, Gruber R., Free PMC Article | 02/16/2023 |
| E2f2 Attenuates Apoptosis of Activated T Lymphocytes and Protects from Immune-Mediated Injury through Repression of Fas and FasL. | E2f2 Attenuates Apoptosis of Activated T Lymphocytes and Protects from Immune-Mediated Injury through Repression of Fas and FasL.
Mustafa N, Mitxelena J, Infante A, Zenarruzabeitia O, Eriz A, Iglesias-Ara A, Zubiaga AM., Free PMC Article | 02/5/2022 |
| Fas/FasL Contributes to HSV-1 Brain Infection and Neuroinflammation. | Fas/FasL Contributes to HSV-1 Brain Infection and Neuroinflammation.
Krzyzowska M, Kowalczyk A, Skulska K, Thörn K, Eriksson K., Free PMC Article | 12/25/2021 |
| FasL Is Required for Osseous Healing in Extraction Sockets in Mice. | FasL Is Required for Osseous Healing in Extraction Sockets in Mice.
Apaza Alccayhuaman KA, Heimel P, Lee JS, Tangl S, Strauss FJ, Stähli A, Matalová E, Gruber R., Free PMC Article | 10/30/2021 |
| Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens. | Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens.
Flores-Mendoza G, Rodríguez-Rodríguez N, Rubio RM, Madera-Salcedo IK, Rosetti F, Crispín JC., Free PMC Article | 09/25/2021 |
| LncRNA LINC00324 is upregulated in intervertebral disk degeneration and upregulates FasL in nucleus pulposus cells. | LncRNA LINC00324 is upregulated in intervertebral disk degeneration and upregulates FasL in nucleus pulposus cells.
Chen Y, Wu Y, Chen R, Xu C, Chen Q. | 07/31/2021 |
| FasL-PDPK1 Pathway Promotes the Cytotoxicity of CD8(+) T Cells During Ischemic Stroke. | FasL-PDPK1 Pathway Promotes the Cytotoxicity of CD8(+) T Cells During Ischemic Stroke.
Fan L, Zhang CJ, Zhu L, Chen J, Zhang Z, Liu P, Cao X, Meng H, Xu Y. | 07/24/2021 |
| The cleft palate candidate gene BAG6 supports FoxO1 acetylation topromote FasL-mediated apoptosis during palate fusion. | The cleft palate candidate gene BAG6 supports FoxO1 acetylation to promote FasL-mediated apoptosis during palate fusion.
Xu J, Liu F, Xiong Z, Huo J, Li W, Jiang B, Mao W, He B, Wang X, Li G. | 03/13/2021 |
| Polyubiquitination of p62/SQSTM1 is a prerequisite for Fas/CD95 aggregation to promote caspase-dependent apoptosis in cadmium-exposed mouse monocyte RAW264.7 cells. | Polyubiquitination of p62/SQSTM1 is a prerequisite for Fas/CD95 aggregation to promote caspase-dependent apoptosis in cadmium-exposed mouse monocyte RAW264.7 cells.
Jung KT, Oh SH., Free PMC Article | 10/24/2020 |
| Growth-dependent phenotype in FasL-deficient mandibular/alveolar bone. | Growth-dependent phenotype in FasL-deficient mandibular/alveolar bone.
Svandova E, Sadoine J, Vesela B, Djoudi A, Lesot H, Poliard A, Matalova E., Free PMC Article | 09/19/2020 |
| IL-6-driven FasL promotes NF-kappaBp65/PUMA-mediated apoptosis in portal hypertensive gastropathy. | IL-6-driven FasL promotes NF-κBp65/PUMA-mediated apoptosis in portal hypertensive gastropathy.
Tan S, Xu M, Ke B, Lu Y, Liu H, Jiang J, Wu B., Free PMC Article | 08/22/2020 |
| Increased miR-204-5p might suppress Renal ischemia-reperfusion injury in mice through suppressing Fas/FasL pathway by targeting FasL. | Overexpression of microRNA-204-5p alleviates renal ischemia-reperfusion injury in mice through blockage of Fas/FasL pathway.
Zhu Y, Yin X, Li J, Zhang L. | 06/13/2020 |
| The functionality of FasL/Fas might affect inflammation-driven tumorigenesis in an experimental model of chronic liver disease. | Disruption of the FasL/Fas axis protects against inflammation-derived tumorigenesis in chronic liver disease.
Cubero FJ, Woitok MM, Zoubek ME, de Bruin A, Hatting M, Trautwein C., Free PMC Article | 06/6/2020 |
| FasL-defective gld/gld mice also displayed reduced numbers of liver NK T cells, which have been previously implicated in suppression on liver NK cell activity. The absence of functional FasL in the liver correlates with a heightened, not diminished, resistance to melanoma liver metastases. | Defective FasL expression is associated with increased resistance to melanoma liver metastases and enhanced natural killer cell activity.
Neelam S, Mellon J, Wilkerson A, Niederkorn JY., Free PMC Article | 06/6/2020 |
| Dendritic cell NLRC4 regulates influenza A virus-specific CD4 T cell responses through FasL expression. | Dendritic cell NLRC4 regulates influenza A virus-specific CD4 T cell responses through FasL expression.
Hornick EE, Dagvadorj J, Zacharias ZR, Miller AM, Langlois RA, Chen P, Legge KL, Bishop GA, Sutterwala FS, Cassel SL., Free PMC Article | 05/23/2020 |
| Inflammatory cell infiltration during abdominal aortic aneurysm formation is dependent on CD95L from myelogeous cells. Aneurysm inhibition by deletion of CD95L is mediated in part by down-regulation of caspase 8. | CD95-ligand contributes to abdominal aortic aneurysm progression by modulating inflammation.
Liu Z, Fitzgerald M, Meisinger T, Batra R, Suh M, Greene H, Penrice AJ, Sun L, Baxter BT, Xiong W., Free PMC Article | 05/9/2020 |
| our results indicate that high-dose GluOC triggers necroptosis through upregulation of FasL at the plasma membrane in a manner dependent of activation of CREB-p300, followed by the activation of Fas signaling in neighboring adipocytes | Osteocalcin triggers Fas/FasL-mediated necroptosis in adipocytes via activation of p300.
Otani T, Matsuda M, Mizokami A, Kitagawa N, Takeuchi H, Jimi E, Inai T, Hirata M., Free PMC Article | 12/14/2019 |
| the present study demonstrates that FasL modulates the subsets of CD4+ T cells and plays an important role in mediating M1 microglia shift following ischemic stroke | FasL incapacitation alleviates CD4(+) T cells-induced brain injury through remodeling of microglia polarization in mouse ischemic stroke.
Zhao H, Wan L, Chen Y, Zhang H, Xu Y, Qiu S. | 10/5/2019 |
| Restraint stress of female mice impaired oocyte competence, enhanced expression of CRH and CRH receptor in the ovary, and induced apoptosis while activating the Fas/FasL system in mural granulosa cells and oocytes. | Restraint-induced corticotrophin-releasing hormone elevation triggers apoptosis of ovarian cells and impairs oocyte competence via activation of the Fas/FasL system.
Li CY, Li ZB, Kong QQ, Han X, Xiao B, Li X, Chang ZL, Tan JH. | 09/28/2019 |
| model of systemic autoimmunity that depends on T cell detection of a membrane-bound OVA fusion protein expressed by MHC class II+ cells, expression of TLR7, expression of the type I IFN receptor, and loss of expression of TLR9, with a high frequency of OVA-specific Tbet+, IFN-gamma+, and FasL-expressing Th1 cells as well as autoantibody-producing B cells | Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation.
Mande P, Zirak B, Ko WC, Taravati K, Bride KL, Brodeur TY, Deng A, Dresser K, Jiang Z, Ettinger R, Fitzgerald KA, Rosenblum MD, Harris JE, Marshak-Rothstein A., Free PMC Article | 09/21/2019 |
| Pairing of purified normal CD4 T cells with either pfp or FasL defective CD8 T cell subsets. | Both perforin and FasL are required for optimal CD8 T cell control of autoreactive B cells and autoantibody production in parent-into-F1 lupus mice.
Soloviova K, Puliaiev M, Puliaev R, Puliaeva I, Via CS., Free PMC Article | 08/17/2019 |
| ApoE and Fasl(gld) knockout C57BL/6 mice simultaneously exhibited systemic lupus erythematosus and atherosclerosis characteristics and endothelial cell injury. | Endothelial cell injury is involved in atherosclerosis and lupus symptoms in gld.apoE(-) (/) (-) mice.
Yao G, Qi J, Zhang Z, Huang S, Geng L, Li W, Chen W, Tang X, Wang S, Sun L. | 08/3/2019 |
| Fas/FasL signaling is critical for the survival of exhausted CD8(+) T cells during the tumor immune response. | Fas/FasL signaling is critical for the survival of exhausted antigen-specific CD8(+) T cells during tumor immune response.
Yajima T, Hoshino K, Muranushi R, Mogi A, Onozato R, Yamaki E, Kosaka T, Tanaka S, Shirabe K, Yoshikai Y, Kuwano H. | 05/11/2019 |