| Ficolin A knockout alleviates sepsis-induced severe lung injury in mice by restoring gut Akkermansia to inhibit S100A4/STAT3 pathway. | Ficolin A knockout alleviates sepsis-induced severe lung injury in mice by restoring gut Akkermansia to inhibit S100A4/STAT3 pathway.
Wu X, Xuan W, Yang X, Liu W, Zhang H, Jiang G, Cao B, Jiang Y. | 07/26/2023 |
| FCN-A mediates the inflammatory response and the macrophage polarization in Aspergillus fumigatus keratitis of mice by activating the MAPK signaling pathway. | FCN-A mediates the inflammatory response and the macrophage polarization in Aspergillus fumigatus keratitis of mice by activating the MAPK signaling pathway.
Zhu G, Zhao G, Lin J, Li C, Wang Q, Xu Q, Peng X, Zheng H. | 03/13/2021 |
| Lipopolysaccharide-induced inflammation can induce a significant ficolin response. | The ficolin response to LPS challenge in mice.
Jarlhelt I, Genster N, Kirketerp-Møller N, Skjoedt MO, Garred P. | 05/11/2019 |
| Ficolin-2 induces macrophage activation, promotes M1 polarization and facilitates proliferation and antigen-specific cytotoxicity of CD8(+) T cells. Ficolin-2 binds to Toll-like receptor 4 (TLR4) on macrophages and DCs and promotes their antigen-presenting abilities to CD8(+) T cells. | Ficolin-2 triggers antitumor effect by activating macrophages and CD8(+) T cells.
Ding Q, Shen Y, Li D, Yang J, Yu J, Yin Z, Zhang XL. | 11/26/2017 |
| this study demonstrates that ficolins are important in initial innate host defense against Aspergillus fumigatus infections in vivo | Ficolins Promote Fungal Clearance in vivo and Modulate the Inflammatory Cytokine Response in Host Defense against Aspergillus fumigatus.
Genster N, Præstekjær Cramer E, Rosbjerg A, Pilely K, Cowland JB, Garred P., Free PMC Article | 10/14/2017 |
| this study shows that FCN-A/2 exacerbated the inflammatory pathogenesis of inflammatory bowel disease by stimulating M1 polarization through the TLR4/MyD88/MAPK/NF-kappaB signalling pathway in macrophages | Ficolin-A/2, acting as a new regulator of macrophage polarization, mediates the inflammatory response in experimental mouse colitis.
Yang YF, Zhou YD, Hu JC, Luo FL, Xie Y, Shen YY, Bian WX, Yin ZN, Li HL, Zhang XL., Free PMC Article | 09/16/2017 |
| FcnA-deficient and FcnA/ficolin B double-deficient mice lack FcnA-mediated complement activation in the sera, because of absence of complexes comprising FcnA and MBL-associated serine proteases. | Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection.
Endo Y, Takahashi M, Iwaki D, Ishida Y, Nakazawa N, Kodama T, Matsuzaka T, Kanno K, Liu Y, Tsuchiya K, Kawamura I, Ikawa M, Waguri S, Wada I, Matsushita M, Schwaeble WJ, Fujita T. | 02/23/2013 |
| the binding properties of the murine serum ficolin-A towards a panel of different clinical relevant microorganisms | The interaction pattern of murine serum ficolin-A with microorganisms.
Hummelshøj T, Ma YJ, Munthe-Fog L, Bjarnsholt T, Moser C, Skjoedt MO, Romani L, Fujita T, Endo Y, Garred P., Free PMC Article | 11/3/2012 |
| binds to the glycoproteins hemagglutinin and neuraminidase and inhibits influenza A virus infection both in vitro and in vivo | L-ficolin binds to the glycoproteins hemagglutinin and neuraminidase and inhibits influenza A virus infection both in vitro and in vivo.
Pan Q, Chen H, Wang F, Jeza VT, Hou W, Zhao Y, Xiang T, Zhu Y, Endo Y, Fujita T, Zhang XL., Free PMC Article | 09/1/2012 |
| Recombinant mouse ficolin A, mannose-binding lectin-A, and mannose-binding lectin-C bound to fibrinogen in a dose-dependent manner. The lectin pathway, through mannose-binding lectins, synchronized with blood coagulation. | Interactions of ficolin and mannose-binding lectin with fibrinogen/fibrin augment the lectin complement pathway.
Endo Y, Nakazawa N, Iwaki D, Takahashi M, Matsushita M, Fujita T. | 08/9/2010 |
| A functionally relevant signal peptide of ficolin A was identified by using mass spectrometry analysis to determine the N-terminal sequence of secreted ficolin A. | Identification of a functionally relevant signal peptide of mouse ficolin A.
Kwon S, Kim MS, Kim D, Lee KW, Choi SY, Park J, Kim YH, Lee Y, Kwon HJ. | 01/21/2010 |
| Ficolin A protein (smapshowed a potent complement activating capacity.These results suggest that ficolin A and its variant function as recognition molecules of the lectin pathway. | Carbohydrate-binding specificities of mouse ficolin A, a splicing variant of ficolin A and ficolin B and their complex formation with MASP-2 and sMAP.
Endo Y, Nakazawa N, Liu Y, Iwaki D, Takahashi M, Fujita T, Nakata M, Matsushita M. | 01/21/2010 |
| the expression pattern of ficolin A expression was closely similar to that of mannose-binding lectin-associated serine proteases, suggesting that these molecules may function in coordination as components of the lectin complement pathway | Ficolin A and ficolin B are expressed in distinct ontogenic patterns and cell types in the mouse.
Liu Y, Endo Y, Homma S, Kanno K, Yaginuma H, Fujita T. | 01/21/2010 |