| FGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models. | FGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models.
Galpin KJC, Rodriguez GM, Maranda V, Cook DP, Macdonald E, Murshed H, Zhao S, McCloskey CW, Chruscinski A, Levy GA, Ardolino M, Vanderhyden BC., Free PMC Article | 02/5/2024 |
| Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells. | Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells.
Wu L, Liu X, Lei J, Zhang N, Zhao H, Zhang J, Deng H, Li Y., Free PMC Article | 12/18/2023 |
| Fibrinogen-like protein 2 regulates macrophage glycolytic reprogramming by directly targeting PKM2 and exacerbates alcoholic liver injury. | Fibrinogen-like protein 2 regulates macrophage glycolytic reprogramming by directly targeting PKM2 and exacerbates alcoholic liver injury.
Hu X, Wan X, Diao Y, Shen Z, Zhang Z, Wang P, Hu D, Wang X, Yan W, Yu C, Luo X, Wang H, Ning Q. | 11/1/2023 |
| FGL2 deficiency alleviates maternal inflammation-induced blood-brain barrier damage by blocking PI3K/NF-kappaB mediated endothelial oxidative stress. | FGL2 deficiency alleviates maternal inflammation-induced blood-brain barrier damage by blocking PI3K/NF-κB mediated endothelial oxidative stress.
Huang L, Zhan D, Xing Y, Yan Y, Li Q, Zhang J, Li S, Ning Q, Zhang C, Luo X., Free PMC Article | 04/17/2023 |
| Fibrinogen-like protein 2: Its biological function across cell types and the potential to serve as an immunotherapy target for brain tumors. | Fibrinogen-like protein 2: Its biological function across cell types and the potential to serve as an immunotherapy target for brain tumors.
Zhang S, Rao G, Heimberger A, Li S., Free PMC Article | 02/11/2023 |
| The distinctive role of membrane fibrinogen-like protein 2 in the liver stage of rodent malaria infections. | The distinctive role of membrane fibrinogen-like protein 2 in the liver stage of rodent malaria infections.
Jiao S, Tan N, Zhu C, Fu Y, Zhang K, Ding Y, Xu W. | 01/11/2023 |
| Fibrinogen-like protein 2 contributes to normal murine cardiomyocyte maturation and heart development. | Fibrinogen-like protein 2 contributes to normal murine cardiomyocyte maturation and heart development.
Fan C, Chen H, Liu K, Wang Z. | 04/9/2022 |
| Fibrinogen-like protein 2 deficiency inhibits virus-induced fulminant hepatitis through abrogating inflammatory macrophage activation. | Fibrinogen-like protein 2 deficiency inhibits virus-induced fulminant hepatitis through abrogating inflammatory macrophage activation.
Xiao F, Wang HW, Hu JJ, Tao R, Weng XX, Wang P, Wu D, Wang XJ, Yan WM, Xi D, Luo XP, Wan XY, Ning Q., Free PMC Article | 02/12/2022 |
| Intrauterine inflammation induced white matter injury protection by fibrinogen-like protein 2 deficiency in perinatal mice. | Intrauterine inflammation induced white matter injury protection by fibrinogen-like protein 2 deficiency in perinatal mice.
Zhan D, Zhang C, Long W, Wei L, Jin S, Du C, Li Z, Guo S, Huang L, Ning Q, Luo X., Free PMC Article | 01/15/2022 |
| FGL2-wired macrophages secrete CXCL7 to regulate the stem-like functionality of glioma cells. | FGL2-wired macrophages secrete CXCL7 to regulate the stem-like functionality of glioma cells.
Yan J, Zhao Q, Wang J, Tian X, Wang J, Xia X, Ott M, Rao G, Heimberger AB, Li S., Free PMC Article | 09/18/2021 |
| T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity. | T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity.
Sungnak W, Wagner A, Kowalczyk MS, Bod L, Kye YC, Sage PT, Sharpe AH, Sobel RA, Quintana FJ, Rozenblatt-Rosen O, Regev A, Wang C, Yosef N, Kuchroo VK., Free PMC Article | 04/17/2021 |
| Fibrinogen-like protein 2 deficiency aggravates renal fibrosis by facilitating macrophage polarization. | Fibrinogen-like protein 2 deficiency aggravates renal fibrosis by facilitating macrophage polarization.
Wu S, Li M, Xu F, Li GQ, Han B, He XD, Li SJ, He QH, Lai XY, Zhou S, Zheng QY, Guo B, Chen J, Zhang KQ, Xu GL. | 02/27/2021 |
| Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2. | Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2.
Fu Y, Ding Y, Wang Q, Zhu F, Tan Y, Lu X, Guo B, Zhang Q, Cao Y, Liu T, Cui L, Xu W., Free PMC Article | 11/21/2020 |
| FGL2 suppressed dextran sulfate sodium-induced colitis and regulated NF-kappaB signaling in intestinal epithelial cells, as well as the function of lamina propria dendritic cells. | FGL2 regulates IKK/NF-κB signaling in intestinal epithelial cells and lamina propria dendritic cells to attenuate dextran sulfate sodium-induced colitis.
Li T, Chen RR, Gong HP, Wang BF, Wu XX, Chen YQ, Huang ZM. | 04/11/2020 |
| In the mouse fulminant hepatitis (FH) model revealed that CC10 protects against MHV-3-induced FH via suppression of Fgl2 expression in macrophages. In vitro, CC10 was found to significantly inhibit the expression of Fgl2 in MHV-3-infected mouse peritoneal macrophages. Such effects may be mediated by the transcription factor HBP1. | Clara Cell 10 kDa Protein Alleviates Murine Hepatitis Virus Strain 3-Induced Fulminant Hepatitis by Inhibiting Fibrinogen-Like Protein 2 Expression.
Yu H, Liu Y, Wang H, Wan X, Huang J, Yan W, Xi D, Luo X, Shen G, Ning Q., Free PMC Article | 10/26/2019 |
| The increase in intrahepatic and plasma sFGL2 by Tregs may restrict AIH progression by inhibiting conventional CD8+ T cells and Tc17 cell function. The high correlation between sFGL2 and disease severity may predict AIH outcome. | Soluble Fgl2 restricts autoimmune hepatitis progression via suppressing Tc17 and conventional CD8+ T cell function.
Ai G, Yan W, Yu H, Xiao F, Xi D, Ma K, Huang J, Luo X, Wan X, Ning Q. | 10/5/2019 |
| our results presented herein point to Fgl2 as a novel protective molecule in the pathogenesis of IBD. We found that Fgl2 is critical for limiting DSS-induced colitis and subsequent CAC development through its effects on macrophage polarization | Control of Intestinal Inflammation, Colitis-Associated Tumorigenesis, and Macrophage Polarization by Fibrinogen-Like Protein 2.
Zhu Y, Zhou J, Feng Y, Chen L, Zhang L, Yang F, Zha H, Wang X, Han X, Shu C, Wan YY, Li QJ, Guo B, Zhu B., Free PMC Article | 03/2/2019 |
| These results indicated that FGL2 might be a promising target for attenuating the severity of Severe acute pancreatitis (SAP) and adenovirus-mediated artificial miRNAs targetting FGL2 represented a potential therapeutic approach for the treatment of SAP. | Adenovirus-mediated artificial miRNA targetting fibrinogen-like protein 2 attenuates the severity of acute pancreatitis in mice.
Ye X, Ding J, Chen Y, Dong J., Free PMC Article | 08/4/2018 |
| The results of the present study indicated that, in the colitis model, FGL2 was associated with the immunopathogenesis of inflammatory bowel disease. | Elevated fibrinogen‑like protein 2 in TNBS‑induced colitis mice: Association with Th17 and regulatory T cells.
Lin H, Chen R, Jiang X, Wu X, Huang X, Dong X, Yang X, Lin X, Chen X, Chen X, Huang Z. | 04/21/2018 |
| FGL2-overexpressing regulatory T-cells have enhanced immunosuppressive activity and prevent colitis; FGL2-over-expressing effector T-cells are hypo-proliferative and do not induce colitis | Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis.
Bartczak A, Zhang J, Adeyi O, Amir A, Grant D, Gorczynski R, Selzner N, Chruscinski A, Levy GA., Free PMC Article | 03/31/2018 |
| PD-1 plays a vital role in brain inflammation via regulation of Fgl-2 after ICH, and that manipulation of PD-1 might be a promising therapeutical target in ICH. | Programmed death (PD)-1 attenuates macrophage activation and brain inflammation via regulation of fibrinogen-like protein 2 (Fgl-2) after intracerebral hemorrhage in mice.
Yuan B, Huang S, Gong S, Wang F, Lin L, Su T, Sheng H, Shi H, Ma K, Yang Z. | 12/9/2017 |
| In vitro IL-33 treatment abrogated MHV-3 and IFN-gamma induced FGL2 expression in RAW264.7 and THP-1 cells. | IL-33 protects murine viral fulminant hepatitis by targeting coagulation hallmark protein FGL2/fibroleukin expression.
Yu H, Liu Y, Huang J, Wang H, Yan W, Xi D, Shen G, Luo X, Ning Q. | 09/16/2017 |
| FGL2 appears as one of the key players in immune regulatory processes favoring metacestode survival by promoting Regulatory T-cell activity and IL-17A production that contributes to FGL2-regulation. | Deletion of Fibrinogen-like Protein 2 (FGL-2), a Novel CD4+ CD25+ Treg Effector Molecule, Leads to Improved Control of Echinococcus multilocularis Infection in Mice.
Wang J, Vuitton DA, Müller N, Hemphill A, Spiliotis M, Blagosklonov O, Grandgirard D, Leib SL, Shalev I, Levy G, Lu X, Lin R, Wen H, Gottstein B., Free PMC Article | 02/20/2016 |
| TNF-alpha, and FGL2 form an integral network that contributes to coagulation and complement activation, and suggest that those are potential therapeutic targets in viral FH intervention. | C5aR, TNF-α, and FGL2 contribute to coagulation and complement activation in virus-induced fulminant hepatitis.
Liu J, Tan Y, Zhang J, Zou L, Deng G, Xu X, Wang F, Ma Z, Zhang J, Zhao T, Liu Y, Li Y, Zhu B, Guo B. | 04/4/2015 |
| these data strongly suggest that Treg cells expressing FGL2 mediate rapamycin-induced tolerance. Furthermore, a gene biomarker panel that includes fgl2 can distinguish between rejecting and tolerant grafts. | The regulatory T cell effector molecule fibrinogen-like protein 2 is necessary for the development of rapamycin-induced tolerance to fully MHC-mismatched murine cardiac allografts.
Urbanellis P, Shyu W, Khattar R, Wang J, Zakharova A, He W, Sadozai H, Amir AZ, Shalev I, Phillips MJ, Adeyi O, Ross H, Grant D, Levy GA, Chruscinski A., Free PMC Article | 02/14/2015 |