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    Fgl2 fibrinogen-like protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 14190, updated on 19-Sep-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    FGL2-wired macrophages secrete CXCL7 to regulate the stem-like functionality of glioma cells.

    FGL2-wired macrophages secrete CXCL7 to regulate the stem-like functionality of glioma cells.
    Yan J, Zhao Q, Wang J, Tian X, Wang J, Xia X, Ott M, Rao G, Heimberger AB, Li S.,

    09/18/2021
    T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity.

    T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity.
    Sungnak W, Wagner A, Kowalczyk MS, Bod L, Kye YC, Sage PT, Sharpe AH, Sobel RA, Quintana FJ, Rozenblatt-Rosen O, Regev A, Wang C, Yosef N, Kuchroo VK.,

    04/17/2021
    Fibrinogen-like protein 2 deficiency aggravates renal fibrosis by facilitating macrophage polarization.

    Fibrinogen-like protein 2 deficiency aggravates renal fibrosis by facilitating macrophage polarization.
    Wu S, Li M, Xu F, Li GQ, Han B, He XD, Li SJ, He QH, Lai XY, Zhou S, Zheng QY, Guo B, Chen J, Zhang KQ, Xu GL.

    02/27/2021
    Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2.

    Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2.
    Fu Y, Ding Y, Wang Q, Zhu F, Tan Y, Lu X, Guo B, Zhang Q, Cao Y, Liu T, Cui L, Xu W., Free PMC Article

    11/21/2020
    FGL2 suppressed dextran sulfate sodium-induced colitis and regulated NF-kappaB signaling in intestinal epithelial cells, as well as the function of lamina propria dendritic cells.

    FGL2 regulates IKK/NF-κB signaling in intestinal epithelial cells and lamina propria dendritic cells to attenuate dextran sulfate sodium-induced colitis.
    Li T, Chen RR, Gong HP, Wang BF, Wu XX, Chen YQ, Huang ZM.

    04/11/2020
    In the mouse fulminant hepatitis (FH) model revealed that CC10 protects against MHV-3-induced FH via suppression of Fgl2 expression in macrophages. In vitro, CC10 was found to significantly inhibit the expression of Fgl2 in MHV-3-infected mouse peritoneal macrophages. Such effects may be mediated by the transcription factor HBP1.

    Clara Cell 10 kDa Protein Alleviates Murine Hepatitis Virus Strain 3-Induced Fulminant Hepatitis by Inhibiting Fibrinogen-Like Protein 2 Expression.
    Yu H, Liu Y, Wang H, Wan X, Huang J, Yan W, Xi D, Luo X, Shen G, Ning Q., Free PMC Article

    10/26/2019
    The increase in intrahepatic and plasma sFGL2 by Tregs may restrict AIH progression by inhibiting conventional CD8+ T cells and Tc17 cell function. The high correlation between sFGL2 and disease severity may predict AIH outcome.

    Soluble Fgl2 restricts autoimmune hepatitis progression via suppressing Tc17 and conventional CD8+ T cell function.
    Ai G, Yan W, Yu H, Xiao F, Xi D, Ma K, Huang J, Luo X, Wan X, Ning Q.

    10/5/2019
    our results presented herein point to Fgl2 as a novel protective molecule in the pathogenesis of IBD. We found that Fgl2 is critical for limiting DSS-induced colitis and subsequent CAC development through its effects on macrophage polarization

    Control of Intestinal Inflammation, Colitis-Associated Tumorigenesis, and Macrophage Polarization by Fibrinogen-Like Protein 2.
    Zhu Y, Zhou J, Feng Y, Chen L, Zhang L, Yang F, Zha H, Wang X, Han X, Shu C, Wan YY, Li QJ, Guo B, Zhu B., Free PMC Article

    03/2/2019
    These results indicated that FGL2 might be a promising target for attenuating the severity of Severe acute pancreatitis (SAP) and adenovirus-mediated artificial miRNAs targetting FGL2 represented a potential therapeutic approach for the treatment of SAP.

    Adenovirus-mediated artificial miRNA targetting fibrinogen-like protein 2 attenuates the severity of acute pancreatitis in mice.
    Ye X, Ding J, Chen Y, Dong J., Free PMC Article

    08/4/2018
    The results of the present study indicated that, in the colitis model, FGL2 was associated with the immunopathogenesis of inflammatory bowel disease.

    Elevated fibrinogen‑like protein 2 in TNBS‑induced colitis mice: Association with Th17 and regulatory T cells.
    Lin H, Chen R, Jiang X, Wu X, Huang X, Dong X, Yang X, Lin X, Chen X, Chen X, Huang Z.

    04/21/2018
    FGL2-overexpressing regulatory T-cells have enhanced immunosuppressive activity and prevent colitis; FGL2-over-expressing effector T-cells are hypo-proliferative and do not induce colitis

    Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis.
    Bartczak A, Zhang J, Adeyi O, Amir A, Grant D, Gorczynski R, Selzner N, Chruscinski A, Levy GA., Free PMC Article

    03/31/2018
    PD-1 plays a vital role in brain inflammation via regulation of Fgl-2 after ICH, and that manipulation of PD-1 might be a promising therapeutical target in ICH.

    Programmed death (PD)-1 attenuates macrophage activation and brain inflammation via regulation of fibrinogen-like protein 2 (Fgl-2) after intracerebral hemorrhage in mice.
    Yuan B, Huang S, Gong S, Wang F, Lin L, Su T, Sheng H, Shi H, Ma K, Yang Z.

    12/9/2017
    In vitro IL-33 treatment abrogated MHV-3 and IFN-gamma induced FGL2 expression in RAW264.7 and THP-1 cells.

    IL-33 protects murine viral fulminant hepatitis by targeting coagulation hallmark protein FGL2/fibroleukin expression.
    Yu H, Liu Y, Huang J, Wang H, Yan W, Xi D, Shen G, Luo X, Ning Q.

    09/16/2017
    FGL2 appears as one of the key players in immune regulatory processes favoring metacestode survival by promoting Regulatory T-cell activity and IL-17A production that contributes to FGL2-regulation.

    Deletion of Fibrinogen-like Protein 2 (FGL-2), a Novel CD4+ CD25+ Treg Effector Molecule, Leads to Improved Control of Echinococcus multilocularis Infection in Mice.
    Wang J, Vuitton DA, Müller N, Hemphill A, Spiliotis M, Blagosklonov O, Grandgirard D, Leib SL, Shalev I, Levy G, Lu X, Lin R, Wen H, Gottstein B., Free PMC Article

    02/20/2016
    TNF-alpha, and FGL2 form an integral network that contributes to coagulation and complement activation, and suggest that those are potential therapeutic targets in viral FH intervention.

    C5aR, TNF-α, and FGL2 contribute to coagulation and complement activation in virus-induced fulminant hepatitis.
    Liu J, Tan Y, Zhang J, Zou L, Deng G, Xu X, Wang F, Ma Z, Zhang J, Zhao T, Liu Y, Li Y, Zhu B, Guo B.

    04/4/2015
    these data strongly suggest that Treg cells expressing FGL2 mediate rapamycin-induced tolerance. Furthermore, a gene biomarker panel that includes fgl2 can distinguish between rejecting and tolerant grafts.

    The regulatory T cell effector molecule fibrinogen-like protein 2 is necessary for the development of rapamycin-induced tolerance to fully MHC-mismatched murine cardiac allografts.
    Urbanellis P, Shyu W, Khattar R, Wang J, Zakharova A, He W, Sadozai H, Amir AZ, Shalev I, Phillips MJ, Adeyi O, Ross H, Grant D, Levy GA, Chruscinski A., Free PMC Article

    02/14/2015
    Combined adenovirus-mediated artificial microRNAs targeting mfgl2, mFas, and mTNFR1 protect against fulminant hepatic failure in mice.

    Combined adenovirus-mediated artificial microRNAs targeting mfgl2, mFas, and mTNFR1 protect against fulminant hepatic failure in mice.
    Xi D, Wang M, Ye H, Luo X, Ning Q., Free PMC Article

    10/4/2014
    Mouse susceptibility to MHV-3-induced fulminant hepatitis may rely on C5a/C5aR interactions, for which ERK1/2 and p38 pathways participate in up-regulating Fgl2 expression.

    C5a/C5aR pathway is essential for the pathogenesis of murine viral fulminant hepatitis by way of potentiating Fgl2/fibroleukin expression.
    Xu GL, Chen J, Yang F, Li GQ, Zheng LX, Wu YZ.

    09/13/2014
    Targeted deletion of FGL2 leads to increased early viral replication and enhanced adaptive immunity in a murine model of acute viral hepatitis.

    Targeted deletion of FGL2 leads to increased early viral replication and enhanced adaptive immunity in a murine model of acute viral hepatitis caused by LCMV WE.
    Khattar R, Luft O, Yavorska N, Shalev I, Phillips MJ, Adeyi O, Gao D, Bartczak A, Urbanellis P, Shyu W, Zhang J, Manuel J, Levy GA, Selzner N., Free PMC Article

    07/26/2014
    Cysteines at positions 94, 97, 184 and 187, found in the coiled-coil domain were shown to be crucial for FGL2 oligomerization.

    Characterization of fibrinogen-like protein 2 (FGL2): monomeric FGL2 has enhanced immunosuppressive activity in comparison to oligomeric FGL2.
    Liu H, Yang PS, Zhu T, Manuel J, Zhang J, He W, Shalev I, Zhang L, Cybulsky MI, Grant DR, Phillips MJ, Levy GA.

    07/6/2013
    FGL2 binding to the FcgammaRIIB receptor expressed on sinusoidal endothelial cells (SECs) is a critical event in the initiation of the hepatic reperfusion injury cascade through induction of SEC and hepatocyte death.

    FGL2/fibroleukin mediates hepatic reperfusion injury by induction of sinusoidal endothelial cell and hepatocyte apoptosis in mice.
    Selzner N, Liu H, Boehnert MU, Adeyi OA, Shalev I, Bartczak AM, Xue-Zhong M, Manuel J, Rotstein OD, McGilvray ID, Grant DR, Phillips MJ, Levy GA, Selzner M.

    05/26/2012
    The prothrombinase activity of FGL2 contributes to the pathogenesis of experimental arthritis.

    The prothrombinase activity of FGL2 contributes to the pathogenesis of experimental arthritis.
    Melnyk MC, Shalev I, Zhang J, Bartczak A, Gorczynski RM, Selzner N, Inman R, Marsden PA, Phillips MJ, Clark DA, Levy GA.

    10/15/2011
    FGL2 is an important effector cytokine of egulatory T cells that contributes to susceptibility to mouse hepatitis virus strain 3 induced fulminant viral hepatitis.

    The novel CD4+CD25+ regulatory T cell effector molecule fibrinogen-like protein 2 contributes to the outcome of murine fulminant viral hepatitis.
    Shalev I, Wong KM, Foerster K, Zhu Y, Chan C, Maknojia A, Zhang J, Ma XZ, Yang XC, Gao JF, Liu H, Selzner N, Clark DA, Adeyi O, Phillips MJ, Gorczynski RR, Grant D, McGilvray I, Levy G.

    01/21/2010
    FGL2 binds specifically to Fc gamma receptor (FcgammaR)IIB and FcgammaRIII receptors results in immunosuppression.

    The FGL2-FcgammaRIIB pathway: a novel mechanism leading to immunosuppression.
    Liu H, Shalev I, Manuel J, He W, Leung E, Crookshank J, Liu MF, Diao J, Cattral M, Clark DA, Isenman DE, Gorczynski RM, Grant DR, Zhang L, Phillips MJ, Cybulsky MI, Levy GA.

    01/21/2010
    FGL2 contributes to Treg cell activity and inhibits the development of autoimmune disease.

    Targeted deletion of fgl2 leads to impaired regulatory T cell activity and development of autoimmune glomerulonephritis.
    Shalev I, Liu H, Koscik C, Bartczak A, Javadi M, Wong KM, Maknojia A, He W, Liu MF, Diao J, Winter E, Manuel J, McCarthy D, Cattral M, Gommerman J, Clark DA, Phillips MJ, Gorczynski RR, Zhang L, Downey G, Grant D, Cybulsky MI, Levy G.

    01/21/2010
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