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    Fzd3 frizzled class receptor 3 [ Mus musculus (house mouse) ]

    Gene ID: 14365, updated on 22-Aug-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Topologically correct central projections of tetrapod inner ear afferents require Fzd3.

    Topologically correct central projections of tetrapod inner ear afferents require Fzd3.
    Duncan JS, Fritzsch B, Houston DW, Ketchum EM, Kersigo J, Deans MR, Elliott KL., Free PMC Article

    10/24/2020
    We demonstrate using mice that Fzd3 and Fzd6 similarly regulate axon turning, are functionally redundant with each other, and that Fzd3 genetically interacts with Vangl2 to guide this process

    <i>Frizzled3</i> and <i>Frizzled6</i> Cooperate with <i>Vangl2</i> to Direct Cochlear Innervation by Type II Spiral Ganglion Neurons.
    Ghimire SR, Deans MR., Free PMC Article

    07/4/2020
    Fzd3 and Fzd6 play a redundant role in controlling the polarity of developing skin, but through non-identical mechanisms.

    Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles.
    Dong B, Vold S, Olvera-Jaramillo C, Chang H.

    02/16/2019
    The authors report here that Sonic Hedgehog (Shh)-Smoothened signaling downregulates Shisa2, which inhibits the glycosylation and cell surface presentation of Frizzled3 in rodent commissural axon growth cones.

    Sonic Hedgehog switches on Wnt/planar cell polarity signaling in commissural axon growth cones by reducing levels of Shisa2.
    Onishi K, Zou Y., Free PMC Article

    06/16/2018
    Results suggest that Celsr3 and Fzd3 orchestrate the formation of a scaffold of pioneer neurons and their axons during embryogenesis. This scaffold extends from prethalamus to ventral telencephalon and subcortex, and steers reciprocal corticothalamic fibers.

    Celsr3 and Fzd3 Organize a Pioneer Neuron Scaffold to Steer Growing Thalamocortical Axons.
    Feng J, Xian Q, Guan T, Hu J, Wang M, Huang Y, So KF, Evans SM, Chai G, Goffinet AM, Qu Y, Zhou L., Free PMC Article

    01/20/2018
    Frizzled3 is required to shape the pattern of RBC somas and dendrites, and the structural and functional connectivity between rods and RBCs. Our results highlight novel functions for Fzd3 in regulating retinal development.

    Frizzled3 Shapes the Development of Retinal Rod Bipolar Cells.
    Shen N, Qu Y, Yu Y, So KF, Goffinet AM, Vardi N, Xu Y, Zhou L.

    06/24/2017
    Temporal and spatial expression profiles of Frizzled 3 in the ovary during the estrous cycle has been reported.

    Temporal and spatial expression profiles of Frizzled 3 in the ovary during the estrous cycle.
    Wang SB, Liu YP, Zhang ZH, Wang ZK, Xu YX, Wang ZC.

    11/19/2016
    Celsr3 and Fzd3 enable immature neurons to respond to Wnt7, upregulate Jag1 and thereby facilitate feedback signals that tune the timing of neural progenitor cell fate decisions via Notch activation.

    Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling.
    Wang W, Jossin Y, Chai G, Lien WH, Tissir F, Goffinet AM., Free PMC Article

    07/30/2016
    This study demonstrated that Frizzled3 Controls Axonal Polarity and Intermediate Target Entry during Striatal Pathway Development.

    Frizzled3 Controls Axonal Polarity and Intermediate Target Entry during Striatal Pathway Development.
    Morello F, Prasad AA, Rehberg K, Vieira de Sá R, Antón-Bolaños N, Leyva-Diaz E, Adolfs Y, Tissir F, López-Bendito G, Pasterkamp RJ., Free PMC Article

    01/30/2016
    In Fz3(-/-) limbs, dorsal axons stall at a precise location in the nerve plexus, and, in contrast to the phenotypes of several other axon path-finding mutants, Fz3(-/-) dorsal axons do not reroute to other trajectories

    Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons.
    Hua ZL, Smallwood PM, Nathans J., Free PMC Article

    07/25/2015
    Wnt3a/Frizzled-3 signaling plays important role in regulating the proliferation and differentiation of neural crest cells and various developmental stages of melanocyte precursors.

    The roles of Frizzled-3 and Wnt3a on melanocyte development: in vitro studies on neural crest cells and melanocyte precursor cell lines.
    Chang CH, Tsai RK, Tsai MH, Lin YH, Hirobe T.

    02/21/2015
    Fz3 and Fz6 have partly interchangeable roles in tissue polarity signaling for epithelial orientation and axon growth and guidance

    Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance.
    Hua ZL, Chang H, Wang Y, Smallwood PM, Nathans J., Free PMC Article

    12/20/2014
    The first signal, controlled by cadherin, EGF-like, laminin G-like, seven-pass, G-type receptor (Celsr) 2, Celsr3, Frizzled3 (Fzd3) and Van Gogh like2 (Vangl2) organizes multicilia in individual cells (single-cell polarity)

    A dual role for planar cell polarity genes in ciliated cells.
    Boutin C, Labedan P, Dimidschstein J, Richard F, Cremer H, André P, Yang Y, Montcouquiol M, Goffinet AM, Tissir F., Free PMC Article

    11/8/2014
    Celsr2-3 and Fzd3 regulate axonal navigation in the forebrain by using mechanisms different from classical epithelial core planar cell polarity, and require interacting partners other than Vangl1-2 that remain to be identified.

    Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner.
    Qu Y, Huang Y, Feng J, Alvarez-Bolado G, Grove EA, Yang Y, Tissir F, Zhou L, Goffinet AM., Free PMC Article

    10/4/2014
    Several central nervous system axon tracts require Fz3 function as early as embryonic day 11.5, and that Fz3 is required for pathfinding by dopaminergic and serotonergic axons in the brain and by a subset of optic tract axons.

    Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system.
    Hua ZL, Jeon S, Caterina MJ, Nathans J., Free PMC Article

    10/4/2014
    Frizzled3 endocytosis is part of the key mechanism for growth cone steering

    Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance.
    Onishi K, Shafer B, Lo C, Tissir F, Goffinet AM, Zou Y., Free PMC Article

    02/1/2014
    Celsr3 and Fzd3 are required during murine embryogenesis to specifically control the guidance and growth of enteric neuronal projections relative to the longitudinal and radial gut axes.

    Planar cell polarity genes control the connectivity of enteric neurons.
    Sasselli V, Boesmans W, Vanden Berghe P, Tissir F, Goffinet AM, Pachnis V., Free PMC Article

    05/25/2013
    The results of this study suggested distinct roles for Fz3 during sympathetic neuron development; Fz3 acts at early developmental stages to maintain a pool of dividing sympathetic precursors.

    Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development.
    Armstrong A, Ryu YK, Chieco D, Kuruvilla R., Free PMC Article

    04/2/2011
    Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect.

    Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect.
    Stuebner S, Faus-Kessler T, Fischer T, Wurst W, Prakash N.

    04/12/2010
    commissural axons in mice lacking the Wnt receptor Frizzled3 displayed anterior-posterior guidance defects after midline crossing; Wnt-Frizzled signaling guides commissural axons along the anterior-posterior axis of the spinal cord

    Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling.
    Lyuksyutova AI, Lu CC, Milanesio N, King LA, Guo N, Wang Y, Nathans J, Tessier-Lavigne M, Zou Y.

    01/21/2010
    In the inner ear of a Vangl2 mutant (Looptail; Lp), Fz3 and Fz6 proteins accumulate to normal levels but do not localize correctly at the cell surface.

    The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells.
    Wang Y, Guo N, Nathans J., Free PMC Article

    01/21/2010
    Together, our data support the idea that protein asymmetry plays an important role in the development of PCP, but the colocalization and interaction of Fz3 and Vangl2 suggests that novel PCP mechanisms exist in vertebrates.

    Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals.
    Montcouquiol M, Sans N, Huss D, Kach J, Dickman JD, Forge A, Rachel RA, Copeland NG, Jenkins NA, Bogani D, Murdoch J, Warchol ME, Wenthold RJ, Kelley MW., Free PMC Article

    01/21/2010
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