| Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development of new-onset diabetes after kidney transplantation. | Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development of new-onset diabetes after kidney transplantation.
Luu D, Shah T, Sakharkar P, Min DI. | 12/21/2023 |
| The functions and roles of sestrins in regulating human diseases. | The functions and roles of sestrins in regulating human diseases.
Chen Y, Huang T, Yu Z, Yu Q, Wang Y, Hu J, Shi J, Yang G., Free PMC Article | 04/23/2022 |
| Oncogenic role of early growth response-1 in liver cancer through the regulation of the microRNA-675/sestrin 3 and the Wnt/beta-catenin signaling pathway. | Oncogenic role of early growth response-1 in liver cancer through the regulation of the microRNA-675/sestrin 3 and the Wnt/β-catenin signaling pathway.
Zhang L, Ren R, Yang X, Ge Y, Zhang X, Yuan H., Free PMC Article | 12/25/2021 |
| Colon and liver tissue damage detection using methylated SESN3 and PTK2B genes in circulating cell-free DNA in patients with acute graft-versus-host disease. | Colon and liver tissue damage detection using methylated SESN3 and PTK2B genes in circulating cell-free DNA in patients with acute graft-versus-host disease.
Waterhouse M, Pennisi S, Pfeifer D, Deuter M, von Bubnoff N, Scherer F, Strüssmann T, Wehr C, Duyster J, Bertz H, Finke J, Duque-Afonso J., Free PMC Article | 07/24/2021 |
| Circulating Sestrin Levels Are Increased in Hypertension Patients. | Circulating Sestrin Levels Are Increased in Hypertension Patients.
Fang C, Yang Z, Shi L, Zeng T, Shi Y, Liu L, Liu H, Lin Y., Free PMC Article | 05/29/2021 |
| identified new interactions between miR-200 and the oxidative stress response SESN proteins that affect anoikis resistance in human endometrial cancer cells. | Interactions between microRNA-200 family and Sestrin proteins in endometrial cancer cell lines and their significance to anoikis.
Kozak J, Wdowiak P, Maciejewski R, Torres A., Free PMC Article | 11/23/2019 |
| It is possible that the over expression of the SESN3 gene, known to suppress oxidative damage, may have contributed to the attenuation of fatigue in Puerto Rican Men during Radiotherapy for Prostate Cancer | Gene Expression, and Fatigue in Puerto Rican Men during Radiotherapy for Prostate Cancer: an Exploratory Study.
Gonzalez VJ, Saligan LN, Fridley BL, Ortiz-Zuazaga H, Aaronson LS., Free PMC Article | 07/13/2019 |
| Results suggest that Sesn3 is a target gene for rno-miR-155. Moreover, the rno-miR-155 antagonist may induce the expression of Sesn3, and then indirectly decrease the damage of oxidative stress to protect the brain from epileptogenesis-associated impairments. | Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiological features and cell apoptosis by activating Sestrin-3.
Huang LG, Zou J, Lu QC. | 04/20/2019 |
| The expression of SESN3 and (TSC2 and FOXO1) was identified in Lewy bodies from brainstem. | Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging.
Miki Y, Tanji K, Mori F, Utsumi J, Sasaki H, Kakita A, Takahashi H, Wakabayashi K. | 02/23/2019 |
| in FOXO3-death-resistant cells no point mutations in the TP53-DBD were found-in these cells FOXO3-TP53 complexes are formed and FOXO3-binding to the BIM-promoter, but not the induction of the detoxifying protein SESN3, were prevented, which in turn increased chemo-protection in this type of high-stage-derived neuroblastoma (NB)cells | FOXO3-mediated chemo-protection in high-stage neuroblastoma depends on wild-type TP53 and SESN3.
Rupp M, Hagenbuchner J, Rass B, Fiegl H, Kiechl-Kohlendorfer U, Obexer P, Ausserlechner MJ., Free PMC Article | 11/25/2017 |
| Treatment with cucurbitacin B to sestrin-3 siRNA treated EGFR-mutant cells further amplified the decrease in cell-viability and caused more sustained G2-phase cell cycle arrest, suggesting that these effects are mediated partly through sestrin-3. | Sestrin-3 modulation is essential for therapeutic efficacy of cucurbitacin B in lung cancer cells.
Khan N, Jajeh F, Khan MI, Mukhtar E, Shabana SM, Mukhtar H., Free PMC Article | 09/2/2017 |
| study revealed high confidence set of BMos (integrated with DNase I hypersensitivity sites) in the upstream regulatory regions of SESN3 that could be bound by transcription factors from multiple families including FOXOs, SMADs, SOXs, TCFs and HNF4A. TF-TF network analysis established hubs of interaction that include SMAD3, TCF3, SMAD2, HDAC2, SOX2, TAL1 and TCF12 as well as the likely protein complexes formed between them | Prediction and Validation of Transcription Factors Modulating the Expression of Sestrin3 Gene Using an Integrated Computational and Experimental Approach.
Srivastava R, Zhang Y, Xiong X, Zhang X, Pan X, Dong XC, Liangpunsakul S, Janga SC., Free PMC Article | 08/5/2017 |
| SESN3 positively regulates the gene network module in macrophages, microglia and neurons. | Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus.
Johnson MR, Behmoaras J, Bottolo L, Krishnan ML, Pernhorst K, Santoscoy PLM, Rossetti T, Speed D, Srivastava PK, Chadeau-Hyam M, Hajji N, Dabrowska A, Rotival M, Razzaghi B, Kovac S, Wanisch K, Grillo FW, Slaviero A, Langley SR, Shkura K, Roncon P, De T, Mattheisen M, Niehusmann P, O'Brien TJ, Petrovski S, von Lehe M, Hoffmann P, Eriksson J, Coffey AJ, Cichon S, Walker M, Simonato M, Danis B, Mazzuferi M, Foerch P, Schoch S, De Paola V, Kaminski RM, Cunliffe VT, Becker AJ, Petretto E., Free PMC Article | 02/6/2016 |
| Suggest that inhibitory effect of ethanol on Sesn3 may play an important role in the development of ethanol-induced fatty liver. | The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury.
Kang X, Petyaykina K, Tao R, Xiong X, Dong XC, Liangpunsakul S., Free PMC Article | 08/30/2014 |
| findings suggest the existence of a novel mechanism for the generation of antileukemic responses in CML cells, involving upregulation of SESN3 expression. | Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells.
Vakana E, Arslan AD, Szilard A, Altman JK, Platanias LC., Free PMC Article | 07/12/2014 |
| Sestrin 3 is upregulated in T2D and could influence skeletal muscle differentiation without altering glucose and lipid metabolism. | Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle.
Nascimento EB, Osler ME, Zierath JR., Free PMC Article | 02/15/2014 |
| HSF1/SESN3/reactive oxygen species/p21(Cip1/WAF1)-mediated deceleration of cell growth may contribute to cell defense systems protecting the organism from excessive proliferation of cells that overexpress activated Ras oncoproteins. | Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1 pathways.
Zamkova M, Khromova N, Kopnin BP, Kopnin P., Free PMC Article | 08/31/2013 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor | FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor.
Chen CC, Jeon SM, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I, Park Y, Hay N., Free PMC Article | 05/10/2010 |