| HOXA10 promotes Gdf5 expression in articular chondrocytes. | HOXA10 promotes Gdf5 expression in articular chondrocytes.
Murakami T, Ruengsinpinya L, Takahata Y, Nakaminami Y, Hata K, Nishimura R., Free PMC Article | 01/3/2024 |
| GDF5 deficiency prevents cardiac rupture following acute myocardial infarction in mice. | GDF5 deficiency prevents cardiac rupture following acute myocardial infarction in mice.
Shikatani EA, Wang T, Dingwell LS, White-Dzuro C, Momen A, Husain M. | 12/26/2023 |
| [GDF5: a therapeutic candidate for combating sarcopenia]. | [GDF5: a therapeutic candidate for combating sarcopenia].
Piétri-Rouxel F, Falcone S, Traoré M. | 11/30/2023 |
| Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis. | Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis.
Takahata Y, Hagino H, Kimura A, Urushizaki M, Yamamoto S, Wakamori K, Murakami T, Hata K, Nishimura R., Free PMC Article | 05/28/2022 |
| GDF-5 induces epidermal stem cell migration via RhoA-MMP9 signalling. | GDF-5 induces epidermal stem cell migration via RhoA-MMP9 signalling.
Li X, Wang F, Lan Y, Bian R, Wang Y, Zhang X, Guo Y, Xiao L, Ni W, Zhao X, Luo G, Zhan R., Free PMC Article | 09/25/2021 |
| Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis. | Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis.
Kania K, Colella F, Riemen AHK, Wang H, Howard KA, Aigner T, Dell'Accio F, Capellini TD, Roelofs AJ, De Bari C., Free PMC Article | 11/21/2020 |
| An embryonic CaVbeta1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse. | An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.
Traoré M, Gentil C, Benedetto C, Hogrel JY, De la Grange P, Cadot B, Benkhelifa-Ziyyat S, Julien L, Lemaitre M, Ferry A, Piétri-Rouxel F, Falcone S. | 09/5/2020 |
| These data suggested that GDF5 regulates neuron differentiation through mediating Atoh8 | Growth/differentiation 5 promotes the differentiation of retinal stem cells into neurons via Atoh8.
Li Y, Li H, Zhang L, Xiong S, Wen S, Xia X, Zhou X. | 06/6/2020 |
| mesenchymal cells from a GDF5 origin can contribute to zonal tendon-to-bone attachments within bone tunnels following anterior cruciate ligament reconstruction. | Cells from a GDF5 origin produce zonal tendon-to-bone attachments following anterior cruciate ligament reconstruction.
Hagiwara Y, Dyrna F, Kuntz AF, Adams DJ, Dyment NA., Free PMC Article | 05/9/2020 |
| GDF5 could improve insulin sensitivity and prevent metabolic syndrome, the adaptive thermogenesis in subcutaneous white adipose tissue could mediate the obesity resistance effects of GDF5 in mice and partially resulted in the activation of the p38 MAPK signaling pathway. | GDF5 Promotes White Adipose Tissue Thermogenesis via p38 MAPK Signaling Pathway.
Zhang W, Wu X, Pei Z, Kiess W, Yang Y, Xu Y, Chang Z, Wu J, Sun C, Luo F. | 12/7/2019 |
| Expression patterns of the joint marker Gdf5, tendon and ligament marker Scleraxis, early muscle marker MyoD1, and blood vessel marker Cadherin5 (Cdh5) are presented during the most active phases of embryonic mouse limb patterning. | Expression analysis of limb element markers during mouse embryonic development.
Rafipay A, Berg ALR, Erskine L, Vargesson N., Free PMC Article | 05/18/2019 |
| Hip morphology is profoundly affected by Gdf5 absence, and downstream regulatory sequences mediate its effects by controlling Gdf5 expression during development. | The role of Gdf5 regulatory regions in development of hip morphology.
Kiapour AM, Cao J, Young M, Capellini TD., Free PMC Article | 04/20/2019 |
| Knee morphology is profoundly affected by Gdf5 absence, and downstream regulatory sequences mediate its effects by controlling Gdf5 expression in knee tissues | Impact of broad regulatory regions on Gdf5 expression and function in knee development and susceptibility to osteoarthritis.
Pregizer SK, Kiapour AM, Young M, Chen H, Schoor M, Liu Z, Cao J, Rosen V, Capellini TD., Free PMC Article | 02/2/2019 |
| Microarray analysis of satellite cells showed that expression of growth differentiation factor 5 (Gdf5) mRNA was markedly increased in Dnmt3a-KO mice. The DNA methylation level of the Gdf5 promoter was markedly decreased in Dnmt3a-KO satellite cells. | Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration.
Hatazawa Y, Ono Y, Hirose Y, Kanai S, Fujii NL, Machida S, Nishino I, Shimizu T, Okano M, Kamei Y, Ogawa Y. | 11/10/2018 |
| Study concludes that growth/differentiation factor-5 (GDF-5) protects hippocampal neurons against kainic acid-induced neurodegeneration by signaling through bone morphogenetic protein receptor type IB, suggesting a therapeutic potential for GDF-5 in neurodegenerative diseases. | Signaling by growth/differentiation factor 5 through the bone morphogenetic protein receptor type IB protects neurons against kainic acid-induced neurodegeneration.
Zhao Y, Zhang M, Liu H, Wang J. | 03/31/2018 |
| spatiotemporal dynamics of Gdf5 expression may instruct lineage divergence. | Joint Development Involves a Continuous Influx of Gdf5-Positive Cells.
Shwartz Y, Viukov S, Krief S, Zelzer E., Free PMC Article | 10/14/2017 |
| he large array of modular enhancers for Gdf5 provide a new foundation for studying the spatial specificity of joint patterning in vertebrates, as well as new candidates for regulatory regions that may also influence osteoarthritis risk in human population | Heads, Shoulders, Elbows, Knees, and Toes: Modular Gdf5 Enhancers Control Different Joints in the Vertebrate Skeleton.
Chen H, Capellini TD, Schoor M, Mortlock DP, Reddi AH, Kingsley DM., Free PMC Article | 04/29/2017 |
| Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2-induced Smad1-Smad5-Smad8 phosphorylation. | Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2-induced Smad1/5/8 phosphorylation.
Liu J, Saito K, Maruya Y, Nakamura T, Yamada A, Fukumoto E, Ishikawa M, Iwamoto T, Miyazaki K, Yoshizaki K, Ge L, Fukumoto S., Free PMC Article | 02/4/2017 |
| Combined, these data suggest a possible pathway linking GDF5, ERG and downstream factors in the processes of chondrocyte differentiation during articular joint formation. | The function and interrelationship between GDF5 and ERG-010 during chondrogenesis in vitro.
Howard M, Tuan RS, Wallis GA. | 11/5/2016 |
| Growth differentiation factor 5 is a novel target-derived factor that promotes sympathetic axon growth and branching and makes a distinctive regional contribution to the establishment of sympathetic innervation. | Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation.
O'Keeffe GW, Gutierrez H, Howard L, Laurie CW, Osorio C, Gavaldà N, Wyatt SL, Davies AM., Free PMC Article | 10/22/2016 |
| Dach2 and Hdac9 mediate the effects of muscle activity on muscle reinnervation; Myog and Gdf5 appear to stimulate muscle reinnervation through parallel pathways | Dach2-Hdac9 signaling regulates reinnervation of muscle endplates.
Macpherson PC, Farshi P, Goldman D., Free PMC Article | 05/28/2016 |
| Gdf-5 induced the expression of the alpha5 sub-unit, while Bmp-7 induced the expression of the alphaV sub-unit. | Regulation of α5 and αV Integrin Expression by GDF-5 and BMP-7 in Chondrocyte Differentiation and Osteoarthritis.
Garciadiego-Cázares D, Aguirre-Sánchez HI, Abarca-Buis RF, Kouri JB, Velasquillo C, Ibarra C., Free PMC Article | 04/23/2016 |
| Clonal expansion of Gdf5 progenitors contributes to linear growth of the enthesis. | Gdf5 progenitors give rise to fibrocartilage cells that mineralize via hedgehog signaling to form the zonal enthesis.
Dyment NA, Breidenbach AP, Schwartz AG, Russell RP, Aschbacher-Smith L, Liu H, Hagiwara Y, Jiang R, Thomopoulos S, Butler DL, Rowe DW., Free PMC Article | 10/31/2015 |
| GDF5 might play a critical role in 3T3-L1 preadipocyte differentiation | Dynamic profile and adipogenic role of growth differentiation factor 5 (GDF5) in the differentiation of 3T3-L1 preadipocytes.
Pei Z, Yang Y, Kiess W, Sun C, Luo F. | 11/8/2014 |
| These results suggest that PI3K/Akt signals play a role in the GDF5-mediated brown adipogenesis through a mechanism related to activation of the Smad pathway. | PI3K/Akt is involved in brown adipogenesis mediated by growth differentiation factor-5 in association with activation of the Smad pathway.
Hinoi E, Iezaki T, Fujita H, Watanabe T, Odaka Y, Ozaki K, Yoneda Y. | 09/27/2014 |