| Deciphering the genetic interactions between Pou4f3, Gfi1, and Rbm24 in maintaining mouse cochlear hair cell survival. | Deciphering the genetic interactions between Pou4f3, Gfi1, and Rbm24 in maintaining mouse cochlear hair cell survival.
Wang G, Gu Y, Liu Z., Free PMC Article | 03/18/2024 |
| Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals. | Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals.
Iyer AA, Hosamani I, Nguyen JD, Cai T, Singh S, McGovern MM, Beyer L, Zhang H, Jen HI, Yousaf R, Birol O, Sun JJ, Ray RS, Raphael Y, Segil N, Groves AK., Free PMC Article | 12/3/2022 |
| GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor. | GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor.
Jen HI, Singh S, Tao L, Maunsell HR, Segil N, Groves AK., Free PMC Article | 05/28/2022 |
| Generation of mature and functional hair cells by co-expression of Gfi1, Pou4f3, and Atoh1 in the postnatal mouse cochlea. | Generation of mature and functional hair cells by co-expression of Gfi1, Pou4f3, and Atoh1 in the postnatal mouse cochlea.
Chen Y, Gu Y, Li Y, Li GL, Chai R, Li W, Li H. | 02/19/2022 |
| Gfi1 Loss Protects against Two Models of Induced Diabetes. | Gfi1 Loss Protects against Two Models of Induced Diabetes.
Napolitano T, Avolio F, Silvano S, Forcisi S, Pfeifer A, Vieira A, Navarro-Sanz S, Friano ME, Ayachi C, Garrido-Utrilla A, Atlija J, Hadzic B, Becam J, Sousa-De-Veiga A, Plaisant MD, Balaji S, Pisani DF, Mondin M, Schmitt-Kopplin P, Amri EZ, Collombat P., Free PMC Article | 01/15/2022 |
| IFNgamma suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation. | IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation.
Sarkar MH, Yagi R, Endo Y, Koyama-Nasu R, Wang Y, Hasegawa I, Ito T, Junttila IS, Zhu J, Kimura MY, Nakayama T., Free PMC Article | 01/8/2022 |
| GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors. | GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors.
Helness A, Fraszczak J, Joly-Beauparlant C, Bagci H, Trahan C, Arman K, Shooshtarizadeh P, Chen R, Ayoub M, Côté JF, Oeffinger M, Droit A, Möröy T., Free PMC Article | 01/1/2022 |
| Severe Inflammatory Reactions in Mice Expressing a GFI1(P2A) Mutant Defective in Binding to the Histone Demethylase KDM1A (LSD1). | Severe Inflammatory Reactions in Mice Expressing a GFI1(P2A) Mutant Defective in Binding to the Histone Demethylase KDM1A (LSD1).
Fraszczak J, Arman KM, Lacroix M, Vadnais C, Gaboury L, Möröy T. | 09/25/2021 |
| PAI-1 is involved in delayed bone repair induced by glucocorticoids in mice. | PAI-1 is involved in delayed bone repair induced by glucocorticoids in mice.
Okada K, Okamoto T, Okumoto K, Takafuji Y, Ishida M, Kawao N, Matsuo O, Kaji H. | 05/22/2021 |
| Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea. | Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea.
Lee S, Song JJ, Beyer LA, Swiderski DL, Prieskorn DM, Acar M, Jen HI, Groves AK, Raphael Y., Free PMC Article | 03/28/2021 |
| Gfi1 and Zc3h12c orchestrate a negative feedback loop that inhibits NF-kB activation during inflammation in macrophages. | Gfi1 and Zc3h12c orchestrate a negative feedback loop that inhibits NF-kB activation during inflammation in macrophages.
Guo G, Fu R, Zhang L, Chao T, Jiang Z, Dong L, Huang R, Lu L, Yang W, Gu Y, Liang Y, Zheng Q. | 02/2/2021 |
| A novel regulatory circuit between p53 and GFI1 controls induction of apoptosis in T cells. | A novel regulatory circuit between p53 and GFI1 controls induction of apoptosis in T cells.
Vadnais C, Chen R, Fraszczak J, Hamard PJ, Manfredi JJ, Möröy T., Free PMC Article | 10/10/2020 |
| our data indicate that Gfi1 inhibits the expression of c-Fos, Egr-1 and Egr-2 through direct transcriptional repression and indirect inhibition of Erk1/2 signaling, and that Gfi1-mediated downregulation of c-Fos, Egr-1 and Egr-2 may contribute to the role of Gfi1 in granulopoiesis. | Gfi1-Mediated Repression of c-Fos, Egr-1 and Egr-2, and Inhibition of ERK1/2 Signaling Contribute to the Role of Gfi1 in Granulopoiesis.
Zhang Y, Hu N, Dong F., Free PMC Article | 07/25/2020 |
| These results suggest that increasing GFI1 level in leukemic cells with low GFI1 expression level could be a therapeutic approach. | Enforced GFI1 expression impedes human and murine leukemic cell growth.
Hönes JM, Thivakaran A, Botezatu L, Patnana P, Castro SVDC, Al-Matary YS, Schütte J, Fischer KBI, Vassen L, Görgens A, Dührsen U, Giebel B, Khandanpour C., Free PMC Article | 07/6/2019 |
| Low Gfi1 expression is associated with myeloid leukemia and predisposes to fatal myeloproliferative disease. | Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice.
Fraszczak J, Vadnais C, Rashkovan M, Ross J, Beauchemin H, Chen R, Grapton D, Khandanpour C, Möröy T., Free PMC Article | 06/1/2019 |
| Results demonstrate that obesity produces durable changes in hematopoietic stem cell (HSC) function and phenotype and that elevation of Gfi1 expression in response to the oxidative environment is a key driver of the altered HSC properties observed in obesity. | Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression.
Lee JM, Govindarajah V, Goddard B, Hinge A, Muench DE, Filippi MD, Aronow B, Cancelas JA, Salomonis N, Grimes HL, Reynaud D., Free PMC Article | 04/13/2019 |
| GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer. | GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer.
Xing W, Xiao Y, Lu X, Zhu H, He X, Huang W, Lopez ES, Wong J, Ju H, Tian L, Zhang F, Xu H, Wang SD, Li X, Karin M, Ren H., Free PMC Article | 02/17/2018 |
| AMPK was sufficient to stimulate osteogenesis of MC3T3-E1 cells and inhibit adipogenesis of 3T3-L1 cells through the AMPK-Gfi1-OPN axis. | AMPK promotes osteogenesis and inhibits adipogenesis through AMPK-Gfi1-OPN axis.
Wang YG, Qu XH, Yang Y, Han XG, Wang L, Qiao H, Fan QM, Tang TT, Dai KR. | 12/2/2017 |
| Gfi1 disruption antagonized the tumor-promoting effects of Ezh2 loss; conversely, Gfi1 overexpression collaborated with Myc to bypass effects of Trp53 inactivation in driving medulloblastoma progression in primary cerebellar neuronal progenitors. | Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma.
Vo BT, Li C, Morgan MA, Theurillat I, Finkelstein D, Wright S, Hyle J, Smith SMC, Fan Y, Wang YD, Wu G, Orr BA, Northcott PA, Shilatifard A, Sherr CJ, Roussel MF., Free PMC Article | 11/26/2017 |
| If Gfi1 levels fall below a threshold, Id1 expression increases and renders E2A unable to function, which prevents hematopoietic progenitors from engaging along the B lymphoid lineage | Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1.
Fraszczak J, Helness A, Chen R, Vadnais C, Robert F, Khandanpour C, Möröy T., Free PMC Article | 08/5/2017 |
| These results clearly demonstrate that Gfi1 is a critical transcriptional regulator that controls the development of CD4pos and NK1.1pos Invariant natural killer T cells. | The Transcriptional Repressor Gfi1 Plays a Critical Role in the Development of NKT1- and NKT2-Type iNKT Cells.
Yasuoka T, Kuwahara M, Yamada T, Maruyama S, Suzuki J, Taniguchi M, Yasukawa M, Yamashita M., Free PMC Article | 07/22/2017 |
| this study demonstrates the critical role of Gfi1 in the regulation of myeloid cells, and prevention of spontaneous lupus autoimmunity by negatively controlling TLR7 signaling | The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling.
Desnues B, Macedo AB, Ordoñez-Rueda D, Roussel-Queval A, Malissen B, Bruhns P, Malissen M, Alexopoulou L. | 07/8/2017 |
| is crucial in the process of macrophage polarization, since its absence impedes macrophage polarization towards a leukemia supporting state and favors an anti-tumor state both in vitro and in vivo | Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner.
Al-Matary YS, Botezatu L, Opalka B, Hönes JM, Lams RF, Thivakaran A, Schütte J, Köster R, Lennartz K, Schroeder T, Haas R, Dührsen U, Khandanpour C., Free PMC Article | 06/24/2017 |
| these findings demonstrate a novel regulatory role of Gfi1 in the regulation of the Th1-type immune response. | Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells.
Suzuki J, Maruyama S, Tamauchi H, Kuwahara M, Horiuchi M, Mizuki M, Ochi M, Sawasaki T, Zhu J, Yasukawa M, Yamashita M., Free PMC Article | 08/13/2016 |
| GFI1 proteins recruit the chromatin-modifying protein LSD1, a member of the CoREST repressive complex, to epigenetically silence the endothelial program in haemogenic endothelium and allow the emergence of blood cells | GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1.
Thambyrajah R, Mazan M, Patel R, Moignard V, Stefanska M, Marinopoulou E, Li Y, Lancrin C, Clapes T, Möröy T, Robin C, Miller C, Cowley S, Göttgens B, Kouskoff V, Lacaud G. | 05/14/2016 |