| GNA13 promotes the proliferation and migration of lung squamous cell carcinoma cells through regulating the PI3K/AKT signaling pathway. | GNA13 promotes the proliferation and migration of lung squamous cell carcinoma cells through regulating the PI3K/AKT signaling pathway.
Na J, Zhou W, Yin M, Hu Y, Ma X. | 06/18/2022 |
| G-protein Galpha13 functions as a cytoskeletal and mitochondrial regulator to restrain osteoclast function. | G-protein Gα(13) functions as a cytoskeletal and mitochondrial regulator to restrain osteoclast function.
Nakano S, Inoue K, Xu C, Deng Z, Syrovatkina V, Vitone G, Zhao L, Huang XY, Zhao B., Free PMC Article | 09/26/2020 |
| Here, the authors show that small arteries from mice with smooth muscle-specific loss of G12/G13 or the Rho guanine nucleotide exchange factor ARHGEF12 have lost myogenic vasoconstriction. | Myogenic vasoconstriction requires G(12)/G(13) and LARG to maintain local and systemic vascular resistance.
Chennupati R, Wirth A, Favre J, Li R, Bonnavion R, Jin YJ, Wietelmann A, Schweda F, Wettschureck N, Henrion D, Offermanns S., Free PMC Article | 02/1/2020 |
| results define Galpha13 as a switch regulator of myofiber reprogramming, implying that modulations of Galpha13 and its downstream effectors in skeletal muscle are a potential therapeutic approach to treating metabolic diseases. | Gα13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism.
Koo JH, Kim TH, Park SY, Joo MS, Han CY, Choi CS, Kim SG., Free PMC Article | 10/21/2017 |
| This study demonstrated an almost 100-fold higher agonist sensitivity of the Galpha13 LARG interaction compared to the Galpha13 activation in the absence of LARG. | Potentiation of receptor responses induced by prolonged binding of Gα(13) and leukemia-associated RhoGEF.
Bodmann EL, Krett AL, Bünemann M., Free PMC Article | 10/14/2017 |
| GNA13 loss is associated with GC B-cell persistence, in which impaired apoptosis and ongoing somatic hypermutation may lead to an increased risk of lymphoma development. | GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.
Healy JA, Nugent A, Rempel RE, Moffitt AB, Davis NS, Jiang X, Shingleton JR, Zhang J, Love C, Datta J, McKinney ME, Tzeng TJ, Wettschureck N, Offermanns S, Walzer KA, Chi JT, Rasheed SA, Casey PJ, Lossos IS, Dave SS., Free PMC Article | 06/24/2017 |
| Selective inhibition of G12/13 signaling in macrophages can augment atheroprotective B-cell populations and ameliorate atherosclerosis. | S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population.
Grimm M, Tischner D, Troidl K, Albarrán Juárez J, Sivaraj KK, Ferreirós Bouzas N, Geisslinger G, Binder CJ, Wettschureck N. | 05/7/2016 |
| Gpr56 regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA | The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA.
Ackerman SD, Garcia C, Piao X, Gutmann DH, Monk KR., Free PMC Article | 04/2/2016 |
| findings identify a Galpha13-dependent pathway that exerts dual actions in suppressing growth and blocking dissemination of germinal centre B cells that is frequently disrupted in germinal centre B-cell-derived lymphoma | Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma.
Muppidi JR, Schmitz R, Green JA, Xiao W, Larsen AB, Braun SE, An J, Xu Y, Rosenwald A, Ott G, Gascoyne RD, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Vaidehi N, Staudt LM, Cyster JG., Free PMC Article | 01/31/2015 |
| Direct Galpha13 binding to ITGB3 cytoplasmic domain regulates integrin outside-in signaling and thrombus formation in platelets. | A directional switch of integrin signalling and a new anti-thrombotic strategy.
Shen B, Zhao X, O'Brien KA, Stojanovic-Terpo A, Delaney MK, Kim K, Cho J, Lam SC, Du X., Free PMC Article | 12/5/2014 |
| Galpha 13 is activated in sensory neurons mediated by lysophosphatidylinositol. | A novel biological role for the phospholipid lysophosphatidylinositol in nociceptive sensitization via activation of diverse G-protein signalling pathways in sensory nerves in vivo.
Gangadharan V, Selvaraj D, Kurejova M, Njoo C, Gritsch S, Škoricová D, Horstmann H, Offermanns S, Brown AJ, Kuner T, Tappe-Theodor A, Kuner R. | 07/5/2014 |
| Galpha13 binding to VE-cadherin mediates VE-cadherin internalization and endothelial barrier disruption and inflammation. | Evidence of a common mechanism of disassembly of adherens junctions through Gα13 targeting of VE-cadherin.
Gong H, Gao X, Feng S, Siddiqui MR, Garcia A, Bonini MG, Komarova Y, Vogel SM, Mehta D, Malik AB., Free PMC Article | 05/10/2014 |
| Data indicate that Pyk2 is a common signaling effector downstream of both G12/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation. | Distinct role of Pyk2 in mediating thromboxane generation downstream of both G12/13 and integrin αIIbβ3 in platelets.
Kim S, Cipolla L, Guidetti G, Okigaki M, Jin J, Torti M, Kunapuli SP., Free PMC Article | 09/7/2013 |
| Endothelial G13 regulates VEGFR-2 promoter activity through NF-kappaB activation. | G13 controls angiogenesis through regulation of VEGFR-2 expression.
Sivaraj KK, Takefuji M, Schmidt I, Adams RH, Offermanns S, Wettschureck N. | 08/3/2013 |
| Our data show that the G(12/13) family of heterotrimeric G proteins is centrally involved in pressure overload-induced cardiac remodeling and plays a central role in the transition to heart failure. | G(13)-mediated signaling pathway is required for pressure overload-induced cardiac remodeling and heart failure.
Takefuji M, Wirth A, Lukasova M, Takefuji S, Boettger T, Braun T, Althoff T, Offermanns S, Wettschureck N. | 01/5/2013 |
| Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase | Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase.
Kim S, Kunapuli SP., Free PMC Article | 09/10/2011 |
| new insight into the mechanism by which p115RhoGEF is activated by Galpha(13). | Identification of critical residues in G(alpha)13 for stimulation of p115RhoGEF activity and the structure of the G(alpha)13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex.
Hajicek N, Kukimoto-Niino M, Mishima-Tsumagari C, Chow CR, Shirouzu M, Terada T, Patel M, Yokoyama S, Kozasa T., Free PMC Article | 08/6/2011 |
| A functional role for JLP in the gep oncogene-regulated neoplastic signaling pathway. | Neoplastic transformation induced by the gep oncogenes involves the scaffold protein JNK-interacting leucine zipper protein.
Kashef K, Radhakrishnan R, Lee CM, Reddy EP, Dhanasekaran DN., Free PMC Article | 07/16/2011 |
| Galpha(12/13) regulate AP-1-dependent CYR61 induction in vascular smooth muscle, promoting migration, and they are upregulated with CYR61 in arteriosclerotic lesions. | G(alpha)12/13 induction of CYR61 in association with arteriosclerotic intimal hyperplasia: effect of sphingosine-1-phosphate.
Kim YM, Lim SC, Han CY, Kay HY, Cho IJ, Ki SH, Lee MY, Kwon HM, Lee CH, Kim SG. | 05/21/2011 |
| propose here a novel cascade of PAR1-induced Galpha(13)-DVL axis in cancer and beta-catenin stabilization | Protease-activated receptor-1 (PAR1) acts via a novel Galpha13-dishevelled axis to stabilize beta-catenin levels.
Turm H, Maoz M, Katz V, Yin YJ, Offermanns S, Bar-Shavit R., Free PMC Article | 06/28/2010 |
| In mouse pancreatic acini Galpha13 links cholecystokinin stimulation to activation of RhoA and Rac1 and amylase secretion. | CCK activates RhoA and Rac1 differentially through Galpha13 and Galphaq in mouse pancreatic acini.
Sabbatini ME, Bi Y, Ji B, Ernst SA, Williams JA., Free PMC Article | 04/12/2010 |
| study demonstrates not only a function of integrin alphaIIbbeta3 as a noncanonical Galpha13-coupled receptor but also a new concept of Galpha13-dependent dynamic regulation of RhoA | G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling.
Gong H, Shen B, Flevaris P, Chow C, Lam SC, Voyno-Yasenetskaya TA, Kozasa T, Du X., Free PMC Article | 02/8/2010 |
| Galpha(13) is haploinsufficient for adult angiogenesis in both the female reproductive system and tumor angiogenesis. | Suppression of tumor angiogenesis by Galpha(13) haploinsufficiency.
Chen L, Zhang JJ, Rafii S, Huang XY., Free PMC Article | 01/21/2010 |
| Galpha(12) and Galpha(13) regulate expression of TGFbeta1 gene through an increase in Rho/Rac-dependent AP-1 activity, implying that the G-protein-coupled receptor (GPCR)-Galpha(12) pathway is involved in TGFbeta1-mediated transdifferentiation process | The gep oncogenes, Galpha(12) and Galpha(13), upregulate the transforming growth factor-beta1 gene.
Lee SJ, Yang JW, Cho IJ, Kim WD, Cho MK, Lee CH, Kim SG. | 01/21/2010 |
| Galpha(12/13) proteins exert essential functions linking extracellular signals to microtubule dynamics and cell polarity via RhoGEF and formin activity. | LARG and mDia1 link Galpha12/13 to cell polarity and microtubule dynamics.
Goulimari P, Knieling H, Engel U, Grosse R., Free PMC Article | 01/21/2010 |