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    CSTA cystatin A [ Homo sapiens (human) ]

    Gene ID: 1475, updated on 8-Aug-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Decreased CSTA expression promotes lymphatic metastasis and predicts poor survival in oral squamous cell carcinoma.

    Decreased CSTA expression promotes lymphatic metastasis and predicts poor survival in oral squamous cell carcinoma.
    Wang Y, Wang L, Li X, Qu X, Han N, Ruan M, Zhang C.

    Interplay of ERalpha binding and DNA methylation in the intron-2 determines the expression and estrogen regulation of cystatin A in breast cancer cells.

    Interplay of ERα binding and DNA methylation in the intron-2 determines the expression and estrogen regulation of cystatin A in breast cancer cells.
    John Mary DJS, Sikarwar G, Kumar A, Limaye AM.

    Low CSTA expression is associated with brain metastasis in lung cancer.

    Identification of CD37, cystatin A, and IL-23A gene expression in association with brain metastasis: analysis of a prospective trial.
    Dohm A, Su J, McTyre ER, Taylor JM, Miller LD, Petty WJ, Xing F, Lo HW, Metheny-Barlow LJ, O'Neill S, Bellinger C, Dotson T, Pasche B, Watabe K, Chan MD, Ruiz J., Free PMC Article

    role of cystatin A in breast cancer and its functional link with ERalpha

    The role of cystatin A in breast cancer and its functional link with ERα.
    John Mary DJS, Manjegowda MC, Kumar A, Dutta S, Limaye AM.

    High levels of CSTA expression in Esophageal Squamous Cell Carcinoma were correlated with tumor progression and advanced cancer stage, including lymph node metastasis.

    Clinicopathological significance of cystatin A expression in progression of esophageal squamous cell carcinoma.
    Shiba D, Terayama M, Yamada K, Hagiwara T, Oyama C, Tamura-Nakano M, Igari T, Yokoi C, Soma D, Nohara K, Yamashita S, Dohi T, Kawamura YI., Free PMC Article

    UV phototoxicity-induced pre-elafin inside keratinocytes prior to cornified envelope formation could be involved in UV-induced keratinocyte apoptosis via cystatin-A downregulation resulting in pro-caspase-3 activation.

    Pre-elafin is Involved in Ultraviolet-induced Keratinocyte Apoptosis via Pro-caspase-3 Activation Associated with Cystatin-A Down-regulation.
    Kim H, Noh M, Bae ON, Lee CH, Lee AY.

    Identify myoepithelial cell stefin A as a suppressor of early tumor invasion and a candidate marker to distinguish patients who are at low risk of developing invasive breast cancer.

    Myoepithelial cell-specific expression of stefin A as a suppressor of early breast cancer invasion.
    Duivenvoorden HM, Rautela J, Edgington-Mitchell LE, Spurling A, Greening DW, Nowell CJ, Molloy TJ, Robbins E, Brockwell NK, Lee CS, Chen M, Holliday A, Selinger CI, Hu M, Britt KL, Stroud DA, Bogyo M, Möller A, Polyak K, Sloane BF, O'Toole SA, Parker BS.

    Expression of CSTA was detected in some tumor tissues and many tumor-infiltrating immune cells. Cathepsin B expression was also observed in most tumor tissues and tumor-infiltrating immune cells

    Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma.
    Komura T, Takabatake H, Harada K, Yamato M, Miyazawa M, Yoshida K, Honda M, Wada T, Kitagawa H, Ohta T, Kaneko S, Sakai Y., Free PMC Article

    The results suggest that C12orf39, CSTA, and CALCB are novel ATF4 target genes, and that C12orf39 promoter activity is activated by ATF4 through amino acid response element.

    Searching for novel ATF4 target genes in human hepatoma cells by microarray analysis.
    Maruyama R, Shimizu M, Ishijima T, Nakai Y, Inoue J, Sato R.

    CSTA/TYROBP gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis .

    Identification of crucial genes related to postmenopausal osteoporosis using gene expression profiling.
    Ma M, Chen X, Lu L, Yuan F, Zeng W, Luo S, Yin F, Cai J.

    High expression of stefin A may be an important factor contributing to the development and metastasis of Hepatocellular Carcinoma.

    Tissue Levels of Stefin A and Stefin B in Hepatocellular Carcinoma.
    Lin YY, Chen ZW, Lin ZP, Lin LB, Yang XM, Xu LY, Xie Q.

    Both MIP-3alpha and cystatin A overexpressions in NPC tumor tissues were strong independent factors of poor prognosis in NPC patients.

    Expression and Prognostic Significance of Macrophage Inflammatory Protein-3 Alpha and Cystatin A in Nasopharyngeal Carcinoma.
    Tang M, Ou N, Li C, Lu A, Li J, Ma L, Zhong W, Gao J, Zheng Y, Cai Y., Free PMC Article

    a novel pathway of CSTA regulation involving Dsg2

    Cell cycle- and cancer-associated gene networks activated by Dsg2: evidence of cystatin A deregulation and a potential role in cell-cell adhesion.
    Gupta A, Nitoiu D, Brennan-Crispi D, Addya S, Riobo NA, Kelsell DP, Mahoney MG., Free PMC Article

    We identified a homozygous nonsense mutation (p.Lys22X) in the CSTA gene in acral peeling skin syndrome.

    Acral peeling skin syndrome resulting from a homozygous nonsense mutation in the CSTA gene encoding cystatin A.
    Krunic AL, Stone KL, Simpson MA, McGrath JA.

    High levels of bioactive recombinant stefins A and B can be produced by fermentation in P. pastoris.

    Functional expression of amyloidogenic human stefins A and B in Pichia pastoris using codon optimization.
    Nakamura K, Maeda Y, Morimoto K, Katayama S, Kondo K, Nakamura S.

    Data indicate that desmoplakin (DSP) and cystatin A (CSTA) interaction and insulin-like growth factor 1 (IGF-1), IGF-binding protein 7 (IGFBP7) and syndecan 1 (SDC1) interaction were observed in protein-protein interaction (PPI) network.

    Protein interaction and microRNA network analysis in osteoarthritis meniscal cells.
    Wang M, Liu C, Zhang Y, Hao Y, Zhang X, Zhang YM.

    Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway

    Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.
    Kan Y, Okabayashi T, Yokota S, Yamamoto S, Fujii N, Yamashita T., Free PMC Article

    findings provide a new molecular understanding of the mechanisms of MYOC-causative glaucoma and reveal CSTA, a serum biomarker for cancer, as a potential biomarker and drug for the treatment of MYOC-induced glaucoma

    Cystatin a, a potential common link for mutant myocilin causative glaucoma.
    Kennedy KD, AnithaChristy SA, Buie LK, Borrás T., Free PMC Article

    study identified loss-of-function mutations in the gene for protease inhibitor cystatin A as the underlying genetic cause of exfoliative ichthyosis

    Mutations in CSTA, encoding Cystatin A, underlie exfoliative ichthyosis and reveal a role for this protease inhibitor in cell-cell adhesion.
    Blaydon DC, Nitoiu D, Eckl KM, Cabral RM, Bland P, Hausser I, van Heel DA, Rajpopat S, Fischer J, Oji V, Zvulunov A, Traupe H, Hennies HC, Kelsell DP., Free PMC Article

    CSTA significantly increases the risk of developing psoriasis in HLA-Cw6 individuals

    HLA-C, CSTA and DS12346 susceptibility alleles confer over 100-fold increased risk of developing psoriasis: evidence of gene interaction.
    Vasilopoulos Y, Sagoo GS, Cork MJ, Walters K, Tazi-Ahnini R.

    Findings establish that genetic variability, smoking, and COPD all influence CSTA expression, as does SCC, supporting the concept that CSTA may make pivotal contributions to NSCLC pathogenesis in early and late stages of disease development.

    Modulation of cystatin A expression in human airway epithelium related to genotype, smoking, COPD, and lung cancer.
    Butler MW, Fukui T, Salit J, Shaykhiev R, Mezey JG, Hackett NR, Crystal RG., Free PMC Article

    A higher pretreated serum level of cystatin A was found to be associated with a higher nodal stage and poorer prognosis of nasopharyngeal carcinoma patients.

    Identification of candidate nasopharyngeal carcinoma serum biomarkers by cancer cell secretome and tissue transcriptome analysis: potential usage of cystatin A for predicting nodal stage and poor prognosis.
    Chang KP, Wu CC, Chen HC, Chen SJ, Peng PH, Tsang NM, Lee LY, Liu SC, Liang Y, Lee YS, Hao SP, Chang YS, Yu JS.

    Up-regulation of stefin A, an endogenous inhibitor of cathepsin S, was found in inverted papilloma tissues as compared with its expression level in normal sinus mucosa tissues.

    Expression of cathepsin S and its inhibitor stefin A in sinonasal inverted papilloma.
    Huang CC, Lee TJ, Chang PH, Lee YS, Chuang CC, Jhang YJ, Chen YW, Chen CW, Fu CH, Tsai CN.

    Cystatin A binds reduced forms of mite group 1 allergens Der f 1 and Der p 1, in which the cysteine residue at the catalytic center of the protease activity is reduced by treatment with L-cysteine but does not bind oxidized forms.

    Modulation of allergenicity of major house dust mite allergens Der f 1 and Der p 1 by interaction with an endogenous ligand.
    Takai T, Kato T, Hatanaka H, Inui K, Nakazawa T, Ichikawa S, Mitsuishi K, Ogawa H, Okumura K.

    CSTA TCC haplotype is only associated with psoriasis in those individuals carrying the risk allele at the HLA-Cw6 locus

    Association analysis of the skin barrier gene cystatin A at the PSORS5 locus in psoriatic patients: evidence for interaction between PSORS1 and PSORS5.
    Vasilopoulos Y, Walters K, Cork MJ, Duff GW, Sagoo GS, Tazi-Ahnini R.

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