DP1 (Prostaglandin D2 Receptor 1) Activation Protects Against Vascular Remodeling and Vascular Smooth Muscle Cell Transition to Myofibroblasts in Angiotensin II-Induced Hypertension in Mice. | DP1 (Prostaglandin D(2) Receptor 1) Activation Protects Against Vascular Remodeling and Vascular Smooth Muscle Cell Transition to Myofibroblasts in Angiotensin II-Induced Hypertension in Mice. Zou F, Li Y, Zhang S, Zhang J. | 05/21/2022 |
Role of prostaglandin D2 receptors in the pathogenesis of abdominal aortic aneurysm formation. | Role of prostaglandin D2 receptors in the pathogenesis of abdominal aortic aneurysm formation. Weintraub NL, Blomkalns AL, Ogbi M, Horimatsu T, Benson TW, Huo Y, Fulton DJ, Agarwal G, Lee R, Winkler MA, Young L, Fujise K, Guha A, Fukai T, Ushio-Fukai M, Long X, Annex BH, Kim HW., Free PMC Article | 03/12/2022 |
PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection. | PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection. Oyesola OO, Shanahan MT, Kanke M, Mooney BM, Webb LM, Smita S, Matheson MK, Campioli P, Pham D, Früh SP, McGinty JW, Churchill MJ, Cahoon JL, Sundaravaradan P, Flitter BA, Mouli K, Nadjsombati MS, Kamynina E, Peng SA, Cubitt RL, Gronert K, Lord JD, Rauch I, von Moltke J, Sethupathy P, Tait Wojno ED., Free PMC Article | 11/27/2021 |
ER-anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6. | ER-anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6. Zuo S, Wang B, Liu J, Kong D, Cui H, Jia Y, Wang C, Xu X, Chen G, Wang Y, Yang L, Zhang K, Ai D, Du J, Shen Y, Yu Y., Free PMC Article | 11/22/2021 |
The Prostaglandin D2 Receptor CRTH2 Promotes IL-33-Induced ILC2 Accumulation in the Lung. | The Prostaglandin D(2) Receptor CRTH2 Promotes IL-33-Induced ILC2 Accumulation in the Lung. Oyesola OO, Duque C, Huang LC, Larson EM, Früh SP, Webb LM, Peng SA, Tait Wojno ED., Free PMC Article | 09/26/2020 |
tudies present a novel regulatory role for Crth2 during inflammatory response in macrophages | Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium. Diwakar BT, Yoast R, Nettleford S, Qian F, Lee TJ, Berry S, Huffnagle I, Rossi RM, Trebak M, Paulson RF, Prabhu KS., Free PMC Article | 07/4/2020 |
Prostaglandin D2 (DP2) receptor expression is highest when the hair follicle begins regressing in hair growth cycles in mice strongly suggesting that the PGD2-DP2 receptor pathway plays a key role in the inhibition of hair growth. | Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression. Kang YR, Bak SS, Kim MK, Joo HW, Mali NM, Shin MJ, Kim MK, Kim JC, Oh JW, Sung YK. | 06/6/2020 |
The disease model is driven by gammadeltaT cells that express CRTH2. | Deficiency of CRTH2, a Prostaglandin D(2) Receptor, Aggravates Bleomycin-induced Pulmonary Inflammation and Fibrosis. Ueda S, Fukunaga K, Takihara T, Shiraishi Y, Oguma T, Shiomi T, Suzuki Y, Ishii M, Sayama K, Kagawa S, Hirai H, Nagata K, Nakamura M, Miyasho T, Betsuyaku T, Asano K. | 12/21/2019 |
Our study revealed that rising temperature of POA alters the activity of Ptgds-expressing neurons so as to increase PGD2 production. | Thermoregulation via Temperature-Dependent PGD(2) Production in Mouse Preoptic Area. Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY., Free PMC Article | 10/26/2019 |
the beneficial effects of DP2 blockade or DP1 agonism were associated with increased interferon-lambda (IFN-lambda) [interleukin-28A/B (IL-28A/B)] expression and were lost upon IL-28A neutralization. | PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production. Werder RB, Lynch JP, Simpson JC, Zhang V, Hodge NH, Poh M, Forbes-Blom E, Kulis C, Smythe ML, Upham JW, Spann K, Everard ML, Phipps S. | 09/21/2019 |
These results demonstrate the critical role of CRTH2-mediated Th2 response in Pulmonary arterial hypertension pathogenesis. | Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice. Chen G, Zuo S, Tang J, Zuo C, Jia D, Liu Q, Liu G, Zhu Q, Wang Y, Zhang J, Shen Y, Chen D, Yuan P, Qin Z, Ruan C, Ye J, Wang XJ, Zhou Y, Gao P, Zhang P, Liu J, Jing ZC, Lu A, Yu Y., Free PMC Article | 06/22/2019 |
These findings revealed an unexpected role of CRTH2 in promoting endoplasmic reticulum stress-induced cardiomyocyte apoptosis. | CRTH2 promotes endoplasmic reticulum stress-induced cardiomyocyte apoptosis through m-calpain. Zuo S, Kong D, Wang C, Liu J, Wang Y, Wan Q, Yan S, Zhang J, Tang J, Zhang Q, Lyu L, Li X, Shan Z, Qian L, Shen Y, Yu Y., Free PMC Article | 02/9/2019 |
CRTh2 mediates most prostaglandin D2 pro-inflammatory effects and long receptor residence time of antagonist LAS191859 translates into long-lasting in vivo efficacy. | Pharmacological characterization of CRTh2 antagonist LAS191859: Long receptor residence time translates into long-lasting in vivo efficacy. Calbet M, Andrés M, Armengol C, Bravo M, Eichhorn P, López R, García-González V, Roberts R, Miralpeix M. | 12/30/2017 |
Prostaglandin D2 suppressed the lipolysis by repression of the cAMP-PKA-hormone-sensitive lipase axis through CRTH2 in adipocytes. | Prostaglandin D(2) enhances lipid accumulation through suppression of lipolysis via DP2 (CRTH2) receptors in adipocytes. Wakai E, Aritake K, Urade Y, Fujimori K. | 08/5/2017 |
CRTH2 plays a pro-inflammatory role in TNBS-induced colitis. Eosinophils contribute to the severity of the inflammation, which is improved by a selective CRTH2 antagonist. | Eosinophils Contribute to Intestinal Inflammation via Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CRTH2, in Experimental Crohn's Disease. Radnai B, Sturm EM, Stančić A, Jandl K, Labocha S, Ferreirós N, Grill M, Hasenoehrl C, Gorkiewicz G, Marsche G, Heinemann Á, Högenauer C, Schicho R., Free PMC Article | 06/10/2017 |
Consistent with this, murine group 2 innate lymphoid cells expressed CRTH2, migrated toward PGD2 in vitro, and accumulated in the lung in response to PGD2 in vivo | The prostaglandin D₂ receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung. Wojno ED, Monticelli LA, Tran SV, Alenghat T, Osborne LC, Thome JJ, Willis C, Budelsky A, Farber DL, Artis D., Free PMC Article | 08/20/2016 |
PGD2 markedly augments disease activity through its ability to enhance the proinflammatory actions of macrophages and subsequent neutrophil activation. | Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung. Jandl K, Stacher E, Bálint Z, Sturm EM, Maric J, Peinhaupt M, Luschnig P, Aringer I, Fauland A, Konya V, Dahlen SE, Wheelock CE, Kratky D, Olschewski A, Marsche G, Schuligoi R, Heinemann A., Free PMC Article | 08/13/2016 |
Using various depression-related animal models, study demonstrated that the central CRTH2-mediated pathway is involved in depression | CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice. Onaka Y, Shintani N, Nakazawa T, Haba R, Ago Y, Wang H, Kanoh T, Hayata-Takano A, Hirai H, Nagata KY, Nakamura M, Hashimoto R, Matsuda T, Waschek JA, Kasai A, Nagayasu K, Baba A, Hashimoto H. | 12/12/2015 |
A deficiency in the prostaglandin D2 receptor CRTH2 exacerbates adjuvant-induced joint inflammation. | A deficiency in the prostaglandin D2 receptor CRTH2 exacerbates adjuvant-induced joint inflammation. Tsubosaka Y, Nakamura T, Hirai H, Hori M, Nakamura M, Ozaki H, Murata T. | 03/21/2015 |
Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. | Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. Moniot B, Ujjan S, Champagne J, Hirai H, Aritake K, Nagata K, Dubois E, Nidelet S, Nakamura M, Urade Y, Poulat F, Boizet-Bonhoure B. | 11/8/2014 |
Our study provides the first evidence that central CRTH2 regulates specific emotional behaviors | Central CRTH2, a second prostaglandin D2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model. Haba R, Shintani N, Onaka Y, Kanoh T, Wang H, Takenaga R, Hayata A, Hirai H, Nagata KY, Nakamura M, Kasai A, Hashimoto R, Nagayasu K, Nakazawa T, Hashimoto H, Baba A., Free PMC Article | 04/5/2014 |
Pyl upregulates CR3 via CRTH2. | The CRTH2 agonist Pyl A prevents lipopolysaccharide-induced fetal death but induces preterm labour. Sykes L, Herbert BR, Macintyre DA, Hunte E, Ponnampalam S, Johnson MR, Teoh TG, Bennett PR., Free PMC Article | 08/31/2013 |
PGD2 inhibits hair follicle regeneration through the Gpr44 receptor and imply that inhibition of PGD2 production or Gpr44 signaling will promote skin regeneration. | Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44. Nelson AM, Loy DE, Lawson JA, Katseff AS, Fitzgerald GA, Garza LA., Free PMC Article | 05/11/2013 |
L-PGDS-derived PGD(2) contributes to the progression of renal fibrosis via CRTH2-mediated activation of Th2 lymphocytes. | PGD2-CRTH2 pathway promotes tubulointerstitial fibrosis. Ito H, Yan X, Nagata N, Aritake K, Katsumata Y, Matsuhashi T, Nakamura M, Hirai H, Urade Y, Asano K, Kubo M, Utsunomiya Y, Hosoya T, Fukuda K, Sano M., Free PMC Article | 01/12/2013 |
Genetic ablation of CRTH2 improves impaired neutrophil migration and survival during severe sepsis | CRTH2 is a critical regulator of neutrophil migration and resistance to polymicrobial sepsis. Ishii M, Asano K, Namkoong H, Tasaka S, Mizoguchi K, Asami T, Kamata H, Kimizuka Y, Fujiwara H, Funatsu Y, Kagawa S, Miyata J, Ishii K, Nakamura M, Hirai H, Nagata K, Kunkel SL, Hasegawa N, Betsuyaku T., Free PMC Article | 08/18/2012 |