| Hsa_circ_0080608 Attenuates Lung Cancer Progression by Functioning as a Competitive Endogenous RNA to Regulate the miR-661/ADRA1A Pathway. | Hsa_circ_0080608 Attenuates Lung Cancer Progression by Functioning as a Competitive Endogenous RNA to Regulate the miR-661/ADRA1A Pathway.
Ren C, Cui L, Li R, Song X, Li J, Xi Q, Zhang Z, Zhao L. | 12/14/2023 |
| Alpha1A- and Beta3-Adrenoceptors Interplay in Adipose Multipotent Mesenchymal Stromal Cells: A Novel Mechanism of Obesity-Driven Hypertension. | Alpha1A- and Beta3-Adrenoceptors Interplay in Adipose Multipotent Mesenchymal Stromal Cells: A Novel Mechanism of Obesity-Driven Hypertension.
Chechekhin V, Ivanova A, Kulebyakin K, Sysoeva V, Naida D, Arbatsky M, Basalova N, Karagyaur M, Skryabina M, Efimenko A, Grigorieva O, Kalinina N, Tkachuk V, Tyurin-Kuzmin P., Free PMC Article | 03/2/2023 |
| Hypermethylation in the promoter region of the ADRA1A gene is associated with opioid use disorder in Han Chinese. | Hypermethylation in the promoter region of the ADRA1A gene is associated with opioid use disorder in Han Chinese.
Zhang J, Fu X, Lu Y, Cheng C, Wang K, Zhu Y, Xie Q. | 09/17/2022 |
| Vascular Reactions of the Diving Reflex in Men and Women Carrying Different ADRA1A Genotypes. | Vascular Reactions of the Diving Reflex in Men and Women Carrying Different ADRA1A Genotypes.
Baranova T, Podyacheva E, Zemlyanukhina T, Berlov D, Danilova M, Glotov O, Glotov A., Free PMC Article | 09/3/2022 |
| MiR-3682 promotes the progression of hepatocellular carcinoma (HCC) via inactivating AMPK signaling by targeting ADRA1A. | MiR-3682 promotes the progression of hepatocellular carcinoma (HCC) via inactivating AMPK signaling by targeting ADRA1A.
Zhao W, Liu X. | 04/9/2022 |
| Role of alpha- and beta-adrenergic signaling in phenotypic targeting: significance in benign and malignant urologic disease. | Role of α- and β-adrenergic signaling in phenotypic targeting: significance in benign and malignant urologic disease.
Archer M, Dogra N, Dovey Z, Ganta T, Jang HS, Khusid JA, Lantz A, Mihalopoulos M, Stockert JA, Zahalka A, Björnebo L, Gaglani S, Noh MR, Kaplan SA, Mehrazin R, Badani KK, Wiklund P, Tsao K, Lundon DJ, Mohamed N, Lucien F, Padanilam B, Gupta M, Tewari AK, Kyprianou N., Free PMC Article | 02/26/2022 |
| Association study of Catechol-o-methyltransferase and Alpha-1-adrenergic receptor gene polymorphisms with multiple phenotypes of heroin use disorder. | Association study of Catechol-o-methyltransferase and Alpha-1-adrenergic receptor gene polymorphisms with multiple phenotypes of heroin use disorder.
Deji C, Li Y, Chen Y, Lai J, Wei S. | 08/21/2021 |
| Deacetylation as a receptor-regulated direct activation switch for pannexin channels. | Deacetylation as a receptor-regulated direct activation switch for pannexin channels.
Chiu YH, Medina CB, Doyle CA, Zhou M, Narahari AK, Sandilos JK, Gonye EC, Gao HY, Guo SY, Parlak M, Lorenz UM, Conrads TP, Desai BN, Ravichandran KS, Bayliss DA., Free PMC Article | 08/14/2021 |
| Class A G protein-coupled receptors assemble into functional higher-order hetero-oligomers. | Class A G protein-coupled receptors assemble into functional higher-order hetero-oligomers.
Gao X, Enten GA, DeSantis AJ, Majetschak M., Free PMC Article | 08/7/2021 |
| Promoter aberrant methylation status of ADRA1A is associated with hepatocellular carcinoma. | Promoter aberrant methylation status of ADRA1A is associated with hepatocellular carcinoma.
Chen G, Fan X, Li Y, He L, Wang S, Dai Y, Bin C, Zhou D, Lin H., Free PMC Article | 05/15/2021 |
| Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and alpha1-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays. | Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and α(1)-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays.
Gao X, Enten GA, DeSantis AJ, Volkman BF, Gaponenko V, Majetschak M., Free PMC Article | 01/16/2021 |
| Probing the correlation between ligand efficacy and conformational diversity at the alpha1A-adrenoreceptor reveals allosteric coupling of its microswitches. | Probing the correlation between ligand efficacy and conformational diversity at the α(1A)-adrenoreceptor reveals allosteric coupling of its microswitches.
Wu FJ, Williams LM, Abdul-Ridha A, Gunatilaka A, Vaid TM, Kocan M, Whitehead AR, Griffin MDW, Bathgate RAD, Scott DJ, Gooley PR., Free PMC Article | 12/26/2020 |
| ADRA1 expression was greater on vascular smooth muscle in burn scars than in unscarred tissue, and greater on dermal nerve fibres, blood vessels and fibroblasts in keloid scars than in either burn scars or unscarred skin. | Up-regulation of α(1)-adrenoceptors in burn and keloid scars.
Drummond PD, Dawson LF, Wood FM, Fear MW. | 03/16/2019 |
| This study provided proof that SNPs within ADRA1 is significantly associated with the susceptibility to and the prognosis of cervical vertigo, so that NPY and NA might serve as the precise diagnostic marker and treatment target of cervical vertigo. | The correlation between SNPs within the gene of adrenergic receptor and neuropeptide Y and risk of cervical vertigo.
Han J, Zuo J, Zhu D, Gao C., Free PMC Article | 10/13/2018 |
| Our novel data, describing the alpha1A-AR phosphorylation sites, suggest that the observed different phosphorylation patterns may participate in defining adrenoceptor localization and action, under the different conditions examined | Noradrenaline, oxymetazoline and phorbol myristate acetate induce distinct functional actions and phosphorylation patterns of α(1A)-adrenergic receptors.
Alcántara-Hernández R, Hernández-Méndez A, Romero-Ávila MT, Alfonzo-Méndez MA, Pupo AS, García-Sáinz JA. | 02/10/2018 |
| The presence of ADRA1A autoantibodies is an independent predictor for aortic stiffness progression in normotensive subjects. | Autoantibodies against AT(1) and α(1)-adrenergic receptors predict arterial stiffness progression in normotensive subjects over a 5-year period.
Li G, Cao Z, Wu XW, Wu HK, Ma Y, Wu B, Wang WQ, Cheng J, Zhou ZH, Tu YC. | 12/30/2017 |
| A mutation of rs2322333, located in the intronic and 3'UTR part of the gene ADRA1A in chromosome 8, has a probability of being deleterious the abolition of ELAV-like protein 1 (ELAVL1) binding site rs2695260. SNP rs2322333 in adrenergic receptor alpha1 (ADRA1A) was higher in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis compared with healthy controls | A targeted genome association study examining transient receptor potential ion channels, acetylcholine receptors, and adrenergic receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.
Johnston S, Staines D, Klein A, Marshall-Gradisnik S., Free PMC Article | 05/20/2017 |
| Demonstrate the utility of alpha1 -AR agonists in the treatment of traction alopecia and hair shedding during cosmetic procedures. | α1 -AR agonist induced piloerection protects against the development of traction alopecia.
Goren A, Shapiro J, Sinclair R, Kovacevic M, McCoy J. | 03/25/2017 |
| Immunoreactivity for ADRA1A was densely distributed in vascular smooth muscle of nasal turbinates. | Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate.
Shirasaki H, Kanaizumi E, Himi T. | 01/14/2017 |
| alpha1A-adrenoceptor subtypes predominantly contributed to human IAS contraction | Characterizations of the α1-adrenoceptor subtypes mediating contractions of the human internal anal sphincter.
Owaki H, Sadahiro S, Takaki M. | 03/19/2016 |
| Data are presented that indicate that Iso represents a novel type of alpha1A-AR partial agonist with signaling bias toward MAPK/ERK signaling cascade that is likely independent of coupling to Galphaq. | Isoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.
Copik AJ, Baldys A, Nguyen K, Sahdeo S, Ho H, Kosaka A, Dietrich PJ, Fitch B, Raymond JR, Ford AP, Button D, Milla ME., Free PMC Article | 01/2/2016 |
| alpha1A-adrenergic receptors are stably expressed and stimulate cell migration and TGF-beta1, IGF-1, hyaluronan and PIP production in human skin fibroblasts. | The stimulatory effects of alpha1-adrenergic receptors on TGF-beta1, IGF-1 and hyaluronan production in human skin fibroblasts.
Liao MH, Liu SS, Peng IC, Tsai FJ, Huang HH. | 09/5/2015 |
| Data suggested ADRA1A Arg347Cys polymorphism as susceptibility factor in patients with vasovagal syncope; ArgArg genotype could be a marker for vasovagal syncope susceptibility in the Mexican population | Arg347Cys polymorphism of α1a-adrenergic receptor in vasovagal syncope. Case-control study in a Mexican population.
Hernández-Pacheco G, González-Hermosillo A, Murata C, Yescas P, Espínola-Zavaleta N, Martínez M, Serrano H. | 07/25/2015 |
| heteromeric receptor complexes between alpha1A-AR and CXCR4 and between alpha1B-AR and CXCR4 are constitutively expressed in rat and human vascular smooth muscle cells; the quaternary structure of the receptor complex is important for signaling and contraction | Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function.
Tripathi A, Vana PG, Chavan TS, Brueggemann LI, Byron KL, Tarasova NI, Volkman BF, Gaponenko V, Majetschak M., Free PMC Article | 06/27/2015 |
| The ADRA1A mutant triggers two distinct EGFR transactivation-dependent signaling pathways: 1) constitutive Gq-independent beta-arrestin-1/Src/MMP/EGFR/ERK-dependent hyperproliferation and 2) agonist-induced Gq- and EGFR/STAT-dependent hypertrophy. | Alpha1a-adrenoceptor genetic variant induces cardiomyoblast-to-fibroblast-like cell transition via distinct signaling pathways.
Kleine-Brueggeney M, Gradinaru I, Babaeva E, Schwinn DA, Oganesian A., Free PMC Article | 03/7/2015 |