| Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice. | Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice.
Park HJ, Kim MJ, Han C, White K, Ding D, Boyd K, Salvi R, Someya S., Free PMC Article | 05/8/2021 |
| GSTA4-dependent detoxification may play a role in estrogen-mediated neuroprotection. | GSTA4 mediates reduction of cisplatin ototoxicity in female mice.
Park HJ, Kim MJ, Rothenberger C, Kumar A, Sampson EM, Ding D, Han C, White K, Boyd K, Manohar S, Kim YH, Ticsa MS, Gomez AS, Caicedo I, Bose U, Linser PJ, Miyakawa T, Tanokura M, Foster TC, Salvi R, Someya S., Free PMC Article | 12/28/2019 |
| Long-term adaptation to ethanol consumption in wild-type mice does not occur in GSTA4(-/-) mice. | Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet.
Shearn CT, Pulliam CF, Pedersen K, Meredith K, Mercer KE, Saba LM, Orlicky DJ, Ronis MJ, Petersen DR., Free PMC Article | 09/28/2019 |
| Together, these results demonstrate the critical role of GSTA4 in blocking CKD-induced neointima formation and AVF failure. | Reduced Expression of Glutathione S-Transferase α 4 Promotes Vascular Neointimal Hyperplasia in CKD.
Luo J, Chen G, Liang M, Xie A, Li Q, Guo Q, Sharma R, Cheng J., Free PMC Article | 07/13/2019 |
| Data define a role for GSTA4-4 in buffering hepatic oxidative stress associated with chronic alcohol consumption and that this GST isoform plays an important role in protecting against carbonylation of mitochondrial proteins. | Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice.
Shearn CT, Fritz KS, Shearn AH, Saba LM, Mercer KE, Engi B, Galligan JJ, Zimniak P, Orlicky DJ, Ronis MJ, Petersen DR., Free PMC Article | 10/22/2016 |
| although loss of GSTA4-4 led to enhanced susceptibility of cardiac mitochondria to radiation-induced loss of morphology, cardiac function was preserved in Gsta4-null mice | Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model.
Boerma M, Singh P, Sridharan V, Tripathi P, Sharma S, Singh SP., Free PMC Article | 08/29/2015 |
| These results indicate that 4-HNE significantly contributes to the mechanisms of tubule injury and fibrosis and that these effects can be inhibited by the enhanced expression of GSTA4-4. | Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis.
Liang A, Wang Y, Woodard LE, Wilson MH, Sharma R, Awasthi YC, Du J, Mitch WE, Cheng J., Free PMC Article | 01/10/2015 |
| In the absence of GSTA4-4 to modulate both physiological and pathological 4-hydroxynonenal (HNE) levels, the adaptive NRF-E2-related (Nrf)2 factor pathway may be primed to contribute to a preconditioned cardiac phenotype in the Gsta4-null mouse. | Protection from oxidative and electrophilic stress in the Gsta4-null mouse heart.
Beneš H, Vuong MK, Boerma M, McElhanon KE, Siegel ER, Singh SP., Free PMC Article | 08/16/2014 |
| The naturally occurring variation in Gsta4 expression in rats affects neurodegeneration after TBI. Further studies are needed to explore if genetic variability in Gsta4 can be associated to outcome also in human TBI. | Naturally occurring variation in the Glutathione-S-Transferase 4 gene determines neurodegeneration after traumatic brain injury.
Al Nimer F, Ström M, Lindblom R, Aeinehband S, Bellander BM, Nyengaard JR, Lidman O, Piehl F., Free PMC Article | 06/28/2014 |
| 2-APB treatment restrained nasal lavage fluid LTC4, ECP, ovalbumin-specific IgE, and IL-4 and their corresponding mRNAs in the previously mentioned tissues of treated mice in comparison with those of control ones. | 2-Aminoethoxydiphenyl borate administration into the nostril alleviates murine allergic rhinitis.
Lin L, Zheng C, Zhang L, Da C, Zhao K. | 12/17/2011 |
| Gsta4/GSTA4 is a novel susceptibility gene for NMSC that affects risk in both mice and humans. | Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans.
Abel EL, Angel JM, Riggs PK, Langfield L, Lo HH, Person MD, Awasthi YC, Wang LE, Strom SS, Wei Q, DiGiovanni J., Free PMC Article | 11/27/2010 |
| Results indicate that downregulation of GSTA4 in adipose tissue leads to increased protein carbonylation, ROS production, and mitochondrial dysfunction and may contribute to the development of insulin resistance and type 2 diabetes. | Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction.
Curtis JM, Grimsrud PA, Wright WS, Xu X, Foncea RE, Graham DW, Brestoff JR, Wiczer BM, Ilkayeva O, Cianflone K, Muoio DE, Arriaga EA, Bernlohr DA., Free PMC Article | 05/31/2010 |
| mGsta4-null mice, in which 4-HNE detoxification is impaired, have an extended life span. | Disruption of the mGsta4 gene increases life span of C57BL mice.
Singh SP, Niemczyk M, Saini D, Sadovov V, Zimniak L, Zimniak P., Free PMC Article | 01/21/2010 |
| Compensatory induced GSTA4 plays a protective role against oxidative stress in young SOD1 KO mouse kidneys. | Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice.
Yoshihara D, Fujiwara N, Ookawara T, Kato S, Sakiyama H, Yokoe S, Eguchi H, Suzuki K. | 01/21/2010 |
| 4-HNE is involved in p53-mediated signaling in in vitro cell cultures as well as in vivo that can be regulated by glutathione transferase | 4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells.
Sharma A, Sharma R, Chaudhary P, Vatsyayan R, Pearce V, Jeyabal PV, Zimniak P, Awasthi S, Awasthi YC., Free PMC Article | 01/21/2010 |
| Excessive malonyl-CoA synthesized by the more abundant and/or allosterically activated ACC in mGsta4 null mice leads to fat accumulation by the well-known mechanisms of promoting fatty acid synthesis and inhibiting fatty acid beta-oxidation. | Role of the electrophilic lipid peroxidation product 4-hydroxynonenal in the development and maintenance of obesity in mice.
Singh SP, Niemczyk M, Saini D, Awasthi YC, Zimniak L, Zimniak P. | 01/21/2010 |
| The Gsta4 gene was represented by two EST clones with similar levels of downregulation. | Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins.
Bakin AV, Stourman NV, Sekhar KR, Rinehart C, Yan X, Meredith MJ, Arteaga CL, Freeman ML. | 01/21/2010 |
| mitochondrial Gsta4 is induced under oxidative stress | Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress.
Raza H, Robin MA, Fang JK, Avadhani NG., Free PMC Article | 01/21/2010 |
| mGSTA4 is strongly increased during oxidative stress via JNK activation. | Activation of C-Jun N-terminal kinase is required for glutathione transferase A4 induction during oxidative stress, not during cell proliferation, in mouse hepatocytes.
Desmots F, Loyer P, Rissel M, Guillouzo A, Morel F. | 01/21/2010 |
| demonstrated for the first time that protein kinase A and protein kinase C modulate the cytoplasmic and mitochondrial pools GATA4-4 | Phosphorylation enhances mitochondrial targeting of GSTA4-4 through increased affinity for binding to cytoplasmic Hsp70.
Robin MA, Prabu SK, Raza H, Anandatheerthavarada HK, Avadhani NG. | 01/21/2010 |
| in regenerating hepatocytes, several GST isoforms are induced and that cytokines TNFalpha and IL-6 and survival factor EGF positively regulate mGSTA4 via survival signaling pathways. | Pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 and survival factor epidermal growth factor positively regulate the murine GSTA4 enzyme in hepatocytes.
Desmots F, Rissel M, Gilot D, Lagadic-Gossmann D, Morel F, Guguen-Guillouzo C, Guillouzo A, Loyer P. | 01/21/2010 |