MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis. | MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis. Matsuzawa K, Ohga H, Shigetomi K, Shiiya T, Hirashima M, Ikenouchi J., Free PMC Article | 08/14/2021 |
Study in mouse model of atherosclerosis suggests that MAGI1 simultaneously regulates endothelial cells activation and endoplasmic reticulum stress-induced apoptosis, which are critical molecular events for atherogenesis, via MAGI1-S741 phosphorylation by p90RSK and sentrin/SUMO-specific protease 2 T368 phosphorylation-mediated MAGI1-K931 deSUMOylation. | MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. Abe JI, Ko KA, Kotla S, Wang Y, Paez-Mayorga J, Shin IJ, Imanishi M, Vu HT, Tao Y, Leiva-Juarez MM, Thomas TN, Medina JL, Won JH, Fujii Y, Giancursio CJ, McBeath E, Shin JH, Guzman L, Abe RJ, Taunton J, Mochizuki N, Faubion W, Cooke JP, Fujiwara K, Evans SE, Le NT., Free PMC Article | 07/4/2020 |
the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure | MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure through Enhanced Rap1 Activation in Podocytes. Ni J, Bao S, Johnson RI, Zhu B, Li J, Vadaparampil J, Smith CM, Campbell KN, Grahammer F, Huber TB, He JC, D'Agati VD, Chan A, Kaufman L., Free PMC Article | 05/27/2017 |
Cx32 expression is in part related to induction of tight junctions through modulation of Magi1 expression in an immortalized hepatic cell line. | Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis. Murata M, Kojima T, Yamamoto T, Go M, Takano K, Chiba H, Tokino T, Sawada N. | 06/16/2014 |
ARIP1 and ARIP2 are co-expressed in some nerve cells and their biological activities are distinct. | Co-expression of activin receptor-interacting protein 1 and 2 in mouse nerve cells. Qi Y, Ge JY, Wang YN, Liu HY, Li YM, Liu ZH, Cui XL. | 08/31/2013 |
Data conclude that the up-regulation of sdk-1 in podocytes is an important pathogenic factor in glomerulosclerosis and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 function. | Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis. Kaufman L, Potla U, Coleman S, Dikiy S, Hata Y, Kurihara H, He JC, D'Agati VD, Klotman PE., Free PMC Article | 09/6/2010 |
Depletion of MAGI-1 from photorecptors by RNA interference blocks synaptic localization of Sidekick-2 in photoreceptors without affecting localization of postsynaptic density (PSD)-95. | Synaptic localization and function of Sidekick recognition molecules require MAGI scaffolding proteins. Yamagata M, Sanes JR., Free PMC Article | 04/12/2010 |
MAGI-1 together with JAM4 provides an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells | JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1. Hirabayashi S, Tajima M, Yao I, Nishimura W, Mori H, Hata Y., Free PMC Article | 01/21/2010 |
We found MAGI-1 to be associated with cell-cell contacts in human umbilical vein endothelial cells (HUVECs) and in mouse endothelium, where it colocalizes with ESAM. | Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contacts. Wegmann F, Ebnet K, Du Pasquier L, Vestweber D, Butz S. | 01/21/2010 |
Dll1 is presented on the surface of AJs formed at the apical termini of processes through interaction with MAGI1 to activate Notch on neighboring cells in the developing central nervous system | MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface. Mizuhara E, Nakatani T, Minaki Y, Sakamoto Y, Ono Y, Takai Y. | 01/21/2010 |
MAGI-1 cleavage appears to be an important step in the disassembly of cell-cell contacts during apoptosis. | Cleavage of MAGI-1, a tight junction PDZ protein, by caspases is an important step for cell-cell detachment in apoptosis. Gregorc U, Ivanova S, Thomas M, Guccione E, Glaunsinger B, Javier R, Turk V, Banks L, Turk B., Free PMC Article | 01/21/2010 |