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    Gzma granzyme A [ Mus musculus (house mouse) ]

    Gene ID: 14938, updated on 23-Jun-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Granzyme A-producing T helper cells are critical for acute graft-versus-host disease.

    Granzyme A-producing T helper cells are critical for acute graft-versus-host disease.
    Park S, Griesenauer B, Jiang H, Adom D, Mehrpouya-Bahrami P, Chakravorty S, Kazemian M, Imam T, Srivastava R, Hayes TA, Pardo J, Janga SC, Paczesny S, Kaplan MH, Olson MR., Free PMC Article

    Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation.

    Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation.
    Santiago L, Castro M, Sanz-Pamplona R, Garzón M, Ramirez-Labrada A, Tapia E, Moreno V, Layunta E, Gil-Gómez G, Garrido M, Peña R, Lanuza PM, Comas L, Jaime-Sanchez P, Uranga-Murillo I, Del Campo R, Pelegrín P, Camerer E, Martínez-Lostao L, Muñoz G, Uranga JA, Alcalde A, Galvez EM, Ferrandez A, Bird PI, Metkar S, Arias MA, Pardo J.

    Granzyme A in Chikungunya and Other Arboviral Infections.

    Granzyme A in Chikungunya and Other Arboviral Infections.
    Schanoski AS, Le TT, Kaiserman D, Rowe C, Prow NA, Barboza DD, Santos CA, Zanotto PMA, Magalhães KG, Aurelio L, Muller D, Young P, Zhao P, Bird PI, Suhrbier A., Free PMC Article

    Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN.

    Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN.
    Shimizu K, Yamasaki S, Sakurai M, Yumoto N, Ikeda M, Mishima-Tsumagari C, Kukimoto-Niino M, Watanabe T, Kawamura M, Shirouzu M, Fujii SI., Free PMC Article

    GzmA and gzmB were predominantly expressed by natural killer cells, and during abdominal sepsis, the percentage of these cells expressing gzms in peritoneal lavage fluid decreased, while the amount of expression in the gzm(+) cells increased

    Expression and Function of Granzymes A and B in <i>Escherichia coli</i> Peritonitis and Sepsis.
    García-Laorden MI, Stroo I, Terpstra S, Florquin S, Medema JP, van T Veer C, de Vos AF, van der Poll T., Free PMC Article

    a novel endogenous trigger for autoimmune diabetes and an in vivo role for granzyme A in maintaining immune tolerance.

    Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway.
    Mollah ZUA, Quah HS, Graham KL, Jhala G, Krishnamurthy B, Dharma JFM, Chee J, Trivedi PM, Pappas EG, Mackin L, Chu EPF, Akazawa S, Fynch S, Hodson C, Deans AJ, Trapani JA, Chong MMW, Bird PI, Brodnicki TC, Thomas HE, Kay TWH.

    this study shows that gzmA and gzmB partly regulate local inflammation during early pneumonia but eventually play an insignificant role during pneumosepsis by the common human pathogen Klebsiella pneumoniae

    Granzymes A and B Regulate the Local Inflammatory Response during Klebsiella pneumoniae Pneumonia.
    García-Laorden MI, Stroo I, Blok DC, Florquin S, Medema JP, de Vos AF, van der Poll T., Free PMC Article

    Granzyme A does not have a crucial role in vivo in the protective response to tuberculosis.

    Granzyme A Is Expressed in Mouse Lungs during Mycobacterium tuberculosis Infection but Does Not Contribute to Protection In Vivo.
    Uranga S, Marinova D, Martin C, Pardo J, Aguilo N., Free PMC Article

    Data indicate N-terminomics on the human and mouse granzymes A and K by combined fractional diagonal chromatography (COFRADIC).

    Substrate specificities of the granzyme tryptases A and K.
    Plasman K, Demol H, Bird PI, Gevaert K, Van Damme P.

    The results, in susceptible B6 mice for GzmB and in resistant 129/Sv mice for GzmA and/or the GzmB cluster, point to granzyme-mediated host defense regulation in the liver in experimental visceral leishmaniasis.

    Granzyme-mediated regulation of host defense in the liver in experimental Leishmania donovani infection.
    Murray HW, Mitchell-Flack M, Zheng H, Ma X., Free PMC Article

    Estrogen increases the extracellular expression and interleukin (IL)-12-induced activity of a critical member of serine protease family granzyme A.

    Serine protease inhibition attenuates rIL-12-induced GZMA activity and proinflammatory events by modulating the Th2 profile from estrogen-treated mice.
    Karpuzoglu E, Schmiedt CW, Pardo J, Hansen M, Guo TL, Holladay SD, Gogal RM Jr., Free PMC Article

    functional divergence between human and mouse granzyme A

    Identification of Serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A.
    Kaiserman D, Stewart SE, Plasman K, Gevaert K, Van Damme P, Bird PI., Free PMC Article

    We have demonstrated that cell death can be induced when mGzmA is delivered by primary natural killer cells via authentic Cytotoxic lymphocyte/target cell interactions.

    Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis.
    Susanto O, Stewart SE, Voskoboinik I, Brasacchio D, Hagn M, Ellis S, Asquith S, Sedelies KA, Bird PI, Waterhouse NJ, Trapani JA., Free PMC Article

    Regulated secretion of granzyme A and cytotoxic killing was enhanced and correlated with increased vesicle-associated membrane protein 7 availability.

    The sorting receptor Sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
    Herda S, Raczkowski F, Mittrücker HW, Willimsky G, Gerlach K, Kühl AA, Breiderhoff T, Willnow TE, Dörken B, Höpken UE, Rehm A.

    GzmA deficiency in filarial infection is linked with reduced inflammation and a trend toward increased alternatively activated macrophages.

    A novel and divergent role of granzyme A and B in resistance to helminth infection.
    Hartmann W, Marsland BJ, Otto B, Urny J, Fleischer B, Korten S.

    granzyme A- and B-cluster deficiency delays the acute progression of pneumovirus disease by reducing alveolar injury.

    Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected mice.
    Bem RA, van Woensel JB, Lutter R, Domachowske JB, Medema JP, Rosenberg HF, Bos AP., Free PMC Article

    Neither gzmA nor gzmB is required for rapid and efficient in vivo cytotoxicity by cytotoxic T (Tc) cells.

    Cutting edge: rapid and efficient in vivo cytotoxicity by cytotoxic T cells is independent of granzymes A and B.
    Regner M, Pavlinovic L, Koskinen A, Young N, Trapani JA, Müllbacher A.

    the granule secretory pathway plays an unexpected role in inflammation, with GzmA acting as an endogenous modulator.

    Human and mouse granzyme A induce a proinflammatory cytokine response.
    Metkar SS, Menaa C, Pardo J, Wang B, Wallich R, Freudenberg M, Kim S, Raja SM, Shi L, Simon MM, Froelich CJ.

    grzK plays an important role in CD8(+) T-cell cytotoxicity both in the presence and absence of grzA and B.

    Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice.
    Jenkins MR, Trapani JA, Doherty PC, Turner SJ.

    GzmA accesses the mitochondrial matrix to cleave the complex I protein NDUFS3, an iron-sulfur subunit of the NADH:ubiquinone oxidoreductase complex I.

    Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death.
    Martinvalet D, Dykxhoorn DM, Ferrini R, Lieberman J., Free PMC Article

    Skin-, but not lung-associated primary mast cells as well as in vitro-differentiated bone marrow-derived mast cells (BMMC) express granzyme (gzm) B, but not gzmA or perforin (perf).

    Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin.
    Pardo J, Wallich R, Ebnet K, Iden S, Zentgraf H, Martin P, Ekiciler A, Prins A, Müllbacher A, Huber M, Simon MM.

    granzyme A and granzyme B have a similar potential to induce rapid perf-mediated apoptosis but that their individual contribution to the underlying intracellular process is dictated by the quality of the target cell

    The differential contribution of granzyme A and granzyme B in cytotoxic T lymphocyte-mediated apoptosis is determined by the quality of target cells.
    Pardo J, Balkow S, Anel A, Simon MM.

    gzmA and gzmB induce multiple independent cell death pathways; all gzm-induced apoptotic features analyzed depend critically on perf.

    Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis.
    Pardo J, Bosque A, Brehm R, Wallich R, Naval J, Müllbacher A, Anel A, Simon MM., Free PMC Article

    In all tumor models examined thus far, granzyme A is not necessary for tumor rejection mediated by the perforin pathway in vivo.

    Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection.
    Smyth MJ, Street SE, Trapani JA.

    Mouse granzyme B is 30 times less cytotoxic than human granzyme B and does not require Bid for killing but regains cytotoxicity on engineering of its active site cleft. Mouse granzyme A is considerably more cytotoxic than human granzyme A.

    The major human and mouse granzymes are structurally and functionally divergent.
    Kaiserman D, Bird CH, Sun J, Matthews A, Ung K, Whisstock JC, Thompson PE, Trapani JA, Bird PI., Free PMC Article

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