| HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy. | HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy.
Chen M, Menon MC, Wang W, Fu J, Yi Z, Sun Z, Liu J, Li Z, Mou L, Banu K, Lee SW, Dai Y, Anandakrishnan N, Azeloglu EU, Lee K, Zhang W, Das B, He JC, Wei C., Free PMC Article | 07/24/2023 |
| Inhibition of HCK in myeloid cells restricts pancreatic tumor growth and metastasis. | Inhibition of HCK in myeloid cells restricts pancreatic tumor growth and metastasis.
Poh AR, O'Brien M, Chisanga D, He H, Baloyan D, Traichel J, Dijkstra C, Chopin M, Nutt S, Whitehead L, Boon L, Parkin A, Lowell C, Pajic M, Shi W, Nikfarjam M, Ernst M. | 10/22/2022 |
| Hematopoietic cell kinase enhances osteosarcoma development via the MEK/ERK pathway. | Hematopoietic cell kinase enhances osteosarcoma development via the MEK/ERK pathway.
Liu W, Li T, Hu W, Ji Q, Hu F, Wang Q, Yang X, Qi D, Chen H, Zhang X., Free PMC Article | 02/26/2022 |
| Genetic Ablation of Hematopoietic Cell Kinase Accelerates Alzheimer's Disease-Like Neuropathology in Tg2576 Mice. | Genetic Ablation of Hematopoietic Cell Kinase Accelerates Alzheimer's Disease-Like Neuropathology in Tg2576 Mice.
Lim SL, Tran DN, Kieu Z, Chen C, Villanueva E, Ghiaar S, Gallup V, Zumkehr J, Cribbs DH, Rodriguez-Ortiz CJ, Kitazawa M., Free PMC Article | 02/6/2021 |
| Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly. | Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly.
Ku M, MacKinnon RN, Wall M, Narayan N, Walkley C, Cheng HC, Campbell LJ, Purton LE, Nandurkar H., Free PMC Article | 11/21/2020 |
| Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice. | Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice.
Poh AR, Dwyer AR, Eissmann MF, Chand AL, Baloyan D, Boon L, Murrey MW, Whitehead L, O'Brien M, Lowell CA, Putoczki TL, Pixley FJ, O'Donoghue RJJ, Ernst M., Free PMC Article | 11/21/2020 |
| Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice. | Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice.
Matsuura VKSK, Yoshida CA, Komori H, Sakane C, Yamana K, Jiang Q, Komori T., Free PMC Article | 10/10/2020 |
| These results suggest that the estrogen-autophagy-STAT3-HCK axis participates in the differentiation of PTGS2(high) IFNG(low) PRF1(low) GZMB(low) FCGR3(-) NK cells in ectopic lesion microenvironment. | Suppression of autophagy and HCK signaling promotes PTGS2(high) FCGR3(-) NK cell differentiation triggered by ectopic endometrial stromal cells.
Mei J, Zhou WJ, Zhu XY, Lu H, Wu K, Yang HL, Fu Q, Wei CY, Chang KK, Jin LP, Wang J, Wang YM, Li DJ, Li MQ., Free PMC Article | 10/12/2019 |
| the Hck, Fgr and Lyn kinases are also necessary for amastigote uptake by macrophages. Src-mediated Arg activation is required for efficient uptake. | The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.
Wetzel DM, Rhodes EL, Li S, McMahon-Pratt D, Koleske AJ., Free PMC Article | 08/5/2017 |
| Hematopoietic Hck promotes tumorigenesis. | Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression.
Poh AR, Love CG, Masson F, Preaudet A, Tsui C, Whitehead L, Monard S, Khakham Y, Burstroem L, Lessene G, Sieber O, Lowell C, Putoczki TL, O'Donoghue RJJ, Ernst M., Free PMC Article | 06/24/2017 |
| Data suggest that Hck is a key mediator of renal fibrosis | Genomic Analysis of Kidney Allograft Injury Identifies Hematopoietic Cell Kinase as a Key Driver of Renal Fibrosis.
Wei C, Li L, Menon MC, Zhang W, Fu J, Kidd B, Keung KL, Woytovich C, Greene I, Xiao W, Salem F, Yi Z, He JC, Dudley JT, Murphy B., Free PMC Article | 06/3/2017 |
| Data indicate that Src-Family Kinases Hck and Fgr regulate cytokine secretion by macrophages. | The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines.
Mazzi P, Caveggion E, Lapinet-Vera JA, Lowell CA, Berton G., Free PMC Article | 12/19/2015 |
| Hck is not only progressively overexpressed in atherosclerosis, but it also controls critical molecular processes in monocyte influx, blood monocyte subset balance, macrophage accumulation, and the maintenance of atherosclerotic lesion stability. | Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility.
Medina I, Cougoule C, Drechsler M, Bermudez B, Koenen RR, Sluimer J, Wolfs I, Döring Y, Herias V, Gijbels M, Bot I, de Jager S, Weber C, Cleutjens J, van Berkel TJC, Sikkink KJ, Mócsai A, Maridonneau-Parini I, Soehnlein O, Biessen EAL., Free PMC Article | 11/7/2015 |
| The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment. | The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
Kovács M, Németh T, Jakus Z, Sitaru C, Simon E, Futosi K, Botz B, Helyes Z, Lowell CA, Mócsai A., Free PMC Article | 11/22/2014 |
| tyrosine phosphorylation of WASP by Hck is required for proper macrophage functions | Tyrosine phosphorylation of Wiskott-Aldrich syndrome protein (WASP) by Hck regulates macrophage function.
Park H, Dovas A, Hanna S, Lastrucci C, Cougoule C, Guiet R, Maridonneau-Parini I, Cox D., Free PMC Article | 05/17/2014 |
| Hck is one of the very few effectors of preosteoclast recruitment described to date and thereby plays a critical role in bone remodeling. | Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors.
Vérollet C, Gallois A, Dacquin R, Lastrucci C, Pandruvada SN, Ortega N, Poincloux R, Behar A, Cougoule C, Lowell C, Al Saati T, Jurdic P, Maridonneau-Parini I., Free PMC Article | 11/16/2013 |
| Despite possessing enhanced killing, alveolar macrophage Hck/Fgr/Lyn-deficient ("triple-knockout") mice do not demonstrate enhanced inflammatory responses to Pneumocystis murina. | IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina.
Nelson MP, Christmann BS, Werner JL, Metz AE, Trevor JL, Lowell CA, Steele C., Free PMC Article | 04/30/2011 |
| Taken together, PKR and Hck were critical for DON-induced ribosomal recruitment of p38, its subsequent phosphorylation, and, ultimately, p38-driven proinflammatory cytokine expression. | Hematopoietic cell kinase associates with the 40S ribosomal subunit and mediates the ribotoxic stress response to deoxynivalenol in mononuclear phagocytes.
Bae H, Gray JS, Li M, Vines L, Kim J, Pestka JJ., Free PMC Article | 08/16/2010 |
| Nef participates in HIV-1-induced multinucleated giant cells formation via a p61Hck- and lysosomal enzyme-dependent pathway | HIV-1 Nef triggers macrophage fusion in a p61Hck- and protease-dependent manner.
Vérollet C, Zhang YM, Le Cabec V, Mazzolini J, Charrière G, Labrousse A, Bouchet J, Medina I, Biessen E, Niedergang F, Bénichou S, Maridonneau-Parini I. | 06/28/2010 |
| spatial organization of podosomes as large rosettes, proteolytic degradation of extracellular matrix, and 3D migration appeared to be functionally linked and regulated by Hck in macrophages | Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis.
Cougoule C, Le Cabec V, Poincloux R, Al Saati T, Mège JL, Tabouret G, Lowell CA, Laviolette-Malirat N, Maridonneau-Parini I., Free PMC Article | 03/29/2010 |
| Hck functions in neutrophils to be realized, at least in part, via its interaction with mDia1 and WASp, and identifies the mDia1/Hck/WASp axis as a cytoskeletal signaling interface. | Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils.
Shi Y, Dong B, Miliotis H, Liu J, Alberts AS, Zhang J, Siminovitch KA. | 01/21/2010 |
| a myeloproliferative transformation-sensitive signaling pathway, composed of Lyn/Hck, SHIP, autocrine/paracrine cytokines, and Stat5, that regulates HSC differentiation and M2 macrophage programming. | Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5.
Xiao W, Hong H, Kawakami Y, Lowell CA, Kawakami T., Free PMC Article | 01/21/2010 |
| Lyn activity is elevated in hck(-/-) cells, leading to increased phosphorylation of several negative regulators | The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.
Hong H, Kitaura J, Xiao W, Horejsi V, Ra C, Lowell CA, Kawakami Y, Kawakami T., Free PMC Article | 01/21/2010 |
| de novo actin polymerization process was functionally dependent on the kinase activity of Hck, WASp, the Arp2/3 complex, and Cdc42 but not Rac or Rho. | Activation of p61Hck triggers WASp- and Arp2/3-dependent actin-comet tail biogenesis and accelerates lysosomes.
Vincent C, Maridonneau-Parini I, Le Clainche C, Gounon P, Labrousse A. | 01/21/2010 |
| Hck plays no role in chemoattractant-induced, inside-out beta 2 integrin activation of neutrophils but regulates their outside-in, signaling-dependent sustained adhesion. | The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating beta 2 integrin affinity and valency in neutrophils, but are required for beta 2 integrin-mediated outside-in signaling involved in sustained adhesion.
Giagulli C, Ottoboni L, Caveggion E, Rossi B, Lowell C, Constantin G, Laudanna C, Berton G. | 01/21/2010 |