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    CX3CR1 C-X3-C motif chemokine receptor 1 [ Homo sapiens (human) ]

    Gene ID: 1524, updated on 29-May-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling.

    Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling.
    Frias-Anaya E, Gallego-Gutierrez H, Gongol B, Weinsheimer S, Lai CC, Orecchioni M, Sriram A, Bui CM, Nelsen B, Hale P, Pham A, Shenkar R, DeBiasse D, Lightle R, Girard R, Li Y, Srinath A, Daneman R, Nudleman E, Sun H, Guma M, Dubrac A, Mesarwi OA, Ley K, Kim H, Awad IA, Ginsberg MH, Lopez-Ramirez MA.,

    05/29/2024
    CX3CR1 is a potential biomarker of immune microenvironment and prognosis in epithelial ovarian cancer.

    CX3CR1 is a potential biomarker of immune microenvironment and prognosis in epithelial ovarian cancer.
    Shao D, Zhou H, Yu H, Zhu X., Free PMC Article

    02/1/2024
    Validating Fractalkine receptor as a target and identifying candidates for drug discovery against type 2 diabetes.

    Validating Fractalkine receptor as a target and identifying candidates for drug discovery against type 2 diabetes.
    Yadav M, Akhter Y.

    01/17/2024
    Obesity-related Plasma CXCL10 Drives CX3CR1-dependent Monocytic Secretion of Macrophage Migration Inhibitory Factor.

    Obesity-related Plasma CXCL10 Drives CX3CR1-dependent Monocytic Secretion of Macrophage Migration Inhibitory Factor.
    Meyhöfer S, Steffen A, Plötze-Martin K, Marquardt JU, Meyhöfer SM, Bruchhage KL, Pries R., Free PMC Article

    01/8/2024
    Significant association of CX3CR1+CD8 T cells with aging and distinct clinical features in Sjogren's syndrome and IgG4-related disease.

    Significant association of CX3CR1+CD8 T cells with aging and distinct clinical features in Sjögren's syndrome and IgG4-related disease.
    Akiyama M, Yoshimoto K, Kaneko Y.

    01/6/2024
    Upregulation of CX3CR1 expression in circulating T cells of systemic lupus erythematosus patients as a reflection of autoimmune status through characterization of cytotoxic capacity.

    Upregulation of CX3CR1 expression in circulating T cells of systemic lupus erythematosus patients as a reflection of autoimmune status through characterization of cytotoxic capacity.
    Li Q, Yuan Z, Bahabayi A, Zhang Z, Zeng X, Kang R, Xu Q, Guan Z, Wang P, Liu C.

    01/4/2024
    Exploring the role of miR-200 family in regulating CX3CR1 and CXCR1 in lung adenocarcinoma tumor microenvironment: implications for therapeutic intervention.

    Exploring the role of miR-200 family in regulating CX3CR1 and CXCR1 in lung adenocarcinoma tumor microenvironment: implications for therapeutic intervention.
    Sharma A, Singh P, Jha R, Almatroodi SA, Alrumaihi F, Rahmani AH, Alharbi HO, Dohare R, Syed MA., Free PMC Article

    10/2/2023
    Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation.

    Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation.
    Zwijnenburg AJ, Pokharel J, Varnaitė R, Zheng W, Hoffer E, Shryki I, Comet NR, Ehrström M, Gredmark-Russ S, Eidsmo L, Gerlach C.

    08/11/2023
    Low shear stress induces inflammatory response via CX3CR1/NF-kappaB signal pathway in human umbilical vein endothelial cells.

    Low shear stress induces inflammatory response via CX3CR1/NF-κB signal pathway in human umbilical vein endothelial cells.
    Huang H, Ren P, Zhao Y, Weng H, Jia C, Yu F, Nie Y.

    06/22/2023
    The Cytokine CX3CL1 and ADAMs/MMPs in Concerted Cross-Talk Influencing Neurodegenerative Diseases.

    The Cytokine CX3CL1 and ADAMs/MMPs in Concerted Cross-Talk Influencing Neurodegenerative Diseases.
    Iemmolo M, Ghersi G, Bivona G., Free PMC Article

    06/7/2023
    High CX3CR1 expression predicts poor prognosis in paediatric acute myeloid leukaemia undergoing hyperleukocytosis.

    High CX3CR1 expression predicts poor prognosis in paediatric acute myeloid leukaemia undergoing hyperleukocytosis.
    Mei N, Su H, Gong S, Du H, Zhang X, Wang L, Wang H., Free PMC Article

    01/21/2023
    Structure and Function of Ligand CX3CL1 and its Receptor CX3CR1 in Cancer.

    Structure and Function of Ligand CX3CL1 and its Receptor CX3CR1 in Cancer.
    Lu X.

    10/29/2022
    Evaluation of CX3CR1 gene DNA methylation in developmental dysplasia of the hip (DDH).

    Evaluation of CX3CR1 gene DNA methylation in developmental dysplasia of the hip (DDH).
    Nejadhosseinian M, Haerian H, Shirkoohi R, Karami J, Mortazavi SMJ., Free PMC Article

    10/8/2022
    Defective fractalkine-CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone-induced demyelination.

    Defective fractalkine-CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone-induced demyelination.
    Mendiola AS, Church KA, Cardona SM, Vanegas D, Garcia SA, Macklin W, Lira SA, Ransohoff RM, Kokovay E, Lin CA, Cardona AE., Free PMC Article

    09/3/2022
    Activation of the human chemokine receptor CX3CR1 regulated by cholesterol.

    Activation of the human chemokine receptor CX3CR1 regulated by cholesterol.
    Lu M, Zhao W, Han S, Lin X, Xu T, Tan Q, Wang M, Yi C, Chu X, Yang W, Zhu Y, Wu B, Zhao Q., Free PMC Article

    07/9/2022
    CX3CR1 Acts as a Protective Biomarker in the Tumor Microenvironment of Colorectal Cancer.

    CX3CR1 Acts as a Protective Biomarker in the Tumor Microenvironment of Colorectal Cancer.
    Yue Y, Zhang Q, Sun Z., Free PMC Article

    02/26/2022
    Human CD16+ monocytes promote a pro-atherosclerotic endothelial cell phenotype via CX3CR1-CX3CL1 interaction.

    Human CD16+ monocytes promote a pro-atherosclerotic endothelial cell phenotype via CX3CR1-CX3CL1 interaction.
    Roy-Chowdhury E, Brauns N, Helmke A, Nordlohne J, Bräsen JH, Schmitz J, Volkmann J, Fleig SV, Kusche-Vihrog K, Haller H, von Vietinghoff S.

    01/29/2022
    Interleukin-34 accelerates intrauterine adhesions progress related to CX3CR1(+) monocytes/macrophages.

    Interleukin-34 accelerates intrauterine adhesions progress related to CX3CR1(+) monocytes/macrophages.
    Wang J, Li D, Pan Y, Li J, Jiang Q, Liu D, Hou Y.

    12/25/2021
    The potential association between a new angiogenic marker fractalkine and a placental vascularization in preeclampsia.

    The potential association between a new angiogenic marker fractalkine and a placental vascularization in preeclampsia.
    Szewczyk G, Pyzlak M, Pankiewicz K, Szczerba E, Stangret A, Szukiewicz D, Skoda M, Bierła J, Cukrowska B, Fijałkowska A., Free PMC Article

    10/30/2021
    Increased expression of CX3CL1 and CX3CR1 in papillary thyroid carcinoma.

    Increased expression of CX3CL1 and CX3CR1 in papillary thyroid carcinoma.
    Wu W, Ren F, Guo M, Yang J, Xiao Y, Liu W.

    10/2/2021
    Driving T cells to human atherosclerotic plaques: CCL3/CCR5 and CX3CL1/CX3CR1 migration axes.

    Driving T cells to human atherosclerotic plaques: CCL3/CCR5 and CX3CL1/CX3CR1 migration axes.
    Komissarov A, Potashnikova D, Freeman ML, Gontarenko V, Maytesyan D, Lederman MM, Vasilieva E, Margolis L.

    10/2/2021
    MiR-1207-5p/CX3CR1 axis regulates the progression of osteoarthritis via the modulation of the activity of NF-kappaB pathway.

    MiR-1207-5p/CX3CR1 axis regulates the progression of osteoarthritis via the modulation of the activity of NF-κB pathway.
    Liu XC, Xu L, Cai YL, Zheng ZY, Dai EN, Sun S.

    10/2/2021
    Platelets are recruited to hepatocellular carcinoma tissues in a CX3CL1-CX3CR1 dependent manner and induce tumour cell apoptosis.

    Platelets are recruited to hepatocellular carcinoma tissues in a CX3CL1-CX3CR1 dependent manner and induce tumour cell apoptosis.
    Miao S, Lu M, Liu Y, Shu D, Zhu Y, Song W, Ma Y, Ma R, Zhang B, Fang C, Ming ZY., Free PMC Article

    09/11/2021
    Fractalkine Elicits Chemotactic, Phenotypic, and Functional Effects on CX3CR1(+)CD27(-) NK Cells in Obesity-Associated Cancer.

    Fractalkine Elicits Chemotactic, Phenotypic, and Functional Effects on CX3CR1(+)CD27(-) NK Cells in Obesity-Associated Cancer.
    Mylod E, Melo AM, Donlon NE, Davern M, Bhardwaj A, Reynolds JV, Lysaght J, Conroy MJ.

    08/21/2021
    Diminished levels of the chemokine fractalkine in post-mortem prefrontal cortex in schizophrenia but not bipolar disorder.

    Diminished levels of the chemokine fractalkine in post-mortem prefrontal cortex in schizophrenia but not bipolar disorder.
    Hill SL, Shao L, Beasley CL.

    08/21/2021
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