| CXADR promote epithelial-mesenchymal transition in endometriosis by modulating AKT/GSK-3beta signaling. | CXADR promote epithelial-mesenchymal transition in endometriosis by modulating AKT/GSK-3β signaling.
Tan HJ, Deng ZH, Zhang C, Deng HW, Xiao HM., | 02/2/2024 |
| CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders. | CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders.
Oliviero F, Klement W, Mary L, Dauwe Y, Lippi Y, Naylies C, Gayrard V, Marchi N, Mselli-Lakhal L., Free PMC Article | 09/29/2023 |
| Induction of the Coxsackievirus and Adenovirus Receptor in Macrophages During the Formation of Atherosclerotic Plaques. | Induction of the Coxsackievirus and Adenovirus Receptor in Macrophages During the Formation of Atherosclerotic Plaques.
Nilchian A, Plant E, Parniewska MM, Santiago A, Rossignoli A, Skogsberg J, Hedin U, Matic L, Fuxe J., Free PMC Article | 04/3/2021 |
| Naturally occurring variants in the transmembrane and cytoplasmic domains of the human Coxsackie- and adenovirus receptor have no impact on virus internalisation. | Naturally occurring variants in the transmembrane and cytoplasmic domains of the human Coxsackie- and adenovirus receptor have no impact on virus internalisation.
Herrmann L, Filip A, Lapuente D, Tenbusch M, Niehaus K, Rudolph V, Farr M. | 01/9/2021 |
| CAR transcription levels were significantly lower (P=0.012) in patients with myocarditis compared with controls, and a significant decrease was observed (P=0.023) in CAR mRNA levels among patients with borderline myocarditis compared with the no myocarditis group. | Differential expression of coxsackievirus and adenovirus receptor in endomyocardial tissue of patients with myocarditis.
García-Becerril GE, Cruz-Montalvo AE, De La Cruz MA, Ares MA, Moreno-Ruiz LA, García-Chequer AJ, Maldonado-Bernal C, Gómez-Jiménez LM, Flores-García CA, Garrido-Garduño MH, Cárdenas-Mondragón MG., Free PMC Article | 01/11/2020 |
| Loss of CXADR expression is associated with Epithelial-Mesenchymal Plasticity in breast cancer. | CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial-Mesenchymal Plasticity in Breast Cancer.
Nilchian A, Johansson J, Ghalali A, Asanin ST, Santiago A, Rosencrantz O, Sollerbrant K, Vincent CT, Sund M, Stenius U, Fuxe J. | 10/26/2019 |
| EGF suppresses specifically CAR signaling mainly through transcriptional regulation and drives the xenobiotic response toward a pregnane X receptor (PXR)-mediated mechanism. | Epidermal Growth Factor Represses Constitutive Androstane Receptor Expression in Primary Human Hepatocytes and Favors Regulation by Pregnane X Receptor.
de Boussac H, Gondeau C, Briolotti P, Duret C, Treindl F, Römer M, Fabre JM, Herrero A, Ramos J, Maurel P, Templin M, Gerbal-Chaloin S, Daujat-Chavanieu M. | 10/20/2018 |
| The results pf this study demonstrated that CAR is expressed by mature neurons throughout the brain. In addition, we propose divergent roles for CAR in immature neurons, during neurogenesis, and at the mature synapse. | Coxsackievirus Adenovirus Receptor Loss Impairs Adult Neurogenesis, Synapse Content, and Hippocampus Plasticity.
Zussy C, Loustalot F, Junyent F, Gardoni F, Bories C, Valero J, Desarménien MG, Bernex F, Henaff D, Bayo-Puxan N, Chen JW, Lonjon N, de Koninck Y, Malva JO, Bergelson JM, di Luca M, Schiavo G, Salinas S, Kremer EJ., Free PMC Article | 08/26/2017 |
| data indicate that glycosylation of the extracellular CAR domain has only minor importance for the function of CAR as Coxsackievirus B3 (CVB3) receptor and that the D2 domain is not essential per se but contributes to receptor function by promoting the exposure of the D1 domain on the cell surface | The Coxsackievirus and Adenovirus Receptor: Glycosylation and the Extracellular D2 Domain Are Not Required for Coxsackievirus B3 Infection.
Pinkert S, Röger C, Kurreck J, Bergelson JM, Fechner H., Free PMC Article | 05/6/2017 |
| CAR expression has potential as a marker for monitoring and/or predicting the outcome of gene therapy, and increasing its expression levels may contribute to the upregulation of cellular sensitivity towards adenovirus infection. | Loss of coxsackie and adenovirus receptor expression in human colorectal cancer: A potential impact on the efficacy of adenovirus-mediated gene therapy in Chinese Han population.
Ma YY, Wang XJ, Han Y, Li G, Wang HJ, Wang SB, Chen XY, Liu FL, He XL, Tong XM, Mou XZ., Free PMC Article | 04/8/2017 |
| Membrane Dynamics and Signaling of the Coxsackievirus and Adenovirus Receptor. | Membrane Dynamics and Signaling of the Coxsackievirus and Adenovirus Receptor.
Loustalot F, Kremer EJ, Salinas S. | 12/17/2016 |
| Combining CAR activation with limited beta-catenin activation induces tumorigenesis, and the tumours share a conserved gene expression signature with beta-catenin-positive human hepatocellular carcinoma. | Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis.
Dong B, Lee JS, Park YY, Yang F, Xu G, Huang W, Finegold MJ, Moore DD., Free PMC Article | 02/6/2016 |
| Glycan microarray, flow cytometry, surface plasmon resonance and ELISA analyses reveal that the terminal knob domain of the long fiber (52LFK) binds to CAR, and the knob domain of the short fiber (52SFK) binds to sialylated glycoproteins. | Human adenovirus 52 uses sialic acid-containing glycoproteins and the coxsackie and adenovirus receptor for binding to target cells.
Lenman A, Liaci AM, Liu Y, Årdahl C, Rajan A, Nilsson E, Bradford W, Kaeshammer L, Jones MS, Frängsmyr L, Feizi T, Stehle T, Arnberg N., Free PMC Article | 01/16/2016 |
| Lovastatin enhances adenovirus-mediated TRAIL induced apoptosis by depleting cholesterol of lipid rafts and affecting CAR and death receptor expression of prostate cancer cells. | Lovastatin enhances adenovirus-mediated TRAIL induced apoptosis by depleting cholesterol of lipid rafts and affecting CAR and death receptor expression of prostate cancer cells.
Liu Y, Chen L, Gong Z, Shen L, Kao C, Hock JM, Sun L, Li X., Free PMC Article | 11/28/2015 |
| Suggest that distinct forms of CAR play different roles in the undifferentiated state and tight junction formation of human embryos and embryonic stem cells. | CAR expression in human embryos and hESC illustrates its role in pluripotency and tight junctions.
Krivega M, Geens M, Van de Velde H. | 06/20/2015 |
| CAR might play a role in adipose tissue dysfunction, given its dual associations with adipogenic and inflammatory genes. | Coxsackie and adenovirus receptor is increased in adipose tissue of obese subjects: a role for adenovirus infection?
Serrano M, Moreno M, Bassols J, Moreno-Navarrete JM, Ortega F, Ricart W, Fernández-Real JM. | 05/16/2015 |
| Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively | miR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor.
Lam WY, Cheung AC, Tung CK, Yeung AC, Ngai KL, Lui VW, Chan PK, Tsui SK. | 04/4/2015 |
| This study shows for the first time that lovastatin reduces the expression of CAR and subsequently the replication of CVB3 in human umbilical vein endothelial cells. | Effect of lovastatin on coxsackievirus B3 infection in human endothelial cells.
Werner B, Dittmann S, Funke C, Überla K, Piper C, Niehaus K, Horstkotte D, Farr M. | 11/8/2014 |
| CAR regulates epithelial cell junction stability through control of E-cadherin trafficking. | CAR regulates epithelial cell junction stability through control of E-cadherin trafficking.
Morton PE, Hicks A, Nastos T, Santis G, Parsons M., Free PMC Article | 06/28/2014 |
| Kinetic analyses show that the apparent first-order rate constant for the inactivation of coxsackievirus B3 by soluble CAR (sCAR) at physiological temperatures varies nonlinearly with sCAR concentration. | Kinetic and structural analysis of coxsackievirus B3 receptor interactions and formation of the A-particle.
Organtini LJ, Makhov AM, Conway JF, Hafenstein S, Carson SD., Free PMC Article | 06/21/2014 |
| CAR substantially impacts the growth and survival of oral squamous cell carcinoma cells as a negative regulator of ROCK in vitro and in vivo. | Coxsackie and adenovirus receptor is a critical regulator for the survival and growth of oral squamous carcinoma cells.
Saito K, Sakaguchi M, Iioka H, Matsui M, Nakanishi H, Huh NH, Kondo E. | 05/3/2014 |
| novel modifier of ventricular conduction and arrhythmia vulnerability in the setting of myocardial ischemia | Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia.
Marsman RF, Bezzina CR, Freiberg F, Verkerk AO, Adriaens ME, Podliesna S, Chen C, Purfürst B, Spallek B, Koopmann TT, Baczko I, Dos Remedios CG, George AL Jr, Bishopric NH, Lodder EM, de Bakker JM, Fischer R, Coronel R, Wilde AA, Gotthardt M, Remme CA., Free PMC Article | 04/12/2014 |
| CAR belongs to the increasing list of cell surface molecules that undergo ectodomain shedding and that are substrates for -secretase-mediated RIP. | The Coxsackievirus and Adenovirus Receptor (CAR) undergoes ectodomain shedding and regulated intramembrane proteolysis (RIP).
Houri N, Huang KC, Nalbantoglu J., Free PMC Article | 04/5/2014 |
| The expression of CAR was detected in all normal organs, except in the brain. In malignancies, a high degree of variability was notable, ranging from significantly elevated CAR expression to decreased CAR expression. | Presence of the coxsackievirus and adenovirus receptor (CAR) in human neoplasms: a multitumour array analysis.
Reeh M, Bockhorn M, Görgens D, Vieth M, Hoffmann T, Simon R, Izbicki JR, Sauter G, Schumacher U, Anders M., Free PMC Article | 12/7/2013 |
| CAR expression in tumor tissues was significantly higher than that in normal lung tissues. CAR expression had a correlation with the histological grade of lung squamous cell carcinoma. | Expression of the coxsackie and adenovirus receptor in human lung cancers.
Chen Z, Wang Q, Sun J, Gu A, Jin M, Shen Z, Qiu Z, Wang J, Wang X, Zhan Z, Li JW. | 03/30/2013 |