| Systematic pan-cancer analyses of the potential function of the Golgi scaffold protein PAQR3. | Systematic pan-cancer analyses of the potential function of the Golgi scaffold protein PAQR3.
Ling ZN, Hong LL, Wu J, Ling ZQ., Free PMC Article | 02/14/2024 |
| Golgi scaffold protein PAQR3 as a candidate suppressor of gastric cardia adenocarcinoma via regulating TGF-beta/Smad pathway. | Golgi scaffold protein PAQR3 as a candidate suppressor of gastric cardia adenocarcinoma via regulating TGF-β/Smad pathway.
Wu YL, Hong LL, Ling ZN, Hu XY, Liu Z, Li P, Ling ZQ., Free PMC Article | 09/24/2022 |
| Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis. | Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis.
Zhang C, Liu P, Huang J, Liao Y, Pan C, Liu J, Du Q, Liu T, Shang C, Ooi S, Chen R, Xia M, Jiang H, Xu M, Zou Q, Zhou Y, Huang H, Pan Y, Yuan L, Wang W, Yao S., Free PMC Article | 02/5/2022 |
| PAQR3 inhibits proliferation and aggravates ferroptosis in acute lymphoblastic leukemia through modulation Nrf2 stability. | PAQR3 inhibits proliferation and aggravates ferroptosis in acute lymphoblastic leukemia through modulation Nrf2 stability.
Jin L, Tong L., Free PMC Article | 10/23/2021 |
| PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy. | PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy.
Cao Q, You X, Xu L, Wang L, Chen Y., Free PMC Article | 07/31/2021 |
| Associations of the BRAF V600E Mutation and PAQR3 Protein Expression with Papillary Thyroid Carcinoma Clinicopathological Features. | Associations of the BRAF V600E Mutation and PAQR3 Protein Expression with Papillary Thyroid Carcinoma Clinicopathological Features.
Gao J, Ma XP, Deng FS, Jiang L, Jia WD, Li M. | 04/13/2021 |
| MiR-15b facilitates breast cancer progression via repressing tumor suppressor PAQR3. | MiR-15b facilitates breast cancer progression via repressing tumor suppressor PAQR3.
Qi LQ, Sun B, Yang BB, Lu S. | 02/13/2021 |
| PAQR3 might regulate the phosphorylation of FoxO1 and the expressions of GCK and LDLR through NF-kappaB pathway, thereby regulating the glucose and lipid metabolism disorders induced by insulin resistance. | PAQR3 regulates phosphorylation of FoxO1 in insulin-resistant HepG2 cells via NF-κB signaling pathway.
Chen L, Sun X, Xiao H, Xu F, Yang Y, Lin Z, Chen Z, Quan S, Huang H. | 06/13/2020 |
| Ubiquitination modification through the coordinated action of PAQR3 with HUWE1 plays a crucial role in regulating the activity of hepatic PPARalpha in response to starvation. | Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1.
Zhao Z, Xu D, Wang Z, Wang L, Han R, Wang Z, Liao L, Chen Y., Free PMC Article | 12/29/2018 |
| Silencing of PAQR3 suppresses extracellular matrix accumulation in high glucose-stimulated human glomerular mesangial cells via PI3K/AKT signaling pathway | Silencing of PAQR3 suppresses extracellular matrix accumulation in high glucose-stimulated human glomerular mesangial cells via PI3K/AKT signaling pathway.
Li H, Wang Y, Chen B, Shi J. | 10/13/2018 |
| that PAQR3 can be a promising methylation marker candidate for the detection and monitoring of prostate cancer | Aberrant promoter methylation of the PAQR3 gene is associated with prostate cancer.
Lounglaithong K, Bychkov A, Sampatanukul P. | 09/1/2018 |
| PAQR3 is epigenetically silenced in esophageal squamous cell carcinoma (ESCC) and restoration of PAQR3 suppresses the aggressive phenotype of ESCC cells | PAQR3 overexpression suppresses the aggressive phenotype of esophageal squamous cell carcinoma cells via inhibition of ERK signaling.
Bai G, Chu J, Eli M, Bao Y, Wen H. | 06/2/2018 |
| Low expression of PAQR3 is associated with gastric cancer metastasis. | Overexpression of miR-15b-5p promotes gastric cancer metastasis by regulating PAQR3.
Zhao C, Li Y, Chen G, Wang F, Shen Z, Zhou R. | 05/19/2018 |
| Data suggest that expression of PAQR3 is down-regulated in glioma tissues and cell lines; PAQR3 overexpression suppresses cell migration of glioma cells, suppresses invasivness of glioma in xenograft experiments, and prevents epithelial-mesenchymal transition. | PAQR3 inhibits the proliferation, migration and invasion in human glioma cells.
Tang SL, Gao YL, Hu WZ. | 02/10/2018 |
| our study pinpoints that PAQR3 functions as an adaptor protein to promote Nrf2-Keap1 complex formation, thereby modulating the Nrf2-Keap2 pathway and playing an important role in controlling antioxidant response of the cell | Identification of an adaptor protein that facilitates Nrf2-Keap1 complex formation and modulates antioxidant response.
Zhang Y, Hou Y, Liu C, Li Y, Guo W, Wu JL, Xu D, You X, Pan Y, Chen Y. | 01/13/2018 |
| This finding reveals a new mode of regulation of mTORC1 signaling and autophagy by PAQR3 in response to alterations of amino acids. | PAQR3 augments amino acid deprivation-induced autophagy by inhibiting mTORC1 signaling.
Wang L, Pan Y, Huang M, You X, Guo F, Chen Y. | 12/2/2017 |
| we demonstrated that overexpression of PAQR3 suppresses cell proliferation, migration, and invasion in esophageal cancer in vitro and in vivo. | PAQR3 Inhibits the Proliferation and Tumorigenesis in Esophageal Cancer Cells.
Zhou F, Wang S, Wang J., Free PMC Article | 11/4/2017 |
| The expression of PAQR3 protein significantly decreased in lung cancer. | [Expression and Clinical Significance of Progesterone and Adiponectin Receptor Family Member 3 in Lung Cancer].
Liang X, Sun B, Han J, Zhao X, Liu Z., Free PMC Article | 07/1/2017 |
| our results suggested that the aberrant methylation of PAQR3 underlies its downregulation in breast cancer and our data indicated that epigenetic silencing of PAQR3 gene expression by promoter hypermethylation may play an important role in breast cancer | The role of PAQR3 gene promoter hypermethylation in breast cancer and prognosis.
Chen J, Wang F, Xu J, He Z, Lu Y, Wang Z. | 03/18/2017 |
| PAQR3 plays a tumor suppressive role in laryngeal squamous cell carcinoma | PAQR3 plays a suppressive role in laryngeal squamous cell carcinoma.
Wu Q, Zhuang K, Li H. | 02/18/2017 |
| A novel role for the newly characterized, Golgi-localized PAQR3 in regulating heterotrimeric G-proteins at the non-canonical subcellular location of the Golgi. | PAQR3 regulates Golgi vesicle fission and transport via the Gβγ-PKD signaling pathway.
Hewavitharana T, Wedegaertner PB., Free PMC Article | 09/24/2016 |
| findings not only pinpoint that Twist1 mediates the modulatory function of PAQR3 on EMT and metastasis but also suggest that targeting Twist1 is a promising strategy to control metastasis of tumors with downregulation of PAQR3 | PAQR3 enhances Twist1 degradation to suppress epithelial-mesenchymal transition and metastasis of gastric cancer cells.
Guo W, You X, Xu D, Zhang Y, Wang Z, Man K, Wang Z, Chen Y. | 08/6/2016 |
| PAQR3 regulates cholesterol homeostasis by anchoring Scap/SREBP to the Golgi and disruption of such function reduces cholesterol biosynthesis. | PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus.
Xu D, Wang Z, Zhang Y, Jiang W, Pan Y, Song BL, Chen Y., Free PMC Article | 04/30/2016 |
| Our data indicate that PAQR3 functions as a tumor suppressor in the development of human breast cancers. | PAQR3 expression is downregulated in human breast cancers and correlated with HER2 expression.
Li Z, Ling ZQ, Guo W, Lu XX, Pan Y, Wang Z, Chen Y., Free PMC Article | 03/26/2016 |
| DDB2 is involved in ubiquitination and degradation of PAQR3 in gastric cancer cells. | DDB2 is involved in ubiquitination and degradation of PAQR3 and regulates tumorigenesis of gastric cancer cells.
Qiao S, Guo W, Liao L, Wang L, Wang Z, Zhang R, Xu D, Zhang Y, Pan Y, Wang Z, Chen Y. | 11/14/2015 |