| Transcription Factor Hb9 Is Expressed in Glial Cell Lineages in the Developing Mouse Spinal Cord. | Transcription Factor Hb9 Is Expressed in Glial Cell Lineages in the Developing Mouse Spinal Cord.
Letchuman S, Tucker A, Miranda D, Adkins RL, Aceves M, Dietz V, Jagrit V, Leonards A, Lee YI, Dulin JN., Free PMC Article | 11/12/2022 |
| the novel findings of HB9-dependent premature senescence and myeloid-biased perturbed hematopoietic differentiation, for the first time shed light on the oncogenic properties of HB9 in translocation t(7;12) acute myeloid leukemia. | The homeobox transcription factor HB9 induces senescence and blocks differentiation in hematopoietic stem and progenitor cells.
Ingenhag D, Reister S, Auer F, Bhatia S, Wildenhain S, Picard D, Remke M, Hoell JI, Kloetgen A, Sohn D, Jänicke RU, Koegler G, Borkhardt A, Hauer J., Free PMC Article | 05/2/2020 |
| excitatory Hb9::Cre-derived interneurons constitute a distinct population of neurons that participates in the rhythm generating kernel for spinal locomotion. | Spinal Hb9::Cre-derived excitatory interneurons contribute to rhythm generation in the mouse.
Caldeira V, Dougherty KJ, Borgius L, Kiehn O., Free PMC Article | 10/27/2018 |
| Inactivating Mnx1 in embryonic beta-cells (Mnx1(Deltabeta)) caused beta-to-delta-like cell transdifferentiation, which was delayed until postnatal stages; findings identify Mnx1 as an important factor in beta-cell differentiation and proliferation. | Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing β-cells to a δ-like fate and reveals a facultative proliferative capacity in aged β-cells.
Pan FC, Brissova M, Powers AC, Pfaff S, Wright CV., Free PMC Article | 03/12/2016 |
| provide mechanistic insights into the role of phospho-HLXB9 as a pro-oncogenic factor by interacting with a survival factor and by promoting the oncogenic c-Met pathway | Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b).
Desai SS, Kharade SS, Parekh VI, Iyer S, Agarwal SK., Free PMC Article | 02/20/2016 |
| NKX2-2 and MNX1 are etiological genes for neonatal diabetes. | Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man.
Flanagan SE, De Franco E, Lango Allen H, Zerah M, Abdul-Rasoul MM, Edge JA, Stewart H, Alamiri E, Hussain K, Wallis S, de Vries L, Rubio-Cabezas O, Houghton JA, Edghill EL, Patch AM, Ellard S, Hattersley AT., Free PMC Article | 06/14/2014 |
| Both pHLXB9 and active GSK-3beta are elevated in beta cells with menin knockdown, in MEN1-associated beta cell tumors (insulinomas) | GSK-3β protein phosphorylates and stabilizes HLXB9 protein in insulinoma cells to form a targetable mechanism of controlling insulinoma cell proliferation.
Desai SS, Modali SD, Parekh VI, Kebebew E, Agarwal SK., Free PMC Article | 04/26/2014 |
| Hlxb9 expression is increased in mouse islet tumor. | The embryonic transcription factor Hlxb9 is a menin interacting partner that controls pancreatic β-cell proliferation and the expression of insulin regulators.
Shi K, Parekh VI, Roy S, Desai SS, Agarwal SK., Free PMC Article | 07/6/2013 |
| we developed recombinant lentiviral vectors carrying motor neuron specific regulatory sequences derived from the promoter of homeobox gene Hb9 | Lentiviral vectors carrying enhancer elements of Hb9 promoter drive selective transgene expression in mouse spinal cord motor neurons.
Peviani M, Kurosaki M, Terao M, Lidonnici D, Gensano F, Battaglia E, Tortarolo M, Piva R, Bendotti C. | 06/16/2012 |
| Mnx1, a gene that is absolutely required in pancreas progenitors, is a major direct target of Ptf1a and is regulated by a distant enhancer element. | RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors.
Thompson N, Gésina E, Scheinert P, Bucher P, Grapin-Botton A., Free PMC Article | 04/14/2012 |
| This study suggested that Hb9 interneurons are part of the sensorimotor circuitry that regulates the pattern of locomotor rhythms in the isolated cord. | Sensory modulation of locomotor-like membrane oscillations in Hb9-expressing interneurons.
Hinckley CA, Wiesner EP, Mentis GZ, Titus DJ, Ziskind-Conhaim L., Free PMC Article | 09/13/2010 |
| Hlxb9 and Tcfap2b were identified as genes whose expression was elevated in the ZPA compared to the rest of the developing limb bud. | Identification of genes expressed in the mouse limb using a novel ZPA microarray approach.
Rock JR, Lopez MC, Baker HV, Harfe BD. | 01/21/2010 |
| Hb9 interneurons are both endogenous bursters and rhythmically active within a heterogeneous electrotonically coupled network | Heterogeneous electrotonic coupling and synchronization of rhythmic bursting activity in mouse Hb9 interneurons.
Wilson JM, Cowan AI, Brownstone RM. | 01/21/2010 |
| Hb9+ interneurons exhibit strong postinhibitory rebound and demonstrate pronounced membrane potential oscillations in response to chemical stimuli that induce locomotor activity. | Conditional rhythmicity of ventral spinal interneurons defined by expression of the Hb9 homeodomain protein.
Wilson JM, Hartley R, Maxwell DJ, Todd AJ, Lieberam I, Kaltschmidt JA, Yoshida Y, Jessell TM, Brownstone RM., Free PMC Article | 01/21/2010 |
| the molecular pathways regulating Hb9 expression are evolutionarily conserved, and that MN-specific gene expression may be directed and achieved using a small 125-bp 5' enhancer | Identification of a conserved 125 base-pair Hb9 enhancer that specifies gene expression to spinal motor neurons.
Nakano T, Windrem M, Zappavigna V, Goldman SA. | 01/21/2010 |