| NR4a1/2 deletion promotes accumulation of TCF1[+] stem-like precursors of exhausted CD8[+] T cells in the tumor microenvironment. | NR4a1/2 deletion promotes accumulation of TCF1(+) stem-like precursors of exhausted CD8(+) T cells in the tumor microenvironment.
Srirat T, Hayakawa T, Mise-Omata S, Nakagawara K, Ando M, Shichino S, Ito M, Yoshimura A. | 04/3/2024 |
| NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway. | NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway.
Zhu J, Li J, Yang K, Chen Y, Wang J, He Y, Shen K, Wang K, Shi T, Chen W. | 03/5/2024 |
| Nur77 mitigates endothelial dysfunction through activation of both nitric oxide production and anti-oxidant pathways. | Nur77 mitigates endothelial dysfunction through activation of both nitric oxide production and anti-oxidant pathways.
Lu L, Jang S, Zhu J, Qin Q, Sun L, Sun J., Free PMC Article | 02/28/2024 |
| Knockdown of NR4A1 alleviates doxorubicin-induced cardiotoxicity through inhibiting the activation of the NLRP3 inflammasome. | Knockdown of NR4A1 alleviates doxorubicin-induced cardiotoxicity through inhibiting the activation of the NLRP3 inflammasome.
Hu H, Zhong Z, Meng L, Chen J, Yu Z, Lu K. | 02/28/2024 |
| Orphan nuclear receptor 4 A1 involvement in transforming growth factor beta1-induced myocardial fibrosis in diabetic mice. | Orphan nuclear receptor 4 A1 involvement in transforming growth factor beta1-induced myocardial fibrosis in diabetic mice.
Ma MF, Chen ZY, Wang LJ, Li N, Guo BY. | 02/20/2024 |
| Nur77 alleviates cardiac fibrosis by upregulating GSK-3beta transcription during aging. | Nur77 alleviates cardiac fibrosis by upregulating GSK-3β transcription during aging.
Zhang T, Ma R, Li Z, Liu T, Yang S, Li N, Wang D. | 02/12/2024 |
| NR4A1 deletion promotes pro-angiogenic polarization of macrophages derived from classical monocytes in a mouse model of neovascular age-related macular degeneration. | NR4A1 deletion promotes pro-angiogenic polarization of macrophages derived from classical monocytes in a mouse model of neovascular age-related macular degeneration.
Droho S, Voigt AP, Sterling JK, Rajesh A, Chan KS, Cuda CM, Perlman H, Lavine JA., Free PMC Article | 10/30/2023 |
| Nr4a1 marks a distinctive ILC2 activation subset in the mouse inflammatory lung. | Nr4a1 marks a distinctive ILC2 activation subset in the mouse inflammatory lung.
Xu S, Zhang Y, Liu X, Liu H, Zou X, Zhang L, Wang J, Zhang Z, Xu X, Li M, Li K, Shi S, Zhang Y, Miao Z, Zha J, Yu Y., Free PMC Article | 10/24/2023 |
| Dexmedetomidine attenuates inflammation and organ injury partially by upregulating Nur77 in sepsis. | Dexmedetomidine attenuates inflammation and organ injury partially by upregulating Nur77 in sepsis.
Zhang Q, Huang Y, Gong C, Tang Y, Xiong J, Wang D, Liu X., Free PMC Article | 07/7/2023 |
| Oxidative stress impairs the Nur77-Sirt1 axis resulting in a decline in organism homeostasis during aging. | Oxidative stress impairs the Nur77-Sirt1 axis resulting in a decline in organism homeostasis during aging.
Yu Y, Song X, Wang X, Zheng L, Ma G, Liu W, Su H, Liu X, Liu T, Cao L, Wang D., Free PMC Article | 05/30/2023 |
| Nr4a1 promotes renal interstitial fibrosis by regulating the p38 MAPK phosphorylation. | Nr4a1 promotes renal interstitial fibrosis by regulating the p38 MAPK phosphorylation.
Tao Y, Tang C, Wei J, Shan Y, Fang X, Li Y., Free PMC Article | 05/11/2023 |
| Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice. | Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice.
Cai X, Jiang Y, Cao Z, Zhang M, Kong N, Yu L, Tang Y, Kong S, Deng W, Wang H, Sun J, Ding L, Jiang R, Sun H, Yan G., Free PMC Article | 02/22/2023 |
| NR4A1 modulates intestinal smooth muscle cell phenotype and dampens inflammation-associated intestinal remodeling. | NR4A1 modulates intestinal smooth muscle cell phenotype and dampens inflammation-associated intestinal remodeling.
Szczepanski HE, Flannigan KL, Mainoli B, Alston L, Baruta GM, Lee JW, Venu VKP, Shearer J, Dufour A, Hirota SA. | 10/22/2022 |
| Nuclear receptor Nur77 protects against oxidative stress by maintaining mitochondrial homeostasis via regulating mitochondrial fission and mitophagy in smooth muscle cell. | Nuclear receptor Nur77 protects against oxidative stress by maintaining mitochondrial homeostasis via regulating mitochondrial fission and mitophagy in smooth muscle cell.
Geng N, Chen T, Chen L, Zhang H, Sun L, Lyu Y, Che X, Xiao Q, Tao Z, Shao Q. | 08/27/2022 |
| Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages. | Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages.
Li Q, Li Y, Huang W, Wang X, Liu Z, Chen J, Fan Y, Peng T, Sadayappan S, Wang Y, Fan GC., Free PMC Article | 07/2/2022 |
| Nur77 Deficiency Exacerbates Macrophage NLRP3 Inflammasome-Mediated Inflammation and Accelerates Atherosclerosis. | Nur77 Deficiency Exacerbates Macrophage NLRP3 Inflammasome-Mediated Inflammation and Accelerates Atherosclerosis.
Yuan R, Zhang W, Nie P, Lan K, Yang X, Yin A, Xiao Q, Shen Y, Xu K, Wang X, Pan X, Shen L, He B., Free PMC Article | 04/30/2022 |
| mPGES-2 blockade antagonizes beta-cell senescence to ameliorate diabetes by acting on NR4A1. | mPGES-2 blockade antagonizes β-cell senescence to ameliorate diabetes by acting on NR4A1.
Zhong D, Wan Z, Cai J, Quan L, Zhang R, Teng T, Gao H, Fan C, Wang M, Guo D, Zhang H, Jia Z, Sun Y. | 04/30/2022 |
| Nur77 Prevents Osteoporosis by Inhibiting the NF-kappaB Signalling Pathway and Osteoclast Differentiation. | Nur77 Prevents Osteoporosis by Inhibiting the NF-κB Signalling Pathway and Osteoclast Differentiation.
Tian H, Chen F, Wang Y, Liu Y, Ma G, Zhao Y, Ma Y, Tian T, Ma R, Yu Y, Wang D., Free PMC Article | 04/23/2022 |
| NR4A1 promotes oxidative stresses after myocardial ischemia reperfusion injury in aged mice. | NR4A1 promotes oxidative stresses after myocardial ischemia reperfusion injury in aged mice.
Peng X, Wang W, Wang W, Qi J. | 04/9/2022 |
| Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus. | Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus.
Han X, Xu T, Ding C, Wang D, Yao G, Chen H, Fang Q, Hu G, Sun L., Free PMC Article | 04/9/2022 |
| NR4A family members regulate T cell tolerance to preserve immune homeostasis and suppress autoimmunity. | NR4A family members regulate T cell tolerance to preserve immune homeostasis and suppress autoimmunity.
Hiwa R, Nielsen HV, Mueller JL, Mandla R, Zikherman J., Free PMC Article | 03/26/2022 |
| NR4A1 Promotes LPS-Induced Acute Lung Injury through Inhibition of Opa1-Mediated Mitochondrial Fusion and Activation of PGAM5-Related Necroptosis. | NR4A1 Promotes LPS-Induced Acute Lung Injury through Inhibition of Opa1-Mediated Mitochondrial Fusion and Activation of PGAM5-Related Necroptosis.
Zhu P, Wang J, Du W, Ren J, Zhang Y, Xie F, Xu G., Free PMC Article | 03/19/2022 |
| Negative feedback by NUR77/Nr4a1 restrains B cell clonal dominance during early T-dependent immune responses. | Negative feedback by NUR77/Nr4a1 restrains B cell clonal dominance during early T-dependent immune responses.
Brooks JF, Tan C, Mueller JL, Hibiya K, Hiwa R, Vykunta V, Zikherman J., Free PMC Article | 02/19/2022 |
| Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m(6)A demethylation of Nr4a1 mRNA. | Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m(6)A demethylation of Nr4a1 mRNA.
Liu B, Liu N, Zhu X, Yang L, Ye B, Li H, Zhu P, Lu T, Tian Y, Fan Z., Free PMC Article | 01/29/2022 |
| Nur77 ameliorates age-related renal tubulointerstitial fibrosis by suppressing the TGF-beta/Smads signaling pathway. | Nur77 ameliorates age-related renal tubulointerstitial fibrosis by suppressing the TGF-β/Smads signaling pathway.
Ma G, Chen F, Liu Y, Zheng L, Jiang X, Tian H, Wang X, Song X, Yu Y, Wang D. | 01/15/2022 |