| The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors. | The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors.
Horisawa K, Udono M, Ueno K, Ohkawa Y, Nagasaki M, Sekiya S, Suzuki A. | 09/26/2020 |
| FOXA3 is a marker of the Sertoli cell lineage and of the adult Leydig cell population, and is a regulator of Pdgfra transcription in Leydig cells. | FOXA3 Is Expressed in Multiple Cell Lineages in the Mouse Testis and Regulates Pdgfra Expression in Leydig Cells.
Garon G, Bergeron F, Brousseau C, Robert NM, Tremblay JJ. | 09/9/2017 |
| These findings reveal an obligatory coregulatory role of Foxa3 in the regulation of ER-alpha expression and of the Foxa3/ER-alpha cascade, at least in part, in the pathogenesis of androgen deficiency caused by type 2 diabetes mellitus. | Regulation of testicular steroidogenesis by Foxa3 via transcriptional modulation of ERα signaling in type 2 diabetes mellitus (T2DM).
Zhao Y, Li HX, Wang K, Yan BY, Li W. | 08/19/2017 |
| These results demonstrated the crucial role of Hnf1b and Foxa3 in hepatogenesis in vitro and provided a valuable tool for the efficient differentiation of HLCs from ES cells. | Forced expression of Hnf1b/Foxa3 promotes hepatic fate of embryonic stem cells.
Yahoo N, Pournasr B, Rostamzadeh J, Hakhamaneshi MS, Ebadifar A, Fathi F, Baharvand H. | 05/13/2017 |
| studies provide the first demonstration, to our knowledge, that Foxa3 is a direct target of GC action in adipose tissues and point to a role of Foxa3 as a mediator of the side effects induced in fat tissues by chronic treatment with synthetic steroids | Forkhead box A3 mediates glucocorticoid receptor function in adipose tissue.
Ma X, Xu L, Mueller E., Free PMC Article | 09/10/2016 |
| transcription factor Foxa3 was a strong promoter of liver regeneration. | A genetic screen reveals Foxa3 and TNFR1 as key regulators of liver repopulation.
Wangensteen KJ, Zhang S, Greenbaum LE, Kaestner KH., Free PMC Article | 07/4/2015 |
| during aging, Foxa3 is up-regulated in brown and inguinal white fat depots, and midage Foxa3-null mice have increased white fat browning and thermogenic capacity, decreased adipose tissue expansion, improved insulin sensitivity, and increased longevity | Role of forkhead box protein A3 in age-associated metabolic decline.
Ma X, Xu L, Gavrilova O, Mueller E., Free PMC Article | 05/2/2015 |
| Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity in asthma and chronic obstructive pulmonary disease. | Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity.
Chen G, Korfhagen TR, Karp CL, Impey S, Xu Y, Randell SH, Kitzmiller J, Maeda Y, Haitchi HM, Sridharan A, Senft AP, Whitsett JA., Free PMC Article | 04/5/2014 |
| Foxa3 promotes adipocyte differentiation by cooperating with C/EBP beta and - delta to transcriptionally induce PPAR gamma expression. | The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion.
Xu L, Panel V, Ma X, Du C, Hugendubler L, Gavrilova O, Liu A, McLaughlin T, Kaestner KH, Mueller E., Free PMC Article | 10/26/2013 |
| these results suggested that oxidative stress inhibited Akt signaling and facilitated the FOXO-3a/FBXO-dependent BK-beta(1) degradation in diabetic vessels. | Reactive oxygen species signaling facilitates FOXO-3a/FBXO-dependent vascular BK channel β1 subunit degradation in diabetic mice.
Lu T, Chai Q, Yu L, d'Uscio LV, Katusic ZS, He T, Lee HC., Free PMC Article | 09/15/2012 |
| FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program | FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program.
Ionescu A, Kozhemyakina E, Nicolae C, Kaestner KH, Olsen BR, Lassar AB., Free PMC Article | 08/4/2012 |
| Intraovarian excess androgen in polycystic ovary syndrome may result in excess follicles by inducind Foxo 3a translocation. | Testosterone induces redistribution of forkhead box-3a and down-regulation of growth and differentiation factor 9 messenger ribonucleic acid expression at early stage of mouse folliculogenesis.
Yang JL, Zhang CP, Li L, Huang L, Ji SY, Lu CL, Fan CH, Cai H, Ren Y, Hu ZY, Gao F, Liu YX. | 03/1/2010 |
| Unlike FOXA2, FOXA3 did not regulate mucous metaplasia in allergic airway disease and asthma. | Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.
Park SW, Verhaeghe C, Nguyenvu LT, Barbeau R, Eisley CJ, Nakagami Y, Huang X, Woodruff PG, Fahy JV, Erle DJ., Free PMC Article | 01/21/2010 |
| the results document that the hepatic FOXA family of genes are differentially regulated by amino acid availability | Protein or amino acid deprivation differentially regulates the hepatic forkhead box protein A (FOXA) genes through an activating transcription factor-4-independent pathway.
Su N, Thiaville MM, Awad K, Gjymishka A, Brant JO, Yang TP, Kilberg MS., Free PMC Article | 01/21/2010 |
| binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression. | Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression.
Liu Y, Shen W, Brubaker PL, Kaestner KH, Drucker DJ., Free PMC Article | 01/21/2010 |
| Foxa3 is a transcriptional regulator with a dominant phenotype in germ cell maintenance | Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3.
Behr R, Sackett SD, Bochkis IM, Le PP, Kaestner KH., Free PMC Article | 01/21/2010 |