| HNF4alpha ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy. | HNF4α ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy.
Hou Y, Shi P, Du H, Zhu C, Tang C, Que L, Zhu G, Liu L, Chen Q, Li C, Shao G, Li Y, Li J., Free PMC Article | 02/17/2024 |
| HNF4alpha isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver. | HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver.
Deans JR, Deol P, Titova N, Radi SH, Vuong LM, Evans JR, Pan S, Fahrmann J, Yang J, Hammock BD, Fiehn O, Fekry B, Eckel-Mahan K, Sladek FM., Free PMC Article | 01/3/2024 |
| Protective roles of adiponectin and molecular signatures of HNF4alpha and PPARalpha as downstream targets of adiponectin in pancreatic beta cells. | Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells.
Onodera T, Kim DS, Ye R, Wang MY, Chen S, Field BC, Straub L, Sun XN, Li C, Lee C, Paredes M, Crewe C, Zhao S, Kusminski CM, Gordillo R, Scherer PE., Free PMC Article | 11/30/2023 |
| Hepatocyte nuclear factor 4alpha mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury. | Hepatocyte nuclear factor 4α mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury.
Clark AJ, Saade MC, Vemireddy V, Vu KQ, Flores BM, Etzrodt V, Ciampa EJ, Huang H, Takakura A, Zandi-Nejad K, Zsengellér ZK, Parikh SM., | 11/27/2023 |
| Spontaneous episodic inflammation in the intestines of mice lacking HNF4A is driven by microbiota and associated with early life microbiota alterations. | Spontaneous episodic inflammation in the intestines of mice lacking HNF4A is driven by microbiota and associated with early life microbiota alterations.
Kelly C, Jawahar J, Davey L, Everitt JI, Galanko JA, Anderson C, Avendano JE, McCann JR, Sartor RB, Valdivia RH, Rawls JF., Free PMC Article | 09/27/2023 |
| Pharmacologic inhibition of HNF4alpha prevents parenteral nutrition associated cholestasis in mice. | Pharmacologic inhibition of HNF4α prevents parenteral nutrition associated cholestasis in mice.
Ghosh S, Devereaux MW, Orlicky DJ, Sokol RJ., Free PMC Article | 05/18/2023 |
| Reactive oxygen species induce HNF-4alpha expression via the ASK1-CREB pathway, promoting ChREBP expression and lipogenesis in hepatocytes. | Reactive oxygen species induce HNF-4α expression via the ASK1-CREB pathway, promoting ChREBP expression and lipogenesis in hepatocytes.
Seo E, Nam H, Jun HS. | 01/28/2023 |
| Impaired hepatic glucose metabolism and liver-alpha-cell axis in mice with liver-specific ablation of the Hepatocyte Nuclear Factor 4alpha (Hnf4a) gene. | Impaired hepatic glucose metabolism and liver-α-cell axis in mice with liver-specific ablation of the Hepatocyte Nuclear Factor 4α (Hnf4a) gene.
Thymiakou E, Tzardi M, Kardassis D. | 01/7/2023 |
| Mettl3-mediated mRNA m(6)A modification controls postnatal liver development by modulating the transcription factor Hnf4a. | Mettl3-mediated mRNA m(6)A modification controls postnatal liver development by modulating the transcription factor Hnf4a.
Xu Y, Zhou Z, Kang X, Pan L, Liu C, Liang X, Chu J, Dong S, Li Y, Liu Q, Sun Y, Yu S, Zhang Q., Free PMC Article | 08/13/2022 |
| hsa-miR-34a-5p Ameliorates Hepatic Ischemia/Reperfusion Injury Via Targeting HNF4alpha. | hsa-miR-34a-5p Ameliorates Hepatic Ischemia/Reperfusion Injury Via Targeting HNF4α.
Zheng X, Wang G, Yuan J, Li N, Yan B, Yan J, Sheng Y., Free PMC Article | 07/30/2022 |
| Crosstalk of hepatocyte nuclear factor 4a and glucocorticoid receptor in the regulation of lipid metabolism in mice fed a high-fat-high-sugar diet. | Crosstalk of hepatocyte nuclear factor 4a and glucocorticoid receptor in the regulation of lipid metabolism in mice fed a high-fat-high-sugar diet.
Lu H, Lei X, Winkler R, John S, Kumar D, Li W, Alnouti Y., Free PMC Article | 06/11/2022 |
| HNF4A modulates glucocorticoid action in the liver. | HNF4A modulates glucocorticoid action in the liver.
Hunter AL, Poolman TM, Kim D, Gonzalez FJ, Bechtold DA, Loudon ASI, Iqbal M, Ray DW., Free PMC Article | 04/30/2022 |
| Antagonistic epistasis of Hnf4alpha and FoxO1 metabolic networks through enhancer interactions in beta-cell function. | Antagonistic epistasis of Hnf4α and FoxO1 metabolic networks through enhancer interactions in β-cell function.
Kuo T, Du W, Miyachi Y, Dadi PK, Jacobson DA, Segrè D, Accili D., Free PMC Article | 03/26/2022 |
| Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver. | Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver.
Cholico GN, Nault R, Zacharewski TR., Free PMC Article | 03/12/2022 |
| The transcription factor hepatocyte nuclear factor 4A acts in the intestine to promote white adipose tissue energy storage. | The transcription factor hepatocyte nuclear factor 4A acts in the intestine to promote white adipose tissue energy storage.
Girard R, Tremblay S, Noll C, St-Jean S, Jones C, Gélinas Y, Maloum-Rami F, Perreault N, Laplante M, Carpentier AC, Boudreau F., Free PMC Article | 02/12/2022 |
| Hepatocyte Nuclear Factor 4-alpha (HNF4alpha) controls the insulin resistance-induced pancreatic beta-cell mass expansion. | Hepatocyte Nuclear Factor 4-α (HNF4α) controls the insulin resistance-induced pancreatic β-cell mass expansion.
Barth R, Ruoso C, Ferreira SM, de Ramos FC, Lima FB, Boschero AC, Santos GJD. | 01/15/2022 |
| Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4alpha Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage. | Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.
Gárate-Rascón M, Recalde M, Jimenez M, Elizalde M, Azkona M, Uriarte I, Latasa MU, Urtasun R, Bilbao I, Sangro B, Garcia-Ruiz C, Fernandez-Checa JC, Corrales FJ, Esquivel A, Pineda-Lucena A, Fernández-Barrena MG, Ávila MA, Arechederra M, Berasain C. | 01/15/2022 |
| Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4alpha. | Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4α.
Ren H, Hu F, Wang D, Kang X, Feng X, Zhang L, Zhou B, Liu S, Yuan G., Free PMC Article | 01/8/2022 |
| Hepatocyte Nuclear Factor 4alpha Prevents the Steatosis-to-NASH Progression by Regulating p53 and Bile Acid Signaling (in mice). | Hepatocyte Nuclear Factor 4α Prevents the Steatosis-to-NASH Progression by Regulating p53 and Bile Acid Signaling (in mice).
Xu Y, Zhu Y, Hu S, Xu Y, Stroup D, Pan X, Bawa FC, Chen S, Gopoju R, Yin L, Zhang Y., Free PMC Article | 01/1/2022 |
| Hepatocyte-Specific Hepatocyte Nuclear Factor 4 Alpha (HNF4) Deletion Decreases Resting Energy Expenditure by Disrupting Lipid and Carbohydrate Homeostasis. | Hepatocyte-Specific Hepatocyte Nuclear Factor 4 Alpha (HNF4) Deletion Decreases Resting Energy Expenditure by Disrupting Lipid and Carbohydrate Homeostasis.
Huck I, Morris EM, Thyfault J, Apte U., Free PMC Article | 12/18/2021 |
| HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape. | HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape.
Qu M, Qu H, Jia Z, Kay SA., Free PMC Article | 12/11/2021 |
| Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4alpha and SIX1/4. | Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4.
Camolotto SA, Belova VK, Torre-Healy L, Vahrenkamp JM, Berrett KC, Conway H, Shea J, Stubben C, Moffitt R, Gertz J, Snyder EL., Free PMC Article | 12/4/2021 |
| A Novel Organoid Model of Damage and Repair Identifies HNF4alpha as a Critical Regulator of Intestinal Epithelial Regeneration. | A Novel Organoid Model of Damage and Repair Identifies HNF4α as a Critical Regulator of Intestinal Epithelial Regeneration.
Montenegro-Miranda PS, van der Meer JHM, Jones C, Meisner S, Vermeulen JLM, Koster J, Wildenberg ME, Heijmans J, Boudreau F, Ribeiro A, van den Brink GR, Muncan V., Free PMC Article | 07/10/2021 |
| The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac. | The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac.
Chen L, Luo S, Dupre A, Vasoya RP, Parthasarathy A, Aita R, Malhotra R, Hur J, Toke NH, Chiles E, Yang M, Cao W, Flores J, Ellison CE, Gao N, Sahota A, Su X, Bonder EM, Verzi MP., Free PMC Article | 06/12/2021 |
| CTRP12 inhibits triglyceride synthesis and export in hepatocytes by suppressing HNF-4alpha and DGAT2 expression. | CTRP12 inhibits triglyceride synthesis and export in hepatocytes by suppressing HNF-4α and DGAT2 expression.
Tan SY, Little HC, Sarver DC, Watkins PA, Wong GW., Free PMC Article | 05/15/2021 |