| HOXA10 promotes Gdf5 expression in articular chondrocytes. | HOXA10 promotes Gdf5 expression in articular chondrocytes.
Murakami T, Ruengsinpinya L, Takahata Y, Nakaminami Y, Hata K, Nishimura R., Free PMC Article | 01/3/2024 |
| LncRNA NEAT1 affects endometrial receptivity by regulating HOXA10 promoter activity. | LncRNA NEAT1 affects endometrial receptivity by regulating HOXA10 promoter activity.
Geng J, Cui C, Yin Y, Zhao Y, Zhang C., Free PMC Article | 09/3/2022 |
| Loss of HOXA10 causes endometrial hyperplasia progressing to endometrial cancer. | Loss of HOXA10 causes endometrial hyperplasia progressing to endometrial cancer.
Mishra A, Ganguli N, Majumdar SS, Modi D. | 09/3/2022 |
| Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle. | Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle.
Yoshioka K, Nagahisa H, Miura F, Araki H, Kamei Y, Kitajima Y, Seko D, Nogami J, Tsuchiya Y, Okazaki N, Yonekura A, Ohba S, Sumita Y, Chiba K, Ito K, Asahina I, Ogawa Y, Ito T, Ohkawa Y, Ono Y., Free PMC Article | 07/16/2022 |
| Bone-targeted lncRNA OGRU alleviates unloading-induced bone loss via miR-320-3p/Hoxa10 axis. | Bone-targeted lncRNA OGRU alleviates unloading-induced bone loss via miR-320-3p/Hoxa10 axis.
Wang K, Wang Y, Hu Z, Zhang L, Li G, Dang L, Tan Y, Cao X, Shi F, Zhang S, Zhang G., Free PMC Article | 04/13/2021 |
| IHC profiling of HOXA10 revealed inverse correlations between HOXA10 expression and Gleason pattern, Gleason score, and pathological stage (P < 0.01). | HOXA10 expression profiling in prostate cancer.
Hatanaka Y, de Velasco MA, Oki T, Shimizu N, Nozawa M, Yoshimura K, Yoshikawa K, Nishio K, Uemura H. | 12/14/2019 |
| CAPN7 impairs embryo implantation via downregulating HOXA10 expression. | Calpain7 impairs embryo implantation by downregulating β3-integrin expression via degradation of HOXA10.
Yan Q, Huang C, Jiang Y, Shan H, Jiang R, Wang J, Liu J, Ding L, Yan G, Sun H., Free PMC Article | 10/26/2019 |
| These results suggest that progesterone receptor overexpression in endometrial stromal cells, likely due to high progesterone levels, triggers cyclin D3 and Hoxa-10 overexpression, which may be involved in the pathological mechanisms of the mouse uterine decidual reaction. | Hoxa-10 and Cyclin D3 Overexpression in the Decidual Reaction in a Superovulation Protocol in Young Adult C57BL/6J Mice.
Robles TG, Fernández RA, García-Palencia P, Arrabal MD, Maldonado BS, Pérez MA, Rollan E, Caballero JM, Flores JM. | 11/4/2017 |
| Gene-environment interactions driven by early life xenoestrogen exposure likely contributes to increased risk of estrogen-related disease in adults.- | Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol-A) exposure.
Jorgensen EM, Alderman MH 3rd, Taylor HS., Free PMC Article | 08/26/2017 |
| Hmgn5 might act downstream of Hoxa10 to regulate the expression of Cox-2, Vegf and Mmp2. | Hmgn5 functions downstream of Hoxa10 to regulate uterine decidualization in mice.
Li DD, Zhao SY, Yang ZQ, Duan CC, Guo CH, Zhang HL, Geng S, Yue ZP, Guo B., Free PMC Article | 06/24/2017 |
| Our results suggest that NA10HD increases the number of gamma-globin-transduced HSCs that engraft, leading to an elevated number of fetal hemoglobin-containing red cells. | Lentiviral Transfer of γ-Globin with Fusion Gene NUP98-HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine β-Thalassemia.
Zhao HF, Abraham A, Kim YS, Wang YD, Pestina T, Zhan J, Humphries K, Nienhuis AW, Persons DA., Free PMC Article | 06/10/2017 |
| we suggest that proper regional decidualization and polyploidy development requires FoxM1 signaling downstream of Hoxa10 and cyclin D3. | Control of regional decidualization in implantation: Role of FoxM1 downstream of Hoxa10 and cyclin D3.
Gao F, Bian F, Ma X, Kalinichenko VV, Das SK., Free PMC Article | 08/20/2016 |
| these studies demonstrate a previously undescribed role for HoxA10 in terminating emergency granulopoiesis, suggesting an important contribution by Hox proteins to the innate immune response. | HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1.
Wang H, Bei L, Shah CA, Hu L, Eklund EA., Free PMC Article | 08/22/2015 |
| Hoxa10 cooperates with Nkx2-5 to regulate the timing of cardiac mesoderm differentiation. | Nkx2-5 mediates differential cardiac differentiation through interaction with Hoxa10.
Behrens AN, Iacovino M, Lohr JL, Ren Y, Zierold C, Harvey RP, Kyba M, Garry DJ, Martin CM., Free PMC Article | 02/8/2014 |
| results show that reduced APC activity is sufficient to induce formation of epithelial inclusion cysts and support ovarian endometrioid adenocarcinoma development and suggest that induced HOXA10 expression and loss of PTEN are key mechanisms driving endometrioid histotype differentiation and progression | PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression.
Tanwar PS, Kaneko-Tarui T, Lee HJ, Zhang L, Teixeira JM., Free PMC Article | 06/22/2013 |
| a molecular mechanisms through which increased expression of HoxA10 increases Cdx4 expression by direct CDX4 activation and by Fgf2-induced beta-catenin activity. This results in Cdx4-induced HoxA10-expression, creating a positive feedback mechanism | β-Catenin activates the HOXA10 and CDX4 genes in myeloid progenitor cells.
Bei L, Shah C, Wang H, Huang W, Roy R, Eklund EA., Free PMC Article | 02/23/2013 |
| Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10. | Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10.
Oakley K, Han Y, Vishwakarma BA, Chu S, Bhatia R, Gudmundsson KO, Keller J, Chen X, Vasko V, Jenkins NA, Copeland NG, Du Y., Free PMC Article | 09/15/2012 |
| found that increased Fgf2 production by HoxA10-overexpressing myeloid progenitor cells induced a phosphoinositol 3-kinase-dependent increase in beta-catenin protein | HoxA10 protein regulates transcription of gene encoding fibroblast growth factor 2 (FGF2) in myeloid cells.
Shah CA, Bei L, Wang H, Platanias LC, Eklund EA., Free PMC Article | 08/18/2012 |
| Results suggest that maternal obesity impairs fetal skeletal development through down-regulation of the HoxA10 gene, which may lead to an increase in the prevalence of low bone mass in the offspring later in life. | Inhibition of fetal bone development through epigenetic down-regulation of HoxA10 in obese rats fed high-fat diet.
Chen JR, Zhang J, Lazarenko OP, Kang P, Blackburn ML, Ronis MJ, Badger TM, Shankar K. | 05/26/2012 |
| Data show that the extra-embryonic function of Hoxa10, -11, and -13 genes stems from their specific expression in the allantois, an extra-embryonic hallmark of amniote vertebrates. | Recruitment of 5' Hoxa genes in the allantois is essential for proper extra-embryonic function in placental mammals.
Scotti M, Kmita M., Free PMC Article | 03/17/2012 |
| PBX1 plays a central role in attenuating the activity of HOXA10 as an activator of osteoblast-related genes. | Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex.
Gordon JA, Hassan MQ, Koss M, Montecino M, Selleri L, van Wijnen AJ, Stein JL, Stein GS, Lian JB., Free PMC Article | 12/31/2011 |
| positive feedback relationship between HoxA10 and Cdx4, which potentially amplified the contribution of either transcription factor to the pathogenesis of AML. | HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells.
Bei L, Huang W, Wang H, Shah C, Horvath E, Eklund E., Free PMC Article | 07/30/2011 |
| HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1 | HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1.
Wang H, Bei L, Shah CA, Horvath E, Eklund EA., Free PMC Article | 07/16/2011 |
| Data show that NUP98-HOXA10HD, a novel, canonical NUP98-Hox fusion, significantly enhances the self-renewal capacity of hematopoietic stem cells. | Delineating domains and functions of NUP98 contributing to the leukemogenic activity of NUP98-HOX fusions.
Yung E, Sekulovic S, Argiropoulos B, Lai CK, Leung M, Berg T, Vollett S, Chang VC, Wan A, Wong S, Humphries RK., Free PMC Article | 06/18/2011 |
| extrinsic niche-dependent factors are also involved in the host-dependent outgrowth of leukemias after withdrawal of HOXA10 overexpression event that initiates the leukemia. | High levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming event.
Quéré R, Andradottir S, Brun AC, Zubarev RA, Karlsson G, Olsson K, Magnusson M, Cammenga J, Karlsson S., Free PMC Article | 05/14/2011 |