| Increased Risk of Aortic Dissection with Perlecan Deficiency. | Increased Risk of Aortic Dissection with Perlecan Deficiency.
Nonaka R, Iesaki T, Kerever A, Arikawa-Hirasawa E., Free PMC Article | 02/5/2022 |
| Is HSPG2 a modifier gene for Marfan syndrome? | Is HSPG2 a modifier gene for Marfan syndrome?
Gerdes Gyuricza I, Barbosa de Souza R, Farinha-Arcieri LE, Ribeiro Fernandes G, Veiga Pereira L., Free PMC Article | 06/5/2021 |
| Perlecan Knockdown Significantly Alters Extracellular Matrix Composition and Organization During Cartilage Development. | Perlecan Knockdown Significantly Alters Extracellular Matrix Composition and Organization During Cartilage Development.
Ocken AR, Ku MM, Kinzer-Ursem TL, Calve S., Free PMC Article | 05/15/2021 |
| Trabecular Bone Deficit and Enhanced Anabolic Response to Re-Ambulation after Disuse in Perlecan-Deficient Skeleton. | Trabecular Bone Deficit and Enhanced Anabolic Response to Re-Ambulation after Disuse in Perlecan-Deficient Skeleton.
Parajuli A, Pei S, Zhao H, Martinez JR, Lu XL, Liu XS, Farach-Carson MC, Kirn-Safran CB, Wang L., Free PMC Article | 04/3/2021 |
| Endorepellin evokes an angiostatic stress signaling cascade in endothelial cells. | Endorepellin evokes an angiostatic stress signaling cascade in endothelial cells.
Kapoor A, Chen CG, Iozzo RV., Free PMC Article | 12/26/2020 |
| The Perlecan therefore appears to regulate pericyte recruitment through the cooperative functioning of PDGFRbeta and integrin alpha5beta1 to support BBB maintenance and repair following ischemic stroke. | Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.
Nakamura K, Ikeuchi T, Nara K, Rhodes CS, Zhang P, Chiba Y, Kazuno S, Miura Y, Ago T, Arikawa-Hirasawa E, Mukouyama YS, Yamada Y., Free PMC Article | 05/16/2020 |
| Exostosis-like, ectopic bone formation occurred in Hspg2 exon 3 null intervertebral discs, and differences were evident in disc cell maturation and in matrix deposition in this genotype, indicating that perlecan HS/CS chains had cell and matrix interactive properties which repressively maintained tissue homeostasis in the adult intervertebral disc. | Elevated hypertrophy, growth plate maturation, glycosaminoglycan deposition, and exostosis formation in the Hspg2 exon 3 null mouse intervertebral disc.
Shu CC, Smith SM, Little CB, Melrose J. | 09/7/2019 |
| Monolayers of murine hip articular chondrocytes from C57BL/6 and Hspg2 exon 3 null mice also displayed pericellular perlecan localisations, however type XI collagen was only evident in the Wild type mice | Type XI collagen-perlecan-HS interactions stabilise the pericellular matrix of annulus fibrosus cells and chondrocytes providing matrix stabilisation and homeostasis.
Smith SM, Melrose J. | 09/7/2019 |
| Confocal laser scanning microscopy co-localised perlecan with type VI collagen as pericellular components of intervertebral disc (IVD) cells and translamellar cross-bridges in ovine and murine IVDs. | Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc.
Hayes AJ, Shu CC, Lord MS, Little CB, Whitelock JM, Melrose J. | 09/16/2017 |
| Perlecan knockdown altered matrix organization and significantly decreased the stiffness of both chondrocytes and interstitial matrix as a function of age and genotype. | Knockdown of the pericellular matrix molecule perlecan lowers in situ cell and matrix stiffness in developing cartilage.
Xu X, Li Z, Leng Y, Neu CP, Calve S., Free PMC Article | 05/20/2017 |
| Perlecan is required for the chondrogenic and adipogenic differentiation from SMCs via its regulation of the Sox9 and PPARgamma gene expression, but not for osteogenic differentiation via Runx2 | Perlecan is required for the chondrogenic differentiation of synovial mesenchymal cells through regulation of Sox9 gene expression.
Sadatsuki R, Kaneko H, Kinoshita M, Futami I, Nonaka R, Culley KL, Otero M, Hada S, Goldring MB, Yamada Y, Kaneko K, Arikawa-Hirasawa E, Ishijima M. | 05/13/2017 |
| The reduced deposition of TGF-beta1 observed in the present study would be expected to impact detrimentally on the remodelling and healing capacity of skin in mutant mice compounding on the poor wound-healing properties already reported for perlecan exon 3 null mice due to an inability to signal with FGF-2 and promote angiogenic repair processes. | The heparan sulphate deficient Hspg2 exon 3 null mouse displays reduced deposition of TGF-β1 in skin compared to C57BL/6 wild type mice.
Shu C, Smith SM, Melrose J. | 02/18/2017 |
| Hspg2 inhibits autophagy to maintain muscle homeostasis in mouse soleus muscle. | Perlecan inhibits autophagy to maintain muscle homeostasis in mouse soleus muscle.
Ning L, Xu Z, Furuya N, Nonaka R, Yamada Y, Arikawa-Hirasawa E. | 09/10/2016 |
| Perlecan HS has significant roles in directing the development of posttraumatic OA, potentially via the alteration of FGF/HS/FGFR signaling. | Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis.
Shu CC, Jackson MT, Smith MM, Smith SM, Penm S, Lord MS, Whitelock JM, Little CB, Melrose J. | 08/20/2016 |
| An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage. | An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage.
Fujikawa K, Yokohama-Tamaki T, Morita T, Baba O, Qin C, Shibata S., Free PMC Article | 07/16/2016 |
| LG3, through interactions with alpha2beta1 integrins on recipient-derived cells leading to activation of ERK1/2 and increased migration, favors myointimal thickening | The perlecan fragment LG3 regulates homing of mesenchymal stem cells and neointima formation during vascular rejection.
Pilon EA, Dieudé M, Qi S, Hamelin K, Pomerleau L, Beillevaire D, Durocher Y, Zutter M, Coutu D, Perreault C, Hébert MJ. | 01/16/2016 |
| Corneal epithelial cells require HS for maintaining corneal homeostasis, and the loss of epithelial HS leads to both impaired wound healing and impaired corneal stratification | Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing.
Coulson-Thomas VJ, Chang SH, Yeh LK, Coulson-Thomas YM, Yamaguchi Y, Esko J, Liu CY, Kao W., Free PMC Article | 10/17/2015 |
| Perlecan binds the clustering molecule gliomedin and enhances clustering of node of Ranvier components. | Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin.
Colombelli C, Palmisano M, Eshed-Eisenbach Y, Zambroni D, Pavoni E, Ferri C, Saccucci S, Nicole S, Soininen R, McKee KK, Yurchenco PD, Peles E, Wrabetz L, Feltri ML., Free PMC Article | 03/28/2015 |
| perlecan deficiency alters cartilage matrix patterning and, as we now show, coordinately influences bone formation and calcification | Deficiency in perlecan/HSPG2 during bone development enhances osteogenesis and decreases quality of adult bone in mice.
Lowe DA, Lepori-Bui N, Fomin PV, Sloofman LG, Zhou X, Farach-Carson MC, Wang L, Kirn-Safran CB., Free PMC Article | 01/24/2015 |
| applied a fluorescent technique to older mice expressing or deficient for perlecan/HSPG2, a large heparan-sulfate proteoglycan normally secreted in osteocytic PCM | Perlecan-containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar-canalicular system.
Wang B, Lai X, Price C, Thompson WR, Li W, Quabili TR, Tseng WJ, Liu XS, Zhang H, Pan J, Kirn-Safran CB, Farach-Carson MC, Wang L., Free PMC Article | 12/6/2014 |
| [review] Perlecan domain V is present acutely and chronically after ischemic stroke and could have a role in acute neuroprotection and chronic neurorepair at the site of stroke brain injury. | Perlecan domain V therapy for stroke: a beacon of hope?
Bix GJ., Free PMC Article | 12/14/2013 |
| Synovial perlecan plays an important role in osteophyte development in osteoarthritis. | Synovial perlecan is required for osteophyte formation in knee osteoarthritis.
Kaneko H, Ishijima M, Futami I, Tomikawa-Ichikawa N, Kosaki K, Sadatsuki R, Yamada Y, Kurosawa H, Kaneko K, Arikawa-Hirasawa E., Free PMC Article | 11/16/2013 |
| Perlecan supports the maintenance of brain and skin subendothelial basement membranes and promotes vasculo- and angiogenesis by modulating FGF-2 function | Perlecan maintains microvessel integrity in vivo and modulates their formation in vitro.
Gustafsson E, Almonte-Becerril M, Bloch W, Costell M., Free PMC Article | 08/31/2013 |
| The neuroprotective effects of perlecan domain V on astrocytes under physiological and pathological situations are studied in both in vitro and in vivo models. | Perlecan domain V modulates astrogliosis in vitro and after focal cerebral ischemia through multiple receptors and increased nerve growth factor release.
Al-Ahmad AJ, Lee B, Saini M, Bix GJ. | 07/13/2013 |
| Report immunolocalization of fibrillin-1/perlecan in HS-deficient hspg2 exon 3 null mutant mouse intervertebral disc. | Comparative immunolocalisation of fibrillin-1 and perlecan in the human foetal, and HS-deficient hspg2 exon 3 null mutant mouse intervertebral disc.
Hayes AJ, Smith SM, Melrose J. | 06/15/2013 |