| Structural basis of microtubule depolymerization by the kinesin-like activity of HIV-1 Rev. | Structural basis of microtubule depolymerization by the kinesin-like activity of HIV-1 Rev.
Eren E, Watts NR, Randazzo D, Palmer I, Sackett DL, Wingfield PT., | 10/10/2023 |
| CBP80/20-dependent translation initiation factor (CTIF) inhibits HIV-1 Gag synthesis by targeting the function of the viral protein Rev. | CBP80/20-dependent translation initiation factor (CTIF) inhibits HIV-1 Gag synthesis by targeting the function of the viral protein Rev.
García-de-Gracia F, Gaete-Argel A, Riquelme-Barrios S, Pereira-Montecinos C, Rojas-Araya B, Aguilera P, Oyarzún-Arrau A, Rojas-Fuentes C, Acevedo ML, Chnaiderman J, Valiente-Echeverría F, Toro-Ascuy D, Soto-Rifo R., Free PMC Article | 12/11/2021 |
| CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs. | CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs.
Xiao H, Wyler E, Milek M, Grewe B, Kirchner P, Ekici A, Silva ABOV, Jungnickl D, Full F, Thomas M, Landthaler M, Ensser A, Überla K., Free PMC Article | 09/11/2021 |
| Sequence and Functional Variation in the HIV-1 Rev Regulatory Axis. | Sequence and Functional Variation in the HIV-1 Rev Regulatory Axis.
Jackson PEH, Dzhivhuho G, Rekosh D, Hammarskjold ML., Free PMC Article | 07/3/2021 |
| HIV-1 resists MxB inhibition of viral Rev protein. | HIV-1 resists MxB inhibition of viral Rev protein.
Wang Z, Chai K, Liu Q, Yi DR, Pan Q, Huang Y, Tan J, Qiao W, Guo F, Cen S, Liang C., Free PMC Article | 04/24/2021 |
| Native mass spectrometry reveals the initial binding events of HIV-1 rev to RRE stem II RNA. | Native mass spectrometry reveals the initial binding events of HIV-1 rev to RRE stem II RNA.
Schneeberger EM, Halper M, Palasser M, Heel SV, Vušurović J, Plangger R, Juen M, Kreutz C, Breuker K., Free PMC Article | 12/12/2020 |
| Premature Stop Codon at Residue 101 within HIV-1 Rev Does Not Influence Viral Replication of Clade BC but Severely Reduces Viral Fitness of Clade B. | Premature Stop Codon at Residue 101 within HIV-1 Rev Does Not Influence Viral Replication of Clade BC but Severely Reduces Viral Fitness of Clade B.
Wang Z, Ji X, Hao Y, Hong K, Ma L, Li D, Shao Y., Free PMC Article | 11/28/2020 |
| Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability. | Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability.
Jayaraman B, Fernandes JD, Yang S, Smith C, Frankel AD., Free PMC Article | 10/3/2020 |
| ANP32A and ANP32B mediate the export of unspliced or partially spliced viral mRNA via interactions with Rev and CRM1. | ANP32A and ANP32B are key factors in the Rev-dependent CRM1 pathway for nuclear export of HIV-1 unspliced mRNA.
Wang Y, Zhang H, Na L, Du C, Zhang Z, Zheng YH, Wang X., Free PMC Article | 06/27/2020 |
| The HIV Rev protein can functionally interact with many HERV-K mRNAs (RcREs) present in the human genome, depending on the RcRE sequence, as well as the Rev sequence. | HIV-1 Rev interacts with HERV-K RcREs present in the human genome and promotes export of unspliced HERV-K proviral RNA.
Gray LR, Jackson RE, Jackson PEH, Bekiranov S, Rekosh D, Hammarskjöld ML., Free PMC Article | 05/23/2020 |
| The Rev ULM is an example of viral mimicry of host short linear motifs that enables the virus to interfere with the host molecular machinery. | Modulation of HIV-1 gene expression by binding of a ULM motif in the Rev protein to UHM-containing splicing factors.
Pabis M, Corsini L, Vincendeau M, Tripsianes K, Gibson TJ, Brack-Werner R, Sattler M., Free PMC Article | 11/30/2019 |
| HIV-1 replication ceases with rev gene products(Rev) mutations lacking nucleolar access due to loss or replacement of multiple arginine residues. Rev mutations missing single arginine residues remain strictly nucleolar in pattern and participate in proviral production, however, with reduced efficiency. Viral RNA packaging also decreases in efficiency after expression of nucleolar-localizing mutations. | Nucleolar Localization of HIV-1 Rev Is Required, Yet Insufficient for Production of Infectious Viral Particles.
Arizala JAC, Takahashi M, Burnett JC, Ouellet DL, Li H, Rossi JJ., Free PMC Article | 09/28/2019 |
| Results suggest that rev protein, HIV-1 (Rev) regulates the association of nuclear cap-binding protein NCBP 80 kDa subunit (CBP80) and eukaryotic translation initiation factor 4A1 (eIF4AI) with the unspliced mRNA in the cytoplasm and the nucleus, respectively, during HIV-1 replication. | A Rev-CBP80-eIF4AI complex drives Gag synthesis from the HIV-1 unspliced mRNA.
Toro-Ascuy D, Rojas-Araya B, García-de-Gracia F, Rojas-Fuentes C, Pereira-Montecinos C, Gaete-Argel A, Valiente-Echeverría F, Ohlmann T, Soto-Rifo R., Free PMC Article | 07/6/2019 |
| DDX21 is both an ATP-dependent and ATP-independent helicase, and both ATPase and ATP-dependent helicase activities are inhibited by Rev in a dose-dependent manner, although ATP-independent helicase activity is not. A conserved binding interaction between DDX protein's DEAD domain and Rev was identified, with Rev's nuclear diffusion inhibitory signal motif playing a significant role in binding. | A Survey of DDX21 Activity During Rev/RRE Complex Formation.
Hammond JA, Zhou L, Lamichhane R, Chu HY, Millar DP, Gerace L, Williamson JR., Free PMC Article | 03/9/2019 |
| These results suggest a differential interaction between human Crm1 and mouse Crm1 and many lentiviral Rev proteins, which may partially explain the HIV replicative defect in mice. | Differential interaction between human and murine Crm1 and lentiviral Rev proteins.
Yue Y, Coskun AK, Jawanda N, Auer J, Sutton RE., Free PMC Article | 12/16/2017 |
| DDX1 binds HIV-1 rev response element to promote virus assembly. | A DEAD-box protein acts through RNA to promote HIV-1 Rev-RRE assembly.
Lamichhane R, Hammond JA, Pauszek RF 3rd, Anderson RM, Pedron I, van der Schans E, Williamson JR, Millar DP., Free PMC Article | 09/9/2017 |
| Results indicate that the binding between ctDNA and REV peptide is a specific electrostatic interaction governed by oppositely charged molecules. | Binding and thermodynamics of REV peptide-ctDNA interaction.
Upadhyay SK. | 04/29/2017 |
| Results support the model that proper folding of Rev is critical in ensuring that the flexible Rev-response element is able to correctly position Rev molecules for specific ribonucleoprotein assembly. | Cooperative dimerization of a stably folded protein directed by a flexible RNA in the assembly of the HIV Rev dimer-RRE stem II complex.
Tanamura S, Terakado H, Harada K. | 12/24/2016 |
| Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11 | Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11.
Nouri K, Moll JM, Milroy LG, Hain A, Dvorsky R, Amin E, Lenders M, Nagel-Steger L, Howe S, Smits SH, Hengel H, Schmitt L, Münk C, Brunsveld L, Ahmadian MR., Free PMC Article | 06/28/2016 |
| The DEAG-box of human MOV10 was required for the enhancement of Rev/RRE-dependent nuclear export. | RNA helicase MOV10 functions as a co-factor of HIV-1 Rev to facilitate Rev/RRE-dependent nuclear export of viral mRNAs.
Huang F, Zhang J, Zhang Y, Geng G, Liang J, Li Y, Chen J, Liu C, Zhang H. | 06/11/2016 |
| Posttranscriptional regulatory Rev protein function and HIV-1 replication in astrocytes proceed unperturbed. | Unperturbed posttranscriptional regulatory Rev protein function and HIV-1 replication in astrocytes.
Chauhan A., Free PMC Article | 12/5/2015 |
| Sequestration od DDX1 led to destabilization of the Rev nucleocytoplasmic transport complex and decreased levels of Rev-dependent viral transcripts. | A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1.
Lin MH, Sivakumaran H, Jones A, Li D, Harper C, Wei T, Jin H, Rustanti L, Meunier FA, Spann K, Harrich D., Free PMC Article | 10/17/2015 |
| RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev-Rev response element complex. | RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev-Rev response element complex.
Jayaraman B, Crosby DC, Homer C, Ribeiro I, Mavor D, Frankel AD., Free PMC Article | 09/12/2015 |
| This study identifies a cellular protein named RBM14 that is associated with XPO1 (CRM1), a nuclear protein that binds to the HIV-1 Rev protein and mediates nuclear export of incompletely spliced HIV-1 viral RNAs | Mining the human complexome database identifies RBM14 as an XPO1-associated protein involved in HIV-1 Rev function.
Budhiraja S, Liu H, Couturier J, Malovannaya A, Qin J, Lewis DE, Rice AP., Free PMC Article | 05/23/2015 |
| RNA-guided assembly of Rev-Rev response element nuclear export complexes has been described. | RNA-guided assembly of Rev-RRE nuclear export complexes.
Bai Y, Tambe A, Zhou K, Doudna JA., Free PMC Article | 05/16/2015 |