Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis. | Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis. Mooring M, Yeung GA, Luukkonen P, Liu S, Akbar MW, Zhang GJ, Balogun O, Yu X, Mo R, Nejak-Bowen K, Poyurovsky MV, Booth CJ, Konnikova L, Shulman GI, Yimlamai D., Free PMC Article | 10/24/2023 |
CCN1 expression is regulated by mechanical stimuli in tendons. | CCN1 expression is regulated by mechanical stimuli in tendons. Leong NL, Greskovich K, Blommer J, Jiang J. | 05/23/2023 |
[Effect of Cyr61 on Imatinib Resistance in Chronic Myeloid Leukemia and Its Mechanism]. | [Effect of Cyr61 on Imatinib Resistance in Chronic Myeloid Leukemia and Its Mechanism]. Song YF, Luo L, Shi PC, Li ZZ, Zhang TG, Cao YP, Zhu XJ. | 02/27/2023 |
Matrix-bound Cyr61/CCN1 is required to retain the properties of the bone marrow mesenchymal stem cell niche but is depleted with aging. | Matrix-bound Cyr61/CCN1 is required to retain the properties of the bone marrow mesenchymal stem cell niche but is depleted with aging. Marinkovic M, Dai Q, Gonzalez AO, Tran ON, Block TJ, Harris SE, Salmon AB, Yeh CK, Dean DD, Chen XD., Free PMC Article | 09/17/2022 |
Effects of umbilical cord mesenchymal stem cells on expression of CYR61, FSH, and AMH in mice with premature ovarian failure. | Effects of umbilical cord mesenchymal stem cells on expression of CYR61, FSH, and AMH in mice with premature ovarian failure. Jie H, Jinxiang W, Ye L, Jing Z, Iangqing ZX, Jinxiu H, Zian L, Xinghua P. | 07/16/2022 |
CCN1 interacts with integrins to regulate intestinal stem cell proliferation and differentiation. | CCN1 interacts with integrins to regulate intestinal stem cell proliferation and differentiation. Won JH, Choi JS, Jun JI., Free PMC Article | 06/11/2022 |
CCN1 Promotes Inflammation by Inducing IL-6 Production via alpha6beta1/PI3K/Akt/NF-kappaB Pathway in Autoimmune Hepatitis. | CCN1 Promotes Inflammation by Inducing IL-6 Production via α6β1/PI3K/Akt/NF-κB Pathway in Autoimmune Hepatitis. Jiang R, Tang J, Zhang X, He Y, Yu Z, Chen S, Xia J, Lin J, Ou Q., Free PMC Article | 06/11/2022 |
Endothelial cyclin I reduces vulnerability to angiotensin II-induced vascular remodeling and abdominal aortic aneurysm risk. | Endothelial cyclin I reduces vulnerability to angiotensin II-induced vascular remodeling and abdominal aortic aneurysm risk. Zhao W, Yao M, Zhang Y, Xiong D, Dai G, Zhang J, Cao Y, Li H. | 06/11/2022 |
Expression of Cyr61 in ApoE(-/-) mice with chronic unilateral renal artery ligation. | Expression of Cyr61 in ApoE(-/-) mice with chronic unilateral renal artery ligation. Pathak AS, Rojas M, Stouffer GA., Free PMC Article | 11/13/2021 |
CCN1/Cyr61 Is Required in Osteoblasts for Responsiveness to the Anabolic Activity of PTH. | CCN1/Cyr61 Is Required in Osteoblasts for Responsiveness to the Anabolic Activity of PTH. Zhao G, Kim EW, Jiang J, Bhoot C, Charles KR, Baek J, Mohan S, Adams JS, Tetradis S, Lyons KM., Free PMC Article | 09/18/2021 |
MiR-181b suppresses angiogenesis by directly targeting cellular communication network factor 1. | MiR-181b suppresses angiogenesis by directly targeting cellular communication network factor 1. Li Y, Fan S, Xia W, Qiao B, Huang K, Zhou J, Liang M. | 09/4/2021 |
CCN1 promotes hepatic steatosis and inflammation in non-alcoholic steatohepatitis. | CCN1 promotes hepatic steatosis and inflammation in non-alcoholic steatohepatitis. Ju L, Sun Y, Xue H, Chen L, Gu C, Shao J, Lu R, Luo X, Wei J, Ma X, Bian Z., Free PMC Article | 01/2/2021 |
Alveolar CCN1 is associated with mechanical stretch and acute respiratory distress syndrome severity. | Alveolar CCN1 is associated with mechanical stretch and acute respiratory distress syndrome severity. Morrell ED, Grazioli S, Hung C, Kajikawa O, Kosamo S, Stapleton RD, Gharib SA, Amado-Rodríguez L, Albaiceta G, Wurfel MM, Matute-Bello G., Free PMC Article | 12/12/2020 |
Ependyma-expressed CCN1 restricts the size of the neural stem cell pool in the adult ventricular-subventricular zone. | Ependyma-expressed CCN1 restricts the size of the neural stem cell pool in the adult ventricular-subventricular zone. Wu J, Tian WJ, Liu Y, Wang HJ, Zheng J, Wang X, Pan H, Li J, Luo J, Yang X, Lau LF, Ghashghaei HT, Shen Q., Free PMC Article | 11/21/2020 |
CCN1 induced the differentiation of the fibro/adipogenic progenitor cells into adipocytes in the chronic kidney disease model mice. | CCN1 induces adipogenic differentiation of fibro/adipogenic progenitors in a chronic kidney disease model. Hu F, Lin Y, Zuo Y, Chen R, Luo S, Su Z. | 07/25/2020 |
Ccn1 binds bacterial pathogen-associated molecular patterns including peptidoglycans of Gram-positive bacteria and lipopolysaccharides of Gram-negative bacteria. Ccn1 opsonizes methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa and accelerates their removal by phagocytosis and increased production of bactericidal reactive oxygen species in macrophages through the engagement of integrin alphav... | CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling. Jun JI, Lau LF., Free PMC Article | 07/11/2020 |
CCN1 has causative role in atherosclerosis by modulating endothelial phenotypes. | Shear-Induced CCN1 Promotes Atheroprone Endothelial Phenotypes and Atherosclerosis. Hsu PL, Chen JS, Wang CY, Wu HL, Mo FE. | 03/28/2020 |
CCN1 secretion from cardiomyocytes results in fibroblast senescence, which promotes neonatal heart regeneration by enhancing cardiomyocyte proliferation and reducing cardiac fibrosis. | CCN1-Induced Cellular Senescence Promotes Heart Regeneration. Feng T, Meng J, Kou S, Jiang Z, Huang X, Lu Z, Zhao H, Lau LF, Zhou B, Zhang H. | 03/7/2020 |
Overexpression of CYR61/CCN1 can suppress Sost expression in both control and Cyr61 knockout cells, and blocking Sost with siRNA can rescue Wnt responsiveness in Cyr61 knockout cells in vitro. | CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance. Zhao G, Huang BL, Rigueur D, Wang W, Bhoot C, Charles KR, Baek J, Mohan S, Jiang J, Lyons KM., Free PMC Article | 10/26/2019 |
study provides evidence that CYR61 regulates adipocyte differentiation via multiple signaling pathways that involve at least the inactivation of mTORC1 signaling and the activation of canonical Wnt signaling. | Cysteine-rich protein 61 regulates adipocyte differentiation from mesenchymal stem cells through mammalian target of rapamycin complex 1 and canonical Wnt signaling. Yang Y, Qi Q, Wang Y, Shi Y, Yang W, Cen Y, Zhu E, Li X, Chen D, Wang B. | 01/19/2019 |
Study shows that the interplay between CYR61-CTGF-NOV1 (CCN1) and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy. Data highlight the significance of CCN1-EC and CCN1-pericyte communication signals in driving physiological and pathological angiogenesis. | Interplay between CCN1 and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy. Lee S, Elaskandrany M, Lau LF, Lazzaro D, Grant MB, Chaqour B., Free PMC Article | 12/22/2018 |
Mechanical cyclic stretch led to increased Cyr61 mRNA and protein expression, mobilized NF-kappaB from the cytoplasm to the nucleus and increased IL-8 secretion in A549 cells. | Stretch-induced Expression of CYR61 Increases the Secretion of IL-8 in A549 Cells via the NF-κβ/lκβ Pathway. Zhang Y, Guf P, Yao SL, Yang D, Lv Y, Ding DF. | 11/3/2018 |
Study describes how cysteine-rich 61 (CCN1) promotes monocyte migration by upregulating monocyte chemoattractant protein-1 (CCL2) expression in osteoblasts in rheumatoid arthritis (RA) disease. CCN1 could serve as a potential target for RA treatment. | Enhancement of CCL2 expression and monocyte migration by CCN1 in osteoblasts through inhibiting miR-518a-5p: implication of rheumatoid arthritis therapy. Chen CY, Fuh LJ, Huang CC, Hsu CJ, Su CM, Liu SC, Lin YM, Tang CH., Free PMC Article | 09/1/2018 |
Blocking or knockdown CCN1 expression ameliorated skin inflammation and reduced the expression of CCL20 in both imiquimod and IL-23-induced psoriasis-like mouse models. | Cyr61/CCN1 induces CCL20 production by keratinocyte via activating p38 and JNK/AP-1 pathway in psoriasis. Li H, Li H, Huo R, Wu P, Shen Z, Xu H, Shen B, Li N. | 05/26/2018 |
refine the leukocyte recruitment cascade model by introducing endothelium-bound CCN1 as an inflammation mediator and by demonstrating a role for platelets and patrolling Ly6C(low) monocytes in acute vascular inflammation. | CCN1/CYR61-mediated meticulous patrolling by Ly6Clow monocytes fuels vascular inflammation. Imhof BA, Jemelin S, Ballet R, Vesin C, Schapira M, Karaca M, Emre Y., Free PMC Article | 01/27/2018 |