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    Ccn1 cellular communication network factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 16007, updated on 23-Jun-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CCN1 promotes hepatic steatosis and inflammation in non-alcoholic steatohepatitis.

    CCN1 promotes hepatic steatosis and inflammation in non-alcoholic steatohepatitis.
    Ju L, Sun Y, Xue H, Chen L, Gu C, Shao J, Lu R, Luo X, Wei J, Ma X, Bian Z., Free PMC Article

    Alveolar CCN1 is associated with mechanical stretch and acute respiratory distress syndrome severity.

    Alveolar CCN1 is associated with mechanical stretch and acute respiratory distress syndrome severity.
    Morrell ED, Grazioli S, Hung C, Kajikawa O, Kosamo S, Stapleton RD, Gharib SA, Amado-Rodríguez L, Albaiceta G, Wurfel MM, Matute-Bello G.,

    Ependyma-expressed CCN1 restricts the size of the neural stem cell pool in the adult ventricular-subventricular zone.

    Ependyma-expressed CCN1 restricts the size of the neural stem cell pool in the adult ventricular-subventricular zone.
    Wu J, Tian WJ, Liu Y, Wang HJ, Zheng J, Wang X, Pan H, Li J, Luo J, Yang X, Lau LF, Ghashghaei HT, Shen Q., Free PMC Article

    CCN1 induced the differentiation of the fibro/adipogenic progenitor cells into adipocytes in the chronic kidney disease model mice.

    CCN1 induces adipogenic differentiation of fibro/adipogenic progenitors in a chronic kidney disease model.
    Hu F, Lin Y, Zuo Y, Chen R, Luo S, Su Z.

    Ccn1 binds bacterial pathogen-associated molecular patterns including peptidoglycans of Gram-positive bacteria and lipopolysaccharides of Gram-negative bacteria. Ccn1 opsonizes methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa and accelerates their removal by phagocytosis and increased production of bactericidal reactive oxygen species in macrophages through the engagement of integrin alphav...

    CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling.
    Jun JI, Lau LF., Free PMC Article

    CCN1 has causative role in atherosclerosis by modulating endothelial phenotypes.

    Shear-Induced CCN1 Promotes Atheroprone Endothelial Phenotypes and Atherosclerosis.
    Hsu PL, Chen JS, Wang CY, Wu HL, Mo FE.

    CCN1 secretion from cardiomyocytes results in fibroblast senescence, which promotes neonatal heart regeneration by enhancing cardiomyocyte proliferation and reducing cardiac fibrosis.

    CCN1-Induced Cellular Senescence Promotes Heart Regeneration.
    Feng T, Meng J, Kou S, Jiang Z, Huang X, Lu Z, Zhao H, Lau LF, Zhou B, Zhang H.

    Overexpression of CYR61/CCN1 can suppress Sost expression in both control and Cyr61 knockout cells, and blocking Sost with siRNA can rescue Wnt responsiveness in Cyr61 knockout cells in vitro.

    CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance.
    Zhao G, Huang BL, Rigueur D, Wang W, Bhoot C, Charles KR, Baek J, Mohan S, Jiang J, Lyons KM., Free PMC Article

    study provides evidence that CYR61 regulates adipocyte differentiation via multiple signaling pathways that involve at least the inactivation of mTORC1 signaling and the activation of canonical Wnt signaling.

    Cysteine-rich protein 61 regulates adipocyte differentiation from mesenchymal stem cells through mammalian target of rapamycin complex 1 and canonical Wnt signaling.
    Yang Y, Qi Q, Wang Y, Shi Y, Yang W, Cen Y, Zhu E, Li X, Chen D, Wang B.

    Study shows that the interplay between CYR61-CTGF-NOV1 (CCN1) and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy. Data highlight the significance of CCN1-EC and CCN1-pericyte communication signals in driving physiological and pathological angiogenesis.

    Interplay between CCN1 and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy.
    Lee S, Elaskandrany M, Lau LF, Lazzaro D, Grant MB, Chaqour B., Free PMC Article

    Mechanical cyclic stretch led to increased Cyr61 mRNA and protein expression, mobilized NF-kappaB from the cytoplasm to the nucleus and increased IL-8 secretion in A549 cells.

    Stretch-induced Expression of CYR61 Increases the Secretion of IL-8 in A549 Cells via the NF-κβ/lκβ Pathway.
    Zhang Y, Guf P, Yao SL, Yang D, Lv Y, Ding DF.

    Study describes how cysteine-rich 61 (CCN1) promotes monocyte migration by upregulating monocyte chemoattractant protein-1 (CCL2) expression in osteoblasts in rheumatoid arthritis (RA) disease. CCN1 could serve as a potential target for RA treatment.

    Enhancement of CCL2 expression and monocyte migration by CCN1 in osteoblasts through inhibiting miR-518a-5p: implication of rheumatoid arthritis therapy.
    Chen CY, Fuh LJ, Huang CC, Hsu CJ, Su CM, Liu SC, Lin YM, Tang CH., Free PMC Article

    Blocking or knockdown CCN1 expression ameliorated skin inflammation and reduced the expression of CCL20 in both imiquimod and IL-23-induced psoriasis-like mouse models.

    Cyr61/CCN1 induces CCL20 production by keratinocyte via activating p38 and JNK/AP-1 pathway in psoriasis.
    Li H, Li H, Huo R, Wu P, Shen Z, Xu H, Shen B, Li N.

    refine the leukocyte recruitment cascade model by introducing endothelium-bound CCN1 as an inflammation mediator and by demonstrating a role for platelets and patrolling Ly6C(low) monocytes in acute vascular inflammation.

    CCN1/CYR61-mediated meticulous patrolling by Ly6Clow monocytes fuels vascular inflammation.
    Imhof BA, Jemelin S, Ballet R, Vesin C, Schapira M, Karaca M, Emre Y., Free PMC Article

    This study is the first to describe how CCN1 promotes VEGF expression in osteoblasts and increased endothelial progenitor cells angiogenesis in rheumatoid arthritis disease.

    CCN1 Promotes VEGF Production in Osteoblasts and Induces Endothelial Progenitor Cell Angiogenesis by Inhibiting miR-126 Expression in Rheumatoid Arthritis.
    Chen CY, Su CM, Hsu CJ, Huang CC, Wang SW, Liu SC, Chen WC, Fuh LJ, Tang CH.

    Data show that cysteine rich protein 61 protein (CCN1) critically mediates doxorubicin (DOX)-induced cardiotoxicity.

    Matricellular protein CCN1 mediates doxorubicin-induced cardiomyopathy in mice.
    Hsu PL, Mo FE., Free PMC Article

    Our results not only reveal a novel mechanism illustrating the role of Cyr61 in epidermis pathogenesis but also suggest that therapies targeting Cyr61 may represent a novel strategy in the treatment of psoriasis vulgaris.

    Cyr61/CCN1 is involved in the pathogenesis of psoriasis vulgaris via promoting IL-8 production by keratinocytes in a JNK/NF-κB pathway.
    Wu P, Ma G, Zhu X, Gu T, Zhang J, Sun Y, Xu H, Huo R, Wang B, Shen B, Chen X, Li N.

    The LPA1-CCN1 axis may be the central control for SMC migration.

    Lysophosphatidic acid-induced vascular neointimal formation in mouse carotid arteries is mediated by the matricellular protein CCN1/Cyr61.
    Hao F, Zhang F, Wu DD, An D, Shi J, Li G, Xu X, Cui MZ., Free PMC Article

    these data suggest that the WNT/beta-catenin signaling pathway enhances pancreatic cancer development and malignancy in part via up-regulation of CYR61.

    Activation of WNT/β-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61.
    Sano M, Driscoll DR, DeJesus-Monge WE, Quattrochi B, Appleman VA, Ou J, Zhu LJ, Yoshida N, Yamazaki S, Takayama T, Sugitani M, Nemoto N, Klimstra DS, Lewis BC., Free PMC Article

    Lysophosphatidic acid induced time-dependent phosphorylation of serum response factor and CRE-binding protein in in smooth muscle cells, inducing transcription of CCN1.

    CRE and SRE mediate LPA-induced CCN1 transcription in mouse aortic smooth muscle cells.
    Dou Q, Hao F, Sun L, Xu X, Cui MZ., Free PMC Article

    Data show that Cysteine-rich 61 (CYR61) acts as a tumor-promoting gene in pancreatic neuroendocrine tumors.

    The matricellular protein CYR61 interferes with normal pancreatic islets architecture and promotes pancreatic neuroendocrine tumor progression.
    Huang YT, Lan Q, Ponsonnet L, Blanquet M, Christofori G, Zaric J, Rüegg C., Free PMC Article

    CCN1 is an important regulator of chondrocyte maturation during cartilage development and homeostasis.

    CCN1 Regulates Chondrocyte Maturation and Cartilage Development.
    Zhang Y, Sheu TJ, Hoak D, Shen J, Hilton MJ, Zuscik MJ, Jonason JH, O'Keefe RJ., Free PMC Article

    CCN1 exacerbates tracheal obliterative bronchiolitis by enhancing fibroproliferation via an alphavbeta3-integrin-independent pathway.

    Systemic overexpression of matricellular protein CCN1 exacerbates obliterative bronchiolitis in mouse tracheal allografts.
    Raissadati A, Nykänen AI, Tuuminen R, Syrjälä SO, Krebs R, Arnaudova R, Rouvinen E, Wang X, Poller W, Lemström KB.

    Data show that RNA silencing of CCN family member 1 protein (CCN1) inhibits retinal neovascularization (RNV) by inhibiting phosphoinositide 3-kinase (PI3K)/AKT protein signaling in mouse pup model of oxygen-induced retinopathy (OIR).

    CCN1/Cyr61-PI3K/AKT signaling promotes retinal neovascularization in oxygen-induced retinopathy.
    Di Y, Zhang Y, Nie Q, Chen X., Free PMC Article

    CCN genes are activated in heart failure.

    Transcriptional and post-transcriptional regulation of CCN genes in failing heart.
    Bonda TA, Kożuch M, Litvinovich S, Bialuk I, Taranta A, Lipiec P, Szymczyk E, Musiał WJ, Winnicka MM, Kamiński KA.

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