| CD74 deficiency reduces trophoblast invasion and proliferation mediated by SIRT1 in preeclampsia. | CD74 deficiency reduces trophoblast invasion and proliferation mediated by SIRT1 in preeclampsia.
Liu Z, Pei J, Zhang X, Wang C, Tang Y, Liu H, Yu Y, Luo S, Gu W. | 11/7/2023 |
| Tumor Necrosis Factor alpha-Dependent Lung Inflammation Promotes the Progression of Lung Adenocarcinoma Originating From Alveolar Type II Cells by Upregulating MIF-CD74. | Tumor Necrosis Factor α-Dependent Lung Inflammation Promotes the Progression of Lung Adenocarcinoma Originating From Alveolar Type II Cells by Upregulating MIF-CD74.
Cao L, Wang X, Liu X, Meng W, Guo W, Duan C, Liang X, Kang L, Lv P, Lin Q, Zhang R, Zhang X, Shen H. | 03/22/2023 |
| Decreased expression of surfactant Protein-C and CD74 in alveolar epithelial cells during influenza virus A(H1N1)pdm09 and H3N2 infection. | Decreased expression of surfactant Protein-C and CD74 in alveolar epithelial cells during influenza virus A(H1N1)pdm09 and H3N2 infection.
Ibañez LI, Martinez VP, Iglesias AA, Bellomo CM, Alonso DO, Coelho RM, Martinez Peralta L, Periolo N. | 03/3/2023 |
| Soluble cluster of differentiation 74 regulates lung inflammation through the nuclear factor-kappaB signaling pathway. | Soluble cluster of differentiation 74 regulates lung inflammation through the nuclear factor-κB signaling pathway.
Zhu B, Wu G, Wang C, Xiao Y, Jin J, Wang K, Jiang Y, Sun Y, Ben D, Xia Z. | 11/6/2021 |
| CD74 is a regulator of hematopoietic stem cell maintenance. | CD74 is a regulator of hematopoietic stem cell maintenance.
Becker-Herman S, Rozenberg M, Hillel-Karniel C, Gil-Yarom N, Kramer MP, Barak A, Sever L, David K, Radomir L, Lewinsky H, Levi M, Friedlander G, Bucala R, Peled A, Shachar I., Free PMC Article | 07/31/2021 |
| alpha-Hemolysin suppresses osteogenesis by inducing lipid rafts accumulation in bone marrow stromal cells. | α-Hemolysin suppresses osteogenesis by inducing lipid rafts accumulation in bone marrow stromal cells.
Liu G, Cheng C, Guan X, Ji Z, Su J, Zhang X, Yu B. | 05/15/2021 |
| CD74 Signaling Links Inflammation to Intestinal Epithelial Cell Regeneration and Promotes Mucosal Healing. | CD74 Signaling Links Inflammation to Intestinal Epithelial Cell Regeneration and Promotes Mucosal Healing.
Farr L, Ghosh S, Jiang N, Watanabe K, Parlak M, Bucala R, Moonah S., Free PMC Article | 05/15/2021 |
| CD74 is dispensable for development of chronic lymphocytic leukemia in Emicro-TCL1 transgenic mice. | CD74 is dispensable for development of chronic lymphocytic leukemia in Eµ-TCL1 transgenic mice.
Barthel R, Fedorchenko O, Velmans T, Rosen N, Nguyen PH, Reinart N, Florin A, Herling M, Hallek M, Fingerle-Rowson G. | 05/8/2021 |
| Macrophage migration inhibitory factor increases atrial arrhythmogenesis through CD74 signaling. | Macrophage migration inhibitory factor increases atrial arrhythmogenesis through CD74 signaling.
Cheng WL, Kao YH, Chen YC, Lin YK, Chen SA, Chen YJ. | 10/3/2020 |
| CD74 knockout protects against ethanol-induced alterations in autophagy, AMPK hyperphosphorylation and mTOR dephosphorylation. The permissive role for Sirt1 in CD74 ablation-offered beneficial responses in autophagy and cardiac function against ethanol received consolidation from the SRT1720-induced removal of CD74 knockout-induced contractile and autophagy benefits. | CD74 knockout attenuates alcohol intake-induced cardiac dysfunction through AMPK-Skp2-mediated regulation of autophagy.
Yang L, Wang S, Ma J, Li J, Yang J, Bucala R, Ren J. | 05/9/2020 |
| The amount of soluble MHC class II molecules in serum was decreased in Invariant chain (Ii), also called CD74, -deficient mice compared to wild-type mice. | Invariant chain p41 mediates production of soluble MHC class II molecules.
Shishido T, Kohyama M, Nakai W, Matsumoto M, Miyata H, Suenaga T, Arase H. | 10/12/2019 |
| TWEAK upregulates CD74 and its ligands MIF and DDT in renal tubular cells. | TWEAK increases CD74 expression and sensitizes to DDT proinflammatory actions in tubular cells.
Valiño-Rivas L, Cuarental L, Grana O, Bucala R, Leng L, Sanz A, Gomez G, Ortiz A, Sanchez-Niño MD., Free PMC Article | 04/20/2019 |
| House dust mites sensitization lowered humoral immune responses to intact pneumococcus and this effect was significantly modified by the HLA-DR polymorphism. | Influence of HLA-DR polymorphism and allergic sensitization on humoral immune responses to intact pneumococcus in a transgenic mouse model.
Sheen YH, Rajagopalan G, Snapper CM, Kita H, Wi CI, Umaretiya PJ, Juhn YJ., Free PMC Article | 01/20/2018 |
| Data highlight the complexity of the MIF/CD74 signaling pathway in the development of mesothelioma. | Role of MIF/CD74 signaling pathway in the development of pleural mesothelioma.
D'Amato-Brito C, Cipriano D, Colin DJ, Germain S, Seimbille Y, Robert JH, Triponez F, Serre-Beinier V., Free PMC Article | 12/2/2017 |
| We demonstrate that MHCII is dispensable for the B cell phenotype of (signal peptide peptidase-like 2a) SPPL2a(-/-) mice, further supporting a CD74-intrinsic effect. | The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments.
Schneppenheim J, Loock AC, Hüttl S, Schweizer M, Lüllmann-Rauch R, Oberg HH, Arnold P, Lehmann CHK, Dudziak D, Kabelitz D, Lucius R, Lennon-Duménil AM, Saftig P, Schröder B. | 09/30/2017 |
| CLIP expression and activated gamma-delta T cells are responsible for the development of preeclampsia. | Depletion of MHC class II invariant chain peptide or γ-δ T-cells ameliorates experimental preeclampsia.
Chatterjee P, Chiasson VL, Seerangan G, De Guzman E, Milad M, Bounds KR, Gasheva O, Tobin RP, Hatahet M, Kopriva S, Jones KA, Newell-Rogers MK, Mitchell BM. | 09/30/2017 |
| MIF-CD74 signaling inhibits interferon (IFN)-gamma secretion in microglia through phosphorylation of microglial ERK1/2 (extracellular signal-regulated protein kinases 1 and 2). The inhibition of MIF signaling or its receptor CD74 promotes IFN-gamma release and amplifies tumor death either through pharmacological inhibition or through siRNA-mediated knockdown. | MIF-CD74 signaling impedes microglial M1 polarization and facilitates brain tumorigenesis.
Ghoochani A, Schwarz MA, Yakubov E, Engelhorn T, Doerfler A, Buchfelder M, Bucala R, Savaskan NE, Eyüpoglu IY. | 09/9/2017 |
| Ii mediated pathways play a vital role in the initiation and propagation of liver inflammation. | Role of antigen presenting cell invariant chain in the development of hepatic steatosis in mouse model.
Mishra A, Iyer S, Kesarwani A, Baligar P, Arya SP, Arindkar S, Kumar MJ, Upadhyay P, Majumdar SS, Nagarajan P. | 05/20/2017 |
| CD74-knockout mice showed disturbed placental morphology, reduced junctional zone, smaller placentas, and impaired spiral artery remodeling with fetal growth restriction. | CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia.
Przybyl L, Haase N, Golic M, Rugor J, Solano ME, Arck PC, Gauster M, Huppertz B, Emontzpohl C, Stoppe C, Bernhagen J, Leng L, Bucala R, Schulz H, Heuser A, Weedon-Fekjær MS, Johnsen GM, Peetz D, Luft FC, Staff AC, Müller DN, Dechend R, Herse F., Free PMC Article | 04/29/2017 |
| explored CD74 expression, which can form a complex with CD44, in glomerular parietal epithelial cells during the progression of a model of focal segmental glomerulosclerosis | Up-Regulation of CD74 Expression in Parietal Epithelial Cells in a Mouse Model of Focal Segmental Glomerulosclerosis.
Yamazaki T, Sasaki S, Okamoto T, Sato Y, Hayashi A, Ariga T. | 03/11/2017 |
| might play roles in both the middle ear and inner ear in lipopolysaccharide-induced otitis media | Expression of macrophage migration inhibitory factor and CD74 in the inner ear and middle ear in lipopolysaccharide-induced otitis media.
Ishihara H, Kariya S, Okano M, Zhao P, Maeda Y, Nishizaki K. | 02/18/2017 |
| Data show that cathepsins S (CatS) regulates CCL2 chemokine expression by modulation of CD74 antigen processing. | CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner.
Wilkinson RD, Magorrian SM, Williams R, Young A, Small DM, Scott CJ, Burden RE., Free PMC Article | 08/6/2016 |
| Suggest that the DQA1*0103/CD74 dimer may result in presentation of unique antigens and susceptibility to develop arthritis. | CD74/DQA1 dimers predispose to the development of arthritis in humanized mice.
David L, Gokhale A, Jois S, Johnson A, Behrens M, Luthra H, Taneja V., Free PMC Article | 06/4/2016 |
| CD74 plays a critical role in the MIF inhibition of osteoclastogenesis. | Deletion of CD74, a putative MIF receptor, in mice enhances osteoclastogenesis and decreases bone mass.
Mun SH, Won HY, Hernandez P, Aguila HL, Lee SK., Free PMC Article | 04/2/2016 |
| Genetic deletion of CD74 restored the ability of infected dendritic cells to present a parasite antigen in the context of MHC-II. | Parasite Manipulation of the Invariant Chain and the Peptide Editor H2-DM Affects Major Histocompatibility Complex Class II Antigen Presentation during Toxoplasma gondii Infection.
Leroux LP, Nishi M, El-Hage S, Fox BA, Bzik DJ, Dzierszinski FS., Free PMC Article | 02/20/2016 |