| Low IL-13Ralpha1 expression on mast cells tunes them unresponsive to IL-13. | Low IL-13Rα1 expression on mast cells tunes them unresponsive to IL-13.
Salomaa T, Kummola L, González-Rodríguez MI, Hiihtola L, Järvinen TAH, Junttila IS. | 07/31/2023 |
| Interleukin-13 Receptor alpha1-Mediated Signaling Regulates Age-Associated/Autoimmune B Cell Expansion and Lupus Pathogenesis. | Interleukin-13 Receptor α1-Mediated Signaling Regulates Age-Associated/Autoimmune B Cell Expansion and Lupus Pathogenesis.
Chen Z, Flores Castro D, Gupta S, Phalke S, Manni M, Rivera-Correa J, Jessberger R, Zaghouani H, Giannopoulou E, Pannellini T, Pernis AB., Free PMC Article | 09/17/2022 |
| IL-13Ralpha1 Suppresses Tumor Progression in Two-Stage Skin Carcinogenesis Model by Regulating Regulatory T Cells. | IL-13Rα1 Suppresses Tumor Progression in Two-Stage Skin Carcinogenesis Model by Regulating Regulatory T Cells.
Salomaa T, Pemmari T, Määttä J, Kummola L, Salonen N, González-Rodríguez M, Parviainen L, Hiihtola L, Vähätupa M, Järvinen TAH, Junttila IS. | 06/11/2022 |
| Expression of IL4Ralpha and IL13Ralpha1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum. | Expression of IL4Rα and IL13Rα1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum.
Kim KM, Hussein UK, Park SH, Moon YJ, Zhang Z, Ahmed AG, Ahn AR, Park HS, Kim JR, Jang KY., Free PMC Article | 11/6/2021 |
| Two single nucleotide polymorphisms in IL13 and IL13RA1 from individuals with idiopathic Parkinson's disease increase cellular susceptibility to oxidative stress. | Two single nucleotide polymorphisms in IL13 and IL13RA1 from individuals with idiopathic Parkinson's disease increase cellular susceptibility to oxidative stress.
Aguirre CA, Concetta Morale M, Peng Q, Sanchez-Alavez M, Cintrón-Colón R, Feng K, Fazelpour S, Maher P, Conti B., Free PMC Article | 05/8/2021 |
| IL-13 receptor alpha 1 (IL-13Ralpha1) dendritic cell are able to take up antigen from the peritoneum and carry it to the the thymus. | A distinct dendritic cell population arises in the thymus of IL-13Rα1-sufficient but not IL-13Rα1-deficient mice.
Barik S, Miller M, Cattin-Roy A, Ukah T, Zaghouani H., Free PMC Article | 07/6/2019 |
| Chronic stress significantly reduced the number of substantia nigra dopaminergic neurons in Il13a1 knock-out mice. | Lack of interleukin-13 receptor α1 delays the loss of dopaminergic neurons during chronic stress.
Mori S, Sugama S, Nguyen W, Michel T, Sanna MG, Sanchez-Alavez M, Cintron-Colon R, Moroncini G, Kakinuma Y, Maher P, Conti B., Free PMC Article | 01/13/2018 |
| Delivery of sIL13ralpha1 to mice by either gene transfer or recombinant protein decreases blood glucose levels. Surprisingly, the glucose-lowering effect of sIL13ralpha1 was preserved in mice lacking IL-13, demonstrating that IL-13 was not required for the effect. In contrast, deletion of IL-4 in mice eliminated the hypoglycemic effect of sIL13ralpha1. | Soluble interleukin-13rα1: a circulating regulator of glucose.
Rachmin I, O'Meara CC, Ricci-Blair EM, Feng Y, Christensen EM, Duffy JF, Zitting KM, Czeisler CA, Pancoast JR, Cannon CP, O'Donoghue ML, Morrow DA, Lee RT., Free PMC Article | 12/23/2017 |
| findings indicate that NOD mice lacking the IL-4Ralpha/IL-13Ralpha1 heteroreceptor (HR) display resistance to Type 1 Diabetes as the rise in blood glucose level and islet inflammation were significantly delayed in these HR-deficient relative to HR-sufficient mice | On the Role IL-4/IL-13 Heteroreceptor Plays in Regulation of Type 1 Diabetes.
Ukah TK, Cattin-Roy AN, Chen W, Miller MM, Barik S, Zaghouani H., Free PMC Article | 10/14/2017 |
| IL-13Ralpha1 has a protective role in bleomycin-induced pulmonary injury and repair. | A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair.
Karo-Atar D, Bordowitz A, Wand O, Pasmanik-Chor M, Fernandez IE, Itan M, Frenkel R, Herbert DR, Finkelman FD, Eickelberg O, Munitz A., Free PMC Article | 10/1/2016 |
| These results show that activation of IL-13Ralpha1 is critical for key aspects of the immune and functional responses to Hb2 infection that facilitate expulsion. | Interleukin-13 Receptor α1-Dependent Responses in the Intestine Are Critical to Parasite Clearance.
Sun R, Urban JF Jr, Notari L, Vanuytsel T, Madden KB, Bohl JA, Ramalingam TR, Wynn TA, Zhao A, Shea-Donohue T., Free PMC Article | 08/13/2016 |
| These data establish for the first time a molecular mechanism by which Mac-1 regulates the signaling activity of IL-13 in macrophages. | Mac-1 Regulates IL-13 Activity in Macrophages by Directly Interacting with IL-13Rα1.
Cao C, Zhao J, Doughty EK, Migliorini M, Strickland DK, Kann MG, Zhang L., Free PMC Article | 11/21/2015 |
| CAR T cells killed IL13Ra1- and/or IL13Ra2-positive cells in contrast to IL13Ra1- and IL13Ra2-negative controls | T cells redirected to interleukin-13Rα2 with interleukin-13 mutein--chimeric antigen receptors have anti-glioma activity but also recognize interleukin-13Rα1.
Krebs S, Chow KK, Yi Z, Rodriguez-Cruz T, Hegde M, Gerken C, Ahmed N, Gottschalk S., Free PMC Article | 02/21/2015 |
| IL-13Ralpha1 is a surface marker for M2 macrophages influencing their differentiation and function. | IL-13Rα1 is a surface marker for M2 macrophages influencing their differentiation and function.
Dhakal M, Hardaway JC, Guloglu FB, Miller MM, Hoeman CM, Zaghouani AA, Wan X, Rowland LM, Cascio JA, Sherman MP, Zaghouani H., Free PMC Article | 05/10/2014 |
| in neonatal mice, IL-12 uses IL-12Rbeta2 to counter IL-13Ralpha1 expression in addition to promoting Th1 differentiation | Developmental expression of IL-12Rβ2 on murine naive neonatal T cells counters the upregulation of IL-13Rα1 on primary Th1 cells and balances immunity in the newborn.
Hoeman CM, Dhakal M, Zaghouani AA, Cascio JA, Wan X, Khairallah MT, Chen W, Zaghouani H., Free PMC Article | 08/31/2013 |
| Expression of IL-13Ralpha1 on dopaminergic neurons can increase their susceptibility to oxidative stress-mediated damage, thereby contributing to their preferential loss. | Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide.
Morrison BE, Marcondes MC, Nomura DK, Sanchez-Alavez M, Sanchez-Gonzalez A, Saar I, Kim KS, Bartfai T, Maher P, Sugama S, Conti B., Free PMC Article | 02/23/2013 |
| The extracellular and transmembrane domains of the gammaC and interleukin (IL)-13 receptor alpha1 chains, not their cytoplasmic domains, dictate the nature of signaling responses to IL-4 and IL-13 | The extracellular and transmembrane domains of the γC and interleukin (IL)-13 receptor α1 chains, not their cytoplasmic domains, dictate the nature of signaling responses to IL-4 and IL-13.
Heller NM, Qi X, Gesbert F, Keegan AD., Free PMC Article | 12/8/2012 |
| IL-13Ralpha1 is the key receptor mediating airway hypersensitivity responses, mucus production, and transforming growth factor (TGF)-beta induction in response to aeroallergens. | IL-13 receptor α1 differentially regulates aeroallergen-induced lung responses.
Rothenberg ME, Wen T, Shik D, Cole ET, Mingler MM, Munitz A., Free PMC Article | 01/28/2012 |
| The loss of IL-13Ralpha1 on islet-reactive T cells may be a biomarker for fading regional immune regulation and progression to overt diabetes. | IL-13Rα1 expression on β-cell-specific T cells in NOD mice.
Rasche SS, Phillips M, McInerney MF, Sercarz EE, Quinn A., Free PMC Article | 07/16/2011 |
| a central role for the IL-13/IL-13Ralpha1 pathway in the regulation of intestinal epithelial cell Cl(-) secretion via up-regulation of cystic fibrosis transmembrane conductance regulator | Interleukin-13 (IL-13)/IL-13 receptor alpha1 (IL-13Ralpha1) signaling regulates intestinal epithelial cystic fibrosis transmembrane conductance regulator channel-dependent Cl- secretion.
Wu D, Ahrens R, Osterfeld H, Noah TK, Groschwitz K, Foster PS, Steinbrecher KA, Rothenberg ME, Shroyer NF, Matthaei KI, Finkelman FD, Hogan SP., Free PMC Article | 07/2/2011 |
| peaks of upregulation in allergic bronchial asthma at 6 hours and 3-12 hours after the last antigen inhalation | Upregulation of interleukin-13 receptor chains in bronchial smooth muscle tissues of mouse experimental asthma.
Chiba Y, Onoda S, Todoroki M, Nishida Y, Misawa M. | 07/19/2010 |
| Differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. | Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity.
Junttila IS, Mizukami K, Dickensheets H, Meier-Schellersheim M, Yamane H, Donnelly RP, Paul WE., Free PMC Article | 01/21/2010 |
| IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor have direct roles in asthma pathogenesis | Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis.
Munitz A, Brandt EB, Mingler M, Finkelman FD, Rothenberg ME., Free PMC Article | 01/21/2010 |
| Il13ra1-/- mice showed less mortality after infection with Schistosoma mansoni and more susceptibility to Nippostrongylus brasiliensis. IL-13Ralpha1 was essential for allergen-induced airway hyperreactivity and mucus hypersecretion. | Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain.
Ramalingam TR, Pesce JT, Sheikh F, Cheever AW, Mentink-Kane MM, Wilson MS, Stevens S, Valenzuela DM, Murphy AJ, Yancopoulos GD, Urban JF Jr, Donnelly RP, Wynn TA, Ramalingam TR, Pesce JT, Sheikh F, Cheever AW, Mentink-Kane MM, Wilson MS, Stevens S, Valenzuela DM, Murphy AJ, Yancopoulos GD, Urban JF Jr, Donnelly RP, Wynn TA., Free PMC Articles: PMC2692551, PMC2692551 | 01/21/2010 |
| IL-13R alpha 1 is required for allergen-induced airway hyperreactivity and mucus production but not for alternative macrophage activation. | Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain.
Ramalingam TR, Pesce JT, Sheikh F, Cheever AW, Mentink-Kane MM, Wilson MS, Stevens S, Valenzuela DM, Murphy AJ, Yancopoulos GD, Urban JF Jr, Donnelly RP, Wynn TA, Ramalingam TR, Pesce JT, Sheikh F, Cheever AW, Mentink-Kane MM, Wilson MS, Stevens S, Valenzuela DM, Murphy AJ, Yancopoulos GD, Urban JF Jr, Donnelly RP, Wynn TA., Free PMC Articles: PMC2692551, PMC2692551 | 01/29/2008 |