| Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection. | Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection.
Griffith JW, Faustino LD, Cottrell VI, Nepal K, Hariri LP, Chiu RS, Jones MC, Julé A, Gabay C, Luster AD. | 12/5/2023 |
| The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization. | The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization.
Cao M, Chen P, Peng B, Cheng Y, Xie J, Hou Z, Chen H, Ye L, Li H, Wang H, Ren L, Xiong L, Geng L, Gong S., Free PMC Article | 12/4/2023 |
| Microglial IL-1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1-mediated neutrophil recruitment and microvessel occlusion. | Microglial IL-1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1-mediated neutrophil recruitment and microvessel occlusion.
Huang X, Guo M, Zhang Y, Xie J, Huang R, Zuo Z, Saw PE, Cao M. | 05/12/2023 |
| Hypoxia inducible factor 1alpha promotes interleukin-1 receptor antagonist expression during hepatic ischemia-reperfusion injury. | Hypoxia inducible factor 1α promotes interleukin-1 receptor antagonist expression during hepatic ischemia-reperfusion injury.
Wang ZY, Liu Y, Li SP, Li JJ, Zhang Z, Xiao XC, Ou Y, Wang H, Cai JZ, Yang S., Free PMC Article | 11/5/2022 |
| Dexmedetomidine attenuates hippocampal neuroinflammation in postoperative neurocognitive disorders by inhibiting microRNA-329-3p and activating the CREB1/IL1RA axis. | Dexmedetomidine attenuates hippocampal neuroinflammation in postoperative neurocognitive disorders by inhibiting microRNA-329-3p and activating the CREB1/IL1RA axis.
Chen J, Ding Q, Jiao X, Wang B, Sun Z, Zhang Y, Zhao J. | 06/25/2022 |
| Enterotoxigenic Escherichia coli Enterotoxins Regulate Epithelial to Immune Relay of IL-33 and IL-1Ra Cytokines. | Enterotoxigenic Escherichia coli Enterotoxins Regulate Epithelial to Immune Relay of IL-33 and IL-1Ra Cytokines.
Motyka NI, Stewart SR, Porretta CP, Hollifield IE, Bauer DL, Bitoun JP., Free PMC Article | 04/30/2022 |
| IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines. | IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines.
Tahtinen S, Tong AJ, Himmels P, Oh J, Paler-Martinez A, Kim L, Wichner S, Oei Y, McCarron MJ, Freund EC, Amir ZA, de la Cruz CC, Haley B, Blanchette C, Schartner JM, Ye W, Yadav M, Sahin U, Delamarre L, Mellman I. | 04/23/2022 |
| Impact of thermogenesis induced by chronic beta3-adrenergic receptor agonist treatment on inflammatory and infectious response during bacteremia in mice. | Impact of thermogenesis induced by chronic β3-adrenergic receptor agonist treatment on inflammatory and infectious response during bacteremia in mice.
Munro P, Rekima S, Loubat A, Duranton C, Pisani DF, Boyer L., Free PMC Article | 12/11/2021 |
| Bone Marrow-Derived IL-1Ra Increases TNF Levels Poststroke. | Bone Marrow-Derived IL-1Ra Increases TNF Levels Poststroke.
von Linstow CU, Hindkjær SM, Nielsen PV, Degn M, Lambertsen KL, Finsen B, Clausen BH., Free PMC Article | 10/23/2021 |
| Activation of Toll-Like Receptor 3 Induces Interleukin-1 Receptor Antagonist Expression by Activating the Interferon Regulatory Factor 3. | Activation of Toll-Like Receptor 3 Induces Interleukin-1 Receptor Antagonist Expression by Activating the Interferon Regulatory Factor 3.
Liu Y, Mo CF, Luo XY, Li H, Guo HJ, Sun H, Hu S, Li LM, Wang YT, Yang SX, Chang S, Zou Q., Free PMC Article | 07/3/2021 |
| IL1RN promotes osteoblastic differentiation via interacting with ITGB3 in osteoporosis. | IL1RN promotes osteoblastic differentiation via interacting with ITGB3 in osteoporosis.
Zou Z, Liu R, Wang Y, Xing Y, Shi Z, Wang K, Dong D. | 06/12/2021 |
| Inhibition of interleukin-6 signaling attenuates aortitis, left ventricular hypertrophy and arthritis in interleukin-1 receptor antagonist deficient mice. | Inhibition of interleukin-6 signaling attenuates aortitis, left ventricular hypertrophy and arthritis in interleukin-1 receptor antagonist deficient mice.
Hada Y, Uchida HA, Mukai T, Kojima F, Yoshida M, Takeuchi H, Kakio Y, Otaka N, Morita Y, Wada J. | 03/28/2021 |
| Increase in the Number of Bone Marrow Osteoclast Precursors at Different Skeletal Sites, Particularly in Long Bone and Jaw Marrow in Mice Lacking IL-1RA. | Increase in the Number of Bone Marrow Osteoclast Precursors at Different Skeletal Sites, Particularly in Long Bone and Jaw Marrow in Mice Lacking IL-1RA.
Ascone G, Cao Y, Jansen IDC, Di Ceglie I, van den Bosch MHJ, Blom AB, van Lent PLEM, Everts V, de Vries TJ., Free PMC Article | 02/13/2021 |
| Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1alpha. | Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α.
Martin P, Palmer G, Rodriguez E, Palomo J, Lemeille S, Goldstein J, Gabay C. | 09/26/2020 |
| IL-1Ra is an important mediator of type I IFN-driven susceptibility to Mycobacterium tuberculosis infections in vivo. | Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra.
Ji DX, Yamashiro LH, Chen KJ, Mukaida N, Kramnik I, Darwin KH, Vance RE., Free PMC Article | 07/11/2020 |
| Newly Defined ATP-Binding Cassette Subfamily B Member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing of Chronic Iron-Overload Wounds via Secretion of Interleukin-1 Receptor Antagonist. | Newly Defined ATP-Binding Cassette Subfamily B Member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing of Chronic Iron-Overload Wounds via Secretion of Interleukin-1 Receptor Antagonist.
Vander Beken S, de Vries JC, Meier-Schiesser B, Meyer P, Jiang D, Sindrilaru A, Ferreira FF, Hainzl A, Schatz S, Muschhammer J, Scheurmann NJ, Kampilafkos P, Seitz AM, Dürselen L, Ignatius A, Kluth MA, Ganss C, Wlaschek M, Singh K, Maity P, Frank NY, Frank MH, Scharffetter-Kochanek K., Free PMC Article | 06/27/2020 |
| Hepatic stellate cells treated with IL1RN had significantly decreased cellular activation and its associated fibrogenic responses. Collectively, manipulation of TLR5 signaling may be a promising therapeutic strategy for the treatment of liver fibrosis. | Toll-Like Receptor 5 Signaling Ameliorates Liver Fibrosis by Inducing Interferon β-Modulated IL-1 Receptor Antagonist in Mice.
Zhou Z, Kim JW, Qi J, Eo SK, Lim CW, Kim B. | 05/23/2020 |
| Combinatorial Prg4 and Il-1ra Gene Therapy Protects Against Hyperalgesia and Cartilage Degeneration in Post-Traumatic Osteoarthritis. | Combinatorial Prg4 and Il-1ra Gene Therapy Protects Against Hyperalgesia and Cartilage Degeneration in Post-Traumatic Osteoarthritis.
Stone A, Grol MW, Ruan MZC, Dawson B, Chen Y, Jiang MM, Song IW, Jayaram P, Cela R, Gannon F, Lee BHL., Free PMC Article | 03/14/2020 |
| these data reveal that IL-1Ra and IL-36Ra have opposing effects on the outcome of Pseudomonas aeruginosa keratitis | Opposing Effects of IL-1Ra and IL-36Ra on Innate Immune Response to Pseudomonas aeruginosa Infection in C57BL/6 Mouse Corneas.
Gao N, Me R, Dai C, Seyoum B, Yu FX., Free PMC Article | 07/6/2019 |
| Beta cell IL-1Ra knockout mice had impaired insulin secretion, reduced beta cell proliferation, and decreased expression of islet proliferation genes, along with impaired glucose tolerance. | β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion.
Böni-Schnetzler M, Häuselmann SP, Dalmas E, Meier DT, Thienel C, Traub S, Schulze F, Steiger L, Dror E, Martin P, Herrera PL, Gabay C, Donath MY. | 06/8/2019 |
| Findings identify a critical role for IL1Ra in maintaining the natural diversity and composition of intestinal microbiota, and suggest a role for TLR4 in mucosal Th17 cell induction associated with the development of autoimmune disease in mice. | Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis.
Rogier R, Ederveen THA, Boekhorst J, Wopereis H, Scher JU, Manasson J, Frambach SJCM, Knol J, Garssen J, van der Kraan PM, Koenders MI, van den Berg WB, van Hijum SAFT, Abdollahi-Roodsaz S., Free PMC Article | 01/20/2018 |
| Following vasectomy, IL1alpha, IL1beta, IL1ra, IL10, and TNF-alpha may mediate immune reaction in whole epididymis, whereas IL6 and TGF-beta1 may mediate regionally different immune response primarily in the lower part of epididymis. | Effects of bilateral vasectomy on the interleukin 1 system in mouse epididymis.
Oh YS, Na EJ, Gye MC. | 12/16/2017 |
| The current study is the first to demonstrate ex vivo airway hyperreactivity caused by systemic maternal inflammation and postnatal hyperoxia, and it reveals further preclinical mechanistic insights into IL-1Ra as a treatment targeting key pathophysiological features of Bronchopulmonary dysplasia. | Airway Remodeling and Hyperreactivity in a Model of Bronchopulmonary Dysplasia and Their Modulation by IL-1 Receptor Antagonist.
Royce SG, Nold MF, Bui C, Donovan C, Lam M, Lamanna E, Rudloff I, Bourke JE, Nold-Petry CA. | 07/1/2017 |
| the suppressed early innate/inflammatory responses instigated by the imbalance between IL-1beta and IL-1Ra is an underlying cause for delayed wound healing in the diabetic corneas | Targeting Imbalance between IL-1β and IL-1 Receptor Antagonist Ameliorates Delayed Epithelium Wound Healing in Diabetic Mouse Corneas.
Yan C, Gao N, Sun H, Yin J, Lee P, Zhou L, Fan X, Yu FS., Free PMC Article | 05/13/2017 |
| we demonstrate that the release of IL1RA in response to genotoxic stress contributes to the immunosuppressive effects of apoptotic cells. | Apoptotic Cells Release IL1 Receptor Antagonist in Response to Genotoxic Stress.
Chwee JY, Khatoo M, Tan NY, Gasser S. | 12/24/2016 |