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    Il2rg interleukin 2 receptor, gamma chain [ Mus musculus (house mouse) ]

    Gene ID: 16186, updated on 12-Oct-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Homodimeric sgammac has pathogenic roles to exacerbate rheumatoid arthritis progression with differentiation of local Th17, NKT1, and NKT17 cells. Therefore, sgammac is suggested as target of a therapeutic strategy for rheumatoid arthritis.

    Specific Inhibition of Soluble γc Receptor Attenuates Collagen-Induced Arthritis by Modulating the Inflammatory T Cell Responses.
    Lee B, Jo Y, Kim G, Ali LA, Sohn DH, Lee SG, Kim K, Shin E, Ryu SH, Hong C., Free PMC Article

    02/29/2020
    Data indicate a role for ROR-gamma (RORgammat) and Bcl-XL protein (Bcl-xL) in limiting interleukin 2 receptor gamma chain (gammac) abundance at the cell surface.

    RORγt limits the amount of the cytokine receptor γc through the prosurvival factor Bcl-x<sub>L</sub> in developing thymocytes.
    Ligons DL, Hwang S, Waickman AT, Park JY, Luckey MA, Park JH., Free PMC Article

    10/12/2019
    IL2RG mutations cause X-linked severe combined immunodeficiency in humans and mice that can be corrected by gene editing.

    Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
    Alzubi J, Pallant C, Mussolino C, Howe SJ, Thrasher AJ, Cathomen T., Free PMC Article

    06/29/2019
    Suggest that soluble common gamma chain may be one of the target molecules for the control of immunopathogenic progresses in COPD.

    Soluble common gamma chain exacerbates COPD progress through the regulation of inflammatory T cell response in mice.
    Lee B, Ko E, Lee J, Jo Y, Hwang H, Goh TS, Joo M, Hong C., Free PMC Article

    10/14/2017
    Results indicate that conjugated-interleukin-2 (IL2) protein derived from NKTR-214 occupy interleukin-2 (IL2) receptor complex (IL2Ralphabetagamma) to a greater extent compared to free-IL2 protein.

    Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy.
    Charych D, Khalili S, Dixit V, Kirk P, Chang T, Langowski J, Rubas W, Doberstein SK, Eldon M, Hoch U, Zalevsky J., Free PMC Article

    10/7/2017
    Renal lesions are indeed modulated by intrinsic glomerular cells through the gamma-C/IL-2-beta receptor response, to date classically described only in immune cells.

    Glomerular common gamma chain confers B- and T-cell-independent protection against glomerulonephritis.
    Luque Y, Cathelin D, Vandermeersch S, Xu X, Sohier J, Placier S, Xu-Dubois YC, Louis K, Hertig A, Bories JC, Vasseur F, Campagne F, Di Santo JP, Vosshenrich C, Rondeau E, Mesnard L.

    09/30/2017
    degree to which immune rejection contributes to these disappointing outcomes using an immunodeficient IL2 receptor gamma (IL2rgamma)-null mouse model, was examined.

    Immunosuppression via Loss of IL2rγ Enhances Long-Term Functional Integration of hESC-Derived Photoreceptors in the Mouse Retina.
    Zhu J, Cifuentes H, Reynolds J, Lamba DA.

    08/5/2017
    We have confirmed the activation of human peripheral blood lymphocytes after being xenografted in immunodeficient Rag2-/-IL2Rgnull mice.

    Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2-/-IL2Rγnull Immunodeficient Mice.
    Sanmamed MF, Rodriguez I, Schalper KA, Oñate C, Azpilikueta A, Rodriguez-Ruiz ME, Morales-Kastresana A, Labiano S, Pérez-Gracia JL, Martín-Algarra S, Alfaro C, Mazzolini G, Sarno F, Hidalgo M, Korman AJ, Jure-Kunkel M, Melero I.

    11/28/2015
    Results demonstrate that IL2Rgamma has an onogenic role in JAK3-mutation-positive leukemias.

    Functional RNAi screen targeting cytokine and growth factor receptors reveals oncorequisite role for interleukin-2 gamma receptor in JAK3-mutation-positive leukemia.
    Agarwal A, MacKenzie RJ, Eide CA, Davare MA, Watanabe-Smith K, Tognon CE, Mongoue-Tchokote S, Park B, Braziel RM, Tyner JW, Druker BJ., Free PMC Article

    08/8/2015
    findings demonstrate that NOD SCID IL2R common gamma chain -/- mice are capable of engraftment of canine PBLs yet develop graft versus host disease similar to Hu-PBL-SCID mice

    Engraftment of canine peripheral blood lymphocytes into nonobese diabetic-severe combined immune deficient IL-2R common gamma chain null mice.
    Foote JB, Kabir FM, Graff EC, Cattley RC, DeInnocentes P, Smith BF, Bird RC.

    10/18/2014
    Human colon cancer xenografts propagated in NSG and NRG mice maintain structural fidelity while replacing human stromal cells with murine stromal cells.

    NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer.
    Maykel J, Liu JH, Li H, Shultz LD, Greiner DL, Houghton J., Free PMC Article

    07/19/2014
    The potential for dysregulated T cell and dendritic cell (DC) activation in the gamma(c)-deficient environment leading to allergic lung inflammation.

    Absence of the common gamma chain (γ(c)), a critical component of the Type I IL-4 receptor, increases the severity of allergic lung inflammation.
    Dasgupta P, Qi X, Smith EP, Keegan AD., Free PMC Article

    04/19/2014
    Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor.

    Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor.
    Metcalfe C, Cresswell P, Barclay AN., Free PMC Article

    06/22/2013
    gammac expression was required to signal the differentiation of MHC class I-specific thymocytes into CD8+ cytotoxic lineage T cells and into invariant natural killer T cells.

    Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus.
    McCaughtry TM, Etzensperger R, Alag A, Tai X, Kurtulus S, Park JH, Grinberg A, Love P, Feigenbaum L, Erman B, Singer A., Free PMC Article

    01/26/2013
    critical for intestinal T-cell reconstitution in humanized mice

    IL-2 receptor γ-chain molecule is critical for intestinal T-cell reconstitution in humanized mice.
    Denton PW, Nochi T, Lim A, Krisko JF, Martinez-Torres F, Choudhary SK, Wahl A, Olesen R, Zou W, Di Santo JP, Margolis DM, Garcia JV., Free PMC Article

    01/12/2013
    analysis of multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-;Il2rg-/- mice and treatment with PI3K inhibitor

    Multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-;Il2rg-/- mice and treatment with PI3K inhibitor.
    Nanni P, Nicoletti G, Palladini A, Croci S, Murgo A, Ianzano ML, Grosso V, Stivani V, Antognoli A, Lamolinara A, Landuzzi L, di Tomaso E, Iezzi M, De Giovanni C, Lollini PL., Free PMC Article

    12/22/2012
    Results indicated that the extracellular and transmembrane domains of gammaC and IL-13Ralpha1 controlled the magnitude of the intracellular signaling response to IL-4 and IL-13.

    The extracellular and transmembrane domains of the γC and interleukin (IL)-13 receptor α1 chains, not their cytoplasmic domains, dictate the nature of signaling responses to IL-4 and IL-13.
    Heller NM, Qi X, Gesbert F, Keegan AD., Free PMC Article

    12/8/2012
    physiologic impact of CB hematopoietic progenitor cell hypofucosylation was investigated in vivo in NOD-SCID interleukin (IL)-2Rgamma(null) (NSG) mice

    Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2Rγ(null) mice.
    Robinson SN, Simmons PJ, Thomas MW, Brouard N, Javni JA, Trilok S, Shim JS, Yang H, Steiner D, Decker WK, Xing D, Shultz LD, Savoldo B, Dotti G, Bollard CM, Miller L, Champlin RE, Shpall EJ, Zweidler-McKay PA., Free PMC Article

    07/14/2012
    Letter: Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2rgammanull Ins2Akita mice.

    Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2rγnull Ins2Akita mice.
    Diiorio P, Jurczyk A, Yang C, Racki WJ, Brehm MA, Atkinson MA, Powers AC, Shultz LD, Greiner DL, Bortell R., Free PMC Article

    01/14/2012
    CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rgamma-/- (NSG) mice

    Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rγ-/- (NSG) mice.
    Drake AC, Khoury M, Leskov I, Iliopoulou BP, Fragoso M, Lodish H, Chen J., Free PMC Article

    12/3/2011
    IL-2 receptor complex has an essential protective role in immunity to blood-stage malaria. Protection is achieved by gammac cytokine family members signalling through the IL-2Rgammac.

    Signalling through the IL-2 receptor γ(c) peptide (CD132) is essential for the expression of immunity to Plasmodium chabaudi adami blood-stage malaria.
    Weidanz WP, Lafleur G, Kita-Yarbro A, Nelson K, Burns JM Jr., Free PMC Article

    12/3/2011
    Hematopoietic stem cells -infused HLA-DR4.NOD.Rag1knockout (KO) .IL-2RgammacKO mice developed a very high reconstitution rate (>90%) with long-lived and functional human T and B cells.

    Expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice is critical for development and function of human T and B cells.
    Danner R, Chaudhari SN, Rosenberger J, Surls J, Richie TL, Brumeanu TD, Casares S., Free PMC Article

    09/17/2011
    Results reflect the suppression of the leaky phenomenon in NOG mice through the inactivation of the IL-2Rgamma gene, which is commonly expressed in T and B cell growth factor receptors to IL-2, IL-4 and IL-7.

    Immunodeficient NOD-scid IL-2Rγ(null) mice do not display T and B cell leakiness.
    Katano I, Ito R, Eto T, Aiso S, Ito M.

    08/27/2011
    IL2Rgamma and its co-receptor IL15Ralpha are localized along with interleukin-15 in cerebral endothelia during robust upregulation of neuroinflammation.

    Rapid endocytosis of interleukin-15 by cerebral endothelia.
    Stone KP, Kastin AJ, Hsuchou H, Yu C, Pan W., Free PMC Article

    03/26/2011
    IL2Rgamma KO mice showed more depressive-like behavior than controls in both genders, and male mice showed improved contextual fear memory.

    The effects of IL2Rgamma knockout on depression and contextual memory.
    Wu X, Kastin AJ, Hsuchou H, Pan W., Free PMC Article

    10/23/2010
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