| Characterization of Glycoproteoforms of Integrins alpha2 and beta1 in Megakaryocytes in the Occurrence of JAK2V617F Mutation-Induced Primary Myelofibrosis. | Characterization of Glycoproteoforms of Integrins α2 and β1 in Megakaryocytes in the Occurrence of JAK2V617F Mutation-Induced Primary Myelofibrosis.
Gaye MM, Ward CM, Piasecki AJ, Stahl VL, Karagianni A, Costello CE, Ravid K., Free PMC Article | 05/7/2022 |
| The Commensal Microbiota Enhances ADP-Triggered Integrin alphaIIbbeta3 Activation and von Willebrand Factor-Mediated Platelet Deposition to Type I Collagen. | The Commensal Microbiota Enhances ADP-Triggered Integrin α(IIb)β(3) Activation and von Willebrand Factor-Mediated Platelet Deposition to Type I Collagen.
Kiouptsi K, Jäckel S, Wilms E, Pontarollo G, Winterstein J, Karwot C, Groß K, Jurk K, Reinhardt C., Free PMC Article | 02/27/2021 |
| Increased Collagen Turnover Impairs Tendon Microstructure and Stability in Integrin alpha2beta1-Deficient Mice. | Increased Collagen Turnover Impairs Tendon Microstructure and Stability in Integrin α2β1-Deficient Mice.
Kronenberg D, Michel PA, Hochstrat E, Wei M, Brinckmann J, Müller M, Frank A, Hansen U, Eckes B, Stange R., Free PMC Article | 02/6/2021 |
| Type I Collagen Signaling Regulates Opposing Fibrotic Pathways through alpha2beta1 Integrin. | Type I Collagen Signaling Regulates Opposing Fibrotic Pathways through α(2)β(1) Integrin.
Agarwal M, Goheen M, Jia S, Ling S, White ES, Kim KK., Free PMC Article | 12/12/2020 |
| CD49b defines functionally mature Treg cells that survey skin and vascular tissues. | CD49b defines functionally mature Treg cells that survey skin and vascular tissues.
Fan X, Moltedo B, Mendoza A, Davydov AN, Faire MB, Mazutis L, Sharma R, Pe'er D, Chudakov DM, Rudensky AY., Free PMC Article | 09/7/2019 |
| Study in a mouse model of collagen-induced arthritis identified the integrin alpha2 gene (Itga2) as an additional and novel biomarker for rheumatoid arthritis. | Gene and Protein Expression Profiles in a Mouse Model of Collagen-Induced Arthritis.
Gwon SY, Rhee KJ, Sung HJ., Free PMC Article | 08/18/2018 |
| P15 does not directly activate integrins by binding, but does upregulate integrin signaling to enhance differentiation of both osteoblasts and chondrocytes to increase both intramembranous and endochondral bone formation. | P15 peptide stimulates chondrogenic commitment and endochondral ossification.
Zhang J, Eisenhauer P, Kaya O, Vaccaro AR, Diallo C, Fertala A, Freeman TA. | 04/21/2018 |
| low expression of alpha2beta1 integrin increased protein kinase B (AKT) activation and alpha-smooth muscle actin (alpha-SMA) expression. This occurred due to the instability of phosphatase and tensin homolog (PTEN) in myofibroblasts on fibrillar collagen. | Fibrillar Type I Collagen Enhances the Differentiation and Proliferation of Myofibroblasts by Lowering α2β1 Integrin Expression in Cardiac Fibrosis.
Hong J, Chu M, Qian L, Wang J, Guo Y, Xu D., Free PMC Article | 03/18/2017 |
| A sulfonamide-type small-molecule inhibitor of alpha2beta1 integrin decreased average platelet adhesion in individuals with the C/T807T genotype but not in those harboring C807C. | Platelet response to a small molecule inhibitor of α2β1 integrin is associated with ITGA2 C807T dimorphism.
Nissinen L, Rappu P, Ollikka P, Nieminen J, Marjamäki A, Heino J. | 03/18/2017 |
| Ceacam1 is essential for normal integrin aIIbb3-mediated platelet function; the disruption of mouse Ceacam1 induced moderate integrin aIIbb3-mediated functional defects. | CEACAM1 regulates integrin αIIbβ3-mediated functions in platelets.
Yip J, Alshahrani M, Beauchemin N, Jackson DE. | 11/12/2016 |
| HRG binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I. | Histidine-rich glycoprotein blocks collagen-binding integrins and adhesion of endothelial cells through low-affinity interaction with α2 integrin.
Roche F, Sipilä K, Honjo S, Johansson S, Tugues S, Heino J, Claesson-Welsh L. | 09/10/2016 |
| LG3, through interactions with alpha2beta1 integrins on recipient-derived cells leading to activation of ERK1/2 and increased migration, favors myointimal thickening | The perlecan fragment LG3 regulates homing of mesenchymal stem cells and neointima formation during vascular rejection.
Pilon EA, Dieudé M, Qi S, Hamelin K, Pomerleau L, Beillevaire D, Durocher Y, Zutter M, Coutu D, Perreault C, Hébert MJ. | 01/16/2016 |
| IFN-gamma induces aberrant CD49b+ NK cell recruitment and pregnancy failure through regulating CX3CL1. | IFN-γ induces aberrant CD49b⁺ NK cell recruitment through regulating CX3CL1: a novel mechanism by which IFN-γ provokes pregnancy failure.
Li ZY, Chao HH, Liu HY, Song ZH, Li LL, Zhang YJ, Yang Y, Peng JP., Free PMC Article | 07/4/2015 |
| alphaIIbbeta3 regulates Syk through an ITAM-independent pathway in mice and provide novel insight into the course of events underlying Syk activation and hemITAM phosphorylation by CLEC-2 | The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets.
Hughes CE, Finney BA, Koentgen F, Lowe KL, Watson SP., Free PMC Article | 03/21/2015 |
| the collagen receptors DDR1 and integrin a2b1 contribute to regulate GBM-maturation and to control matrix accumulation. | Collagen receptors integrin alpha2beta1 and discoidin domain receptor 1 regulate maturation of the glomerular basement membrane and loss of integrin alpha2beta1 delays kidney fibrosis in COL4A3 knockout mice.
Rubel D, Frese J, Martin M, Leibnitz A, Girgert R, Miosge N, Eckes B, Müller GA, Gross O. | 01/3/2015 |
| Synthesis and modeling of linear and cyclic KTS-containing peptides is described that leads to their use as inhibitors of integrin alpha1beta1/alpha2beta1-mediated adhesion and other antiangiogenetic activity in human serum. | Vimocin and vidapin, cyclic KTS peptides, are dual antagonists of α1β1/α2β1 integrins with antiangiogenic activity.
Momic T, Katzehendler J, Benny O, Lahiani A, Cohen G, Noy E, Senderowitz H, Eble JA, Marcinkiewicz C, Lazarovici P. | 10/4/2014 |
| alpha2beta1 integrin contributes to the pathogenesis of retinopathy. We describe a newly identified role for alpha2beta1 integrin in mediating hypoxia-induced Muller cell VEGF-A production. | Mitigation of oxygen-induced retinopathy in α2β1 integrin-deficient mice.
Madamanchi A, Capozzi M, Geng L, Li Z, Friedman RD, Dickeson SK, Penn JS, Zutter MM., Free PMC Article | 09/13/2014 |
| required for the migration of memory CD4 T-cell precursors into their survival niches of the bone marrow | CD49b-dependent establishment of T helper cell memory.
Hanazawa A, Hayashizaki K, Shinoda K, Yagita H, Okumura K, Löhning M, Hara T, Tani-ichi S, Ikuta K, Eckes B, Radbruch A, Tokoyoda K, Nakayama T. | 04/5/2014 |
| alpha2beta1 integrin is expressed on synovial Th17 cells from CIA mice. Its neutralization reduced inflammation, cartilage degradation, bone erosion, RANKL & IL-17 levels, & the numbers of osteoclasts and TH17 cells. | α2β1 integrin regulates Th17 cell activity and its neutralization decreases the severity of collagen-induced arthritis.
El Azreq MA, Boisvert M, Cesaro A, Pagé N, Loubaki L, Allaeys I, Chakir J, Poubelle PE, Tessier PA, Aoudjit F. | 02/22/2014 |
| the absence of integrin alpha2beta1 alleviates the effects of age related bone degradation through over-expression of collagen type I. | Age-related bone deterioration is diminished by disrupted collagen sensing in integrin α2β1 deficient mice.
Stange R, Kronenberg D, Timmen M, Everding J, Hidding H, Eckes B, Hansen U, Holtkamp M, Karst U, Pap T, Raschke MJ. | 02/8/2014 |
| TNF-alpha stimulated cerebral pericyte remodeling in an alpha2 integrin-dependent manner. | TNF-α promotes cerebral pericyte remodeling in vitro, via a switch from α1 to α2 integrins.
Tigges U, Boroujerdi A, Welser-Alves JV, Milner R., Free PMC Article | 10/26/2013 |
| observed a significant reduction in mean platelet volume, which is consistent with the reported role of alpha2beta1 in MK maturation and proplatelet formation in vivo | Conditional knockout of integrin α2β1 in murine megakaryocytes leads to reduced mean platelet volume.
Habart D, Cheli Y, Nugent DJ, Ruggeri ZM, Kunicki TJ., Free PMC Article | 09/7/2013 |
| Blocking integrin alpha2beta1 and ERK 1/2 pathways alleviated the effects of AMBN on osteoclast differentiation. | Ameloblastin modulates osteoclastogenesis through the integrin/ERK pathway.
Lu X, Ito Y, Atsawasuwan P, Dangaria S, Yan X, Wu T, Evans CA, Luan X., Free PMC Article | 09/7/2013 |
| Expression of integrin alpha2 receptor in human cord blood CD34+CD38-CD90+ stem cells determines its long-term engrafting in NOD/SCID-IL2Rgamma(c) null mice. | Expression of integrin α2 receptor in human cord blood CD34+CD38-CD90+ stem cells engrafting long-term in NOD/SCID-IL2Rγ(c) null mice.
Wong WM, Sigvardsson M, Åstrand-Grundström I, Hogge D, Larsson J, Qian H, Ekblom M. | 07/20/2013 |
| These data show for the first time that decorin has an impact on the biology of alpha2beta1 integrin and the vimentin intermediate filament system. | The dermatan sulfate proteoglycan decorin modulates α2β1 integrin and the vimentin intermediate filament system during collagen synthesis.
Jungmann O, Nikolovska K, Stock C, Schulz JN, Eckes B, Riethmüller C, Owens RT, Iozzo RV, Seidler DG., Free PMC Article | 05/25/2013 |