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    Itgae integrin alpha E, epithelial-associated [ Mus musculus (house mouse) ]

    Gene ID: 16407, updated on 21-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Escherichia coli adhesion protein FimH exacerbates colitis via CD11b[+]CD103[-] dendritic cell activation.

    Escherichia coli adhesion protein FimH exacerbates colitis via CD11b(+)CD103(-) dendritic cell activation.
    Zhang W, An EK, Kim SJ, Park HB, Lee PCW, Jin JO., Free PMC Article

    12/20/2023
    Immunological characteristics of CD103[+]CD8[+] Tc cells in the liver of C57BL/6 mouse infected with plasmodium NSM.

    Immunological characteristics of CD103(+)CD8(+) Tc cells in the liver of C57BL/6 mouse infected with plasmodium NSM.
    Shi F, Tang S, Chen D, Mo F, Li J, Fang C, Wei H, Xing J, Liu L, Gong Y, Tan Z, Zhang Z, Pan X, Zhao S, Huang J.

    11/7/2023
    CD103 Regulates Dermal Regulatory T Cell Motility and Interactions with CD11c-Expressing Leukocytes to Control Skin Inflammation.

    CD103 Regulates Dermal Regulatory T Cell Motility and Interactions with CD11c-Expressing Leukocytes to Control Skin Inflammation.
    Norman MU, Chow Z, Hall P, Le AC, O'Sullivan KM, Snelgrove SL, Deane JA, Hickey MJ.

    08/9/2023
    gammadelta Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release.

    γδ Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release.
    Hu MD, Golovchenko NB, Burns GL, Nair PM, Kelly TJ 4th, Agos J, Irani MZ, Soh WS, Zeglinski MR, Lemenze A, Bonder EM, Sandrock I, Prinz I, Granville DJ, Keely S, Watson AJM, Edelblum KL., Free PMC Article

    03/12/2022
    Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal.

    Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal.
    Morikawa R, Nemoto Y, Yonemoto Y, Tanaka S, Takei Y, Oshima S, Nagaishi T, Tsuchiya K, Nozaki K, Mizutani T, Nakamura T, Watanabe M, Okamoto R., Free PMC Article

    03/12/2022
    Dual targeting of lymphocyte homing and retention through alpha4beta7 and alphaEbeta7 inhibition in inflammatory bowel disease.

    Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease.
    Dai B, Hackney JA, Ichikawa R, Nguyen A, Elstrott J, Orozco LD, Sun KH, Modrusan Z, Gogineni A, Scherl A, Gubatan J, Habtezion A, Deswal M, Somsouk M, Faubion WA, Chai A, Sharafali Z, Hassanali A, Oh YS, Tole S, McBride J, Keir ME, Yi T., Free PMC Article

    03/5/2022
    The molecular basis and cellular effects of distinct CD103 expression on CD4 and CD8 T cells.

    The molecular basis and cellular effects of distinct CD103 expression on CD4 and CD8 T cells.
    Keller HR, Ligons DL, Li C, Hwang S, Luckey MA, Prakhar P, Liman N, Crossman A, Lazarevic V, Park YK, Park JH., Free PMC Article

    08/7/2021
    Lung CD103(+) Dendritic cells of mice infected with Paracoccidioides brasiliensis contribute to Treg differentiation.

    Lung CD103(+) Dendritic cells of mice infected with Paracoccidioides brasiliensis contribute to Treg differentiation.
    Peron G, Oliveira J, Fernandes FF, Verinaud L.

    07/24/2021
    Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells.

    Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells.
    Duhan V, Khairnar V, Kitanovski S, Hamdan TA, Klein AD, Lang J, Ali M, Adomati T, Bhat H, Friedrich SK, Li F, Krebs P, Futerman AH, Addo MM, Hardt C, Hoffmann D, Lang PA, Lang KS., Free PMC Article

    06/26/2021
    CD103(+) cDC1 and endogenous CD8(+) T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.

    CD103(+) cDC1 and endogenous CD8(+) T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.
    Kuhn NF, Lopez AV, Li X, Cai W, Daniyan AF, Brentjens RJ., Free PMC Article

    12/19/2020
    Apoptotic cells induce CD103 expression and immunoregulatory function in myeloid dendritic cell precursors through integrin alphav and TGF-beta activation.

    Apoptotic cells induce CD103 expression and immunoregulatory function in myeloid dendritic cell precursors through integrin αv and TGF-β activation.
    Zhang A, Paidassi H, Lacy-Hulbert A, Savill J., Free PMC Article

    09/12/2020
    TRM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection.

    T(RM) integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection.
    Reilly EC, Lambert Emo K, Buckley PM, Reilly NS, Smith I, Chaves FA, Yang H, Oakes PW, Topham DJ., Free PMC Article

    09/5/2020
    An anti-CD103 antibody-drug conjugate prolongs the survival of pancreatic islet allografts in mice.

    An anti-CD103 antibody-drug conjugate prolongs the survival of pancreatic islet allografts in mice.
    Xue D, Liu P, Chen W, Zhang C, Zhang L., Free PMC Article

    08/22/2020
    CD103(+) cDCs counterregulated CD11b(+) cDC-mediated Th1 activation directly by producing the immune-suppressive cytokine IL-10.

    CD11b(+) Dendritic Cell-Mediated Anti-Mycobacterium tuberculosis Th1 Activation Is Counterregulated by CD103(+) Dendritic Cells via IL-10.
    Lai R, Jeyanathan M, Afkhami S, Zganiacz A, Hammill JA, Yao Y, Kaushic C, Xing Z.

    02/16/2019
    the data show that CD103 is dispensable for pneumococcal colonization-induced adaptive immune responses in mice

    Colonization-induced protection against invasive pneumococcal disease in mice is independent of CD103 driven adaptive immune responses.
    Dommaschk A, Lang LF, Maus R, Stolper J, Welte T, Maus UA.

    02/2/2019
    The adoptive transfer of CD103(+) cDC1s to Batf3 deficient animals reversed these observed changes and more importantly could attenuate cellular damage and inflammation in established steatohepatitis.

    Murine CD103(+) dendritic cells protect against steatosis progression towards steatohepatitis.
    Heier EC, Meier A, Julich-Haertel H, Djudjaj S, Rau M, Tschernig T, Geier A, Boor P, Lammert F, Lukacs-Kornek V.

    03/24/2018
    AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.

    Blockade of αEβ7 integrin suppresses accumulation of CD8(+) and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo.
    Zundler S, Schillinger D, Fischer A, Atreya R, López-Posadas R, Watson A, Neufert C, Atreya I, Neurath MF.

    10/21/2017
    Mesenteric lymph node CD11b(-) CD103(+) PD-L1(High) dendritic cell subset probably takes up luminal antigens in the intestine, migrates to MLNs, and highly induces regulatory T cells through TGF-beta activation.

    Mesenteric lymph node CD11b(-) CD103(+) PD-L1(High) dendritic cells highly induce regulatory T cells.
    Shiokawa A, Kotaki R, Takano T, Nakajima-Adachi H, Hachimura S., Free PMC Article

    09/23/2017
    NR4A3 plays an important role in the regulation of CD103+ mDCs by regulating CCR7-dependent cell migration.

    The transcription factor NR4A3 controls CD103+ dendritic cell migration.
    Park K, Mikulski Z, Seo GY, Andreyev AY, Marcovecchio P, Blatchley A, Kronenberg M, Hedrick CC., Free PMC Article

    09/2/2017
    Oral treatment with the mucosal adjuvant cholera toxin (CT) induces expression of T cell immunoglobulin and mucin domain containing 4 (TIM-4) on a proportion of CD103+ CD11b+ dendritic cell (DC) in the intestinal lamina propria (LP).

    Activation-Induced TIM-4 Expression Identifies Differential Responsiveness of Intestinal CD103+ CD11b+ Dendritic Cells to a Mucosal Adjuvant.
    Hilligan KL, Connor LM, Schmidt AJ, Ronchese F., Free PMC Article

    08/5/2017
    while alphaE (CD103) expression is indeed associated with hTGFbeta1 in vivo, it has little, if any, influence on the course of the psoriasis-like phenotype in K5.hTGFbeta1 transgenic mice

    Integrin αE (CD103) is induced but plays no pathogenic role in psoriasiform skin lesions of TGFβ1 transgenic mice.
    Braun A, Schlickum S, Dewert N, Schön M, Schön MP.

    02/18/2017
    Intestinal CD103(+)CD11b(-) dendritic cells restrain colitis via IFN-gamma-induced anti-inflammatory response in epithelial cells.

    Intestinal CD103(+)CD11b(-) dendritic cells restrain colitis via IFN-γ-induced anti-inflammatory response in epithelial cells.
    Muzaki AR, Tetlak P, Sheng J, Loh SC, Setiagani YA, Poidinger M, Zolezzi F, Karjalainen K, Ruedl C., Free PMC Article

    12/17/2016
    Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammation.

    Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammation.
    Daniels NJ, Hyde E, Ghosh S, Seo K, Price KM, Hoshino K, Kaisho T, Okada T, Ronchese F.

    10/1/2016
    CD103 on FoxP3+ Treg cells was involved in Treg retention to inflamed skin.

    Integrin αE(CD103) Is Involved in Regulatory T-Cell Function in Allergic Contact Hypersensitivity.
    Braun A, Dewert N, Brunnert F, Schnabel V, Hardenberg JH, Richter B, Zachmann K, Cording S, Claßen A, Brans R, Hamann A, Huehn J, Schön MP.

    03/5/2016
    Interleukin-12-producing CD103+ CD11b- CD8+ dendritic cells are responsible for eliciting gut intraepithelial lymphocyte response against Encephalitozoon cuniculi.

    Interleukin-12-producing CD103+ CD11b- CD8+ dendritic cells are responsible for eliciting gut intraepithelial lymphocyte response against Encephalitozoon cuniculi.
    Moretto MM, Harrow DI, Hawley TS, Khan IA., Free PMC Article

    02/20/2016
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