| Transcription factor EBF1 mitigates neuropathic pain by rescuing Kv1.2 expression in primary sensory neurons. | Transcription factor EBF1 mitigates neuropathic pain by rescuing Kv1.2 expression in primary sensory neurons.
Liang Y, Sharma D, Wang B, Wang H, Feng X, Ma R, Berkman T, Char S, Bekker A, Tao YX., | 12/26/2023 |
| Sound Localization in Preweanling Mice Was More Severely Affected by Deleting the Kcna1 Gene Compared to Deleting Kcna2, and a Curious Inverted-U Course of Development That Appeared to Exceed Adult Performance Was Observed in All Groups. | Sound Localization in Preweanling Mice Was More Severely Affected by Deleting the Kcna1 Gene Compared to Deleting Kcna2, and a Curious Inverted-U Course of Development That Appeared to Exceed Adult Performance Was Observed in All Groups.
Ison JR, Allen PD, Tempel BL, Brew HM., Free PMC Article | 09/12/2020 |
| Dorsal root ganglion (DRG) DNMT1 contributes to neuropathic pain genesis partially through repression of DRG Kcna2 gene expression | Contribution of DNMT1 to Neuropathic Pain Genesis Partially through Epigenetically Repressing Kcna2 in Primary Afferent Neurons.
Sun L, Gu X, Pan Z, Guo X, Liu J, Atianjoh FE, Wu S, Mo K, Xu B, Liang L, Bekker A, Tao YX., Free PMC Article | 06/27/2020 |
| Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations | Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations.
Baronas VA, Yang RY, Morales LC, Sipione S, Kurata HT., Free PMC Article | 01/5/2019 |
| G9a contributes to neuropathic pain development through epigenetic silencing of Kcna2 in the axotomized dorsal root ganglion. | G9a participates in nerve injury-induced Kcna2 downregulation in primary sensory neurons.
Liang L, Gu X, Zhao JY, Wu S, Miao X, Xiao J, Mo K, Zhang J, Lutz BM, Bekker A, Tao YX., Free PMC Article | 05/26/2018 |
| Results show that MK2 activation induces MRTF-A phosphorylation at S351 and S371 upon stress. | Stress-dependent phosphorylation of myocardin-related transcription factor A (MRTF-A) by the p38(MAPK)/MK2 axis.
Ronkina N, Lafera J, Kotlyarov A, Gaestel M., Free PMC Article | 05/5/2018 |
| Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 pyramidal cells | Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 pyramidal cells.
Hyun JH, Eom K, Lee KH, Bae JY, Bae YC, Kim MH, Kim S, Ho WK, Lee SH., Free PMC Article | 05/21/2016 |
| analysis of fine-tuning of voltage sensitivity of the Kv1.2 potassium channel by interhelix loop dynamics | Fine-tuning of voltage sensitivity of the Kv1.2 potassium channel by interhelix loop dynamics.
Sand R, Sharmin N, Morgan C, Gallin WJ., Free PMC Article | 06/1/2013 |
| This study showed that MK2 kinase is activated by TcdA and TcdB and regulates the expression of proinflammatory cytokines. | MAPK-activated protein kinase 2 contributes to Clostridium difficile-associated inflammation.
Bobo LD, El Feghaly RE, Chen YS, Dubberke ER, Han Z, Baker AH, Li J, Burnham CA, Haslam DB., Free PMC Article | 04/20/2013 |
| Mk2 homozygous deletion in mice impedes the induction of experimental colitis by dextran sodium sulfate, confirming the notion that p38/Mk2 is involved in this inflammatory response. | Inhibition of p38/Mk2 signaling pathway improves the anti-inflammatory effect of WIN55 on mouse experimental colitis.
Li YY, Yuece B, Cao HM, Lin HX, Lv S, Chen JC, Ochs S, Sibaev A, Deindl E, Schaefer C, Storr M. | 04/20/2013 |
| The dynamic Sig-1R-Kv1.2 complex represents a mechanism that shapes neuronal and behavioral response to cocaine. | Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine.
Kourrich S, Hayashi T, Chuang JY, Tsai SY, Su TP, Bonci A., Free PMC Article | 03/23/2013 |
| Overlapping patterns with differential expression and precise localization of Kv1.1 and Kv1.2 channels targeted to specialized subcellular compartments contribute to distinctive patterns of neuronal excitability --REVIEW | Kv1.1 and Kv1.2: similar channels, different seizure models.
Robbins CA, Tempel BL. | 07/21/2012 |
| the contribution of Kv1.2 in the regulation of nigrostriatal DA release by the D2-AR and thereby offer a novel mechanism by which DA release is regulated. | Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow.
Fulton S, Thibault D, Mendez JA, Lahaie N, Tirotta E, Borrelli E, Bouvier M, Tempel BL, Trudeau LE., Free PMC Article | 05/21/2011 |
| These results suggest that independent of known mutations in Kcna1 encoding Kv1.1, Kcna2 mutations may be important molecular correlates underlying human cerebellar ataxic disease. | A new Kv1.2 channelopathy underlying cerebellar ataxia.
Xie G, Harrison J, Clapcote SJ, Huang Y, Zhang JY, Wang LY, Roder JC., Free PMC Article | 12/11/2010 |
| K(v)1.1 and K(v)1.2 were predominantly expressed in distinct EGC phenotypes. K(v)1.2 was also observed in distinct neuron subpopulations. | Voltage-gated delayed rectifier K v 1-subunits may serve as distinctive markers for enteroglial cells with different phenotypes in the murine ileum.
Costagliola A, Van Nassauw L, Snyders D, Adriaensen D, Timmermans JP. | 01/21/2010 |
| Kcna2-null mice exhibited increased seizure susceptibility but, in contrast to Kcna1-null mice, hypoexcitability and enlarged Kv1 currents in auditory neurons. | Seizures and reduced life span in mice lacking the potassium channel subunit Kv1.2, but hypoexcitability and enlarged Kv1 currents in auditory neurons.
Brew HM, Gittelman JX, Silverstein RS, Hanks TD, Demas VP, Robinson LC, Robbins CA, McKee-Johnson J, Chiu SY, Messing A, Tempel BL. | 01/21/2010 |
| cluster of cytoplasmic C-terminal phosphorylation sites regulates Kv1.2 trafficking | Trafficking-dependent phosphorylation of Kv1.2 regulates voltage-gated potassium channel cell surface expression.
Yang JW, Vacher H, Park KS, Clark E, Trimmer JS., Free PMC Article | 01/21/2010 |
| Kv1.2, a mammalian homologue of Shaker, regulates neuronal excitability and affects NREM sleep | Sleep in Kcna2 knockout mice.
Douglas CL, Vyazovskiy V, Southard T, Chiu SY, Messing A, Tononi G, Cirelli C., Free PMC Article | 01/21/2010 |
| Data show that PSD-95 colocalizes precisely with Kv1 potassium channels and Caspr2 at juxtaparanodes, and that a macromolecular complex of Kv1 channels and PSD-95 can be immunopurified from mammalian brain and spinal cord. | Clustering of neuronal potassium channels is independent of their interaction with PSD-95.
Rasband MN, Park EW, Zhen D, Arbuckle MI, Poliak S, Peles E, Grant SG, Trimmer JS., Free PMC Article | 01/21/2010 |