| Potassium Channels Kv1.3 and Kir2.1 But Not Kv1.5 Contribute to BV2 Cell Line and Primary Microglial Migration. | Potassium Channels Kv1.3 and Kir2.1 But Not Kv1.5 Contribute to BV2 Cell Line and Primary Microglial Migration.
Anton R, Ghenghea M, Ristoiu V, Gattlen C, Suter MR, Cojocaru PA, Popa-Wagner A, Catalin B, Deftu AF., Free PMC Article | 04/17/2021 |
| Intracellular uric acid could stabilize Kv1.5 proteins through phosphorylation of Akt and HSF1 leading to enhanced expression of Hsp70. | Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes.
Taufiq F, Maharani N, Li P, Kurata Y, Ikeda N, Kuwabara M, Otani N, Miake J, Hasegawa A, Tsuneto M, Shirayoshi Y, Ninomiya H, Saitoh T, Nakai A, Yamamoto K, Hisatome I. | 05/9/2020 |
| KV1.5 channels predominantly associate with KVbeta1 and KVbeta2 proteins and that KVbeta2 performs a chaperone function for KV1.5 channels in arterial myocytes, thereby facilitating Kv1alpha trafficking and membrane localization. | Heteromeric complexes of aldo-keto reductase auxiliary K(V)β subunits (AKR6A) regulate sarcolemmal localization of K(V)1.5 in coronary arterial myocytes.
Nystoriak MA, Zhang D, Jagatheesan G, Bhatnagar A., Free PMC Article | 12/2/2017 |
| The findings uncover detailed molecular mechanisms underpinning a channelopathy-linked form of atrial fibrillation and emphasize the inevitability of considering extracardiac mechanisms in genetic arrhythmia syndromes. | Increased aldosterone-dependent Kv1.5 recycling predisposes to pacing-induced atrial fibrillation in Kcne3-/- mice.
Lisewski U, Koehncke C, Wilck N, Buschmeyer B, Pieske B, Roepke TK. | 08/26/2017 |
| Silencing of Kv1.5 improved endothelium-dependent vasodilatation in thoracic aorta from type 2 diabetes mice. | Suppression of Kv1.5 protects against endothelial apoptosis induced by palmitate and in type 2 diabetes mice.
Du JY, Yuan F, Zhao LY, Zhu J, Huang YY, Zhang GS, Wei Y, Liu Y, Yi Q, Tu YS, Zhong X, Sun FY, Sun HS, Guan YY, Chen WL, Wang GL. | 02/4/2017 |
| Intracellular urate taken up by UATs enhanced Kv1.5 protein expression and function in HL-1 atrial myocytes. | Molecular Mechanisms Underlying Urate-Induced Enhancement of Kv1.5 Channel Expression in HL-1 Atrial Myocytes.
Maharani N, Ting YK, Cheng J, Hasegawa A, Kurata Y, Li P, Nakayama Y, Ninomiya H, Ikeda N, Morikawa K, Yamamoto K, Makita N, Yamashita T, Shirayoshi Y, Hisatome I. | 09/10/2016 |
| JAK3 contributes to the regulation of membrane Kv1.5 protein abundance and activity, an effect sensitive to ouabain and thus possibly involving Na(+)/K(+) ATPase activity. | Regulation of Voltage-Gated K+ Channel Kv1.5 by the Janus Kinase JAK3.
Warsi J, Elvira B, Bissinger R, Hosseinzadeh Z, Lang F. | 08/20/2016 |
| KV1.5, a DPO-1-sensitive KDR channel, plays a major role in determining microvascular tone and the response to vasoconstrictors and vasodilators. | Diphenyl phosphine oxide-1-sensitive K(+) channels contribute to the vascular tone and reactivity of resistance arteries from brain and skeletal muscle.
Fancher IS, Butcher JT, Brooks SD, Rottgen TS, Skaff PR, Frisbee JC, Dick GM., Free PMC Article | 01/30/2016 |
| Kv1.5 channels in vascular smooth muscle play a critical role in coupling myocardial blood flow to cardiac metabolism. | Requisite Role of Kv1.5 Channels in Coronary Metabolic Dilation.
Ohanyan V, Yin L, Bardakjian R, Kolz C, Enrick M, Hakobyan T, Kmetz J, Bratz I, Luli J, Nagane M, Khan N, Hou H, Kuppusamy P, Graham J, Fu FK, Janota D, Oyewumi MO, Logan S, Lindner JR, Chilian WM., Free PMC Article | 12/5/2015 |
| the Kv1.5 subunit has a role in electrical remodeling of preoptic GABAergic neurons | Electrical remodeling of preoptic GABAergic neurons involves the Kv1.5 subunit.
Tabarean IV., Free PMC Article | 01/31/2015 |
| MYO5A and MYO5B control functionally distinct steps in the surface trafficking of Kv1.5. | Role for myosin-V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytes.
Schumacher-Bass SM, Vesely ED, Zhang L, Ryland KE, McEwen DP, Chan PJ, Frasier CR, McIntyre JC, Shaw RM, Martens JR., Free PMC Article | 05/17/2014 |
| e-LXA4 promoted a modest upregulation of Kv1.5 mRNA that was suppressed by LPS or IL-4/IL-13. | Modulation of voltage-dependent and inward rectifier potassium channels by 15-epi-lipoxin-A4 in activated murine macrophages: implications in innate immunity.
Moreno C, Prieto P, Macías Á, Pimentel-Santillana M, de la Cruz A, Través PG, Boscá L, Valenzuela C. | 02/22/2014 |
| The combined down-regulation of Kv4.2, Kv1.5 and KChIP2 prior to the onset of HF may play an important role in the premature sudden death in this DCM model. | Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy.
Suzuki T, Shioya T, Murayama T, Sugihara M, Odagiri F, Nakazato Y, Nishizawa H, Chugun A, Sakurai T, Daida H, Morimoto S, Kurebayashi N., Free PMC Article | 09/1/2012 |
| cortactin was required for N-cadherin-mediated enhancement of Kv1.5 channel activity | Cortactin is required for N-cadherin regulation of Kv1.5 channel function.
Cheng L, Yung A, Covarrubias M, Radice GL., Free PMC Article | 08/6/2011 |
| Data confirm KCNA5 in left/right atria & indicate functional interaction of KCNA5 (ultra rapid) & KCNH2 (rapid). Action potentials are longer in right atrial myocytes than in left; this is due partly to smaller amplitude of KCNA5 in right atrium. | Presence and functional role of the rapidly activating delayed rectifier K(+) current in left and right atria of adult mice.
Nakamura H, Ding WG, Sanada M, Maeda K, Kawai H, Maegawa H, Matsuura H. | 03/5/2011 |
| Downregulation of Kv4.3 and Kv1.5 transcripts by estrogen are one mechanism defining gender-related differences in mouse ventricular repolarization. | Estrogen contributes to gender differences in mouse ventricular repolarization.
Saito T, Ciobotaru A, Bopassa JC, Toro L, Stefani E, Eghbali M., Free PMC Article | 01/21/2010 |
| Antiarrhythmic drug-induced internalization of the atrial-specific k+ channel kv1.5. | Antiarrhythmic drug-induced internalization of the atrial-specific k+ channel kv1.5.
Schumacher SM, McEwen DP, Zhang L, Arendt KL, Van Genderen KM, Martens JR., Free PMC Article | 01/21/2010 |
| implicate the traffic and localization of Kv1.3/Kv1.5 heteromers in the complex regulation of immune system cells | Kv1.5 association modifies Kv1.3 traffic and membrane localization.
Vicente R, Villalonga N, Calvo M, Escalada A, Solsona C, Soler C, Tamkun MM, Felipe A., Free PMC Article | 01/21/2010 |
| These results suggest that the inhibition of K(v) channel expression and rise in [Ca(2+)](i) during chronic hypoxia may be the result of HIF-1-dependent induction of ET-1. | Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes.
Whitman EM, Pisarcik S, Luke T, Fallon M, Wang J, Sylvester JT, Semenza GL, Shimoda LA. | 01/21/2010 |
| Our results show that Kcna5 promoter activity in vascular smooth muscle is critically dependent on Sp1 regulation via CACCC box motifs and identify mechanisms that potentially influence the expression of K(V)1.5 channel expression. | K(v)1.5 potassium channel gene regulation by Sp1 transcription factor and oxidative stress.
Fountain SJ, Cheong A, Li J, Dondas NY, Zeng F, Wood IC, Beech DJ. | 01/21/2010 |
| Kv1.5 has a role in Rab-GTPase-dependent endocytic recycling in atrial myocytes | Rab-GTPase-dependent endocytic recycling of Kv1.5 in atrial myocytes.
McEwen DP, Schumacher SM, Li Q, Benson MD, Iñiguez-Lluhí JA, Van Genderen KM, Martens JR. | 01/21/2010 |
| hyperthyroidism resulted in more significant action potential shortening and greater delayed rectifier K(+) current increases in the right vs. the left atrium, which can contribute to the propensity for atrial arrhythmia in hyperthyroid heart | Effects of hyperthyroidism on delayed rectifier K+ currents in left and right murine atria.
Hu Y, Jones SV, Dillmann WH. | 01/21/2010 |
| Kv1.3-based treatments to alter physiological responses, such as proliferation and activation, are impaired by Kv1.5 expression | Kv1.3/Kv1.5 heteromeric channels compromise pharmacological responses in macrophages.
Villalonga N, Escalada A, Vicente R, Sánchez-Tilló E, Celada A, Solsona C, Felipe A. | 01/21/2010 |
| Kv1.5 co-associates with Kv1.3, generating functional heterotetramers in macrophages | Association of Kv1.5 and Kv1.3 contributes to the major voltage-dependent K+ channel in macrophages.
Vicente R, Escalada A, Villalonga N, Texidó L, Roura-Ferrer M, Martín-Satué M, López-Iglesias C, Soler C, Solsona C, Tamkun MM, Felipe A. | 01/21/2010 |
| KChIP2 contributes to the formation of functional mouse ventricular Kv1.5 channels | KChIP2 modulates the cell surface expression of Kv 1.5-encoded K(+) channels.
Li H, Guo W, Mellor RL, Nerbonne JM. | 01/21/2010 |