| Biological Roles of 5-Oxo-6,8,11,14-Eicosatetraenoic Acid and the OXE Receptor in Allergic Diseases: Collegium Internationale Allergologicum Update 2024. | Biological Roles of 5-Oxo-6,8,11,14-Eicosatetraenoic Acid and the OXE Receptor in Allergic Diseases: Collegium Internationale Allergologicum Update 2024.
Lin L, Dai F, Wei J, Chen Z. | 05/6/2024 |
| OXER1 mediates testosterone-induced calcium responses in prostate cancer cells. | OXER1 mediates testosterone-induced calcium responses in prostate cancer cells.
Panagiotopoulos AA, Kalyvianaki K, Serifoglou B, Konstantinou E, Notas G, Castanas E, Kampa M. | 04/2/2022 |
| Enhanced OXER1 expression is indispensable for human cancer cell migration. | Enhanced OXER1 expression is indispensable for human cancer cell migration.
Kalyvianaki K, Drosou I, Notas G, Castanas E, Kampa M. | 01/8/2022 |
| The G protein coupled oxo-eicosanoid receptor 1 (OXER1) (a receptor of the arachidonic acid metabolite, 5-oxoeicosatetraenoic acid, 5-oxoETE) is as a novel mAR involved in the rapid effects of androgens. | Membrane androgen receptors (OXER1, GPRC6A AND ZIP9) in prostate and breast cancer: A comparative study of their expression.
Kalyvianaki K, Panagiotopoulos AA, Malamos P, Moustou E, Tzardi M, Stathopoulos EN, Ioannidis GS, Marias K, Notas G, Theodoropoulos PA, Castanas E, Kampa M. | 06/8/2019 |
| These findings verify that membrane-acting androgens exert specific effects through an antagonistic interaction with OXER1. Additionally, this interaction between androgen and OXER1, which is an arachidonic acid metabolite receptor expressed in prostate cancer, provides a novel link between steroid and lipid actions and renders OXER1 as new player in the disease. | Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer.
Kalyvianaki K, Gebhart V, Peroulis N, Panagiotopoulou C, Kiagiadaki F, Pediaditakis I, Aivaliotis M, Moustou E, Tzardi M, Notas G, Castanas E, Kampa M., Free PMC Article | 11/10/2018 |
| membrane receptor OxeR1 is involved in StAR protein induction and activation of steroidogenesis triggered by cAMP or angiotensin II, acting, at least in part, through ERK1/2 activation. | OxeR1 regulates angiotensin II and cAMP-stimulated steroid production in human H295R adrenocortical cells.
Dattilo M, Neuman I, Muñoz M, Maloberti P, Cornejo Maciel F. | 02/13/2016 |
| Gue1654 as a non-Galphai-biased antagonist of OXE-R that provides a new basis for therapeutic intervention in inflammatory diseases that involve activation of eosinophils, neutrophils, and monocytes. | A biased non-Gαi OXE-R antagonist demonstrates that Gαi protein subunit is not directly involved in neutrophil, eosinophil, and monocyte activation by 5-oxo-ETE.
Konya V, Blättermann S, Jandl K, Platzer W, Ottersbach PA, Marsche G, Gütschow M, Kostenis E, Heinemann A. | 06/28/2014 |
| OXER1 has a role in regulating the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells | OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells.
Sarveswaran S, Ghosh J., Free PMC Article | 08/31/2013 |
| Identification of a novel human receptor coupled to G(i/o). | Identification of a novel human eicosanoid receptor coupled to G(i/o).
Hosoi T, Koguchi Y, Sugikawa E, Chikada A, Ogawa K, Tsuda N, Suto N, Tsunoda S, Taniguchi T, Ohnuki T. | 01/21/2010 |
| identification and cloning of a novel GPCR, R527; 5-oxo-ETE was identified as the ligand for R527; very high level of mRNA expression in eosinophils with high expression also detected in neutrophils and lung macrophages | Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils.
Jones CE, Holden S, Tenaillon L, Bhatia U, Seuwen K, Tranter P, Turner J, Kettle R, Bouhelal R, Charlton S, Nirmala NR, Jarai G, Finan P. | 01/21/2010 |
| 5-oxoER is critical for prostate cancer cell survival. | Expression of 5-oxoETE receptor in prostate cancer cells: critical role in survival.
Sundaram S, Ghosh J. | 01/21/2010 |