| A role for TASK2 channels in the human immunological synapse. | A role for TASK2 channels in the human immunological synapse.
Fernández-Orth J, Rolfes L, Gola L, Bittner S, Andronic J, Sukhorukov VL, Sisario D, Landgraf P, Dieterich DC, Cerina M, Smalla KH, Kähne T, Budde T, Kovac S, Ruck T, Sauer M, Meuth SG. | 04/17/2021 |
| Structural basis for pH gating of the two-pore domain K(+) channel TASK2. | Structural basis for pH gating of the two-pore domain K(+) channel TASK2.
Li B, Rietmeijer RA, Brohawn SG., Free PMC Article | 10/24/2020 |
| Results suggest a mechanism for K2P5.1 up-regulation via HIF-1 in the CD4(+) T cells of the mouse model for inflammatory bowel. | Possible Contribution of Inflammation-Associated Hypoxia to Increased K(2P)5.1 K(+) Channel Expression in CD4(+) T cells of the Mouse Model for Inflammatory Bowel Disease.
Endo K, Kito H, Tanaka R, Kajikuri J, Tanaka S, Elboray EE, Suzuki T, Ohya S., Free PMC Article | 05/9/2020 |
| The apparent affinity of TASK-2 for membrane PI(4,5)P2 is low and it is conceivable that changing competition by intracellular polycationic compounds might mediate the previously reported sensitivity of TASK-2 to changes in cell volume. A decrease in PI(4,5)P2 by activation of Gq-PCRs is also probably responsible for TASK-2 inhibition. | Phosphatidylinositol (4,5)-bisphosphate dynamically regulates the K(2P) background K(+) channel TASK-2.
Niemeyer MI, Cid LP, Paulais M, Teulon J, Sepúlveda FV., Free PMC Article | 11/10/2018 |
| KCNK5 channels are indispensable for the maintenance of hearing. KCNK5 is mainly found in outer sulcus Claudius', Boettcher's and root cells. | KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing.
Cazals Y, Bévengut M, Zanella S, Brocard F, Barhanin J, Gestreau C., Free PMC Article | 05/14/2016 |
| The data identify GPR4 and TASK-2 as distinct, parallel, and essential central mediators of respiratory chemosensitivity. | PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons.
Kumar NN, Velic A, Soliz J, Shi Y, Li K, Wang S, Weaver JL, Sen J, Abbott SB, Lazarenko RM, Ludwig MG, Perez-Reyes E, Mohebbi N, Bettoni C, Gassmann M, Suply T, Seuwen K, Guyenet PG, Wagner CA, Bayliss DA., Free PMC Article | 07/25/2015 |
| TASK-2 is upregulated under hypoxia in a HIF-1alpha-dependent manner in B cells. | HIF-1α-mediated upregulation of TASK-2 K⁺ channels augments Ca²⁺ signaling in mouse B cells under hypoxia.
Shin DH, Lin H, Zheng H, Kim KS, Kim JY, Chun YS, Park JW, Nam JH, Kim WK, Zhang YH, Kim SJ. | 02/28/2015 |
| The strong physiological impairment of KCNK5 in Ehrlich cells after long-term hypotonic stimulation is predominantly due to down-regulation of the KCNK5 protein synthesis. | KCNK5 is functionally down-regulated upon long-term hypotonicity in Ehrlich ascites tumor cells.
Kirkegaard SS, Wulff T, Gammeltoft S, Hoffmann EK. | 08/16/2014 |
| data are compatible with the concept that TASK-2 channels are modulated by Gbetagamma subunits of heterotrimeric G protein; propose that this modulation is a novel way in which TASK-2 can be tuned to its physiological functions | G protein modulation of K2P potassium channel TASK-2 : a role of basic residues in the C terminus domain.
Añazco C, Peña-Münzenmayer G, Araya C, Cid LP, Sepúlveda FV, Niemeyer MI. | 07/12/2014 |
| alkaline-activated TASK-2 channels contribute to pH sensitivity in retrotrapezoid nucleus neurons | TASK-2 channels contribute to pH sensitivity of retrotrapezoid nucleus chemoreceptor neurons.
Wang S, Benamer N, Zanella S, Kumar NN, Shi Y, Bévengut M, Penton D, Guyenet PG, Lesage F, Gestreau C, Barhanin J, Bayliss DA., Free PMC Article | 11/30/2013 |
| Kv1.3/TASK2 channels appear to be mainly responsible for regulatory volume decrease in murine T-lymphocytes. | Volume regulation of murine T lymphocytes relies on voltage-dependent and two-pore domain potassium channels.
Bobak N, Bittner S, Andronic J, Hartmann S, Mühlpfordt F, Schneider-Hohendorf T, Wolf K, Schmelter C, Göbel K, Meuth P, Zimmermann H, Döring F, Wischmeyer E, Budde T, Wiendl H, Meuth SG, Sukhorukov VL. | 08/20/2011 |
| a cycle of protonation/deprotonation of pH(o)-sensing arginine 224 side chain gates the TASK-2 channel by electrostatically tuning the conformational stability of its selectivity filter. | Gating of a pH-sensitive K(2P) potassium channel by an electrostatic effect of basic sensor residues on the selectivity filter.
Zúñiga L, Márquez V, González-Nilo FD, Chipot C, Cid LP, Sepúlveda FV, Niemeyer MI., Free PMC Article | 08/6/2011 |
| The authors report for the first time the expression of TASK-2 in B cells and surmise that the upregulation of TASK-2 by B cell receptor ligation is associated with the apoptosis of immature B cells. | Expression of TASK-2 and its upregulation by B cell receptor stimulation in WEHI-231 mouse immature B cells.
Nam JH, Shin DH, Zheng H, Lee DS, Park SJ, Park KS, Kim SJ. | 07/30/2011 |
| intracellular pH, together with pH(o), is a critical determinant of TASK-2 activity and therefore of its physiological function | Separate gating mechanisms mediate the regulation of K2P potassium channel TASK-2 by intra- and extracellular pH.
Niemeyer MI, Cid LP, Peña-Münzenmayer G, Sepúlveda FV., Free PMC Article | 06/28/2010 |
| the role of the TASK2 channel in the regulation of AVD and apoptosis phenomenon. | Role of TASK2 in the control of apoptotic volume decrease in proximal kidney cells.
L'Hoste S, Poet M, Duranton C, Belfodil R, é Barriere H, Rubera I, Tauc M, Poujeol C, Barhanin J, Poujeol P. | 01/21/2010 |
| Cl(-) influx will be the driving force for HCO(3)(-) exit through the activation of the Cl(-)/HCO(3)(-) exchanger. This efflux of HCO(3)(-) then alkalinizes pH(e), which in turn activates TASK2 channels | Extracellular pH alkalinization by Cl-/HCO3- exchanger is crucial for TASK2 activation by hypotonic shock in proximal cell lines from mouse kidney.
L'Hoste S, Barriere H, Belfodil R, Rubera I, Duranton C, Tauc M, Poujeol C, Barhanin J, Poujeol P. | 01/21/2010 |
| results do not support the notion that KCNK5 potassium channel mediates the capacity of inhaled anesthetics to produce immobility | Mutation of KCNK5 or Kir3.2 potassium channels in mice does not change minimum alveolar anesthetic concentration.
Gerstin KM, Gong DH, Abdallah M, Winegar BD, Eger EI 2nd, Gray AT. | 01/21/2010 |
| pH sensing in TASK2 channels is conferred by the combined action of several charged residues in the large extracellular M1-P1 loop. | pH sensing in the two-pore domain K+ channel, TASK2.
Morton MJ, Abohamed A, Sivaprasadarao A, Hunter M., Free PMC Article | 01/21/2010 |
| The TASK2 channel is expressed in kidney proximal cells and could be the swelling-activated K+ channel responsible for the cell volume regulation process during osmolyte absorptions in the proximal tubules. | Role of TASK2 potassium channels regarding volume regulation in primary cultures of mouse proximal tubules.
Barriere H, Belfodil R, Rubera I, Tauc M, Lesage F, Poujeol C, Guy N, Barhanin J, Poujeol P., Free PMC Article | 01/21/2010 |
| Sensitivity to intracellular Na(+) may be an additional potential regulatory mechanism of TASK-2 channels. | Na(+)-induced inward rectification in the two-pore domain K(+) channel, TASK-2.
Morton MJ, Chipperfield S, Abohamed A, Sivaprasadarao A, Hunter M. | 01/21/2010 |
| consequences of the task2 gene inactivation in mice are reminiscent of the clinical manifestations seen in human proximal renal tubular acidosis syndrome | Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport.
Warth R, Barrière H, Meneton P, Bloch M, Thomas J, Tauc M, Heitzmann D, Romeo E, Verrey F, Mengual R, Guy N, Bendahhou S, Lesage F, Poujeol P, Barhanin J., Free PMC Article | 01/21/2010 |