| Inhibition of KIF11 ameliorates osteoclastogenesis via regulating mTORC1-mediated NF-kappaB signaling. | Inhibition of KIF11 ameliorates osteoclastogenesis via regulating mTORC1-mediated NF-κB signaling.
Miao J, Yao H, Liu J, Huang Z, Shi C, Lu X, Jiang J, Ren R, Wang C, Pan Y, Wang T, Jin H. | 11/8/2023 |
| LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A. | LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A.
Chen D, Wang J, Li Y, Xu C, Fanzheng M, Zhang P, Liu L., Free PMC Article | 09/28/2023 |
| ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11. | ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11.
Fang Q, Li Q, Qi Y, Pan Z, Feng T, Xin W. | 06/16/2023 |
| A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy. | A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy.
Wang Y, Smallwood PM, Williams J, Nathans J., Free PMC Article | 08/7/2021 |
| TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability. | TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability.
Venuto S, Monteonofrio L, Cozzolino F, Monti M, Appolloni I, Mazza T, Canetti D, Giambra V, Panelli P, Fusco C, Squeo GM, Croce AI, Pucci P, Malatesta P, Soddu S, Merla G, Micale L. | 10/10/2020 |
| KIF11 (kinesin-5/Eg5), which functions in spindle formation during mitosis and meiosis in oocytes and early embryos, is expressed in premeiotic germ cells (spermatogonia and spermatocytes). | KIF11 as a Potential Marker of Spermatogenesis Within Mouse Seminiferous Tubule Cross-sections.
Hara-Yokoyama M, Kurihara H, Ichinose S, Matsuda H, Ichinose S, Kurosawa M, Tada N, Iwahara C, Terasawa K, Podyma-Inoue KA, Furukawa K, Iwabuchi K., Free PMC Article | 06/20/2020 |
| Kif11 regulates excitatory synaptic transmission. Kif11 knockdown enhanced dendritic arborization, synapse number, expression of synaptophysin and Piccolo in vitro. | Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms.
Swarnkar S, Avchalumov Y, Raveendra BL, Grinman E, Puthanveettil SV., Free PMC Article | 10/26/2019 |
| NEK7 regulates dendrite morphogenesis in vitro and in vivo. NEK7 kinase activity is required for dendrite growth and branching, as well as spine formation and morphology. NEK7 regulates these processes in part through phosphorylation of the kinesin Eg5/KIF11, promoting its accumulation on microtubules in distal dendrites. | NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization.
Freixo F, Martinez Delgado P, Manso Y, Sánchez-Huertas C, Lacasa C, Soriano E, Roig J, Lüders J., Free PMC Article | 12/22/2018 |
| that Pten, through the Dlg1-binding ability of its PDZ-binding domain , accumulates phosphorylated Eg5 at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes | Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes.
van Ree JH, Nam HJ, Jeganathan KB, Kanakkanthara A, van Deursen JM., Free PMC Article | 06/10/2017 |
| Fbxo30-Eg5 interaction as a critical checkpoint in mammopoiesis. | Fbxo30 Regulates Mammopoiesis by Targeting the Bipolar Mitotic Kinesin Eg5.
Liu Y, Wang Y, Du Z, Yan X, Zheng P, Liu Y., Free PMC Article | 02/25/2017 |
| Data show that the STIM1 Ksp (Eg5)-cre knockout mice produced more urine compared to control. | STIM1fl/fl Ksp-Cre Mouse has Impaired Renal Water Balance.
Cebotaru L, Cebotaru V, Wang H, Arend LJ, Guggino WB., Free PMC Article | 02/18/2017 |
| Data suggest that amyloid-beta (here, Abeta 1-42) induces acute and chronic synaptic dysfunction in part through inhibition of Eg5 (kinesin-5) in hippocampal neurons. | Inhibition of the Motor Protein Eg5/Kinesin-5 in Amyloid β-Mediated Impairment of Hippocampal Long-Term Potentiation and Dendritic Spine Loss.
Freund RK, Gibson ES, Potter H, Dell'Acqua ML., Free PMC Article | 08/20/2016 |
| Disruption of the in vivo interaction of KIF11 with ZBP1 delocalizes beta-actin mRNA and affects cell migration. | Specific interaction of KIF11 with ZBP1 regulates the transport of β-actin mRNA and cell motility.
Song T, Zheng Y, Wang Y, Katz Z, Liu X, Chen S, Singer RH, Gu W., Free PMC Article | 12/26/2015 |
| Its inhibition reduces neutrotrophin and transmitter receptor function. | Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function.
Ari C, Borysov SI, Wu J, Padmanabhan J, Potter H., Free PMC Article | 12/20/2014 |
| These results suggest that 4-(N-(2-(N-acetylcysteine-S-yl) acetyl) amino)-4'- (N-(2-(N-(triphenylmethyl)amino)acetyl)amino)azobenzene could be used as photochromic inhibitor of Eg5 to achieve photocontrol of living cells. | Photocontrol of the mitotic kinesin Eg5 using a novel S-trityl-L-cysteine analogue as a photochromic inhibitor.
Ishikawa K, Tohyama K, Mitsuhashi S, Maruta S. | 12/6/2014 |
| incorporation of photochromic molecules into the key region of loop L5 facilitates the photocontrol of the function of kinesin Eg5. | Photocontrol of mitotic kinesin Eg5 facilitated by thiol-reactive photochromic molecules incorporated into the loop L5 functional loop.
Ishikawa K, Tamura Y, Maruta S. | 11/8/2014 |
| Finally, when kinesin spindle protein (KSP) siRNA was encapsulated in lipid nanoparticles containing a modest amount of PEG, the proliferation of endothelial cells was inhibited due to the efficient knock down of KSP mRNA. | Delivery of kinesin spindle protein targeting siRNA in solid lipid nanoparticles to cellular models of tumor vasculature.
Ying B, Campbell RB. | 05/24/2014 |
| These results show that intratumoral electro-transfer of siRNA is feasible and kinesin spindle protein (KSP)-specific siRNA may provide a novel strategy for therapeutic intervention. | Kinesin spindle protein SiRNA slows tumor progression.
Marra E, Palombo F, Ciliberto G, Aurisicchio L. | 02/8/2013 |
| observations explain the poleward accumulation of Eg5 in early mitosis and its redistribution in anaphase. Inhibition of dynein blocked Eg5 movement on microtubules, whereas depletion of the Eg5-binding protein TPX2 resulted in end-directed Eg5 movement. | Dynamic reorganization of Eg5 in the mammalian spindle throughout mitosis requires dynein and TPX2.
Gable A, Qiu M, Titus J, Balchand S, Ferenz NP, Ma N, Collins ES, Fagerstrom C, Ross JL, Yang G, Wadsworth P., Free PMC Article | 09/15/2012 |
| Eg5 is essential during early mouse development and cannot be compensated by another molecular motor. | Disruption of the mitotic kinesin Eg5 gene (Knsl1) results in early embryonic lethality.
Chauvière M, Kress C, Kress M. | 01/21/2010 |
| Results indicate that Eg5 overexpression disrupts the unique balance of forces associated with normal spindle assembly and function, and thereby leads to the development of spindle defects, genetic instability, and tumors. | Overexpression of Eg5 causes genomic instability and tumor formation in mice.
Castillo A, Morse HC 3rd, Godfrey VL, Naeem R, Justice MJ. | 01/21/2010 |
| Observations further support the conclusion that Eg5 is essential for cell division early in mouse development. | The kinesin related motor protein, Eg5, is essential for maintenance of pre-implantation embryogenesis.
Castillo A, Justice MJ., Free PMC Article | 01/21/2010 |