| Huntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning. | Huntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning.
Vitet H, Bruyère J, Xu H, Séris C, Brocard J, Abada YS, Delatour B, Scaramuzzino C, Venance L, Saudou F., Free PMC Article | 01/30/2024 |
| Lattice light-sheet microscopy and evaluation of dendritic transport in cultured hippocampal tissue reveal high variability in mobility of the KIF1A motor domain and entry into dendritic spines. | Lattice light-sheet microscopy and evaluation of dendritic transport in cultured hippocampal tissue reveal high variability in mobility of the KIF1A motor domain and entry into dendritic spines.
Rierola M, Trushina NI, Holtmannspötter M, Kurre R, Bakota L. | 02/28/2023 |
| Association of variants in the KIF1A gene with amyotrophic lateral sclerosis. | Association of variants in the KIF1A gene with amyotrophic lateral sclerosis.
Liao P, Yuan Y, Liu Z, Hou X, Li W, Wen J, Zhang K, Jiao B, Shen L, Jiang H, Guo J, Tang B, Zhang Z, Hu Z, Wang J., Free PMC Article | 10/29/2022 |
| GSK3beta Impairs KIF1A Transport in a Cellular Model of Alzheimer's Disease but Does Not Regulate Motor Motility at S402. | GSK3β Impairs KIF1A Transport in a Cellular Model of Alzheimer's Disease but Does Not Regulate Motor Motility at S402.
Gan KJ, Akram A, Blasius TL, Ramser EM, Budaitis BG, Gabrych DR, Verhey KJ, Silverman MA., Free PMC Article | 07/3/2021 |
| these findings support a primary role for KIF1A in the anterograde transport of BACE1. | KIF1A mediates axonal transport of BACE1 and identification of independently moving cargoes in living SCG neurons.
Hung CO, Coleman MP., Free PMC Article | 09/16/2017 |
| propose that KIF1A is essential for the survival and function of sensory neurons. | The Molecular Motor KIF1A Transports the TrkA Neurotrophin Receptor and Is Essential for Sensory Neuron Survival and Function.
Tanaka Y, Niwa S, Dong M, Farkhondeh A, Wang L, Zhou R, Hirokawa N. | 07/1/2017 |
| The Doublecortin specifically enhances binding of the ADP-bound Kif1a motor domain to microtubules. Dcx is essential for the function of Kif1a, a kinesin-3 motor protein that traffics synaptic vesicles. | Molecular basis for specific regulation of neuronal kinesin-3 motors by doublecortin family proteins.
Liu JS, Schubert CR, Fu X, Fourniol FJ, Jaiswal JK, Houdusse A, Stultz CM, Moores CA, Walsh CA., Free PMC Article | 01/26/2013 |
| This study demonstrated that KIF1A is indispensable for BDNF-mediated hippocampal synaptogenesis and learning enhancement induced by enrichment. | Motor protein KIF1A is essential for hippocampal synaptogenesis and learning enhancement in an enriched environment.
Kondo M, Takei Y, Hirokawa N. | 04/21/2012 |
| The KIF1A-microtubule binding free energy is dominated by van der Waals interactions and electrostatic interactions. | Probing the structural and energetic basis of kinesin-microtubule binding using computational alanine-scanning mutagenesis.
Li M, Zheng W. | 12/17/2011 |
| propose a model mechanism for microtubule activation of Mg-ADP release from KIF1A | Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin.
Nitta R, Okada Y, Hirokawa N. | 01/21/2010 |
| crystal structures of monomeric KIF1A with three transition-state analogs; structures show that KIF1A uses two microtubule-binding loops in an alternating manner to change its interaction with microtubules during the ATP hydrolysis cycle | KIF1A alternately uses two loops to bind microtubules.
Nitta R, Kikkawa M, Okada Y, Hirokawa N. | 01/21/2010 |