| KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors. | KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors.
Mac Donald A, Guipouy D, Lemieux W, Harvey M, Bordeleau LJ, Guay D, Roméro H, Li Y, Dion R, Béland K, Haddad E., Free PMC Article | 09/8/2023 |
| Combination of NKG2A and PD-1 Blockade Improves Radiotherapy Response in Radioresistant Tumors. | Combination of NKG2A and PD-1 Blockade Improves Radiotherapy Response in Radioresistant Tumors.
Battaglia NG, Murphy JD, Uccello TP, Hughson A, Gavras NW, Caldon JJ, Gerber SA, Lord EM., Free PMC Article | 08/6/2022 |
| NKG2A downregulation evades the HLA-E cancer immune-checkpoint, and increases the anti-tumor activity of NK cell infusions | Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells.
Kamiya T, Seow SV, Wong D, Robinson M, Campana D., Free PMC Article | 04/25/2020 |
| Data suggest that NKG2A Receptor (NKG2A) and the inhibitory members of NK cell lectin-like receptor subfamily A (Ly49) family receptors synergize to regulate NK cell education. | Synergized regulation of NK cell education by NKG2A and specific Ly49 family members.
Zhang X, Feng J, Chen S, Yang H, Dong Z., Free PMC Article | 03/21/2020 |
| Data suggest that the Cd94(LocA)/NKG2A receptor (NKG2A) heterodimeric receptor is widely expressed among M. musculus subspecies musculus. | Evidence of functional Cd94 polymorphism in a free-living house mouse population.
Knutsen LE, Dissen E, Saether PC, Bjørnsen EG, Piálek J, Storset AK, Boysen P. | 09/7/2019 |
| Liver cNK cells' hyporesponsiveness to stimulation through activating receptors is independent of IL-10, but correlates with decreased NKG2A expression compared to trNK cells. | Expression of the inhibitory receptor NKG2A correlates with increased liver and splenic NK cell response to activating receptor engagement.
Meyer CE, Key PN, Zhu T, Shabsovich M, Ni A, Tripathy SK., Free PMC Article | 11/17/2018 |
| Here, we provide a new anti-inflammation mechanism about ANXA1 secreted from injured IECs, where ANXA1 can stimulate the expression of NKG2A in NK cells that affect the recruitment and activity of neutrophils necessary for pathology of colitis. | The ANXA1 released from intestinal epithelial cells alleviate DSS-induced colitis by improving NKG2A expression of Natural Killer cells.
Zou Z, Zuo D, Yang J, Fan H. | 05/27/2017 |
| NKG2A optimizes CD8(+) T cell responses during an acute poxvirus infection. | The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8⁺ T Cells in Response to a Lethal Poxvirus Infection.
Rapaport AS, Schriewer J, Gilfillan S, Hembrador E, Crump R, Plougastel BF, Wang Y, Le Friec G, Gao J, Cella M, Pircher H, Yokoyama WM, Buller RM, Colonna M., Free PMC Article | 05/7/2016 |
| Results demonstrate the immunoregulatory role of CD8(+) NKG2A expression in virus infection, which negatively regulates T cell effector functions and contributes to protection of tissue integrity during virus clearance. | Tissue-protective effects of NKG2A in immune-mediated clearance of virus infection.
Ely KH, Matsuoka M, DeBerge MP, Ruby JA, Liu J, Schneider MJ, Wang Y, Hahn YS, Enelow RI., Free PMC Article | 12/26/2015 |
| role in NK cell-mediated protection from DSS-induced colitis | Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor.
Hall LJ, Murphy CT, Quinlan A, Hurley G, Shanahan F, Nally K, Melgar S. | 04/5/2014 |
| Endogenous NKG2A contributes to the rejection of cells lacking human HLA-Cw3. | HLA reduces killer cell Ig-like receptor expression level and frequency in a humanized mouse model.
van Bergen J, Thompson A, van Pel M, Retière C, Salvatori D, Raulet DH, Trowsdale J, Koning F., Free PMC Article | 05/18/2013 |
| The complex interplay between various stimuli may account for the variable expression of CD94/NKG2A during responses to different pathogens in vivo. | Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cells.
Cho JH, Kim HO, Webster K, Palendira M, Hahm B, Kim KS, King C, Tangye SG, Sprent J. | 09/3/2011 |
| expression of CD94 and its associated NKG2A, NKG2C, and NKG2E subunits is dispensable for NK cell development, education, and many NK cell functions | Development and function of CD94-deficient natural killer cells.
Orr MT, Wu J, Fang M, Sigal LJ, Spee P, Egebjerg T, Dissen E, Fossum S, Phillips JH, Lanier LL., Free PMC Article | 07/9/2011 |
| The NKG2A+KLRG1+ positive phenotype correlates with protective efficacy during antigenic recall from a pool of CD8 T cells during persistent gamma-herpesvirus 68 infection. | KLRG1+NKG2A+ CD8 T cells mediate protection and participate in memory responses during γ-herpesvirus infection.
Cush SS, Flaño E., Free PMC Article | 06/18/2011 |
| Data suggest that the liver environment regulates NK cell receptor expression and that IL-10 contributes to the regulation of liver NK cells, in part, by maintaining a greater percentage of the hyporesponsive NKG2A(+)Ly49(-) NK cells in the liver. | Intrahepatic IL-10 maintains NKG2A+Ly49- liver NK cells in a functionally hyporesponsive state.
Lassen MG, Lukens JR, Dolina JS, Brown MG, Hahn YS., Free PMC Article | 05/10/2010 |
| An NKG2B isoform paired with a CD94 alternatively spliced transcript may contribute to the plasticity of the natural killer cell immunological synapse by insuring an adequate inhibitory signal. | The human CD94 gene encodes multiple, expressible transcripts including a new partner of NKG2A/B.
Lieto LD, Maasho K, West D, Borrego F, Coligan JE. | 01/21/2010 |
| genetic disruption of the Qa-1-CD94/NKG2A interaction unleashes robust CD8 Treg cell activity that completely abolishes development of experimental allergic encephalomyelitis | Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease.
Lu L, Kim HJ, Werneck MB, Cantor H., Free PMC Article | 01/21/2010 |
| CD94/NKG2A transduces a biologically important signal in vivo to activated CD8+ T cells that limits immunopathology in severe influenza infection. | Cutting edge: engagement of NKG2A on CD8+ effector T cells limits immunopathology in influenza pneumonia.
Zhou J, Matsuoka M, Cantor H, Homer R, Enelow RI. | 01/21/2010 |
| results indicate that LTbetaR-mediated signals are not required for Ly49 and CD94/NKG2 receptor acquisition on NK cells | Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-beta receptor expression.
Stevenaert F, Van Beneden K, De Colvenaer V, Franki AS, Debacker V, Boterberg T, Deforce D, Pfeffer K, Plum J, Elewaut D, Leclercq G. | 01/21/2010 |
| the CD94/NKG2A inhibitory receptor plays a critical role in down-regulating invariant NK-cell responses | IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2.
Ota T, Takeda K, Akiba H, Hayakawa Y, Ogasawara K, Ikarashi Y, Miyake S, Wakasugi H, Yamamura T, Kronenberg M, Raulet DH, Kinoshita K, Yagita H, Smyth MJ, Okumura K., Free PMC Article | 01/21/2010 |
| Qa-1-NKG2A interaction protected activated CD4+ T cells from lysis by a subset of NKG2A+ natural-killer cells | Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway.
Lu L, Ikizawa K, Hu D, Werneck MB, Wucherpfennig KW, Cantor H., Free PMC Article | 01/21/2010 |
| Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation. | Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation.
Vance RE, Jamieson AM, Cado D, Raulet DH., Free PMC Article | 01/21/2010 |
| NKG2A-expressing anti-polyoma virus CD8 T cells appear to be essential for antigen-specific recall responses in mice persistently infected by polyoma virus. | CD94/NKG2A expression is associated with proliferative potential of CD8 T cells during persistent polyoma virus infection.
Byers AM, Andrews NP, Lukacher AE. | 01/21/2010 |