| Canonical Wnt signaling promotes HSC glycolysis and liver fibrosis through an LDH-A/HIF-1alpha transcriptional complex. | Canonical Wnt signaling promotes HSC glycolysis and liver fibrosis through an LDH-A/HIF-1α transcriptional complex.
Wang F, Chen L, Kong D, Zhang X, Xia S, Liang B, Li Y, Zhou Y, Zhang Z, Shao J, Zheng S, Zhang F., Free PMC Article | 03/1/2024 |
| Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease. | Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease.
Tian Q, Li J, Wu B, Wang J, Xiao Q, Tian N, Yi L, Luo M, Li Z, Pang Y, Shi X, Dong Z. | 11/10/2023 |
| STUB1 directs FOXQ1-mediated transactivation of Ldha gene and facilitates lactate production in mouse Sertoli cells. | STUB1 directs FOXQ1-mediated transactivation of Ldha gene and facilitates lactate production in mouse Sertoli cells.
Yang Y, Ma Y, Li M, Zhu H, Shi P, An R. | 08/25/2023 |
| Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer. | Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer.
Liu J, Zhang C, Zhang T, Chang CY, Wang J, Bazile L, Zhang L, Haffty BG, Hu W, Feng Z., Free PMC Article | 12/31/2022 |
| LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization. | LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization.
Chen Y, Wu G, Li M, Hesse M, Ma Y, Chen W, Huang H, Liu Y, Xu W, Tang Y, Zheng H, Li C, Lin Z, Chen G, Liao W, Liao Y, Bin J, Chen Y., Free PMC Article | 10/8/2022 |
| Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2. | Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2.
Feng T, Zhao X, Gu P, Yang W, Wang C, Guo Q, Long Q, Liu Q, Cheng Y, Li J, Cheung CKY, Wu D, Kong X, Xu Y, Ye D, Hua S, Loomes K, Xu A, Hui X., Free PMC Article | 09/24/2022 |
| Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development. | Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development.
Serra M, Di Matteo M, Serneels J, Pal R, Cafarello ST, Lanza M, Sanchez-Martin C, Evert M, Castegna A, Calvisi DF, Mazzone M, Columbano A., Free PMC Article | 09/3/2022 |
| Lactate dehydrogenase regulates basal glucose uptake in adipocytes. | Lactate dehydrogenase regulates basal glucose uptake in adipocytes.
Minemura T, Fukuhara A, Otsuki M, Shimomura I. | 05/7/2022 |
| Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function. | Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function.
Sheppard S, Santosa EK, Lau CM, Violante S, Giovanelli P, Kim H, Cross JR, Li MO, Sun JC., Free PMC Article | 02/12/2022 |
| Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH-A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR. | Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH-A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR.
Varma G, Seth P, Coutinho de Souza P, Callahan C, Pinto J, Vaidya M, Sonzogni O, Sukhatme V, Wulf GM, Grant AK., Free PMC Article | 01/22/2022 |
| p107 mediated mitochondrial function controls muscle stem cell proliferative fates. | p107 mediated mitochondrial function controls muscle stem cell proliferative fates.
Bhattacharya D, Shah V, Oresajo O, Scimè A., Free PMC Article | 11/6/2021 |
| Expression of lactate dehydrogenase A and B isoforms in the mouse kidney. | Expression of lactate dehydrogenase A and B isoforms in the mouse kidney.
Osis G, Traylor AM, Black LM, Spangler D, George JF, Zarjou A, Verlander JW, Agarwal A., Free PMC Article | 05/15/2021 |
| the LDHA protein level was remarkably decreased in Ldhc-deficient sperm, indicating that LDHC is required for LDHA expression in the sperm. | Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A.
Dodo M, Kitamura H, Shima H, Saigusa D, Wati SM, Ota N, Katsuoka F, Chiba H, Okae H, Arima T, Igarashi K, Koseki T, Sekine H, Motohashi H. | 03/30/2019 |
| LDH-A depletion inhibits the formation of metastases and prolongs survival through changes in mammary tumor microenvironment that modulate the immune response. We attribute these effects to diminished HIF-1a activity, vascularization, necrosis formation and immune suppression in immune competent animals. | LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response.
Serganova I, Cohen IJ, Vemuri K, Shindo M, Maeda M, Mane M, Moroz E, Khanin R, Satagopan J, Koutcher JA, Blasberg R., Free PMC Article | 03/9/2019 |
| The release of lactate dehydrogenase A (LDHA) from degenerating neurons drives central nervous system (CNS) angiogenesis. | Extracellular Lactate Dehydrogenase A Release From Damaged Neurons Drives Central Nervous System Angiogenesis.
Lin H, Muramatsu R, Maedera N, Tsunematsu H, Hamaguchi M, Koyama Y, Kuroda M, Ono K, Sawada M, Yamashita T., Free PMC Article | 08/18/2018 |
| Hair follicle stem cells maintain a metabolic state that allows them to remain dormant and yet quickly respond to appropriate proliferative stimuli mediated by LDH-A signaling. | Lactate dehydrogenase activity drives hair follicle stem cell activation.
Flores A, Schell J, Krall AS, Jelinek D, Miranda M, Grigorian M, Braas D, White AC, Zhou JL, Graham NA, Graeber T, Seth P, Evseenko D, Coller HA, Rutter J, Christofk HR, Lowry WE., Free PMC Article | 10/7/2017 |
| Results revealed that beta-arrestin-1 regulates lactate metabolism to contribute to beta2-adrenergic receptor functions in improved memory formation. | Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism.
Dong JH, Wang YJ, Cui M, Wang XJ, Zheng WS, Ma ML, Yang F, He DF, Hu QX, Zhang DL, Ning SL, Liu CH, Wang C, Wang Y, Li XY, Yi F, Lin A, Kahsai AW, Cahill TJ 3rd, Chen ZY, Yu X, Sun JP., Free PMC Article | 08/26/2017 |
| The authors identified lactate dehydrogenase (LDH) as a new functional target of AMPKalpha1. | AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis.
Theret M, Gsaier L, Schaffer B, Juban G, Ben Larbi S, Weiss-Gayet M, Bultot L, Collodet C, Foretz M, Desplanches D, Sanz P, Zang Z, Yang L, Vial G, Viollet B, Sakamoto K, Brunet A, Chazaud B, Mounier R., Free PMC Article | 07/15/2017 |
| LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and natural killer cells. | LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Brand A, Singer K, Koehl GE, Kolitzus M, Schoenhammer G, Thiel A, Matos C, Bruss C, Klobuch S, Peter K, Kastenberger M, Bogdan C, Schleicher U, Mackensen A, Ullrich E, Fichtner-Feigl S, Kesselring R, Mack M, Ritter U, Schmid M, Blank C, Dettmer K, Oefner PJ, Hoffmann P, Walenta S, Geissler EK, Pouyssegur J, Villunger A, Steven A, Seliger B, Schreml S, Haferkamp S, Kohl E, Karrer S, Berneburg M, Herr W, Mueller-Klieser W, Renner K, Kreutz M. | 07/1/2017 |
| lactate dehydrogenase A (LDHA) is induced in activated T cells to support aerobic glycolysis but promotes IFN-gamma expression independently of its 3'UTR. | Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism.
Peng M, Yin N, Chhangawala S, Xu K, Leslie CS, Li MO., Free PMC Article | 04/15/2017 |
| LDHA is a direct target of miR-34a in regulating glucose metabolism and tumor growth in breast cancer. | The miR-34a-LDHA axis regulates glucose metabolism and tumor growth in breast cancer.
Xiao X, Huang X, Ye F, Chen B, Song C, Wen J, Zhang Z, Zheng G, Tang H, Xie X., Free PMC Article | 12/24/2016 |
| Findings suggest that RANKL protein-induced lactate dehydrogenase (LDH) activation stimulates glycolytic and mitochondrial respiratory metabolism via transcription factor NFATc1 signaling. | Accelerated Lactate Dehydrogenase Activity Potentiates Osteoclastogenesis via NFATc1 Signaling.
Ahn H, Lee K, Kim JM, Kwon SH, Lee SH, Lee SY, Jeong D., Free PMC Article | 09/3/2016 |
| We propose a profibrotic feed forward loop, in which radiation induces LDHA expression and lactate production, which can lead to further activation of TGF-beta to drive the fibrotic process. | Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase.
Judge JL, Owens KM, Pollock SJ, Woeller CF, Thatcher TH, Williams JP, Phipps RP, Sime PJ, Kottmann RM., Free PMC Article | 04/23/2016 |
| High LDH-A expression is associated with metastases in breast tumors. | Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors.
Rizwan A, Serganova I, Khanin R, Karabeber H, Ni X, Thakur S, Zakian KL, Blasberg R, Koutcher JA., Free PMC Article | 09/6/2014 |
| PGC-1alpha reduces the expression of LDH A and one of its regulators, the transcription factor myelocytomatosis oncogene. | Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A.
Summermatter S, Santos G, Pérez-Schindler J, Handschin C., Free PMC Article | 08/10/2013 |