| Lactate dehydrogenase B regulates macrophage metabolism in the tumor microenvironment. | Lactate dehydrogenase B regulates macrophage metabolism in the tumor microenvironment.
Frank AC, Raue R, Fuhrmann DC, Sirait-Fischer E, Reuse C, Weigert A, Lütjohann D, Hiller K, Syed SN, Brüne B., Free PMC Article | 07/31/2021 |
| Expression of lactate dehydrogenase A and B isoforms in the mouse kidney. | Expression of lactate dehydrogenase A and B isoforms in the mouse kidney.
Osis G, Traylor AM, Black LM, Spangler D, George JF, Zarjou A, Verlander JW, Agarwal A., Free PMC Article | 05/15/2021 |
| these results identified a previously unrecognized Ldhb-driven alteration in muscle mitochondrial function and suggested a mechanism for the adaptive metabolic response induced by exercise training. | Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle.
Liang X, Liu L, Fu T, Zhou Q, Zhou D, Xiao L, Liu J, Kong Y, Xie H, Yi F, Lai L, Vega RB, Kelly DP, Smith SR, Gan Z., Free PMC Article | 05/27/2017 |
| Findings suggest that RANKL protein-induced lactate dehydrogenase (LDH) activation stimulates glycolytic and mitochondrial respiratory metabolism via transcription factor NFATc1 signaling. | Accelerated Lactate Dehydrogenase Activity Potentiates Osteoclastogenesis via NFATc1 Signaling.
Ahn H, Lee K, Kim JM, Kwon SH, Lee SH, Lee SY, Jeong D., Free PMC Article | 09/3/2016 |
| drs regulates glucose metabolism via LDH-B. Downregulating drs may contribute to the Warburg effect, which is closely associated with malignant progression of cancer cells. | The drs tumor suppressor regulates glucose metabolism via lactate dehydrogenase-B.
Tambe Y, Hasebe M, Kim CJ, Yamamoto A, Inoue H. | 05/28/2016 |
| Exercise-induced changes in tumour LDH-B and MCT1 expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice | Exercise-induced changes in tumour LDH-B and MCT1 expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice.
Aveseh M, Nikooie R, Aminaie M., Free PMC Article | 04/2/2016 |
| Data show that PI3K/Akt signalling pathway and lactate dehydrogenase (LDH) play a crucial role in increase of cardiac ATP-binding cassette transporter sub-family C member 9 (SUR2A) induced by in vivo exposure to 18% oxygen. | Mild hypoxia in vivo regulates cardioprotective SUR2A: A role for Akt and LDH.
Mohammed Abdul KS, Jovanović S, Du Q, Sukhodub A, Jovanović A., Free PMC Article | 10/3/2015 |
| PGC-1alpha in skeletal muscle drives the expression of lactate dehydrogenase (LDH) B in an estrogen-related receptor-alpha-dependent manner. | Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A.
Summermatter S, Santos G, Pérez-Schindler J, Handschin C., Free PMC Article | 08/10/2013 |
| the Ldhb gene, which encodes the H isoform of lactate dehydrogenase, as a robust PPARgamma target in trophoblasts. | Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.
Shalom-Barak T, Zhang X, Chu T, Timothy Schaiff W, Reddy JK, Xu J, Sadovsky Y, Barak Y., Free PMC Article | 03/2/2013 |
| findings offer proof of concept for targeting LDHB as a therapeutic strategy in cancers driven by aberrant activation of the RTK-PI3K-AKT-mTOR signaling cascade | Lactate dehydrogenase B is critical for hyperactive mTOR-mediated tumorigenesis.
Zha X, Wang F, Wang Y, He S, Jing Y, Wu X, Zhang H. | 02/5/2011 |
| The increased LDH-A/LDH-B ratio causes high brain lactate levels, which, in turn, are predictive of aging phenotypes. | High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio.
Ross JM, Öberg J, Brené S, Coppotelli G, Terzioglu M, Pernold K, Goiny M, Sitnikov R, Kehr J, Trifunovic A, Larsson NG, Hoffer BJ, Olson L., Free PMC Article | 01/1/2011 |
| Studies suggest that the expression of the ldh2 gene in spermatogonia and early spermatocytes are regulated by SP-mediated transcriptional mechanisms. | Molecular and functional characterization of the murine ldh2 promoter region: Sp-binding GC-box domains are the key cis-elements regulating ldh2 gene expression during spermatogenesis.
Chen X, Yang J, Sung DY, Thompson W, Walker W, Thomas K. | 01/21/2010 |
| beta-agonists increased serum LDH levels, but it was not due to release from the heart. | Beta-agonists enhance the lactic dehydrogenase (LDH) expression in serum and ventricular myocytes of mice.
Kaundal M, Katoch SS, Sharma S. | 01/21/2010 |