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    Lmnb1 lamin B1 [ Mus musculus (house mouse) ]

    Gene ID: 16906, updated on 26-Jul-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Development and Optimization of a High-Content Analysis Platform to Identify Suppressors of Lamin B1 Overexpression as a Therapeutic Strategy for Autosomal Dominant Leukodystrophy.

    Development and Optimization of a High-Content Analysis Platform to Identify Suppressors of Lamin B1 Overexpression as a Therapeutic Strategy for Autosomal Dominant Leukodystrophy.
    Nmezi B, Vollmer LL, Shun TY, Gough A, Rolyan H, Liu F, Jia Y, Padiath QS, Vogt A., Free PMC Article

    07/24/2021
    Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity.

    Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity.
    Bin Imtiaz MK, Jaeger BN, Bottes S, Machado RAC, Vidmar M, Moore DL, Jessberger S.

    05/22/2021
    ROS/p38MAPK-induced lamin B1 accumulation promotes chronic kidney disease-associated vascular smooth muscle cells senescence.

    ROS/p38MAPK-induced lamin B1 accumulation promotes chronic kidney disease-associated vascular smooth muscle cells senescence.
    Wang X, Bi X, Yang K, Huang Y, Liu Y, Zhao J.

    03/13/2021
    Dynamic Lamin B1-Gene Association During Oligodendrocyte Progenitor Differentiation.

    Dynamic Lamin B1-Gene Association During Oligodendrocyte Progenitor Differentiation.
    Yattah C, Hernandez M, Huang D, Park H, Liao W, Casaccia P., Free PMC Article

    12/26/2020
    An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death.

    An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death.
    Chen NY, Yang Y, Weston TA, Belling JN, Heizer P, Tu Y, Kim P, Edillo L, Jonas SJ, Weiss PS, Fong LG, Young SG., Free PMC Article

    04/4/2020
    The results indicate that finely tuned levels of Lmnb1 are required for neural stem cells differentiation into neurons, proper expression of the astrocytic marker GFAP and corticogenesis.

    Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis.
    Mahajani S, Giacomini C, Marinaro F, De Pietri Tonelli D, Contestabile A, Gasparini L., Free PMC Article

    01/12/2019
    By using targeted knockout in olfactory epithelial stem cells in adult mice, we show that lamin B1 deficient neurons exhibit attenuated response to odour stimulation. This deficit can be explained by decreased expression of genes involved in mature neuron function, along with increased expression of genes atypical of the olfactory lineage.

    Lamin B1 is required for mature neuron-specific gene expression during olfactory sensory neuron differentiation.
    Gigante CM, Dibattista M, Dong FN, Zheng X, Yue S, Young SG, Reisert J, Zheng Y, Zhao H., Free PMC Article

    12/22/2018
    The parts of chromatin interact with nuclear lamina proteins like Lamin B1 and, therefore, can be identified in a given cell type by chromatin profiling of these proteins.

    An Inducible DamID System for Profiling Interactions of Nuclear Lamina Protein Component Lamin B1 with Chromosomes in Mouse Cells.
    Kozhevnikova EN, Leshchenko AE, Pindyurin AV.

    06/16/2018
    While the distribution patterns of both lamins closely paralleled the respective stages of mitosis, Nup160 localization in metaphase oocytes corresponded to that in mitotic prometaphase rather than metaphase.

    Dynamics of Lamins B and A/C and Nucleoporin Nup160 during Meiotic Maturation in Mouse Oocytes.
    Nikolova V, Delimitreva S, Chakarova I, Zhivkova R, Hadzhinesheva V, Markova M.

    07/22/2017
    Here we report that in primary mouse cortical neurons, LMNB1 overexpression reduces axonal outgrowth, whereas deficiency of endogenous Lmnb1 results in aberrant dendritic development.

    Lamin B1 protein is required for dendrite development in primary mouse cortical neurons.
    Giacomini C, Mahajani S, Ruffilli R, Marotta R, Gasparini L., Free PMC Article

    11/5/2016
    Analysis of lamin B1 expression in different regions of the brain in wild-type animals showed that the level of Lmnb1 transcript decreased significantly in an age-dependent manner.

    Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior.
    Baek JH, Schmidt E, Viceconte N, Strandgren C, Pernold K, Richard TJ, Van Leeuwen FW, Dantuma NP, Damberg P, Hultenby K, Ulfhake B, Mugnaini E, Rozell B, Eriksson M., Free PMC Article

    11/21/2015
    Data show that lamins B1 and B2 have unique functions and that increased production of one B-type lamin cannot compensate for the loss of the other.

    Do lamin B1 and lamin B2 have redundant functions?
    Lee JM, Jung HJ, Fong LG, Young SG., Free PMC Article

    09/26/2015
    lamins B1 and B2 have unique roles in the developing brain and increased production of one B-type lamin does not fully complement loss of the other.

    Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2.
    Lee JM, Tu Y, Tatar A, Wu D, Nobumori C, Jung HJ, Yoshinaga Y, Coffinier C, de Jong PJ, Fong LG, Young SG., Free PMC Article

    01/17/2015
    Lamin-B1 is required for organization of lamin-A/C and lamin-B2 in mouse embryonic stem cells and Lamin-B1 is required for organization of lamin-A/C and lamin-B2 in differentiated cells

    Concentration-dependent lamin assembly and its roles in the localization of other nuclear proteins.
    Guo Y, Kim Y, Shimi T, Goldman RD, Zheng Y., Free PMC Article

    01/17/2015
    farnesylation of lamin B1--but not lamin B2--is crucial for brain development and for retaining chromatin within the bounds of the nuclear lamina during neuronal migration.

    Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration.
    Jung HJ, Nobumori C, Goulbourne CN, Tu Y, Lee JM, Tatar A, Wu D, Yoshinaga Y, de Jong PJ, Coffinier C, Fong LG, Young SG., Free PMC Article

    08/10/2013
    lamin B1 overexpression mediates oligodendrocyte cell-autonomous neuropathology in adult-onset autosomal-dominant leukodystrophy.

    Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model.
    Heng MY, Lin ST, Verret L, Huang Y, Kamiya S, Padiath QS, Tong Y, Palop JJ, Huang EJ, Ptáček LJ, Fu YH., Free PMC Article

    08/3/2013
    We conclude that lamin B1 is a modifier gene of major effect for Neural tube defects resulting from loss of Grhl3 function

    Lamin b1 polymorphism influences morphology of the nuclear envelope, cell cycle progression, and risk of neural tube defects in mice.
    De Castro SC, Malhas A, Leung KY, Gustavsson P, Vaux DJ, Copp AJ, Greene ND., Free PMC Article

    05/18/2013
    Lamin B1 is lost from primary human and murine cell strains when they are induced to senesce.

    Lamin B1 loss is a senescence-associated biomarker.
    Freund A, Laberge RM, Demaria M, Campisi J., Free PMC Article

    09/29/2012
    Lamin B1 is essential for brain development and is required for the integrity of the nuclear lamina.

    Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons.
    Coffinier C, Jung HJ, Nobumori C, Chang S, Tu Y, Barnes RH 2nd, Yoshinaga Y, de Jong PJ, Vergnes L, Reue K, Fong LG, Young SG., Free PMC Article

    04/14/2012
    study found that embryonic stem cells do not need any lamins for self-renewal and pluripotency; however, B-type lamins are required for proper organogenesis

    Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells.
    Kim Y, Sharov AA, McDole K, Cheng M, Hao H, Fan CM, Gaiano N, Ko MS, Zheng Y., Free PMC Article

    01/28/2012
    Absence of both Lmnb1 and Lmnb2 in keratinocytes has no effect on cell proliferation or the development of skin and hair.

    An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair.
    Yang SH, Chang SY, Yin L, Tu Y, Hu Y, Yoshinaga Y, de Jong PJ, Fong LG, Young SG., Free PMC Article

    01/21/2012
    lamin B1 and miR-23 have roles in the regulation of oligodendroglia development and myelin formation

    miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination.
    Lin ST, Fu YH., Free PMC Article

    01/21/2010
    PLCbeta1 colocalizes and physically interacts with lamin B1.

    Involvement of nuclear PLCbeta1 in lamin B1 phosphorylation and G2/M cell cycle progression.
    Fiume R, Ramazzotti G, Teti G, Chiarini F, Faenza I, Mazzotti G, Billi AM, Cocco L.

    01/21/2010
    Sequestration of Oct-1 at the nuclear periphery by lamin B1 may be a mechanism by which the nuclear envelope can regulate gene expression and contribute to the cellular response to stress, development, and aging.

    Lamin B1 controls oxidative stress responses via Oct-1.
    Malhas AN, Lee CF, Vaux DJ., Free PMC Article

    01/21/2010
    lamin A/C, lamin B1, and viral US3 kinase have roles in viral infectivity, virion egress, and the targeting of herpes simplex virus U(L)34-encoded protein to the inner nuclear membrane

    Effects of lamin A/C, lamin B1, and viral US3 kinase activity on viral infectivity, virion egress, and the targeting of herpes simplex virus U(L)34-encoded protein to the inner nuclear membrane.
    Mou F, Wills EG, Park R, Baines JD., Free PMC Article

    01/21/2010
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